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11.发明授权Perm selective asymmetric hollow fibre membrane for the separation of toxic mediators from blood 有权Perm选择性不对称中空纤维膜用于分离有毒介质与血液公开(公告)号：US08136675B2
公开(公告)日：2012-03-20
申请号：US10539409
申请日：2003-12-18
申请人： Reinhold Buck , Hermann Goehl
发明人： Reinhold Buck , Hermann Goehl
CPC分类号： B01D67/0002 , A61M1/16 , A61M1/34 , A61M1/3403 , B01D67/0006 , B01D69/08 , B01D2325/02 , D01D5/24
摘要： The present invention relates to a permselective asymmetric hollow fibre membrane for the separation of toxic mediators from blood, comprised of at least one hydrophobic polymer and at least one hydrophilic polymer. Further, the present invention relates to a process for the preparation of such a membrane, and the use of said membrane in hemodialysis, hemodiafiltration, and hemofiltration for treatment of toxic mediator-related diseases.
摘要翻译： 本发明涉及一种用于将有毒介质与血液分离的选择性不对称中空纤维膜，由至少一种疏水性聚合物和至少一种亲水性聚合物组成。 此外，本发明涉及一种制备这种膜的方法，以及所述膜在血液透析，血液透析滤过和血液滤过中用于治疗毒性介质相关疾病的用途。
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12.发明授权Degassing device and end-cap assembly for a filter including such a degassing device 有权用于包括这种脱气装置的过滤器的脱气装置和端盖组件公开(公告)号：US08048209B2
公开(公告)日：2011-11-01
申请号：US10595772
申请日：2004-11-02
CPC分类号： A61M1/16 , A61M1/3627 , A61M2205/12 , B01D2313/21
摘要： A degassing device (203) comprises a first chamber (21) having an inlet for a liquid, and a second chamber (22) having an opening (23) closed by a hydrophobic membrane (24) and an outlet (25) for discharging the liquid. The first chamber (21) has a downstream portion that partially extends within the second chamber (22) and communicates therewith by a passageway (28). The second chamber (22) has a downstream portion that extends below the passageway (28) and asymmetrically surrounds the downstream portion of the first chamber (21).
摘要翻译： 脱气装置（203）包括具有用于液体的入口的第一室（21）和具有由疏水膜（24）封闭的开口（23）的第二室（22）和用于将 液体。 第一室（21）具有在第二室（22）内部分地延伸并与通道（28）连通的下游部分。 第二室（22）具有在通道（28）下方延伸并且不对称地包围第一室（21）的下游部分的下游部分。
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公开(公告)号：US07621884B2
公开(公告)日：2009-11-24
申请号：US10508328
申请日：2003-03-07
CPC分类号： A61M1/367 , A61M1/1006 , A61M1/1037 , A61M1/1039 , A61M2205/12 , Y10T428/139
摘要： A tube for medical applications comprises a chlorine-free material and has a layer defining an outer surface of the tube. The tube is manufactured from a polymer material having a solubility parameter within the range 9.9±1.5 (cal/cm3)1/2.
摘要翻译： 用于医疗应用的管包括无氯材料并且具有限定管的外表面的层。 该管由溶解度参数在9.9±1.5（cal / cm 3）1/2范围内的聚合物材料制成。
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14.发明申请Degassing Device and End-Cap Assembly for a Filter Including such a Degassing Device 有权用于包括这种脱气装置的过滤器的脱气装置和端盖组件公开(公告)号：US20090084720A1
公开(公告)日：2009-04-02
申请号：US10595772
申请日：2004-11-02
IPC分类号： B01D19/00
CPC分类号： A61M1/16 , A61M1/3627 , A61M2205/12 , B01D2313/21
摘要： A degassing device (203) comprises a first chamber (21) having an inlet for a liquid, and a second chamber (22) having an opening (23) closed by a hydrophobic membrane (24) and an outlet (25) for discharging the liquid. The first chamber (21) has a downstream portion that partially extends within the second chamber (22) and communicates therewith by a passageway (28). The second chamber (22) has a downstream portion that extends below the passageway (28) and asymmetrically surrounds the downstream portion of the first chamber (21).
摘要翻译： 脱气装置（203）包括具有用于液体的入口的第一室（21）和具有由疏水膜（24）封闭的开口（23）的第二室（22）和用于将 液体。 第一室（21）具有在第二室（22）内部分地延伸并与通道（28）连通的下游部分。 第二室（22）具有在通道（28）下方延伸并且不对称地包围第一室（21）的下游部分的下游部分。
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15.发明授权Fluid distribution module and extracorporeal blood circuit including such a module 有权流体分配模块和体外血液回路包括这样一个模块公开(公告)号：US08142383B2
公开(公告)日：2012-03-27
申请号：US10595705
申请日：2004-10-29
CPC分类号： A61M1/3627 , A61M1/1008 , A61M1/1039 , A61M1/1086 , A61M1/16 , A61M1/3639 , A61M1/3641 , A61M2205/12 , B01D61/30 , B01D63/02
摘要： A fluid distribution module (1) for causing and monitoring the circulation of fluids from and to a patient through an extracorporeal blood treatment device, comprises a degassing device (11) connected to a connecting structure (10). The degassing device (11) comprises a first chamber (12) having a lower inlet (13) for a liquid and a second chamber (14) having an upper opening (79) closed by a hydrophobic membrane (78) and an outlet (15) for discharging the liquid. The connecting structure (10) has at least a first and a second conduits (20, 21) defined therein, wherein the first conduit (20) comprises a first end for connection to a discharge tube (7) from the treatment device and a second end connected to the inlet (13) of the first chamber (12) of the degassing device (11), and the second conduit (21) comprises a first end connected to the outlet (15) of the second chamber (14) of the degassing device (11) and a second end for connection to a blood return tube (6) to a patient.
摘要翻译： 一种用于通过体外血液处理装置引导和监测来自和来自患者的流体循环的流体分配模块（1），包括连接到连接结构（10）的脱气装置（11）。 脱气装置（11）包括具有用于液体的下入口（13）的第一室（12）和具有由疏水膜（78）和出口（15）封闭的上开口（79）的第二室（14） ）用于排出液体。 连接结构（10）具有至少限定在其中的第一和第二导管（20,21），其中第一导管（20）包括用于从治疗装置连接到放电管（7）的第一端和第二导管 端部连接到脱气装置（11）的第一室（12）的入口（13），并且第二导管（21）包括连接到第二室（14）的出口（15）的第一端 脱气装置（11）和用于连接到患者的血液回流管（6）的第二端。
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16.发明申请Method for Making A Filter Device Having More Than One Filtration Compartment 有权制造具有多于一个过滤室的过滤装置的方法公开(公告)号：US20070181488A1
公开(公告)日：2007-08-09
申请号：US11736310
申请日：2007-04-17
IPC分类号： B01D35/00
CPC分类号： B01D63/04 , B01D61/145 , B01D61/243 , B01D61/30 , B01D61/58 , B01D63/02 , B01D65/00 , Y10T29/49613
摘要： A method for manufacturing a filter device having filter means, in particular hollow-fibre membranes, arranged in more than one filtration compartment within a filter housing. For example a dialysis type filtration process such as haemofiltration or haemodiafiltration or haemodialysis may be carried out at the same time as an ultrafiltration process or as another haemofiltration, haemodiafiltration or haemodialysis process. A split shell is bonded or welded together along longitudinal seams. Internal separating walls within the housing are formed integrally with the shell portions of the housing to form adjacent filtration compartments when the housing portions are joined together.
摘要翻译： 一种制造具有过滤装置，特别是中空纤维膜的过滤装置的方法，其布置在过滤器壳体内的多于一个过滤隔室中。 例如，透析型过滤方法如血液过滤或血液透析或血液透析可以在超滤方法的同时进行，或作为另一种血液透析，血液透析或血液透析过程进行。 分裂壳沿着纵向接缝焊接或焊接在一起。 当壳体部分接合在一起时，壳体内部的分隔壁与壳体的壳体部分形成一体，以形成相邻的过滤隔室。
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公开(公告)号：US08206580B2
公开(公告)日：2012-06-26
申请号：US10595546
申请日：2004-11-05
申请人： Jürgen Dannenmaier , Hermann Goehl , Thomas Ertl , Jacques Chevallet , Francesco Ribolzi , Björn Frederik Seidler , Lennart Jönsson , Eddie Nilsson
发明人： Jürgen Dannenmaier , Hermann Goehl , Thomas Ertl , Jacques Chevallet , Francesco Ribolzi , Björn Frederik Seidler , Lennart Jönsson , Eddie Nilsson
CPC分类号： A61M1/3627 , A61M1/1008 , A61M1/1039 , A61M1/1086 , A61M1/16 , A61M1/3639 , A61M1/3641 , A61M2205/12 , B01D61/30 , B01D63/02
摘要： An integrated blood treatment module comprises a blood treatment device (1) having a housing (2) and a first end-cap (4) and a second end-cap (5) closing both ends of the housing (2). A pump hose (17) for a peristaltic pump has a first end (18) that is secured to the housing (2) and a second end (16) that is connected to a blood inlet port (15) of the first end-cap (4) so as to form a loop. A degassing device (30) is connected to the second end-cap (5). The degassing device (30), which, in use, is full of liquid, comprises a hydrophobic membrane through which bubbles and micro-bubbles escape the degassing device.
摘要翻译： 集成血液处理模块包括具有壳体（2）和第一端盖（4）的血液处理装置（1）和封闭壳体（2）的两端的第二端盖（5）。 用于蠕动泵的泵管（17）具有固定到壳体（2）的第一端（18）和连接到第一端盖（16）的血液入口（15）的第二端（16） （4）以形成环路。 脱气装置（30）连接到第二端帽（5）。 在使用中充满液体的脱气装置（30）包括疏水膜，气泡和微气泡通过该疏水膜逸出脱气装置。
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18.发明申请Perm Selective Asymmetric Hollow Fibre Membrane for the Separation of Toxic Mediators From Blood 有权用于从血液中分离毒性调解剂的Perm选择性不对称中空纤维膜公开(公告)号：US20120145631A1
公开(公告)日：2012-06-14
申请号：US13372798
申请日：2012-02-14
申请人： Reinhold Buck , Hermann Goehl
发明人： Reinhold Buck , Hermann Goehl
CPC分类号： B01D67/0002 , A61M1/16 , A61M1/34 , A61M1/3403 , B01D67/0006 , B01D69/08 , B01D2325/02 , D01D5/24
摘要： A permselective asymmetric hollow fiber membrane for the separation of toxic mediators from blood, a process for the preparation of such a membrane, and the use of such a membrane in hemodialysis, hemodiafiltration, and hemofiltration for treatment of toxic mediator-related diseases.
摘要翻译： 用于从血液中分离毒性介质的选择性不对称中空纤维膜，制备这种膜的方法，以及在血液透析，血液透析滤过和血液滤过中用于治疗有毒介质相关疾病的用途。
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19.发明授权Perm selective asymmetric hollow fibre membrane for the separation of toxic mediators from blood 有权Perm选择性不对称中空纤维膜用于分离有毒介质与血液公开(公告)号：US08197745B1
公开(公告)日：2012-06-12
申请号：US13372798
申请日：2012-02-14
申请人： Reinhold Buck , Hermann Goehl
发明人： Reinhold Buck , Hermann Goehl
CPC分类号： B01D67/0002 , A61M1/16 , A61M1/34 , A61M1/3403 , B01D67/0006 , B01D69/08 , B01D2325/02 , D01D5/24
摘要： A permselective asymmetric hollow fiber membrane for the separation of toxic mediators from blood, a process for the preparation of such a membrane, and the use of such a membrane in hemodialysis, hemodiafiltration, and hemofiltration for treatment of toxic mediator-related diseases.
摘要翻译： 用于从血液中分离毒性介质的选择性不对称中空纤维膜，制备这种膜的方法，以及在血液透析，血液透析滤过和血液滤过中用于治疗毒性介质相关疾病的用途。
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20.发明申请Fluid Distribution Module and Extracorporeal Blood Circuit Including Such a Module 有权流体分布模块和体外血液循环包括这样一个模块公开(公告)号：US20070269340A1
公开(公告)日：2007-11-22
申请号：US10595705
申请日：2004-10-29
IPC分类号： B01D61/00
CPC分类号： A61M1/3627 , A61M1/1008 , A61M1/1039 , A61M1/1086 , A61M1/16 , A61M1/3639 , A61M1/3641 , A61M2205/12 , B01D61/30 , B01D63/02
摘要： A fluid distribution module (1) for causing and monitoring the circulation of fluids from and to a patient through an extracorporeal blood treatment device, comprises a degassing device (11) connected to a connecting structure (10). The degassing device (11) comprises a first chamber (12) having a lower inlet (13) for a liquid and a second chamber (14) having an upper opening (79) closed by a hydrophobic membrane (78) and an outlet (15) for discharging the liquid. The connecting structure (10) has at least a first and a second conduits (20, 21) defined therein, wherein the first conduit (20) comprises a first end for connection to a discharge tube (7) from the treatment device and a second end connected to the inlet (13) of the first chamber (12) of the degassing device (11), and the second conduit (21) comprises a first end connected to the outlet (15) of the second chamber (14) of the degassing device (11) and a second end for connection to a blood return tube (6) to a patient.
摘要翻译： 一种用于通过体外血液处理装置引导和监测来自和来自患者的流体循环的流体分配模块（1），包括连接到连接结构（10）的脱气装置（11）。 脱气装置（11）包括具有用于液体的下入口（13）的第一室（12）和具有由疏水膜（78）和出口（15）封闭的上开口（79）的第二室（14） ）用于排出液体。 连接结构（10）具有至少限定在其中的第一和第二导管（20,21），其中第一导管（20）包括用于从治疗装置连接到放电管（7）的第一端和第二导管 端部连接到脱气装置（11）的第一室（12）的入口（13），并且第二导管（21）包括连接到第二室（14）的出口（15）的第一端 脱气装置（11）和用于连接到患者的血液回流管（6）的第二端。
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