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![PROCESS FOR THE PREPARATION OF 6-SUBSTITUTED-IMIDAZO [2,1-B] THIAZOLE-5-SULFONYL HALIDE](/abs-image/US/2010/08/19/US20100210850A1/abs.jpg.150x150.jpg)
11.发明申请PROCESS FOR THE PREPARATION OF 6-SUBSTITUTED-IMIDAZO [2,1-B] THIAZOLE-5-SULFONYL HALIDE 审中-公开制备6-取代的咪唑并[2,1-B]噻唑-5-磺酰卤的方法公开(公告)号：US20100210850A1
公开(公告)日：2010-08-19
申请号：US12738864
申请日：2008-10-22
IPC分类号： C07D513/04
CPC分类号： C07D513/04
摘要： The present invention is related to the a new process for the preparation of 6-substituted-imidazo[2,1-b]thiazole-5-sulfonyl halides of formula (I), comprising gradually adding a compound of formula (II), into a heated solution of R1SO3H where R1 represents F or Cl, and R2 represents H, F, Cl, Br, S, (C1-C6)alkyl, (C1-C6)alkoxy or trifluoromethyl.
摘要翻译： 本发明涉及制备式（I）的6-取代咪唑并[2,1-b]噻唑-5-磺酰卤的新方法，其包括将式（II）化合物逐渐加入到 R 1 SO 3 H的加热溶液，其中R 1表示F或Cl，R 2表示H，F，Cl，Br，S，（C 1 -C 6）烷基，（C 1 -C 6）烷氧基或三氟甲基。
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12.发明授权Heterocyclyl substituted tetrahydronaphthalene derivatives as 5-HT7 receptor ligands 失效杂环取代的四氢萘衍生物作为5-HT7受体配体公开(公告)号：US08097641B2
公开(公告)日：2012-01-17
申请号：US12525461
申请日：2008-02-06
IPC分类号： A61K31/415 , C07D231/12
CPC分类号： C07D231/12 , C07D213/64 , C07D261/08
摘要： The present invention relates to heterocyclyl-substituted-tetrahydro-naphthalen compounds of general formula (I), methods for their preparation, and compositions comprising these compounds as well as their use for the treatment or prophylaxis of various disorders in humans or animals.
摘要翻译： 本发明涉及通式（I）的杂环基 - 取代 - 四氢 - 萘化合物，其制备方法和包含这些化合物的组合物及其用于治疗或预防人或动物各种疾病的用途。
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13.发明授权Heterocyclyl-substituted-tetrahydro-naphthalen-amine derivatives, their preparation and use as medicaments 失效杂环取代 - 四氢 - 萘胺衍生物，其制备和用途作为药物公开(公告)号：US08236845B2
公开(公告)日：2012-08-07
申请号：US12593464
申请日：2008-03-28
IPC分类号： A61K31/415 , C07D231/12
CPC分类号： C07D231/12 , C07D213/38 , C07D261/08 , C07D307/52 , C07D333/20
摘要： The present invention relates to heterocyclyl-substituted-tetrahydro-naphthalen-amine compounds of general formula (I) and compositions thereof, methods for their preparation, and the use of said compounds for the treatment or prophylaxis of various disorders of humans or animals.
摘要翻译： 本发明涉及通式（I）的杂环基 - 取代 - 四氢 - 萘胺化合物及其组合物，其制备方法以及所述化合物用于治疗或预防人或动物各种疾病的用途。
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公开(公告)号：US20110053980A1
公开(公告)日：2011-03-03
申请号：US12667587
申请日：2008-07-04
IPC分类号： A61K31/415 , C07D231/12 , C07C217/74 , C07C211/42 , C07D261/08 , C07D213/64 , C07D401/10 , C07D403/10 , A61K31/135 , A61K31/42 , A61K31/4418 , A61K31/454 , A61P29/00 , A61P25/00 , A61P25/24 , A61P25/06 , A61P25/22 , A61P25/18 , A61P1/00 , A61P13/00
CPC分类号： C07D231/12 , C07D211/42 , C07D261/08
摘要： The present invention relates to indane-amine compounds of general formula (I) and compositions thereof, methods for their preparation, and the use of said compounds for the preparation of a medicament for the treatment of humans or animals.
摘要翻译： 本发明涉及通式（I）的茚满胺化合物及其组合物，其制备方法和所述化合物在制备用于治疗人或动物的药物中的用途。
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15.发明申请Heterocyclyl-substituted-ethylamino-phenyl derivatives, their preparation and use as medicaments 审中-公开杂环取代的 - 乙基氨基 - 苯基衍生物，它们的制备和用作药物公开(公告)号：US20100152252A1
公开(公告)日：2010-06-17
申请号：US12520463
申请日：2007-12-21
IPC分类号： A61K31/415 , C07D231/12 , C07C211/27 , C07C217/56 , C07D261/08 , C07D213/64 , A61K31/137 , A61K31/42 , A61K31/4418 , A61P25/00 , A61P25/06 , A61P25/22 , A61P9/12 , A61P1/00 , A61P29/00 , A61P13/00
CPC分类号： C07D231/12 , C07C211/27 , C07C211/29 , C07C217/60 , C07D261/08
摘要： The present invention relates to heterocyclyl-substituted-ethylamino-phenyl compounds of general formula (I), wherein K-L-M-N, Z and R1, R2, R3, R4 are as described in the claims methods for their preparation, medicaments comprising these compounds as well as their use for the preparation of a medicament for the treatment of humans or animals.
摘要翻译： 本发明涉及通式（I）的杂环基取代的 - 乙基氨基 - 苯基化合物，其中KLMN，Z和R1，R2，R3，R4如权利要求的制备方法所述，包含这些化合物的药物以及 它们用于制备用于治疗人或动物的药物的用途。
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公开(公告)号：US08232307B2
公开(公告)日：2012-07-31
申请号：US12667587
申请日：2008-07-04
IPC分类号： A61K31/415 , C07D231/00
CPC分类号： C07D231/12 , C07D211/42 , C07D261/08
摘要： The present invention relates to indane-amine compounds of general formula (I) and compositions thereof, methods for their preparation, and the use of said compounds for the treatment of humans or animals.
摘要翻译： 本发明涉及通式（I）的茚满胺化合物及其组合物，其制备方法以及所述化合物用于治疗人或动物的用途。
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17.发明申请公开(公告)号：US20100105684A1
公开(公告)日：2010-04-29
申请号：US12593464
申请日：2008-03-28
IPC分类号： A61K31/5377 , C07D231/12 , A61K31/415 , C07D403/02 , A61K31/4155 , A61K31/497 , C07D401/02 , A61K31/445 , C07D413/02
CPC分类号： C07D231/12 , C07D213/38 , C07D261/08 , C07D307/52 , C07D333/20
摘要： The present invention relates to heterocyclyl-substituted-tetrahydro-naphthalen-amine compounds of general formula (I) and compositions thereof, methods for their preparation, and the use of said compounds for the treatment or prophylaxis of various disorders of humans or animals.
摘要翻译： 本发明涉及通式（I）的杂环基 - 取代 - 四氢 - 萘胺化合物及其组合物，其制备方法以及所述化合物用于治疗或预防人或动物各种疾病的用途。
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18.发明申请HETEROCYCLYL SUBSTITUTED TETRAHYDRONAPHTHALENE DERIVATIVES AS 5-HT7 RECEPTOR LIGANDS 失效作为5-HT7受体配体的间苯二酚取代的四氢萘基衍生物公开(公告)号：US20100035936A1
公开(公告)日：2010-02-11
申请号：US12525461
申请日：2008-02-06
IPC分类号： A61K31/44 , C07D231/12 , A61K31/415 , C07D261/06 , A61K31/42 , C07C211/33 , A61K31/135 , C07D213/63 , A61P29/00 , A61P25/00 , A61P9/00 , A61P13/00 , A61P1/00
CPC分类号： C07D231/12 , C07D213/64 , C07D261/08
摘要： The present invention relates to heterocyclyl-substituted-tetrahydro-naphthalen compounds of general formula (I), methods for their preparation, and compositions comprising these compounds as well as their use for the treatment or prophylaxis of various disorders in humans or animals.
摘要翻译： 本发明涉及通式（I）的杂环基 - 取代 - 四氢 - 萘化合物，其制备方法和包含这些化合物的组合物及其用于治疗或预防人或动物各种疾病的用途。
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公开(公告)号：US07041665B2
公开(公告)日：2006-05-09
申请号：US10409235
申请日：2003-04-08
IPC分类号： C07D413/04 , C07D413/12 , A61K31/5365
CPC分类号： C07D413/04 , C07D413/14 , C07D417/14
摘要： The present invention relates to new compounds of general formula (I), as well as to their physiologically acceptable salts, the procedures for their preparation, the intermediate compounds for obtaining them, the application of the compounds of general formula (I) as medicaments in the prevention and treatment of disorders of the Central nervous System and to the pharmaceutical compositions containing them.
摘要翻译： 本发明涉及通式（I）的新化合物及其生理上可接受的盐，其制备方法，获得它们的中间体化合物，通式（I）的化合物作为药物的应用 预防和治疗中枢神经系统疾病以及含有它们的药物组合物。
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