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公开(公告)号:US20070122881A1
公开(公告)日:2007-05-31
申请号:US11580095
申请日:2006-10-11
申请人: Mark Surber
发明人: Mark Surber
CPC分类号: C07K16/00 , C12N15/00 , C12N15/1037 , C12N15/70 , C12N15/74 , C12P21/02 , C40B40/02 , G01N33/5005 , G01N33/543 , G01N33/5432 , G01N33/60 , Y02A90/26
摘要: Rhamnose-inducible expression constructs are described. The expression constructs may be either episomal or chromosomal and may include at least one rhamnose-inducible regulatory element expressing a regulatory protein and at least one promoter that is inducible by the regulatory protein. An open reading frame expressing a protein of interest may be placed under control of the promoter. Also described are optimized Shine-Dalgarno sequences for use with the promoter.
摘要翻译: 描述了鼠李糖诱导型表达构建体。 表达构建体可以是附加型或染色体的,并且可以包括至少一种表达调节蛋白的鼠李糖诱导型调节元件和至少一种可被调节蛋白诱导的启动子。 表达目的蛋白质的开放阅读框可以置于启动子的控制之下。 还描述了与启动子一起使用的优化的亮 - 达加尔诺序列。
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公开(公告)号:US07396822B2
公开(公告)日:2008-07-08
申请号:US10832000
申请日:2004-04-26
申请人: Roger A. Sabbadini , Neil Berkley , Mark Surber
发明人: Roger A. Sabbadini , Neil Berkley , Mark Surber
CPC分类号: C12N15/00 , A61K39/12 , A61K47/6901 , A61K48/0025 , A61K2039/53 , C12N15/1037 , C12N15/74 , C12N15/88 , C12P21/02 , C40B40/02 , G01N33/5005 , G01N33/543 , G01N33/5432 , G01N33/60 , Y02A50/466
摘要: The disclosed invention relates to immunogenic minicells cells (anucleated) and their use to induce an immune response from a subject.
摘要翻译: 所公开的发明涉及免疫原性小细胞细胞(未成核细胞)及其从受试者诱导免疫应答的用途。
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公开(公告)号:US08129166B2
公开(公告)日:2012-03-06
申请号:US12133308
申请日:2008-06-04
申请人: Roger A. Sabbadini , Neil Berkley , Mark Surber
发明人: Roger A. Sabbadini , Neil Berkley , Mark Surber
CPC分类号: C12N15/00 , A61K39/12 , A61K47/6901 , A61K48/0025 , A61K2039/53 , C12N15/1037 , C12N15/74 , C12N15/88 , C12P21/02 , C40B40/02 , G01N33/5005 , G01N33/543 , G01N33/5432 , G01N33/60 , Y02A50/466
摘要: The disclosed invention relates to immunogenic minicells cells (anucleated) and their use to induce an immune response from a subject.
摘要翻译: 所公开的发明涉及免疫原性小细胞细胞(未成核细胞)及其从受试者诱导免疫应答的用途。
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公开(公告)号:US20060002956A1
公开(公告)日:2006-01-05
申请号:US11096646
申请日:2005-04-01
申请人: Mark Surber , Roger Sabbadini , Neil Berkley
发明人: Mark Surber , Roger Sabbadini , Neil Berkley
CPC分类号: C12N15/74 , A61K39/02 , A61K2039/522 , Y02A50/386 , Y02A50/397 , Y02A50/469 , Y02A50/47 , Y02A50/478
摘要: The disclosed invention relates to immunogenic minicells cells (anucleated) and their use to induce an immune response from a subject.
摘要翻译: 所公开的发明涉及免疫原性小细胞细胞(未成核细胞)及其从受试者诱导免疫应答的用途。
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