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公开(公告)号：US09096592B2
公开(公告)日：2015-08-04
申请号：US13819337
申请日：2011-08-31
申请人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Jens Ackerstaff , Nils Griebenow , Andreas Knorr , Frank Wunder , Volkhart Min-Jian Li , Lars Bärfacker , Stefan Weigand
发明人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Jens Ackerstaff , Nils Griebenow , Andreas Knorr , Frank Wunder , Volkhart Min-Jian Li , Lars Bärfacker , Stefan Weigand
IPC分类号： A01N43/00 , A61K31/00 , C07D471/04 , C07D487/04 , C07D519/00 , A61K31/517 , A61K31/519 , A61K31/522 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D473/28 , C07D475/06 , C07D495/04 , C07D498/04 , C07D513/04
CPC分类号： C07D471/04 , A61K31/517 , A61K31/519 , A61K31/522 , A61K31/5377 , A61K31/551 , A61K45/06 , C07D473/28 , C07D475/06 , C07D487/04 , C07D495/04 , C07D498/04 , C07D513/04 , C07D519/00
摘要： The present application relates to novel bicyclic azaheterocycles, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新型双环氮杂环，其制备方法，单独或组合用于治疗和/或预防疾病及其用于生产用于治疗和/或预防疾病的药物的用途 ，特别是用于治疗和/或预防心血管疾病。
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12.发明授权Ring-fused 4-aminopyrimidines and use thereof as stimulators of soluable guanylate cyclases 失效环稠合的4-氨基嘧啶及其可用作可溶性鸟苷酸环化酶的刺激剂公开(公告)号：US08765769B2
公开(公告)日：2014-07-01
申请号：US13704980
申请日：2011-07-05
申请人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Jens Ackerstaff , Nils Griebenow , Andreas Knorr , Frank Wunder , Volkhart Min-Jian Li
发明人： Markus Follmann , Johannes-Peter Stasch , Gorden Redlich , Jens Ackerstaff , Nils Griebenow , Andreas Knorr , Frank Wunder , Volkhart Min-Jian Li
IPC分类号： A01N43/54 , A01N43/90 , A61K31/517 , A61K31/519
CPC分类号： A61K31/519 , A61K45/06 , C07D471/04 , C07D491/20 , C07D519/00
摘要： The present application relates to novel fused 4-aminopyrimidines, to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases and to the use thereof for production of medicaments for the treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of cardiovascular disorders.
摘要翻译： 本申请涉及新型融合的4-氨基嘧啶，其制备方法，单独或组合用于治疗和/或预防疾病的用途及其用于生产用于治疗和/或治疗的药物的用途 预防疾病，特别是用于治疗和/或预防心血管疾病。
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13.发明申请公开(公告)号：US20120028971A1
公开(公告)日：2012-02-02
申请号：US13201924
申请日：2010-02-24
申请人： Thomas Lampe , Michael Hahn , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Stefan Heitmeier , Nils Griebenow , Sherif El Sheikh , Volkhart Min-Jian Li , Eva-Maria Becker , Friederike Stoll , Andreas Knorr
发明人： Thomas Lampe , Michael Hahn , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Stefan Heitmeier , Nils Griebenow , Sherif El Sheikh , Volkhart Min-Jian Li , Eva-Maria Becker , Friederike Stoll , Andreas Knorr
IPC分类号： A61K31/5395 , C07D209/46 , A61K31/4035 , C07D237/14 , A61P7/02 , A61P9/04 , A61P9/10 , A61P9/12 , A61P7/00 , C07D273/04 , A61K31/50
CPC分类号： C07D273/04 , A61K31/4035 , A61K31/495 , A61K31/50 , A61K31/5395 , C07D209/46 , C07D237/14
摘要： The present application relates to novel alkylcarboxylic acids having an oxo-substituted azaheterocyclic partial structure, to processes for their preparation, to their use for the treatment and/or prevention of diseases, and to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及具有氧代取代的氮杂环状部分结构的新型烷基羧酸，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防的药物的用途 的疾病，特别是用于治疗和/或预防心血管疾病。
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14.发明授权公开(公告)号：US08987256B2
公开(公告)日：2015-03-24
申请号：US12937995
申请日：2009-04-06
申请人： Michael Hahn , Eva-Maria Becker , Andreas Knorr , Dirk Schneider , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Friederike Stoll , Stefan Heitmeier , Klaus Münter , Nils Griebenow , Thomas Lampe , Sherif El Sheikh , Volkhart Min-Jian Li
发明人： Michael Hahn , Eva-Maria Becker , Andreas Knorr , Dirk Schneider , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Friederike Stoll , Stefan Heitmeier , Klaus Münter , Nils Griebenow , Thomas Lampe , Sherif El Sheikh , Volkhart Min-Jian Li
IPC分类号： A61K31/5395 , A61K31/502 , A61K31/4245 , A61K31/53 , C07D237/32 , C07D273/04 , C07D271/113 , C07D253/075 , C07D209/46 , C07D209/48 , C07D213/64 , C07D215/227 , C07D231/56 , C07D233/32 , C07D237/14 , C07D239/88 , C07D253/08 , C07D261/20 , C07D263/20 , C07D275/06 , C07D417/12 , A61K31/421 , A61K31/451 , A61K31/426 , C07D263/22 , C07D211/76 , C07D401/12 , C07D405/12 , C07D277/34 , A61P7/02 , A61P9/12 , A61P3/00 , A61P9/04 , A61P9/10
CPC分类号： C07D237/32 , C07D209/46 , C07D209/48 , C07D211/76 , C07D213/64 , C07D215/227 , C07D231/56 , C07D233/32 , C07D237/14 , C07D239/88 , C07D253/075 , C07D253/08 , C07D261/20 , C07D263/20 , C07D271/113 , C07D273/04 , C07D275/06 , C07D277/34 , C07D417/12
摘要： The present application relates to novel carboxylic acid derivatives having an oxo-substituted azaheterocyclic partial structure, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及具有氧代取代的氮杂环状部分结构的新型羧酸衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于治疗和/或预防疾病的药物的用途 ，特别是用于治疗和/或预防心血管疾病。
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公开(公告)号：US08642592B2
公开(公告)日：2014-02-04
申请号：US13201924
申请日：2010-02-24
申请人： Thomas Lampe , Michael Hahn , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Stefan Heitmeier , Nils Griebenow , Sherif El Sheikh , Volkhart Min-Jian Li , Eva-Maria Becker , Friederike Stoll , Andreas Knorr
发明人： Thomas Lampe , Michael Hahn , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Stefan Heitmeier , Nils Griebenow , Sherif El Sheikh , Volkhart Min-Jian Li , Eva-Maria Becker , Friederike Stoll , Andreas Knorr
IPC分类号： C07D209/46 , C07D237/14 , C07D273/04 , A61K31/4035 , A61K31/50 , A61K31/5395 , A61P9/00
CPC分类号： C07D273/04 , A61K31/4035 , A61K31/495 , A61K31/50 , A61K31/5395 , C07D209/46 , C07D237/14
摘要： The present application relates to novel alkylcarboxylic acids having an oxo-substituted azaheterocyclic partial structure, to processes for their preparation, to their use for the treatment and/or prevention of diseases, and to their use for producing medicaments for the treatment and/or prevention of diseases, especially for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及具有氧代取代的氮杂环部分结构的新型烷基羧酸，其制备方法，其用于治疗和/或预防疾病的用途及其用于制备用于治疗和/或预防的药物的用途 的疾病，特别是用于治疗和/或预防心血管疾病。
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16.发明申请公开(公告)号：US20110034450A1
公开(公告)日：2011-02-10
申请号：US12937995
申请日：2009-04-06
申请人： Michael Hahn , Eva-Maria Becker , Andreas Knorr , Dirk Schneider , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Friederike Stoll , Stefan Heitmeier , Klaus Münter , Nils Griebenow , Thomas Lampe , Sherif El Sheikh , Volkhart Min-Jian Li
发明人： Michael Hahn , Eva-Maria Becker , Andreas Knorr , Dirk Schneider , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Friederike Stoll , Stefan Heitmeier , Klaus Münter , Nils Griebenow , Thomas Lampe , Sherif El Sheikh , Volkhart Min-Jian Li
IPC分类号： A61K31/5395 , C07D237/32 , C07D273/04 , C07D271/113 , C07D253/075 , C07D263/22 , C07D211/76 , C07D401/12 , C07D405/12 , C07D277/34 , A61K31/502 , A61K31/4245 , A61K31/53 , A61K31/421 , A61K31/451 , A61K31/426 , A61P7/02 , A61P9/12 , A61P3/00 , A61P9/04 , A61P9/10
CPC分类号： C07D237/32 , C07D209/46 , C07D209/48 , C07D211/76 , C07D213/64 , C07D215/227 , C07D231/56 , C07D233/32 , C07D237/14 , C07D239/88 , C07D253/075 , C07D253/08 , C07D261/20 , C07D263/20 , C07D271/113 , C07D273/04 , C07D275/06 , C07D277/34 , C07D417/12
摘要： The present application relates to novel carboxylic acid derivatives having an oxo-substituted azaheterocyclic partial structure, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及具有氧代取代的氮杂环状部分结构的新型羧酸衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于治疗和/或预防疾病的药物的用途 ，特别是用于治疗和/或预防心血管疾病。
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公开(公告)号：US08796335B2
公开(公告)日：2014-08-05
申请号：US13431934
申请日：2012-03-27
申请人： Michael Hahn , Thomas Lampe , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Volkhart Min-Jian Li , Eva-Maria Becker , Friederike Stoll , Andreas Knorr , Elisabeth Woltering
发明人： Michael Hahn , Thomas Lampe , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Volkhart Min-Jian Li , Eva-Maria Becker , Friederike Stoll , Andreas Knorr , Elisabeth Woltering
IPC分类号： A01N37/12 , A01N37/44 , A61K31/195 , C07C45/00
CPC分类号： C07C231/14 , A61K9/0053 , A61K31/196 , A61K45/06 , C07C233/55 , C07C235/38 , C07C2601/02 , C07C2601/04 , C07C2601/08
摘要： The present application relates to novel 3-phenylpropionic acid derivatives which carry a branched or cyclic alkyl substituent in the 3-position, to processes for their preparation, to their use for the treatment and/or prevention of diseases and to their use for preparing medicaments for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular diseases.
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公开(公告)号：US20100168240A1
公开(公告)日：2010-07-01
申请号：US12529713
申请日：2008-03-15
申请人： Michael Hahn , Eva-Maria Becker , Andreas Knorr , Dirk Schneider , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Dieter Lang
发明人： Michael Hahn , Eva-Maria Becker , Andreas Knorr , Dirk Schneider , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Dieter Lang
IPC分类号： A61K31/194 , C07C65/28 , A61P9/04 , A61P9/12 , A61P9/10
CPC分类号： C07C65/28
摘要： The invention relates to novel substituted dibenzoic acid derivatives of formula (I), wherein A represents a group of formula (II) or (III), to methods for producing the same, and to their use in the treatment and/or prophylaxis of diseases. The invention also relates to the use of said substances in the production of drugs for the treatment and/or prophylaxis of diseases, especially in the treatment and/or prevention of cardiovascular diseases.
摘要翻译： 本发明涉及式（I）的新型取代二苯甲酸衍生物，其中A代表式（II）或（III）的基团，其制备方法及其在治疗和/或预防疾病中的用途 。 本发明还涉及所述物质在制备药物中用于治疗和/或预防疾病的用途，特别是用于治疗和/或预防心血管疾病。
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公开(公告)号：US20090291993A1
公开(公告)日：2009-11-26
申请号：US12083509
申请日：2006-10-09
申请人： Stephan Bartel , Michael Hahn , Wahed Ahmed Moradi , Eva-Maria Becker , Thomas Rölle , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Andreas Knorr
发明人： Stephan Bartel , Michael Hahn , Wahed Ahmed Moradi , Eva-Maria Becker , Thomas Rölle , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Andreas Knorr
IPC分类号： A61K31/41 , A61K31/195 , A61K31/19 , C07D257/04 , C07C229/00 , C07C59/00
CPC分类号： C07C59/68 , C07C229/14 , C07D249/12 , C07D257/04 , C07D271/07 , C07D271/113
摘要： The present application relates to novel difluorophenol derivatives, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新型二氟苯酚衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于治疗和/或预防疾病，特别是用于治疗和/或预防的药物的用途 的心血管疾病。
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公开(公告)号：US08173704B2
公开(公告)日：2012-05-08
申请号：US12083509
申请日：2006-10-09
申请人： Stephan Bartel , Michael Hahn , Wahed Ahmed Moradi , Eva-Maria Becker , Thomas Rölle , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Andreas Knorr
发明人： Stephan Bartel , Michael Hahn , Wahed Ahmed Moradi , Eva-Maria Becker , Thomas Rölle , Johannes-Peter Stasch , Karl-Heinz Schlemmer , Frank Wunder , Andreas Knorr
IPC分类号： A61K31/19 , A61K31/195 , C07C59/00 , C07C65/03 , C07C321/00
CPC分类号： C07C59/68 , C07C229/14 , C07D249/12 , C07D257/04 , C07D271/07 , C07D271/113
摘要： The present application relates to novel difluorophenol derivatives, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for producing medicaments for the treatment and/or prophylaxis of diseases, especially for the treatment and/or prevention of cardiovascular disorders.
摘要翻译： 本申请涉及新型二氟苯酚衍生物，其制备方法，其用于治疗和/或预防疾病的用途及其用于治疗和/或预防疾病，特别是用于治疗和/或预防的药物的用途 的心血管疾病。
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