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    Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase
    17.
    再颁专利
    Bis mono- and bicyclic aryl and heteroaryl compounds which inhibit EGF and/or PDGF receptor tyrosine kinase 失效
    抑制EGF和/或PDGF受体酪氨酸激酶的双单和双环芳基和杂芳基化合物

    公开(公告)号：USRE36256E

    公开(公告)日：1999-07-20

    申请号：US988005

    申请日：1997-12-10

    申请人： Alfred P. Spada ,  Michael R. Myers ,  Martin P. Maguire ,  Paul E. Persons

    发明人： Alfred P. Spada ,  Michael R. Myers ,  Martin P. Maguire ,  Paul E. Persons

    IPC分类号： A61K31/495 ,  A61K31/535 ,  C07D241/52 ,  C07D241/54

    摘要： This invention relates to bis mono- and/or bicyclic aryl and/or heteroaryl compounds exhibiting protein tyrosine kinase inhibition activity. More specifically, it relates to the method of inhibiting abnormal cell proliferation in a patient suffering from a disorder characterized by such proliferation comprising the administration thereto of an EGF and/or PDGF receptor inhibiting effective amount of said bis mono- and/or bicyclic aryl and/or heteroaryl compound and to the preparation of said compounds and their use in pharmaceutical compositions used in this method.

    摘要翻译： 本发明涉及显示蛋白酪氨酸激酶抑制活性的双单和/或双环芳基和/或杂芳基化合物。 更具体地，本发明涉及抑制患有以这种增殖为特征的病症的患者的异常细胞增殖的方法，其包括给予EGF和/或PDGF受体抑制有效量的所述双 - 单 - 和/或双环芳基和 /或杂芳基化合物，以及所述化合物的制备及其在该方法中使用的药物组合物中的用途。

    Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties
    20.
    发明授权
    Compounds having antihypertensive, cardioprotective, anti-ischemic and antilipolytic properties 失效
    具有抗高血压，心脏保护作用，抗缺血性和抗脂解性的化合物

    公开(公告)号：US06376472B1

    公开(公告)日：2002-04-23

    申请号：US09174191

    申请日：1998-10-16

    申请人： Michael R. Myers ,  Martin P. Maguire ,  Alfred P. Spada ,  William R. Ewing ,  Henry W. Pauls ,  Yong Mi Choi-Sledeski

    发明人： Michael R. Myers ,  Martin P. Maguire ,  Alfred P. Spada ,  William R. Ewing ,  Henry W. Pauls ,  Yong Mi Choi-Sledeski

    IPC分类号： C07D47334

    CPC分类号： C07H19/16 ,  C07D401/04 ,  C07D471/04 ,  C07D473/34

    摘要： A compound of the formula wherein K is N; Q is CH2 or O; R6 is hydrogen, alkyl, allyl, 2-methylallyl, 2-butenyl, or cycloalkyl where the nitrogen of the ring of X is substituted by Y; E is O or S; Y is hydrogen, alkyl, aralkyl, substituted aralkyl, aryl, substituted aryl, heterocyclyl, substituted heterocyclyl, heterocyclylalkyl, or substituted heterocyclylalkyl; and n and p are independently 0, 1, 2, or 3, provided that n+p is at least 1; T is hydrogen, alkyl, alkylcarbonyl, alkylthiocarbonyl, halo, carboxyl, A and B are independently hydrogen, alkyl, hydroxyalkyl, alkoxyalkyl, or OR′; or a pharmaceutically acceptable salt thereof, a pharmaceutic-ally acceptable prodrug thereof, an N-oxide thereof, a hydrate thereof or a solvate thereof.

    摘要翻译： 化合物K为N; Q是CH 2或O; R6是氢，烷基，烯丙基，2-甲基烯丙基，2-丁烯基或环烷基，X的环的氮被Y取代; E为O或S; Y是氢，烷基，芳烷基，取代的芳烷基，芳基，取代的芳基，杂环基，取代的杂环基，杂环基烷基或取代的杂环基烷基; n和p独立地为0,1,2或3，条件是n + p为至少1; T为氢，烷基，烷基羰基，烷硫基羰基，卤素，羧基，A和B独立地为氢，烷基，羟基烷基， 烷氧基烷基或OR';或其药学上可接受的盐，其药学上可接受的前药，其N-氧化物，其水合物或其溶剂化物。