公开(公告)号：US09155843B2

公开(公告)日：2015-10-13

申请号：US13559454

申请日：2012-07-26

申请人： James H. Brauker ,  Mark A. Tapsak ,  Sean T. Saint ,  Apurv Ullas Kamath ,  Paul V. Neale ,  Peter C. Simpson ,  Michael Robert Mensinger ,  Dubravka Markovic

发明人： James H. Brauker ,  Mark A. Tapsak ,  Sean T. Saint ,  Apurv Ullas Kamath ,  Paul V. Neale ,  Peter C. Simpson ,  Michael Robert Mensinger ,  Dubravka Markovic

IPC分类号： A61M31/00 ,  A61M1/00 ,  A61M5/315 ,  A61B5/00 ,  A61B5/145 ,  G06F19/00 ,  A61M5/172 ,  A61B5/1486

CPC分类号： A61M5/31525 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/4839 ,  A61B2560/0443 ,  A61M5/1723 ,  A61M11/00 ,  A61M15/0001 ,  A61M2005/1726 ,  A61M2205/18 ,  A61M2205/3303 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2230/201 ,  G06F19/00 ,  G06F19/3468 ,  G16H20/17 ,  G16H40/63

摘要： Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction.

公开(公告)号：US09050413B2

公开(公告)日：2015-06-09

申请号：US13460365

申请日：2012-04-30

申请人： James H. Brauker ,  Mark A. Tapsak ,  Sean T. Saint ,  Apurv Ullas Kamath ,  Paul V. Neale ,  Peter C. Simpson ,  Michael Robert Mensinger ,  Dubravka Markovic

发明人： James H. Brauker ,  Mark A. Tapsak ,  Sean T. Saint ,  Apurv Ullas Kamath ,  Paul V. Neale ,  Peter C. Simpson ,  Michael Robert Mensinger ,  Dubravka Markovic

IPC分类号： A61M5/315 ,  A61B5/00 ,  A61B5/145 ,  G06F19/00 ,  A61B5/1486

CPC分类号： A61M5/31525 ,  A61B5/0002 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/4839 ,  A61B2560/0443 ,  A61M5/1723 ,  A61M11/00 ,  A61M15/0001 ,  A61M2005/1726 ,  A61M2205/18 ,  A61M2205/3303 ,  A61M2205/502 ,  A61M2205/52 ,  A61M2230/201 ,  G06F19/00 ,  G06F19/3468 ,  G16H20/17 ,  G16H40/63

摘要： Systems and methods for integrating a continuous glucose sensor, including a receiver, a medicament delivery device, and optionally a single point glucose monitor are provided. Manual integrations provide for a physical association between the devices wherein a user (for example, patient or doctor) manually selects the amount, type, and/or time of delivery. Semi-automated integration of the devices includes integrations wherein an operable connection between the integrated components aids the user (for example, patient or doctor) in selecting, inputting, calculating, or validating the amount, type, or time of medicament delivery of glucose values, for example, by transmitting data to another component and thereby reducing the amount of user input required. Automated integration between the devices includes integrations wherein an operable connection between the integrated components provides for full control of the system without required user interaction.

公开(公告)号：US07896809B2

公开(公告)日：2011-03-01

申请号：US12264160

申请日：2008-11-03

申请人： Peter C. Simpson ,  James H. Brauker ,  Paul V. Goode ,  Apurv Ullas Kamath ,  James R. Petisce ,  Kum Ming Woo ,  Melissa A. Nicholas ,  Robert J. Boock ,  Monica A. Rixman ,  John Burd ,  Rathburn K. Rhodes ,  Mark A. Tapsak

发明人： Peter C. Simpson ,  James H. Brauker ,  Paul V. Goode ,  Apurv Ullas Kamath ,  James R. Petisce ,  Kum Ming Woo ,  Melissa A. Nicholas ,  Robert J. Boock ,  Monica A. Rixman ,  John Burd ,  Rathburn K. Rhodes ,  Mark A. Tapsak

IPC分类号： A61B5/05

CPC分类号： A61B5/1495 ,  A61B5/14532 ,  A61B5/14865 ,  B33Y70/00

摘要： Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure analyte or non-analyte related signal, both of which electrode include an interference domain.

摘要翻译： 本文公开了用于连续分析物传感器（例如连续葡萄糖传感器）的系统和方法。 一个这样的系统利用第一和第二工作电极来测量分析物或非分析物相关的信号，这两个电极都包括干涉域。

公开(公告)号：US08282550B2

公开(公告)日：2012-10-09

申请号：US12182008

申请日：2008-07-29

申请人： Andrew P. Rasdal ,  James H. Brauker ,  Paul V. Neale ,  Peter C. Simpson ,  Apurv Ullas Kamath ,  Paul V. Goode

发明人： Andrew P. Rasdal ,  James H. Brauker ,  Paul V. Neale ,  Peter C. Simpson ,  Apurv Ullas Kamath ,  Paul V. Goode

IPC分类号： A61B5/00

CPC分类号： A61B5/1495 ,  A61B5/076 ,  A61B5/14532 ,  A61B5/14865 ,  A61B5/7203 ,  A61B2560/0456 ,  A61B2562/247

摘要： A system is provided for monitoring glucose in a host, including a continuous glucose sensor that produces a data stream indicative of a host's glucose concentration and an integrated receiver that receives the data stream from the continuous glucose sensor and calibrates the data stream using a single point glucose monitor that is integral with the integrated receiver. The integrated receiver obtains a glucose value from the single point glucose monitor, calibrates the sensor data stream received from the continuous glucose sensor, and displays one or both of the single point glucose measurement values and the calibrated continuous glucose sensor values on the user interface.

摘要翻译： 提供一种用于监测主机中的葡萄糖的系统，包括产生指示宿主葡萄糖浓度的数据流的连续葡萄糖传感器和从连续葡萄糖传感器接收数据流并使用单点校准数据流的集成接收器 与集成接收器集成的葡萄糖监测器。 集成接收器从单点葡萄糖监测器获得葡萄糖值，校准从连续葡萄糖传感器接收的传感器数据流，并在用户界面上显示单点葡萄糖测量值和校准的连续葡萄糖传感器值中的一个或两个。

公开(公告)号：US09498155B2

公开(公告)日：2016-11-22

申请号：US12253125

申请日：2008-10-16

申请人： James H. Brauker ,  Victoria E. Carr-Brendel ,  Paul V. Goode ,  Apurv Ullas Kamath ,  James P. Thrower ,  Ben Xavier ,  Peter C. Simpson ,  Mark A. Tapsak

发明人： James H. Brauker ,  Victoria E. Carr-Brendel ,  Paul V. Goode ,  Apurv Ullas Kamath ,  James P. Thrower ,  Ben Xavier ,  Peter C. Simpson ,  Mark A. Tapsak

IPC分类号： A61B5/05 ,  A61B5/145 ,  A61B5/1468 ,  A61B5/1486 ,  A61B5/1495 ,  A61B5/00

CPC分类号： A61B5/14532 ,  A61B5/145 ,  A61B5/14503 ,  A61B5/1451 ,  A61B5/1468 ,  A61B5/1473 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/1495 ,  A61B5/7257 ,  A61B5/726 ,  A61B5/7264 ,  A61B5/7275 ,  A61B5/742 ,  A61B5/7455 ,  A61B5/746 ,  A61B5/7475 ,  A61M5/1723 ,  G06F19/00 ,  Y02A90/22 ,  Y02A90/26

摘要： Systems and methods for dynamically and intelligently estimating analyte data from a continuous analyte sensor, including receiving a data stream, selecting one of a plurality of algorithms, and employing the selected algorithm to estimate analyte values. Additional data processing includes evaluating the selected estimative algorithms, analyzing a variation of the estimated analyte values based on statistical, clinical, or physiological parameters, comparing the estimated analyte values with corresponding measure analyte values, and providing output to a user. Estimation can be used to compensate for time lag, match sensor data with corresponding reference data, warn of upcoming clinical risk, replace erroneous sensor data signals, and provide more timely analyte information encourage proactive behavior and preempt clinical risk.

公开(公告)号：US20100198036A1

公开(公告)日：2010-08-05

申请号：US12760432

申请日：2010-04-14

申请人： Apurv Ullas Kamath ,  Peter C. Simpson ,  James H. Brauker ,  Paul V. Goode, JR. ,  Mark Brister ,  Paul V. Neale ,  Sean Saint

发明人： Apurv Ullas Kamath ,  Peter C. Simpson ,  James H. Brauker ,  Paul V. Goode, JR. ,  Mark Brister ,  Paul V. Neale ,  Sean Saint

IPC分类号： A61B5/145 ,  G06F19/00

CPC分类号： A61B5/14865 ,  A61B5/14532 ,  A61B5/1495 ,  A61B5/7203 ,  A61B5/742 ,  A61B2560/0223 ,  B33Y70/00 ,  B33Y80/00

摘要： Disclosed herein are systems and methods for calibrating a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes one or more electrodes to measure an additional analyte. Such measurements may provide a baseline or sensitivity measurement for use in calibrating the sensor. Furthermore, baseline and/or sensitivity measurements may be used to trigger events such as digital filtering of data or suspending display of data.

摘要翻译： 本文公开了用于校准连续分析物传感器（例如连续葡萄糖传感器）的系统和方法。 一个这样的系统利用一个或多个电极来测量另外的分析物。 这样的测量可以提供用于校准传感器的基线或灵敏度测量。 此外，可以使用基线和/或灵敏度测量来触发诸如数字数字滤波或暂停显示数据的事件。

公开(公告)号：US20100198035A1

公开(公告)日：2010-08-05

申请号：US12760358

申请日：2010-04-14

申请人： Apurv Ullas Kamath ,  Peter C. Simpson ,  James H. Brauker ,  Paul V. Goode, JR. ,  Mark Brister ,  Paul V. Neale ,  Sean Saint

发明人： Apurv Ullas Kamath ,  Peter C. Simpson ,  James H. Brauker ,  Paul V. Goode, JR. ,  Mark Brister ,  Paul V. Neale ,  Sean Saint

IPC分类号： A61B5/145

CPC分类号： A61B5/14865 ,  A61B5/14532 ,  A61B5/1495 ,  A61B5/7203 ,  A61B5/742 ,  A61B2560/0223 ,  B33Y70/00 ,  B33Y80/00

摘要： Disclosed herein are systems and methods for calibrating a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes one or more electrodes to measure an additional analyte. Such measurements may provide a baseline or sensitivity measurement for use in calibrating the sensor. Furthermore, baseline and/or sensitivity measurements may be used to trigger events such as digital filtering of data or suspending display of data.

公开(公告)号：US20120078071A1

公开(公告)日：2012-03-29

申请号：US13247856

申请日：2011-09-28

申请人： Sebastian Bohm ,  Mark Dervaes ,  Eric Johnson ,  Apurv Ullas Kamath ,  Shawn Larvenz ,  Jacob S. Leach ,  Phong Lieu ,  Aarthi Mahalingam ,  Tom Miller ,  Paul V. Neale ,  Jack Pryor ,  Thomas A. Peyser ,  Daiting Rong ,  Kenneth San Vicente ,  Mohammad Ali Shariati ,  Peter C. Simpson ,  Matthew Wightlin

发明人： Sebastian Bohm ,  Mark Dervaes ,  Eric Johnson ,  Apurv Ullas Kamath ,  Shawn Larvenz ,  Jacob S. Leach ,  Phong Lieu ,  Aarthi Mahalingam ,  Tom Miller ,  Paul V. Neale ,  Jack Pryor ,  Thomas A. Peyser ,  Daiting Rong ,  Kenneth San Vicente ,  Mohammad Ali Shariati ,  Peter C. Simpson ,  Matthew Wightlin

IPC分类号： A61B5/145

CPC分类号： A61B5/14532 ,  A61B5/14507 ,  A61B5/1451 ,  A61B2560/0209 ,  A61B2560/0214 ,  A61B2562/02 ,  G06F1/3203

摘要： Systems and methods for processing, transmitting, and displaying data received from a continuous analyte (e.g., glucose) sensor are provided. A sensor system can comprise a sensor electronics module that includes power saving features, e.g., a low power measurement circuit that can be switched between a measurement mode and a low power mode, wherein charging circuitry continues to apply power to electrodes of a sensor during the low power mode. The sensor electronics module can be switched between a low power storage mode and a higher power operational mode via a switch, e.g., a reed switch or optical switch. A validation routine can be implemented to ensure an interrupt signal sent from the switch is valid. The sensor can be physically connected to the sensor electronics module in direct wireless communication with a plurality of different display devices.

摘要翻译： 提供了用于处理，传输和显示从连续分析物（例如，葡萄糖）传感器接收的数据的系统和方法。 传感器系统可以包括传感器电子模块，其包括省电功能，例如可以在测量模式和低功率模式之间切换的低功率测量电路，其中充电电路在该期间继续向传感器的电极施加功率 低功耗模式。 传感器电子模块可以通过诸如簧片开关或光开关的开关在低功率存储模式和较高功率操作模式之间切换。 可以实现验证程序，以确保从交换机发送的中断信号有效。 传感器可以与多个不同的显示设备直接无线通信，物理地连接到传感器电子模块。

公开(公告)号：US10349871B2

公开(公告)日：2019-07-16

申请号：US13566678

申请日：2012-08-03

申请人： Phil Mayou ,  Hari Hampapuram ,  David Price ,  Keri Weindel ,  Kostyantyn Snisarenko ,  Michael Robert Mensinger ,  Leif N. Bowman ,  Robert J. Boock ,  Apurv Ullas Kamath ,  Eli Reihman ,  Peter C. Simpson

发明人： Phil Mayou ,  Hari Hampapuram ,  David Price ,  Keri Weindel ,  Kostyantyn Snisarenko ,  Michael Robert Mensinger ,  Leif N. Bowman ,  Robert J. Boock ,  Apurv Ullas Kamath ,  Eli Reihman ,  Peter C. Simpson

IPC分类号： G01N33/48 ,  A61B5/145 ,  G16H50/70 ,  G16H50/20 ,  G16H15/00

摘要： Systems and methods for detecting and reporting patterns in analyte concentration data are provided. According to some implementations, an implantable device for continuous measurement of an analyte concentration is disclosed. The implantable device includes a sensor configured to generate a signal indicative of a concentration of an analyte in a host, a memory configured to store data corresponding at least one of the generated signal and user information, a processor configured to receive data from at least one of the memory and the sensor, wherein the processor is configured to generate pattern data based on the received information, and an output module configured to output the generated pattern data. The pattern data can be based on detecting frequency and severity of analyte data in clinically risky ranges.

公开(公告)号：US20130035865A1

公开(公告)日：2013-02-07

申请号：US13566874

申请日：2012-08-03

申请人： Phil Mayou ,  Hari Hampapuram ,  David Price ,  Keri Weindel ,  Kostyantyn Snisarenko ,  Michael Robert Mensinger ,  Leif N. Bowman ,  Robert J. Boock ,  Apurv Ullas Kamath ,  Eli Reihman ,  Peter C. Simpson

发明人： Phil Mayou ,  Hari Hampapuram ,  David Price ,  Keri Weindel ,  Kostyantyn Snisarenko ,  Michael Robert Mensinger ,  Leif N. Bowman ,  Robert J. Boock ,  Apurv Ullas Kamath ,  Eli Reihman ,  Peter C. Simpson

IPC分类号： G06F19/00

CPC分类号： A61B5/14532 ,  G16H15/00 ,  G16H50/20 ,  G16H50/70 ,  Y02A90/26

摘要： Systems and methods for detecting and reporting patterns in analyte concentration data are provided. According to some implementations, an implantable device for continuous measurement of an analyte concentration is disclosed. The implantable device includes a sensor configured to generate a signal indicative of a concentration of an analyte in a host, a memory configured to store data corresponding at least one of the generated signal and user information, a processor configured to receive data from at least one of the memory and the sensor, wherein the processor is configured to generate pattern data based on the received information, and an output module configured to output the generated pattern data. The pattern data can be based on detecting frequency and severity of analyte data in clinically risky ranges.

摘要翻译： 提供了用于检测和报告分析物浓度数据模式的系统和方法。 根据一些实施方式，公开了用于连续测量分析物浓度的可植入装置。 可植入装置包括被配置为产生指示主体中的分析物的浓度的信号的传感器，被配置为存储对应于所生成的信号和用户信息中的至少一个的数据的存储器，被配置为从至少一个 所述处理器被配置为基于所接收的信息来生成模式数据，以及输出模块，被配置为输出生成的模式数据。 模式数据可以基于检测临床危险范围内分析物数据的频率和严重程度。