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公开(公告)号：US07595337B2
公开(公告)日：2009-09-29
申请号：US11883507
申请日：2006-02-06
申请人： Michael J. Breslin , Paul J. Coleman , Christopher D. Cox , Lou Anne Neilson , David B. Whitman
发明人： Michael J. Breslin , Paul J. Coleman , Christopher D. Cox , Lou Anne Neilson , David B. Whitman
IPC分类号： A61K31/4162 , C07D231/54
CPC分类号： C07D491/052
摘要： The present invention relates to tricyclic pyrazoles that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also relates to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译： 本发明涉及可用于治疗细胞增殖性疾病，用于治疗与KSP驱动蛋白活性相关的疾病和用于抑制KSP驱动蛋白的三环吡唑。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
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公开(公告)号：US20080182843A1
公开(公告)日：2008-07-31
申请号：US11883507
申请日：2006-02-06
申请人： Michael J. Breslin , Paul J. Coleman , Christopher D. Cox , Lou Anne Neilson , David B. Whitman
发明人： Michael J. Breslin , Paul J. Coleman , Christopher D. Cox , Lou Anne Neilson , David B. Whitman
IPC分类号： A61K31/4162 , C07D405/04 , A61K31/5377 , A61P35/00 , C07D413/14
CPC分类号： C07D491/052
摘要： The present invention relates to tricyclic pyrazoles that are useful for treating cellular proliferative diseases, for treating disorders associated with KSP kinesin activity, and for inhibiting KSP kinesin. The invention also relates to compositions which comprise these compounds, and methods of using them to treat cancer in mammals.
摘要翻译： 本发明涉及可用于治疗细胞增殖性疾病，用于治疗与KSP驱动蛋白活性相关的疾病和用于抑制KSP驱动蛋白的三环吡唑。 本发明还涉及包含这些化合物的组合物，以及使用它们治疗哺乳动物癌症的方法。
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公开(公告)号：US20110251237A1
公开(公告)日：2011-10-13
申请号：US13124897
申请日：2009-10-15
申请人： Michael J. Breslin , Paul J. Coleman , Christopher D. Cox , John D. Schreier , David B. Whitman
发明人： Michael J. Breslin , Paul J. Coleman , Christopher D. Cox , John D. Schreier , David B. Whitman
IPC分类号： A61K31/4709 , A61P3/04 , A61K31/4439 , C07D401/10 , C07D215/24
CPC分类号： C07D413/14 , C07D401/10 , C07D401/14 , C07D417/14
摘要： The present invention is directed to 2,5-disubstituted piperidine amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
摘要翻译： 本发明涉及作为食欲素受体的拮抗剂的2,5-二取代的哌啶酰胺化合物，其可用于治疗或预防涉及食欲素受体的神经和精神病症和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。
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公开(公告)号：US08669272B2
公开(公告)日：2014-03-11
申请号：US13124897
申请日：2009-10-15
申请人： Michael J. Breslin , Paul J. Coleman , Christopher D. Cox , John D. Schreier , David B. Whitman
发明人： Michael J. Breslin , Paul J. Coleman , Christopher D. Cox , John D. Schreier , David B. Whitman
IPC分类号： A61K31/4725 , A61K31/472 , A61K31/454 , C07D401/14
CPC分类号： C07D413/14 , C07D401/10 , C07D401/14 , C07D417/14
摘要： The present invention is directed to 2,5-disubstituted piperidine amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
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公开(公告)号：US20090176789A1
公开(公告)日：2009-07-09
申请号：US11990585
申请日：2006-08-24
IPC分类号： A61K31/495 , C07D237/26 , A61P25/20
CPC分类号： C07D471/10
摘要： The present invention is directed to diazaspirodecane compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
摘要翻译： 本发明涉及作为食欲素受体的拮抗剂的二氮杂螺十一烷化合物，其可用于治疗或预防涉及食欲素受体的神经和精神病症和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。
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公开(公告)号：US20100029736A1
公开(公告)日：2010-02-04
申请号：US12302122
申请日：2007-07-13
IPC分类号： A61K31/4184 , C07D403/06 , C07D403/12 , A61P3/04
CPC分类号： C07D403/06 , C07D403/12 , C07D403/14
摘要： The present invention is directed to 2-substituted proline bis-amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
摘要翻译： 本发明涉及作为食欲素受体的拮抗剂的2-取代的脯氨酸双酰胺化合物，其可用于治疗或预防涉及食欲素受体的神经和精神病症和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。
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公开(公告)号：US20090258903A1
公开(公告)日：2009-10-15
申请号：US11989847
申请日：2006-07-31
IPC分类号： A61K31/444 , C07D211/72 , C07D213/02 , A61K31/44 , A61P25/16
CPC分类号： C07D213/76 , C07D213/82 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The present invention is directed to aminoethane sulfonamide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
摘要翻译： 本发明涉及作为食欲素受体的拮抗剂的氨基乙酰磺酰胺化合物，其可用于治疗或预防涉及食欲肽受体的神经和精神病症和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。
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公开(公告)号：US20090124603A1
公开(公告)日：2009-05-14
申请号：US12225506
申请日：2007-03-27
IPC分类号： A61K31/5513 , C07D243/08
CPC分类号： C07D417/04 , C07D401/04 , C07D403/04 , C07D413/04 , C07D413/14
摘要： The present invention is directed to diazepan compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
摘要翻译： 本发明涉及作为食欲肽受体的拮抗剂的二氮杂环庚烷化合物，其可用于治疗或预防涉及食欲肽受体的神经和精神病症和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。
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公开(公告)号：US20090118200A1
公开(公告)日：2009-05-07
申请号：US11920596
申请日：2006-05-22
申请人： Jeffrey M. Bergman , Paul J. Coleman , Christopher D. Cox , George D. Hartman , Craig Lindsley , Swati Pal Mercer , Anthony J. Roecker , David B. Whitman
发明人： Jeffrey M. Bergman , Paul J. Coleman , Christopher D. Cox , George D. Hartman , Craig Lindsley , Swati Pal Mercer , Anthony J. Roecker , David B. Whitman
IPC分类号： A61K38/05 , C07D403/12 , C07D401/14 , C07D413/14 , A61K31/4184 , A61P25/00
CPC分类号： C07D403/12 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D471/04 , C07D487/04 , C07D513/04
摘要： The present invention is directed to proline bis-amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
摘要翻译： 本发明涉及作为食欲素受体的拮抗剂的脯氨酸双酰胺化合物，其可用于治疗或预防涉及食欲素受体的神经和精神病症和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。
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公开(公告)号：US08685961B2
公开(公告)日：2014-04-01
申请号：US12225506
申请日：2007-03-27
IPC分类号： A61P3/04 , A61K31/55 , C07D243/08
CPC分类号： C07D417/04 , C07D401/04 , C07D403/04 , C07D413/04 , C07D413/14
摘要： The present invention is directed to diazepan compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
摘要翻译： 本发明涉及作为食欲肽受体的拮抗剂的二氮杂环庚烷化合物，其可用于治疗或预防涉及食欲肽受体的神经和精神病症和疾病。 本发明还涉及包含这些化合物的药物组合物以及这些化合物和组合物在预防或治疗涉及食欲肽受体的疾病中的用途。
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