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公开(公告)号：US07528135B2
公开(公告)日：2009-05-05
申请号：US11290675
申请日：2005-11-30
IPC分类号： A61K31/496 , C07D213/40 , C07D213/82
CPC分类号： C07D213/74 , C07D213/82 , C07D213/83
摘要： The present invention relates to compounds of formula I wherein R1, R2 and A are as defined in the description and claims, and pharmaceutically acceptable salts thereof as well as to pharmaceutical composition comprising these compounds and to methods for their preparation. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及式I化合物，其中R 1，R 2和A如说明书和权利要求书中所定义，及其药学上可接受的盐以及包含这些化合物的药物组合物及其制备方法。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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公开(公告)号：US07538101B2
公开(公告)日：2009-05-26
申请号：US11605005
申请日：2006-11-28
申请人： Matthias Nettekoven , Jean-Marc Plancher , Hans Richter , Olivier Roche , Rosa Maria Rodriguez Sarmiento , Sven Taylor
发明人： Matthias Nettekoven , Jean-Marc Plancher , Hans Richter , Olivier Roche , Rosa Maria Rodriguez Sarmiento , Sven Taylor
IPC分类号： A01N43/00 , A61K31/54 , A61K31/55 , C07D223/00 , C07D279/00 , C07D285/00 , C07D295/00
CPC分类号： C07D401/12 , C07D401/14 , C07D403/12
摘要： The present invention relates to compounds of formula I wherein R1, R2 and G are as defined in the description and claims and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及式I化合物，其中R 1，R 2和G如说明书和权利要求及其药学上可接受的盐所定义。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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公开(公告)号：US20090029977A1
公开(公告)日：2009-01-29
申请号：US12175476
申请日：2008-07-18
IPC分类号： A61K31/454 , C07D261/20 , C07D413/14 , A61K31/541 , A61P25/18 , A61K31/5377 , C07D279/12
CPC分类号： C07D413/04 , C07D413/14
摘要： The present invention relates to compounds of the formula (I) wherein R1, R2, X and n are as defined in the specification as dual modulators of the serotonin 5-HT2a and dopamine D3 receptors, their manufacture, pharmaceutical compositions containing them and their use for the treatment of psychotic disorders, as well as other diseases such as depression and anxiety, drug dependence, dementias and memory impairment.
摘要翻译： 本发明涉及式（I）化合物，其中R 1，R 2，X和n如说明书中所定义，作为5-羟色胺5-HT2a和多巴胺D3受体的双重调节剂，其制备方法，含有它们的药物组合物及其用途 用于治疗精神病，以及其他疾病如抑郁和焦虑，药物依赖，痴呆和记忆障碍。
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公开(公告)号：US20120040972A1
公开(公告)日：2012-02-16
申请号：US13280523
申请日：2011-10-25
IPC分类号： A61K31/454 , C07D413/14 , A61P25/18 , C07D417/14 , A61K31/541 , A61K31/4545 , C07D413/04 , A61K31/5377
CPC分类号： C07D413/04 , C07D413/14
摘要： The present invention relates to compounds of the formula (I) wherein R1, R2, X and n are as defined in the specification as dual modulators of the serotonin 5-HT2a and dopamine D3 receptors, their manufacture, pharmaceutical compositions containing them and their use for the treatment of psychotic disorders, as well as other diseases such as depression and anxiety, drug dependence, dementias and memory impairment.
摘要翻译： 本发明涉及式（I）化合物，其中R 1，R 2，X和n如说明书中所定义，作为5-羟色胺5-HT2a和多巴胺D3受体的双重调节剂，其制备方法，含有它们的药物组合物及其用途 用于治疗精神病，以及其他疾病如抑郁和焦虑，药物依赖，痴呆和记忆障碍。
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15.发明申请BENZOYL-PIPERIDINE DERIVATIVES AS DUAL MODULATORS OF THE 5-HT2A AND D3 RECEPTORS 失效作为5-HT2A和D3受体双重调节剂的苯甲酰哌啶衍生物公开(公告)号：US20120004208A1
公开(公告)日：2012-01-05
申请号：US13233056
申请日：2011-09-15
申请人： Luca Gobbi , Georg Jaeschke , Thomas Luebbers , Olivier Roche , Rosa Maria Rodriguez-Sarmiento , Lucinda Steward
发明人： Luca Gobbi , Georg Jaeschke , Thomas Luebbers , Olivier Roche , Rosa Maria Rodriguez-Sarmiento , Lucinda Steward
IPC分类号： A61K31/451 , C07D413/08 , A61K31/454 , C07D215/48 , A61K31/4709 , A61P25/18 , A61K31/4545 , C07D409/08 , A61K31/496 , A61K31/5377 , C07D417/08 , C07D211/26 , C07D401/08
CPC分类号： C07D401/06 , C07D413/06 , C07D417/06
摘要： The present invention relates to compounds of the general formula as dual modulators of the 5-HT2a and D3 receptors useful against CNS disorders, wherein A, R1, R2, n, p, q and r are as defined in the specification.
摘要翻译： 本发明涉及通式的化合物作为可用于CNS障碍的5-HT2a和D3受体的双重调节剂，其中A，R1，R2，n，p，q和r如说明书中所定义。
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公开(公告)号：US07795437B2
公开(公告)日：2010-09-14
申请号：US11876007
申请日：2007-10-22
申请人： Luca Claudio Gobbi , Georg Jaeschke , Olivier Roche , Rosa Maria Rodriguez Sarmiento , Lucinda Steward
发明人： Luca Claudio Gobbi , Georg Jaeschke , Olivier Roche , Rosa Maria Rodriguez Sarmiento , Lucinda Steward
IPC分类号： C07D215/12 , C07D401/00
CPC分类号： C07D401/12 , C07D211/46 , C07D401/14 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The present invention relates to ether derivatives according to general formula I, and to their pharmaceutically-acceptable salts, which may be used in treating or preventing cognitive disorders, drug addiction, depression, anxiety, drug dependence, dementias, memory impairment, psychotic disorders comprising schizophrenia, schizoaffective disorders, bipolar disease, mania, psychotic depression, or psychoses comprising paranoia and delusions.
摘要翻译： 本发明涉及根据通式I的醚衍生物及其药学上可接受的盐，其可用于治疗或预防认知障碍，药物成瘾，抑郁，焦虑，药物依赖，痴呆，记忆障碍，精神病，包括 精神分裂症，分裂情感障碍，双相性精神障碍，躁狂症，精神病性抑郁症或精神病，包括偏执狂和妄想。
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17.发明授权Benzoyl-piperidine derivatives as dual modulators of the 5-HT2A and D3 receptors 失效苯甲酰哌啶衍生物作为5-HT2A和D3受体的双重调节剂公开(公告)号：US08415350B2
公开(公告)日：2013-04-09
申请号：US13233056
申请日：2011-09-15
申请人： Luca Gobbi , Georg Jaeschke , Thomas Luebbers , Olivier Roche , Rosa Maria Rodriguez-Sarmiento , Lucinda Steward
发明人： Luca Gobbi , Georg Jaeschke , Thomas Luebbers , Olivier Roche , Rosa Maria Rodriguez-Sarmiento , Lucinda Steward
IPC分类号： A61K31/496 , A61K31/5377 , C07D401/08 , C07D417/08
CPC分类号： C07D401/06 , C07D413/06 , C07D417/06
摘要： The present invention relates to compounds of the general formula as dual modulators of the 5-HT2a and D3 receptors useful against CNS disorders, wherein A, R1, R2, n, p, q and r are as defined in the specification.
摘要翻译： 本发明涉及通式的化合物作为可用于CNS障碍的5-HT2a和D3受体的双重调节剂，其中A，R1，R2，n，p，q和r如说明书中所定义。
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18.发明授权Benzoyl-piperidine derivatives as dual modulators of the 5-HT2A and D3 receptors 失效苯甲酰哌啶衍生物作为5-HT2A和D3受体的双重调节剂公开(公告)号：US08039490B2
公开(公告)日：2011-10-18
申请号：US11705635
申请日：2007-02-13
申请人： Luca Gobbi , Georg Jaeschke , Thomas Luebbers , Olivier Roche , Rosa Maria Rodriguez Sarmiento , Lucinda Steward
发明人： Luca Gobbi , Georg Jaeschke , Thomas Luebbers , Olivier Roche , Rosa Maria Rodriguez Sarmiento , Lucinda Steward
IPC分类号： A61K31/445 , C07D211/32
CPC分类号： C07D401/06 , C07D413/06 , C07D417/06
摘要： The present invention relates to compounds of the general formula as dual modulators of the 5-HT2a and D3 receptors useful against CNS disorders, wherein A, R1, R2, n, p, q and r are as defined in the specification.
摘要翻译： 本发明涉及通式的化合物作为可用于CNS障碍的5-HT2a和D3受体的双重调节剂，其中A，R1，R2，n，p，q和r如说明书中所定义。
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公开(公告)号：US20070281921A1
公开(公告)日：2007-12-06
申请号：US11804949
申请日：2007-05-21
IPC分类号： A61K31/55 , A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/506 , C07D403/14 , C07D413/14 , C07D417/14
CPC分类号： C07D401/12 , C07D239/48 , C07D403/12
摘要： The present invention relates to compounds of formula I and their pharmaceutically acceptable salts wherein formula I is: wherein X, Y, Z, R1 and R2 are as defined in the description and claims. The compounds of the present invention act as antagonists and/or inverse agonists at the histamine 3 receptor and are useful for the treatment and/or prevention of diseases such as obesity, metabolic syndrome (syndrome X), and other eating disorders.
摘要翻译： 本发明涉及式I化合物及其药学上可接受的盐，其中式I是：其中X，Y，Z，R 1和R 2如在 说明和要求。 本发明的化合物作为组胺3受体的拮抗剂和/或反向激动剂起作用，可用于治疗和/或预防诸如肥胖症，代谢综合征（综合征X）和其它进食障碍的疾病。
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公开(公告)号：US07786143B2
公开(公告)日：2010-08-31
申请号：US11502552
申请日：2006-08-10
IPC分类号： A61K31/454 , C07D417/14
CPC分类号： C07D417/04 , C07D417/14
摘要： The present invention relates to compounds of formula I wherein R1, R2 and R3 are as defined in the description and claims. It further relates to pharmaceutically acceptable salts thereof as well as to pharmaceutical compositions comprising these compounds and to methods for their preparation. The compounds are useful for the treatment and/or prevention of diseases which are associated with the modulation of H3 receptors.
摘要翻译： 本发明涉及式I化合物，其中R 1，R 2和R 3如说明书和权利要求中所定义。 它还涉及其药学上可接受的盐以及包含这些化合物的药物组合物及其制备方法。 该化合物可用于治疗和/或预防与H3受体的调节相关的疾病。
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