公开(公告)号：US20060141041A1

公开(公告)日：2006-06-29

申请号：US10342448

申请日：2003-01-14

Applicant: Mark Tracy ,  David Scher

Inventor： Mark Tracy ,  David Scher

IPC: A61K38/21 ,  A61K38/20 ,  A61K38/19 ,  A61K9/14

CPC classification number: A61K9/1647 ,  Y02A50/411 ,  Y02A50/423

Abstract: The present invention relates to a sustained release composition for the targeted delivery of biologically active agents to specific tissues and cells. The composition comprises microparticles containing a biocompatible polymer, a water-soluble polymer and a biologically active agent. In one embodiment, the biologically active agent is an antigen or an immunomodulator. In another embodiment, the biologically is a labile agent. The microparticles have a number median diameter of greater than 20 microns upon administration. The water-soluble polymer is present in the sustained released composition in at least about 20% of the dry weight of the microparticle. the sustained release composition provides for the dissolution of the water-soluble polymer of the composition upon hydration, at a much greater rate than the degradation of the biocompatible polymer. This variance is solubility generates pseudo-microparticles which have a number median diameter which is substantially smaller than the size of the administered microparticles. The pseudo-microparticles can be engulfed by antigen presenting cells of the immune system, or absorbed by the Peyer's patches in the gut.

Abstract translation: 本发明涉及用于将生物活性剂靶向递送至特定组织和细胞的持续释放组合物。 该组合物包含含有生物相容性聚合物，水溶性聚合物和生物活性剂的微粒。 在一个实施方案中，生物活性剂是抗原或免疫调节剂。 在另一个实施方案中，生物学上是不稳定剂。 微粒在给药时的中值直径大于20微米。 水溶性聚合物以至少约20％的微粒干重存在于持续释放的组合物中。 持续释放组合物提供组合物的水溶性聚合物在水合时以比生物相容性聚合物降解更大的速率溶解。 这种方差是溶解度产生具有基本上小于施用的微粒尺寸的数字中值直径的假微粒。 伪微粒可以被免疫系统的抗原呈递细胞吞噬，或被肠道中的派耶氏斑块吸收。

公开(公告)号：US20060104018A1

公开(公告)日：2006-05-18

申请号：US10988368

申请日：2004-11-12

Applicant: Mark Tracy ,  Paul Doczy

Inventor： Mark Tracy ,  Paul Doczy

IPC: G06F1/16

CPC classification number: G06F1/1632

Abstract: A connector protection system comprises a connector accessible through a surface, a door that moves substantially parallel to the surface, and a wedge feature that actuates movement of the door.

Abstract translation: 连接器保护系统包括可通过表面访问的连接器，基本上平行于表面移动的门以及致动门的移动的楔形特征。

公开(公告)号：US20060094347A1

公开(公告)日：2006-05-04

申请号：US10980029

申请日：2004-11-03

Applicant: Mark Tracy ,  Memphis-Zhihong Yin

Inventor： Mark Tracy ,  Memphis-Zhihong Yin

IPC: H05K5/00

CPC classification number: G06F1/203 ,  G06F1/206

Abstract: A computer thermal dissipation system comprises a computer device having a base member and a display member where the computer device has at least one airflow door disposed on the base member adapted to be opened to facilitate thermal energy dissipation from the base member.

Abstract translation: 计算机散热系统包括具有基座构件和显示构件的计算机设备，其中计算机设备具有设置在基座构件上的适于被打开的至少一个气流门，以便于从基座构件散热热能。

公开(公告)号：US06950806B2

公开(公告)日：2005-09-27

申请号：US09862992

申请日：2001-05-22

Applicant: David Dines ,  Mark Tracy ,  Joseph Stone ,  Dennis Inman ,  Jeffrey Seeley

Inventor： David Dines ,  Mark Tracy ,  Joseph Stone ,  Dennis Inman ,  Jeffrey Seeley

IPC: G06Q20/20 ,  G06Q30/06 ,  G06F17/60

CPC classification number: G06Q30/06 ,  G06Q20/201 ,  G06Q40/04

Abstract: A method for transacting transfers of commodities involves observing the price of a commodity at several observation points over a period of time. In one embodiment, a maximum price is specified. For each observation point, the maximum price is selected in the event the observed price is greater than the maximum price, or the observed price is selected in the event the observed price is less than the maximum price. The price for a quantity of the commodity then is calculated based on the average of the selected prices and a premium. Individual contracts can be aggregated to reach more acceptable trading quantities and intervals, enabling participation of a derivative hedging products service provider and intermediate parties such as resellers and reseller services companies. Aggregation can be carried out manually or automatically, and configured to support anonymity of various parties in the transaction chain.

Abstract translation: 处理商品转让的方法涉及在一段时间内在几个观察点观察商品的价格。 在一个实施例中，指定最大价格。 对于每个观察点，如果观察价格大于最大价格，则选择最高价格，或者在观察价格低于最高价格的情况下选择观察价格。 然后，商品数量的价格是根据所选价格和溢价的平均值计算的。 可以汇总个人合约，以达到更可接受的交易数量和间隔时间，使得衍生性套期保值产品服务提供商和中间方（如经销商和经销商服务公司）能够参与。 可以手动或自动执行汇总，并配置为支持交易链中各方的匿名性。

公开(公告)号：US20110097720A1

公开(公告)日：2011-04-28

申请号：US12811503

申请日：2008-12-31

Applicant: Marco A. Ciufolini ,  Thomas D. Madden ,  Michael J. Hope ,  Barbara Mui ,  De Fougerolles Antonin ,  Tatiana Novobrantseva ,  Anna Borodovsky ,  Akin Akinc ,  Mark Tracy ,  Pieter Rutter Cullis

Inventor： Marco A. Ciufolini ,  Thomas D. Madden ,  Michael J. Hope ,  Barbara Mui ,  De Fougerolles Antonin ,  Tatiana Novobrantseva ,  Anna Borodovsky ,  Akin Akinc ,  Mark Tracy ,  Pieter Rutter Cullis

IPC: C12Q1/68 ,  C12Q1/02

CPC classification number: G01N33/5088 ,  A01K2207/05 ,  A01K2227/105 ,  A01K2267/0381 ,  C12N15/111 ,  C12N15/1137 ,  C12N2310/14 ,  C12N2320/10 ,  C12Q1/6876 ,  C12Q2600/136 ,  C12Q2600/158 ,  C12Q2600/178 ,  C12Y304/21021 ,  G01N33/5023 ,  G01N33/5067 ,  G01N33/86 ,  G01N2333/745 ,  G01N2333/96447

Abstract: The invention features a method of identifying therapeutically relevant compositions which include a therapeutic agent and 2,2-Dilinoley 1-4-dimethylaminomethyl-[1,3]-dioxolane by screening for an effect of the agent on the liver of a model subject.

Abstract translation: 本发明的特征在于通过筛选试剂对模型受试者的肝脏的影响来鉴定治疗相关组合物的方法，所述组合物包括治疗剂和2,2-二苯胺基-4-二甲基氨基甲基 - [1,3] - 二氧杂环戊烷。

公开(公告)号：US07228894B2

公开(公告)日：2007-06-12

申请号：US10836511

申请日：2004-04-30

Applicant: David A. Moore ,  Mark Tracy ,  Kerry Hill

Inventor： David A. Moore ,  Mark Tracy ,  Kerry Hill

IPC: F28F7/00

CPC classification number: H05K7/20472 ,  H01L23/36 ,  H01L23/552 ,  H01L2924/0002 ,  H01L2924/00

Abstract: A device for distributing waste heat from a heat source evenly across an exterior surface of an enclosure is disclosed. The device includes a first layer of material that has a high thermal conductivity along a first plane. One or more layers of material that include a controlled thermal conductivity along a second plane are connected with the first layer. At least one of those layers has a low thermal conductivity (e.g. a thermal insulating material) in the second plane and that layer is positioned between the heat source and the enclosure so that heat flow through that layer is substantially inhibited in the second plane and a majority of the waste heat is thermally transferred through the first layer along the first plane to the exterior surface where the waste heat is uniformly distributed thereby reducing hot spots on the exterior surface which can cause user discomfort.

Abstract translation: 公开了一种用于将来自热源的废热均匀地分布在外壳的外表面上的装置。 该装置包括沿着第一平面具有高导热性的第一材料层。 包括沿着第二平面的受控热导率的一层或多层材料与第一层连接。 这些层中的至少一个在第二平面中具有低导热性（例如绝热材料），并且该层位于热源和外壳之间，使得在第二平面中基本上禁止通过该层的热流，并且 大部分废热通过第一层沿着第一平面热传递到外表面，废热均匀分布，从而减少了外表面上的热点，这可能导致用户的不适。

公开(公告)号：US20070024588A1

公开(公告)日：2007-02-01

申请号：US11190256

申请日：2005-07-26

Applicant: Memphis Yin ,  Mark Tracy

Inventor： Memphis Yin ,  Mark Tracy

IPC: G09G5/00

CPC classification number: G06F3/0202

Abstract: A keyboard lighting device is disclosed. In a preferred embodiment, a moving member may be placed in an operating position protruding from the keyboard, or in a retracted position. In the operating position, light is redirected from a light source to the keyboard so that use of the keyboard in dark environments is facilitated. Preferably, when the moving member is in its retracted position, the keyboard light appears to be a key on the keyboard.

Abstract translation: 公开了一种键盘照明装置。 在优选实施例中，移动构件可以放置在从键盘突出或在缩回位置突出的操作位置。 在操作位置，光从光源被重定向到键盘，从而便于在黑暗环境中使用键盘。 优选地，当移动构件处于其缩回位置时，键盘灯看起来是键盘上的键。

公开(公告)号：US5492656A

公开(公告)日：1996-02-20

申请号：US270759

申请日：1994-07-05

Applicant: Mark Tracy

Inventor： Mark Tracy

IPC: E02D29/12 ,  E02D29/14 ,  B28B7/16 ,  B28B7/28 ,  E04B1/16

CPC classification number: E02D29/1445 ,  E02D29/12

Abstract: Apparatus and method for constructing a manhole collar between an existing manhole cone and a precast manhole ring. The apparatus includes a circular slip form tube, tapered from a larger top diameter to a smaller bottom diameter; at least two support arms, radially extending from adjacent the top of the slip form tube for placement on a support surface, such as a road surface, to hold the tube at a selected height relative to ground level within a manhole cone; and a plurality of fasteners for attachment of a precast manhole ring about the exterior periphery of the slip form tube for supporting the ring at a selected height relative to the manhole cone and the roadway surface. The apparatus may include a concrete spill retention ring, placeable upon the top rim of the manhole cone and around the slip form tube to prevent concrete from entering the manhole cone. The method of the invention includes the steps of supporting the slip form tube upon the roadway surface by the arms; fastening the manhole ring to the tube for proper positioning thereof; leveling the tube and ring; and the pouring of concrete about the slip form tube to form a ring-supporting concrete collar between the manhole cone and the manhole ring.

Abstract translation: 在现有的井眼锥体与预制井眼环之间构造井眼环的装置和方法。 该装置包括圆形滑动成形管，从更大的顶部直径向较小的底部直径逐渐变细; 至少两个支撑臂，从邻近滑动成形管的顶部径向延伸，用于放置在支撑表面（例如路面）上，以将管保持在相对于井眼锥体内的地平面的选定高度; 以及多个紧固件，用于将预制井眼环附接在滑动成形管的外周边上，用于将环支撑在相对于井眼锥体和道路表面的选定高度处。 该设备可以包括混凝土溢流保持环，可放置在井眼锥体的顶部边缘周围并且围绕滑动形成管，以防止混凝土进入人孔锥体。 本发明的方法包括以下步骤：通过臂支撑滑动管在道路表面上; 将人孔环固定到管上以使其正确定位; 校平管和环; 并将混凝土浇注在滑模管上，以形成孔眼锥体和人孔环之间的支撑环的混凝土环。

公开(公告)号：US20090105201A1

公开(公告)日：2009-04-23

申请号：US12195878

申请日：2008-08-21

Applicant: Charles D. Blizzard ,  Michael M. Lipp ,  Kevin L. Ward ,  Rachel Ryznal ,  Daniel Leblanc ,  Mark Tracy ,  Rebbeca Martin

Inventor： Charles D. Blizzard ,  Michael M. Lipp ,  Kevin L. Ward ,  Rachel Ryznal ,  Daniel Leblanc ,  Mark Tracy ,  Rebbeca Martin

IPC: A61K31/58 ,  A61P11/06

CPC classification number: A61K31/58 ,  A61K9/0075 ,  A61K9/1617 ,  A61K9/1623 ,  A61K31/13 ,  A61K38/29 ,  A61K45/06 ,  A61K47/36

Abstract: The present invention provides improved pharmaceutical formulations for pulmonary delivery having improved chemical and physical stability of the therapeutic, prophylactic or diagnostic agent as compared to formulations known in the art. The improved pharmaceutical formulations of the invention for administration to the respiratory system of a patient for the treatment of a variety of disease conditions comprise a mass of biocompatible particles comprising an active agent, and a hydrogenated starch hydrosylate (HSH). The improvement over the prior art comprises the presence of HSH in the pharmaceutical formulation. The invention further relates to a method of treating diseases comprising administering the pharmaceutical formulations of the present invention to the respiratory system of a patient in need of treatment.

Abstract translation: 与本领域已知的制剂相比，本发明提供了用于肺部输送的改进的药物制剂，其具有改善的治疗性，预防性或诊断剂的化学和物理稳定性。 用于给患者呼吸系统施用的用于治疗各种疾病状况的本发明改进的药物制剂包含大量包含活性剂和氢化淀粉氢化物（HSH）的生物相容性颗粒。 相对于现有技术的改进包括在药物制剂中存在HSH。 本发明还涉及治疗疾病的方法，包括将本发明的药物制剂施用于需要治疗的患者的呼吸系统。

公开(公告)号：USD574942S1

公开(公告)日：2008-08-12

申请号：US29259038

申请日：2006-05-01

Applicant: Robert Schluter ,  Mark Tracy ,  Andreas Pappas

Designer： Robert Schluter ,  Mark Tracy ,  Andreas Pappas