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30 条记录 (耗时 0.038 秒)

    2-SUBSTITUTED PROLINE BIS-AMIDE OREXIN RECEPTOR ANTAGONISTS
    14.
    发明申请
    2-SUBSTITUTED PROLINE BIS-AMIDE OREXIN RECEPTOR ANTAGONISTS 审中-公开
    2-取代的双胺双磺酰胺受体拮抗剂

    公开(公告)号：US20100029736A1

    公开(公告)日：2010-02-04

    申请号：US12302122

    申请日：2007-07-13

    申请人： Christopher D. Cox ,  David B. Whitman ,  Michael J. Breslin

    发明人： Christopher D. Cox ,  David B. Whitman ,  Michael J. Breslin

    IPC分类号： A61K31/4184 ,  C07D403/06 ,  C07D403/12 ,  A61P3/04

    CPC分类号： C07D403/06 ,  C07D403/12 ,  C07D403/14

    摘要： The present invention is directed to 2-substituted proline bis-amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

    摘要翻译： 本发明涉及作为食欲素受体的拮抗剂的2-取代的脯氨酸双酰胺化合物，其可用于治疗或预防涉及食欲素受体的神经和精神病症和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。

    Diazaspirodecane orexin receptor antagonists
    15.
    发明申请
    Diazaspirodecane orexin receptor antagonists 审中-公开
    二氮芥十一烷食欲素受体拮抗剂

    公开(公告)号：US20090176789A1

    公开(公告)日：2009-07-09

    申请号：US11990585

    申请日：2006-08-24

    申请人： Michael J. Breslin ,  Christopher D. Cox ,  David B. Whitman

    发明人： Michael J. Breslin ,  Christopher D. Cox ,  David B. Whitman

    IPC分类号： A61K31/495 ,  C07D237/26 ,  A61P25/20

    CPC分类号： C07D471/10

    摘要： The present invention is directed to diazaspirodecane compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

    摘要翻译： 本发明涉及作为食欲素受体的拮抗剂的二氮杂螺十一烷化合物，其可用于治疗或预防涉及食欲素受体的神经和精神病症和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。

    Substituted diazepan orexin receptor antagonists
    20.
    发明申请
    Substituted diazepan orexin receptor antagonists 审中-公开
    取代的二氮杂菜素食欲肽受体拮抗剂

    公开(公告)号：US20090192143A1

    公开(公告)日：2009-07-30

    申请号：US12309239

    申请日：2007-07-13

    申请人： Christopher D. Cox ,  Michael J. Breslin ,  Paul J. Coleman

    发明人： Christopher D. Cox ,  Michael J. Breslin ,  Paul J. Coleman

    IPC分类号： A61K31/551 ,  C07D413/14 ,  A61P3/04

    CPC分类号： C07D413/14 ,  C07D403/14 ,  C07D417/14

    摘要： The present invention is directed to substituted diazepan compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.

    摘要翻译： 本发明涉及作为食欲素受体的拮抗剂的取代的二氮杂环庚烷化合物，其可用于治疗或预防涉及食欲肽受体的神经和精神病症和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。