公开(公告)号：US08513272B2

公开(公告)日：2013-08-20

申请号：US13105457

申请日：2011-05-11

Applicant: Stephen Bierlmaier ,  Raymond Scott Field ,  R. Curtis Haltiwanger ,  Martin J. Jacobs ,  Robert E. McKean ,  Mehran Yazdanian ,  Veronique Courvoisier

Inventor： Stephen Bierlmaier ,  Laurent Courvoisier ,  Raymond Scott Field ,  R. Curtis Haltiwanger ,  Martin J. Jacobs ,  Robert E. McKean ,  Mehran Yazdanian

IPC: A61K31/505 ,  C07D401/14

CPC classification number: C07D487/14

Abstract: Alternative chemical and/or solid state forms of Compound I, processes to reproducibly make them and methods of treating patients using them.

Abstract translation: 化合物I的替代化学和/或固体形式，可重复地制备它们的方法和使用它们治疗患者的方法。

公开(公告)号：US20110230508A1

公开(公告)日：2011-09-22

申请号：US13105457

申请日：2011-05-11

Applicant: Stephen Bierlmaier ,  Laurent Courvoisier ,  Raymond Scott Field ,  R. Curtis Haltiwanger ,  Martin J. Jacobs ,  Robert E. McKean ,  Mehran Yazdanian ,  Veronique Courvoisier

Inventor： Stephen Bierlmaier ,  Laurent Courvoisier ,  Raymond Scott Field ,  R. Curtis Haltiwanger ,  Martin J. Jacobs ,  Robert E. McKean ,  Mehran Yazdanian ,  Veronique Courvoisier

IPC: A61K31/506 ,  C07D487/14 ,  A61P9/00 ,  A61P35/00

CPC classification number: C07D487/14

Abstract: Alternative chemical and/or solid state forms of Compound I, processes to reproducibly make them and methods of treating patients using them.

Abstract translation: 化合物I的替代化学和/或固体形式，可重复地制备它们的方法和使用它们治疗患者的方法。

公开(公告)号：US07749540B2

公开(公告)日：2010-07-06

申请号：US09975350

申请日：2001-10-11

Applicant: Martin J. Jacobs ,  Bradley T. McIntyre ,  Piyush R. Patel ,  David A. Dickason

Inventor： Martin J. Jacobs ,  Bradley T. McIntyre ,  Piyush R. Patel ,  David A. Dickason

IPC: A61K9/14 ,  A61K31/165

CPC classification number: H04N7/17327 ,  A61K9/4858 ,  A61K31/165 ,  A61K47/14 ,  A61K47/26 ,  H04N21/2543 ,  H04N21/25816 ,  H04N21/4331 ,  H04N21/4334 ,  H04N21/47214 ,  H04N21/4725 ,  H04N21/6125 ,  H04N21/6581 ,  H04N21/858

Abstract: Particle-forming compositions of modafinil compounds, and aqueous compositions of particles, wherein the particles comprise a modafinil compound, are disclosed, along with methods of their preparation, and their use in the treatment of diseases.

Abstract translation: 莫达非尼化合物的颗粒形成组合物和颗粒的水性组合物，其中颗粒包含莫达非尼化合物，以及其制备方法及其在治疗疾病中的用途。

公开(公告)号：US07141555B2

公开(公告)日：2006-11-28

申请号：US10023441

申请日：2001-12-18

Applicant: Martin J. Jacobs ,  Piyush R. Patel

Inventor： Martin J. Jacobs ,  Piyush R. Patel

IPC: A61K31/724 ,  A61K31/165

CPC classification number: B82Y5/00 ,  A61K31/165 ,  A61K47/6951

Abstract: Mixtures of a modafinil compound with a cyclodextrin, methods for their use, and compositions thereof are disclosed, along with complexes comprising a modafinil compound and a cyclodextrin which are taste-masked and suitable for oral consumption in an aqueous solution.

公开(公告)号：US5593978A

公开(公告)日：1997-01-14

申请号：US166870

申请日：1993-12-15

Applicant: Martin J. Jacobs ,  Fred J. Hart

Inventor： Martin J. Jacobs ,  Fred J. Hart

IPC: A23K1/16 ,  A23K1/165 ,  A23K1/18 ,  A61K31/365 ,  A61K47/48 ,  A61K31/715 ,  C07D313/08

CPC classification number: B82Y5/00 ,  A23K20/126 ,  A23K20/168 ,  A23K50/80 ,  A61K31/365 ,  A61K47/48969 ,  Y10S426/805

Abstract: A method for promoting growth in fish comprising administering a low level dosage amount of zearalanol to fish. The zearalanol may be conveniently administered to the fish via a novel fish feed formulation comprising a conventional feed mixture supplemented with a relatively low dosage amount of zearalanol ranging from 1 to 20 parts per million (ppm) zearalanol in the feed. In another embodiment, the zearalanol may be administered to the fish in the form of a novel complex of zearalanol and a cyclodextrin compound which further enhances the growth process.

Abstract translation: 一种促进鱼类生长的方法，其特征在于，向所述鱼中施用低水平的水杨酸钠。 可以通过新型的鱼饲料制剂将锌橄榄醇方便地施用于鱼，其包含补充有相对低剂量的犹他拉兰的常规饲料混合物，其范围为饲料中百万分之1（ppm）的玉米赤霉醇。 在另一个实施方案中，可以将锌玉米醇以新亚硬脂醇和环糊精化合物复合物的形式施用于鱼，这进一步增强了生长过程。

公开(公告)号：US06919378B2

公开(公告)日：2005-07-19

申请号：US10286573

申请日：2002-11-01

Applicant: Martin J. Jacobs ,  Bradley T. McIntyre ,  Alpa Parikh ,  Piyush R. Patel

Inventor： Martin J. Jacobs ,  Bradley T. McIntyre ,  Alpa Parikh ,  Piyush R. Patel

IPC: A61K9/08 ,  A61K9/00 ,  A61K9/14 ,  A61K9/48 ,  A61K31/165 ,  A61K47/08 ,  A61K47/10 ,  A61K47/22 ,  A61K47/34 ,  A61K47/42 ,  A61P1/14 ,  A61P9/10 ,  A61P25/00 ,  A61P25/14 ,  A61P25/16 ,  A61P25/20 ,  A61P25/26 ,  A61P25/28 ,  A61P43/00 ,  A61K9/20

CPC classification number: A61K9/4866 ,  A61K9/146 ,  A61K31/165 ,  A61K47/10 ,  A61K47/22

Abstract: Pharmaceutical compositions of modafinil compounds, including pharmaceutical, non-aqueous compositions of modafinil compounds in organic solvents and pharmaceutical compositions of a modafinil compound in solid dispersions, are disclosed, along with their use in the treatment of diseases.

Abstract translation: 莫达非尼化合物的药物组合物，包括在有机溶剂中的莫达非尼化合物的药物，非水性组合物和固体分散体中莫达非尼化合物的药物组合物，以及它们在治疗疾病中的用途。

公开(公告)号：US4886899A

公开(公告)日：1989-12-12

申请号：US215873

申请日：1988-07-05

Applicant: Martin J. Jacobs

Inventor： Martin J. Jacobs

IPC: C07C69/92

CPC classification number: C07C69/92

Abstract: Substituted resorcyclic acid esters having the structural formula: ##STR1## wherein R.sub.1 and R.sub.2, which may be the same or different, are H, X, or COX, where X is an alkyl group having from 1-6 carbon atoms; and R.sub.3 is an alkyl group having from 1-12 carbon atoms are synthesized and used as housefly chemosterilants which reduce housefly fecundity.

Abstract translation: 具有以下结构式的取代的聚环酸酯：其中R 1和R 2可以相同或不同，是H，X或COX，其中X是具有1-6个碳原子的烷基; 并且R 3是具有1-12个碳原子的烷基被合成并且被用作降低家蝇繁殖力的家蝇化学增效剂。

公开(公告)号：US4851402A

公开(公告)日：1989-07-25

申请号：US19935

申请日：1987-02-27

Applicant: Martin J. Jacobs ,  John Katzenellenbogen

Inventor： Martin J. Jacobs ,  John Katzenellenbogen

IPC: A23K1/165 ,  A61K31/565 ,  A61P43/00 ,  C07J1/00

CPC classification number: A23K20/168

Abstract: Estriol is administered to ruminants in dosages from about 0.01-4.0 mg/ruminant/day to promote growth and increase feed utilization efficiency.

公开(公告)号：US4543239A

公开(公告)日：1985-09-24

申请号：US642929

申请日：1984-08-21

Applicant: Martin J. Jacobs

Inventor： Martin J. Jacobs

IPC: C01B25/46 ,  C01B25/16

CPC classification number: C01B25/466

Abstract: A method for extracting phosphoric acid from wet process phosphoric acid is disclosed. N,N-dialkyl-.alpha.-aminoacids are contacted with wet process phosphoric acid to extract substantially pure phosphoric acid therefrom. The N,N-dialkyl-.alpha.-aminoacids are dissolved in a diluent.

Abstract translation: 公开了一种从湿法磷酸中提取磷酸的方法。 N，N-二烷基-α-氨基酸与湿法磷酸接触，从中提取基本上纯的磷酸。 将N，N-二烷基-α-氨基酸溶解在稀释剂中。