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    Pulmonary Pharmaceutical Formulations
    11.
    发明申请
    Pulmonary Pharmaceutical Formulations 有权
    肺制剂

    公开(公告)号：US20090105201A1

    公开(公告)日：2009-04-23

    申请号：US12195878

    申请日：2008-08-21

    Applicant: Charles D. Blizzard ,  Michael M. Lipp ,  Kevin L. Ward ,  Rachel Ryznal ,  Daniel Leblanc ,  Mark Tracy ,  Rebbeca Martin

    Inventor： Charles D. Blizzard ,  Michael M. Lipp ,  Kevin L. Ward ,  Rachel Ryznal ,  Daniel Leblanc ,  Mark Tracy ,  Rebbeca Martin

    IPC: A61K31/58 ,  A61P11/06

    CPC classification number: A61K31/58 ,  A61K9/0075 ,  A61K9/1617 ,  A61K9/1623 ,  A61K31/13 ,  A61K38/29 ,  A61K45/06 ,  A61K47/36

    Abstract: The present invention provides improved pharmaceutical formulations for pulmonary delivery having improved chemical and physical stability of the therapeutic, prophylactic or diagnostic agent as compared to formulations known in the art. The improved pharmaceutical formulations of the invention for administration to the respiratory system of a patient for the treatment of a variety of disease conditions comprise a mass of biocompatible particles comprising an active agent, and a hydrogenated starch hydrosylate (HSH). The improvement over the prior art comprises the presence of HSH in the pharmaceutical formulation. The invention further relates to a method of treating diseases comprising administering the pharmaceutical formulations of the present invention to the respiratory system of a patient in need of treatment.

    Abstract translation: 与本领域已知的制剂相比，本发明提供了用于肺部输送的改进的药物制剂，其具有改善的治疗性，预防性或诊断剂的化学和物理稳定性。 用于给患者呼吸系统施用的用于治疗各种疾病状况的本发明改进的药物制剂包含大量包含活性剂和氢化淀粉氢化物（HSH）的生物相容性颗粒。 相对于现有技术的改进包括在药物制剂中存在HSH。 本发明还涉及治疗疾病的方法，包括将本发明的药物制剂施用于需要治疗的患者的呼吸系统。

    Computer display biasing mechanism
    13.
    发明申请
    Computer display biasing mechanism 审中-公开
    计算机显示偏置机构

    公开(公告)号：US20070097613A1

    公开(公告)日：2007-05-03

    申请号：US11261288

    申请日：2005-10-27

    Applicant: Mark Tracy ,  Walter Rankins ,  Paul Doczy

    Inventor： Mark Tracy ,  Walter Rankins ,  Paul Doczy

    IPC: G06F1/16

    CPC classification number: G06F1/1681 ,  G06F1/1616 ,  G06F1/1679

    Abstract: A computer device comprises a display member coupled to a base member by at least one friction clutch hinge. The computer device also comprises a biasing mechanism spaced apart from the at least one friction clutch hinge and adapted to bias the display member away from the base member.

    Abstract translation: 计算机设备包括通过至少一个摩擦离合器铰链联接到基座构件的显示构件。 计算机设备还包括偏置机构，该偏压机构与至少一个摩擦离合器铰链间隔开并且适于将显示构件偏压离开基座构件。

    Computer device display protector
    14.
    发明申请
    Computer device display protector 有权
    计算机设备显示保护

    公开(公告)号：US20060285284A1

    公开(公告)日：2006-12-21

    申请号：US11155084

    申请日：2005-06-17

    Applicant: Mark Tracy ,  Paul Doczy

    Inventor： Mark Tracy ,  Paul Doczy

    IPC: G06F1/16

    CPC classification number: G06F1/1616 ,  G06F1/1637 ,  G06F1/1679

    Abstract: A computer device comprises a display member coupled to a base member. The computer device further comprises a display protector actuatable in response to movement of the display member relative to the base member to protect a display screen of the display member.

    Abstract translation: 计算机设备包括耦合到基座构件的显示构件。 计算机设备还包括可响应于显示构件相对于基座构件的移动而可启动的显示保护器，以保护显示构件的显示屏。

    METHODS AND COMPOSITIONS FOR THE TARGETED DELIVERY OF BIOLOGICALLY ACTIVE AGENTS
    15.
    发明申请
    METHODS AND COMPOSITIONS FOR THE TARGETED DELIVERY OF BIOLOGICALLY ACTIVE AGENTS 失效
    用于有针对性地提供生物活性剂的方法和组合物

    公开(公告)号：US20060141041A1

    公开(公告)日：2006-06-29

    申请号：US10342448

    申请日：2003-01-14

    Applicant: Mark Tracy ,  David Scher

    Inventor： Mark Tracy ,  David Scher

    IPC: A61K38/21 ,  A61K38/20 ,  A61K38/19 ,  A61K9/14

    CPC classification number: A61K9/1647 ,  Y02A50/411 ,  Y02A50/423

    Abstract: The present invention relates to a sustained release composition for the targeted delivery of biologically active agents to specific tissues and cells. The composition comprises microparticles containing a biocompatible polymer, a water-soluble polymer and a biologically active agent. In one embodiment, the biologically active agent is an antigen or an immunomodulator. In another embodiment, the biologically is a labile agent. The microparticles have a number median diameter of greater than 20 microns upon administration. The water-soluble polymer is present in the sustained released composition in at least about 20% of the dry weight of the microparticle. the sustained release composition provides for the dissolution of the water-soluble polymer of the composition upon hydration, at a much greater rate than the degradation of the biocompatible polymer. This variance is solubility generates pseudo-microparticles which have a number median diameter which is substantially smaller than the size of the administered microparticles. The pseudo-microparticles can be engulfed by antigen presenting cells of the immune system, or absorbed by the Peyer's patches in the gut.

    Abstract translation: 本发明涉及用于将生物活性剂靶向递送至特定组织和细胞的持续释放组合物。 该组合物包含含有生物相容性聚合物，水溶性聚合物和生物活性剂的微粒。 在一个实施方案中，生物活性剂是抗原或免疫调节剂。 在另一个实施方案中，生物学上是不稳定剂。 微粒在给药时的中值直径大于20微米。 水溶性聚合物以至少约20％的微粒干重存在于持续释放的组合物中。 持续释放组合物提供组合物的水溶性聚合物在水合时以比生物相容性聚合物降解更大的速率溶解。 这种方差是溶解度产生具有基本上小于施用的微粒尺寸的数字中值直径的假微粒。 伪微粒可以被免疫系统的抗原呈递细胞吞噬，或被肠道中的派耶氏斑块吸收。

    Pulmonary pharmaceutical formulations
    16.
    发明授权
    Pulmonary pharmaceutical formulations 有权
    肺制剂

    公开(公告)号：US08614255B2

    公开(公告)日：2013-12-24

    申请号：US12195878

    申请日：2008-08-21

    Applicant: Charles D. Blizzard ,  Michael M. Lipp ,  Kevin L. Ward ,  Rachel Ryznal ,  Daniel Leblanc ,  Mark Tracy ,  Rebecca Martin

    Inventor： Charles D. Blizzard ,  Michael M. Lipp ,  Kevin L. Ward ,  Rachel Ryznal ,  Daniel Leblanc ,  Mark Tracy ,  Rebecca Martin

    IPC: A01N25/00 ,  A61K47/00 ,  A61K9/50

    CPC classification number: A61K31/58 ,  A61K9/0075 ,  A61K9/1617 ,  A61K9/1623 ,  A61K31/13 ,  A61K38/29 ,  A61K45/06 ,  A61K47/36

    Abstract: The present invention provides improved pharmaceutical formulations for pulmonary delivery having improved chemical and physical stability of the therapeutic, prophylactic or diagnostic agent as compared to formulations known in the art. The improved pharmaceutical formulations of the invention for administration to the respiratory system of a patient for the treatment of a variety of disease conditions comprise a mass of biocompatible particles comprising an active agent, and a hydrogenated starch hydrosylate (HSH). The improvement over the prior art comprises the presence of HSH in the pharmaceutical formulation. The invention further relates to a method of treating diseases comprising administering the pharmaceutical formulations of the present invention to the respiratory system of a patient in need of treatment.

    Abstract translation: 与本领域已知的制剂相比，本发明提供了用于肺部输送的改进的药物制剂，其具有改善的治疗性，预防性或诊断剂的化学和物理稳定性。 用于给患者呼吸系统施用的用于治疗各种疾病状况的本发明改进的药物制剂包含大量包含活性剂和氢化淀粉氢化物（HSH）的生物相容性颗粒。 相对于现有技术的改进包括在药物制剂中存在HSH。 本发明还涉及治疗疾病的方法，包括将本发明的药物制剂施用于需要治疗的患者的呼吸系统。

    Systems and methods for coupling a biometric device to a computer
    18.
    发明申请
    Systems and methods for coupling a biometric device to a computer 审中-公开
    将生物识别装置耦合到计算机的系统和方法

    公开(公告)号：US20070255961A1

    公开(公告)日：2007-11-01

    申请号：US11412522

    申请日：2006-04-27

    Applicant: Mark Tracy ,  Paul Doczy

    Inventor： Mark Tracy ,  Paul Doczy

    IPC: H04K1/00

    CPC classification number: G06F1/1684 ,  G06F1/1616 ,  G06F21/32

    Abstract: A computer comprising a biometric device communicatively coupled to operational electronics of the computer and the biometric device being physically coupled to a housing of the computer in a non-removable fashion, the biometric device having an operative surface for receiving biometric input. The computer further comprising a mechanism associated with the biometric device and configured to control movement of the operative surface between extended and retracted positions, wherein the extended position is characterized such that the operative surface is exposed for use and the retracted position is characterized such that the operative surface is not exposed for use.

    Abstract translation: 一种计算机，包括通信地耦合到计算机的操作电子设备的生物测定设备，并且所述生物测定设备以不可移动的方式物理耦合到所述计算机的外壳，所述生物测定设备具有用于接收生物测定输入的操作表面。 所述计算机还包括与所述生物测定装置相关联并被配置为控制所述操作表面在延伸位置和缩回位置之间的移动的机构，其中所述延伸位置的特征在于所述操作表面暴露以供使用，并且所述缩回位置的特征在于， 操作表面不暴露使用。

    Agricultural transaction system involving non-agricultural inputs
    20.
    发明申请
    Agricultural transaction system involving non-agricultural inputs 审中-公开
    涉及非农业投入的农业交易制度

    公开(公告)号：US20070094115A1

    公开(公告)日：2007-04-26

    申请号：US11544299

    申请日：2006-10-06

    Applicant: Dennis Inman ,  Jeffery Seeley ,  Mark Tracy ,  Eric Glenn

    Inventor： Dennis Inman ,  Jeffery Seeley ,  Mark Tracy ,  Eric Glenn

    IPC: G06Q40/00

    CPC classification number: G06Q30/06 ,  G06Q40/00

    Abstract: The disclosure describes methods for performing agricultural transactions involving the exchange of inputs, such as agricultural equipment, non-equipment agricultural inputs, and non-agricultural inputs, in consideration of a commitment to deliver a specified quantity of an agricultural commodity over a specified period of time. In consideration of the commitment and, in some cases, a payment, the agricultural producer receives the inputs. In effect, the payment may result in a substantial discount of the price that the agricultural producer would otherwise pay for the inputs. The methods also may be applicable to exchange of non-agricultural commodities.

    Abstract translation: 本公开描述了考虑到在特定时期内交付指定数量的农产品的承诺，进行涉及交换投入的农业交易的方法，例如农业设备，非设备农业投入物和非农业投入物 时间。 考虑到承诺，在某些情况下，付款，农业生产者收到投入。 实际上，支付可能会导致农业生产者以其他方式支付投入的价格的大幅折扣。 这些方法也可适用于非农产品的交换。

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