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11.
公开(公告)号:US20090118234A1
公开(公告)日:2009-05-07
申请号:US12288999
申请日:2008-10-24
申请人: Michael N. Greco , Harold R. Almond, JR. , Lawrene de Garavilla , Michael J. Hawkins , Michael J. Humora , Yun Qian , Donald Gilmore Walker , Sergio Cesco-Cancian , Christopher Norman Nilsen , Mitul N. Patel , Kirk Leonard Sorgi , Eugene Powell
发明人: Michael N. Greco , Harold R. Almond, JR. , Lawrene de Garavilla , Michael J. Hawkins , Michael J. Humora , Yun Qian , Donald Gilmore Walker , Sergio Cesco-Cancian , Christopher Norman Nilsen , Mitul N. Patel , Kirk Leonard Sorgi , Eugene Powell
IPC分类号: A61K31/675 , A61P11/06
CPC分类号: C07F9/65586 , C07F9/3882 , C07F9/572 , C07F9/59 , C07F9/650952 , C07F9/65517 , C07F9/65583 , C07F9/6561
摘要: The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.
摘要翻译: 本发明涉及可用作丝氨酸蛋白酶抑制剂的膦酸化合物,其组合物和用于治疗炎性和丝氨酸蛋白酶介导的病症的方法。
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公开(公告)号:US08394804B2
公开(公告)日:2013-03-12
申请号:US12288920
申请日:2008-10-24
申请人: Michael N. Greco , Harold R. Almond, Jr. , Lawrence de Garavilla , Michael J. Hawkins , Michael J. Humora , Yun Qian , Donald Gilmore Walker , Sergio Cesco-Cancian , Christopher Norman Nilsen , Mitul N. Patel , Kirk Leonerd Sorgi , Eugene Powell
发明人: Michael N. Greco , Harold R. Almond, Jr. , Lawrence de Garavilla , Michael J. Hawkins , Michael J. Humora , Yun Qian , Donald Gilmore Walker , Sergio Cesco-Cancian , Christopher Norman Nilsen , Mitul N. Patel , Kirk Leonerd Sorgi , Eugene Powell
IPC分类号: A61K31/4965 , C07D241/04 , C07D295/00
CPC分类号: C07F9/65586 , C07F9/3882 , C07F9/572 , C07F9/59 , C07F9/650952 , C07F9/65517 , C07F9/65583 , C07F9/6561
摘要: The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.
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公开(公告)号:US20090143336A1
公开(公告)日:2009-06-04
申请号:US12288920
申请日:2008-10-24
申请人: Michael N. Greco , Harold R. Almond, JR. , Lawrence de Garavilla , Michael J. Hawkins , Michael J. Humora , Yun Qian , Donald Gilmore Walker , Sergio Cesco-Cancian , Christopher Norman Nilsen , Mitul N. Patel , Kirk Leonerd Sorgi , Eugene Powell
发明人: Michael N. Greco , Harold R. Almond, JR. , Lawrence de Garavilla , Michael J. Hawkins , Michael J. Humora , Yun Qian , Donald Gilmore Walker , Sergio Cesco-Cancian , Christopher Norman Nilsen , Mitul N. Patel , Kirk Leonerd Sorgi , Eugene Powell
IPC分类号: A61K31/675 , C07F9/6509 , A61P29/00
CPC分类号: C07F9/65586 , C07F9/3882 , C07F9/572 , C07F9/59 , C07F9/650952 , C07F9/65517 , C07F9/65583 , C07F9/6561
摘要: The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.
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公开(公告)号:US20090118508A1
公开(公告)日:2009-05-07
申请号:US12288941
申请日:2008-10-24
申请人: Michael N. Greco , Harold R. Almond, JR. , Lawrence Garavilla , Michael J. Hawkins , Michael J. Humora , Yun Qian , Donaid Gilmore Walker , Sergio Cesco-Cancian , Christopher Norman Nilsen , Mitul N. Patel , Kirk Leoperd Sorgi , Eugene Powell
发明人: Michael N. Greco , Harold R. Almond, JR. , Lawrence Garavilla , Michael J. Hawkins , Michael J. Humora , Yun Qian , Donaid Gilmore Walker , Sergio Cesco-Cancian , Christopher Norman Nilsen , Mitul N. Patel , Kirk Leoperd Sorgi , Eugene Powell
IPC分类号: C07F9/28
CPC分类号: C07F9/65586 , C07F9/3882 , C07F9/572 , C07F9/59 , C07F9/650952 , C07F9/65517 , C07F9/65583 , C07F9/6561
摘要: The present invention is directed to phosphonic acid compounds useful as serine protease inhibitors, compositions thereof and methods for treating inflammatory and serine protease mediated disorders.
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公开(公告)号:US08063206B2
公开(公告)日:2011-11-22
申请号:US12840134
申请日:2010-07-20
申请人: Neelakandha S. Mani , David C. Palmer , Chennagiri R. Pandit , Mayra B. Reyes , Tong Xiao , Sergio Cesco-Cancian
发明人: Neelakandha S. Mani , David C. Palmer , Chennagiri R. Pandit , Mayra B. Reyes , Tong Xiao , Sergio Cesco-Cancian
IPC分类号: C07D413/10
CPC分类号: C07D295/192
摘要: The present invention is directed to novel processes for the preparation of cyclopropyl-amide derivatives, useful for the treatment of disorders and conditions mediated by the histamine receptor.
摘要翻译: 本发明涉及用于制备环丙基 - 酰胺衍生物的新方法,其用于治疗由组胺受体介导的病症和病症。
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16.
公开(公告)号:US20100286391A1
公开(公告)日:2010-11-11
申请号:US12840134
申请日:2010-07-20
申请人: Neelakandha S. Mani , David C. Palmer , Chennagiri R. Pandit , Mayra B. Reyes , Tong Xiao , Sergio Cesco-Cancian
发明人: Neelakandha S. Mani , David C. Palmer , Chennagiri R. Pandit , Mayra B. Reyes , Tong Xiao , Sergio Cesco-Cancian
IPC分类号: C07D413/10 , C07D401/10
CPC分类号: C07D295/192
摘要: The present invention is directed to novel processes for the preparation of cyclopropyl-amide derivatives, useful for the treatment of disorders and conditions mediated by the histamine receptor.
摘要翻译: 本发明涉及用于制备环丙基 - 酰胺衍生物的新方法,其用于治疗由组胺受体介导的病症和病症。
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17.
公开(公告)号:US20120283433A1
公开(公告)日:2012-11-08
申请号:US13542821
申请日:2012-07-06
申请人: Neelakandha S. Mani , David C. Palmer , Chennagiri R. Pandit , Mayra B. Reyes , Tong Xiao , Sergio Cesco-Cancian
发明人: Neelakandha S. Mani , David C. Palmer , Chennagiri R. Pandit , Mayra B. Reyes , Tong Xiao , Sergio Cesco-Cancian
IPC分类号: C07D413/10
CPC分类号: C07D295/192
摘要: The present invention is directed to novel processes for the preparation of cyclopropyl-amide derivatives, useful for the treatment of disorders and conditions mediated by the histamine receptor.
摘要翻译: 本发明涉及用于制备环丙基 - 酰胺衍生物的新方法,其用于治疗由组胺受体介导的病症和病症。
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公开(公告)号:US20120029191A1
公开(公告)日:2012-02-02
申请号:US13270924
申请日:2011-10-11
申请人: Neelakandha S. Mani , David C. Palmer , Chennagiri R. Pandit , Mayra B. Reyes , Tong Xiao , Sergio Cesco-Cancian
发明人: Neelakandha S. Mani , David C. Palmer , Chennagiri R. Pandit , Mayra B. Reyes , Tong Xiao , Sergio Cesco-Cancian
IPC分类号: C07D413/10
CPC分类号: C07D295/192
摘要: The present invention is directed to novel processes for the preparation of cyclopropyl-amide derivatives, useful for the treatment of disorders and conditions mediated by the histamine receptor.
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公开(公告)号:US08309720B2
公开(公告)日:2012-11-13
申请号:US12459229
申请日:2009-06-29
申请人: Sergio Cesco-Cancian , Hongfeng Chen , Jeffrey S. Grimm , Neelakandha S. Mani , Christopher M. Mapes , David C. Palmer , Daniel J. Pippel , Kirk L. Sorgi , Tong Xiao
发明人: Sergio Cesco-Cancian , Hongfeng Chen , Jeffrey S. Grimm , Neelakandha S. Mani , Christopher M. Mapes , David C. Palmer , Daniel J. Pippel , Kirk L. Sorgi , Tong Xiao
IPC分类号: C07D211/06 , C07D211/30
CPC分类号: C07D401/12 , C07C211/22 , C07C211/26 , C07D211/22 , C07D211/26
摘要: The present invention is directed to processes for the preparation of substituted pyrimidine derivatives, useful as intermediates in the synthesis of histamine H4 receptor modulators, and to intermediates in H4 modulator synthesis.
摘要翻译: 本发明涉及制备用作合成组胺H 4受体调节剂的中间体的取代嘧啶衍生物的方法,以及H4调节剂合成中的中间体。
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公开(公告)号:US07795426B2
公开(公告)日:2010-09-14
申请号:US11553154
申请日:2006-10-26
申请人: Neelakandha S. Mani , David C. Palmer , Chennagiri R. Pandit , Mayra B. Reyes , Tong Xiao , Sergio Cesco-Cancian
发明人: Neelakandha S. Mani , David C. Palmer , Chennagiri R. Pandit , Mayra B. Reyes , Tong Xiao , Sergio Cesco-Cancian
IPC分类号: C07D413/10
CPC分类号: C07D295/192
摘要: The present invention relates to processes for the preparation of cyclopropyl-amine derivatives of formula (II), as defined in the specification, useful for the treatment of disorders and conditions mediated by the histamine receptor.
摘要翻译: 本发明涉及制备本说明书中定义的式(II)的环丙基 - 胺衍生物的方法,其用于治疗由组胺受体介导的病症和病症。
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