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公开(公告)号：US07041665B2
公开(公告)日：2006-05-09
申请号：US10409235
申请日：2003-04-08
IPC分类号： C07D413/04 , C07D413/12 , A61K31/5365
CPC分类号： C07D413/04 , C07D413/14 , C07D417/14
摘要： The present invention relates to new compounds of general formula (I), as well as to their physiologically acceptable salts, the procedures for their preparation, the intermediate compounds for obtaining them, the application of the compounds of general formula (I) as medicaments in the prevention and treatment of disorders of the Central nervous System and to the pharmaceutical compositions containing them.
摘要翻译： 本发明涉及通式（I）的新化合物及其生理上可接受的盐，其制备方法，获得它们的中间体化合物，通式（I）的化合物作为药物的应用 预防和治疗中枢神经系统疾病以及含有它们的药物组合物。
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2.发明申请SUBSTITUTED INDANYL SULFONAMIDE COMPOUNDS, THEIR PREPARATION AND USE AS MEDICAMENTS 审中-公开取代的索兰磺胺化合物，其制备和用作药物公开(公告)号：US20100069378A1
公开(公告)日：2010-03-18
申请号：US12375922
申请日：2007-07-25
申请人： Jordi Frigola-Constansa , Joerg Holenz , Ramon Merce-Vidal , Maria de las Ermitas Alcalde-Pais , Maria de les Neus Mesquida-Estevez , Sara Lopez-Perez
发明人： Jordi Frigola-Constansa , Joerg Holenz , Ramon Merce-Vidal , Maria de las Ermitas Alcalde-Pais , Maria de les Neus Mesquida-Estevez , Sara Lopez-Perez
IPC分类号： A61K31/18 , C07D295/12 , C07D409/12 , C07D513/04 , C07C311/21 , C07D413/12 , A61K31/4965 , A61K31/496 , A61K31/429 , A61K31/538 , A61P3/00 , A61P25/00 , A61P25/22 , A61P25/24 , A61P25/18 , A61P25/28
CPC分类号： C07D295/135 , C07D333/62 , C07D513/04
摘要： The present invention refers to new indanyl sulphonamide compounds with general formula (I), as well as to their preparation procedure, their application as medicine and the pharmaceuticals composition which they are made up of. The new compounds of formula (I) show affinity for 5-HT6 receptors and are, therefore, effective for treating diseases mediated by these receptors.
摘要翻译： 本发明涉及具有通式（I）的新的茚满基磺酰胺化合物及其制备方法，它们作为药物及其组成的药物组合物的应用。 式（I）的新化合物显示出对5-HT 6受体的亲和力，因此对于治疗由这些受体介导的疾病是有效的。
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3.发明授权Derivatives of cyano-aryl (or cyanoheteroaryl)-carbonyl-piperazinyl-pyrimidines, their preparation and application as medication 失效氰基 - 芳基（或氰基杂芳基） - 羰基 - 哌嗪基 - 嘧啶的衍生物，其制备和作为药物的应用公开(公告)号：US07300937B2
公开(公告)日：2007-11-27
申请号：US10312195
申请日：2001-10-10
申请人： Jordi Corbera-Arjona , David Vano-Domenech , Maria Neus Mesquida-Estevez , Jordi Frigola-Constansa
发明人： Jordi Corbera-Arjona , David Vano-Domenech , Maria Neus Mesquida-Estevez , Jordi Frigola-Constansa
IPC分类号： A61K31/496 , C07D403/04
CPC分类号： C07D239/47 , C07D401/12 , C07D405/12 , C07D409/12
摘要： New derivatives of cyanoaryl (or cyanoheteroaryl)-carbonyl-piperazinyl-pyrimidines (I), where R1 represents an OR3 radical, where R3 represents a radical derived from a saturated hydrocarbon, with a linear or branched chain of 1 to 4 carbon atoms, and R2 represents a phenyl radical substituted at least by one cyan radical (—C≡N), or a radical of a heteroaromatic ring of 5 or 6 members substituted at least by one cyan radical (—C≡N); and their physiologically acceptable salts, are useful for application in human and/or veterinary therapeutics as sedatives, anticonvulsants, hypnotics and general anaesthetics
摘要翻译： 氰基芳基（或氰基杂芳基） - 羰基 - 哌嗪基 - 嘧啶（I）的新衍生物，其中R 1表示OR 3，其中R 3
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公开(公告)号：US20070167448A1
公开(公告)日：2007-07-19
申请号：US11707571
申请日：2007-02-16
IPC分类号： A61K31/5377 , A61K31/498 , A61K31/496 , A61K31/4745 , A61K31/454 , A61K31/405 , C07D413/02 , C07D403/02
CPC分类号： C04B35/632 , C07D209/14 , C07D209/16 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D409/12 , C07D409/14 , C07D417/12 , C07D471/04 , C07D513/04
摘要： The present invention relates to new derivatives of sulphonamides, with the general formula (I), as well as to their physiologically acceptable salts, the processes for their preparation, their application as medicaments in human and/or veterinary therapy and the pharmaceutical compositions that contain them.
摘要翻译： 本发明涉及具有通式（I）的磺酰胺的新衍生物，以及它们的生理上可接受的盐，其制备方法，它们作为人和/或兽医治疗中的药物的用途，以及含有 他们。
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5.发明授权公开(公告)号：US06353117B1
公开(公告)日：2002-03-05
申请号：US09701276
申请日：2000-11-28
申请人： María Rosa Cuberes-Altisent , Juana María Berrocal-Romero , María Montserrat Contijoch-Llobet , Jordi Frigola-Constansa
发明人： María Rosa Cuberes-Altisent , Juana María Berrocal-Romero , María Montserrat Contijoch-Llobet , Jordi Frigola-Constansa
IPC分类号： C07D23106
CPC分类号： C07D231/06
摘要： The present invention relates to new pyazoline derivatives of formula and to physiologically acceptable salts thereof, to the method for their preparation and to their application as medicaments.
摘要翻译： 本发明涉及式的新的吡唑啉衍生物及其生理上可接受的盐，其制备方法及其作为药物的应用。
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6.发明授权Topical ophthalmic composition comprising a 2-[4-(azolylbutyl)piperazinylmethyl]benzimidazole derivative, in particular for the treatment of allergic conjunctivitis 失效包含2- [4-（唑基丁基）哌嗪基甲基]苯并咪唑衍生物的局部眼用组合物，特别是用于治疗过敏性结膜炎
公开(公告)号：US5641781A
公开(公告)日：1997-06-24
申请号：US613843
申请日：1996-03-11
IPC分类号： C07D403/12 , A61K31/495 , A61K31/496 , A61K31/55 , A61K31/551 , A61P27/02
CPC分类号： A61K31/551 , A61K31/496
摘要： The present invention relates to a topical ophthalmic composition comprising at least one compound of general formula I ##STR1## in which n may have the values 0 or 1,m may have the values 2 or 3,and Het represents a heteroaromatic radical of formula ##STR2## in which X, Y, Z and W, which may be the same or different, represent a nitrogen atom or a carbon atom linked to a hydrogen atom, a halogen atom, a methyl radical, an ethyl carboxylate radical, a carboxylic radical or a sulphonic radical, and the pharmaceutically acceptable salts thereof, combined with an ophthalmically acceptable vehicle, in particular for the treatment of allergic conjunctivitis.
摘要翻译： 本发明涉及包含至少一种通式I的化合物（I）的局部眼用组合物，其中n可以具有0或1的数值，m可以具有2或3的值，并且Het表示杂芳族基团 其中X，Y，Z和W可以相同或不同，表示与氢原子，卤素原子，甲基，羧酸乙酯基团连接的氮原子或碳原子， 羧基或磺酰基及其药学上可接受的盐，与眼科可接受的载体组合，特别是用于治疗过敏性结膜炎。
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7.发明授权Aryl(or heteroaryl) piperazinylalkylazole derivatives, their preparation and their application as medicaments 失效芳基（或杂芳基）哌嗪基烷基衍生物，其制备及其作为药物的应用
公开(公告)号：US5292739A
公开(公告)日：1994-03-08
申请号：US825929
申请日：1992-01-27
IPC分类号： A61K31/495 , A61K31/496 , A61P9/12 , A61P25/20 , A61P25/22 , A61P25/24 , A61P25/26 , A61P25/28 , A61P25/30 , C07D207/32 , C07D207/325 , C07D207/335 , C07D231/12 , C07D231/16 , C07D231/38 , C07D233/61 , C07D233/68 , C07D233/88 , C07D403/06 , C07D403/12 , C07D403/14 , C07D417/12 , C07D471/04 , C07D521/00 , C02D403/00
CPC分类号： C07D207/325 , C07D231/12 , C07D231/16 , C07D231/38 , C07D233/56 , C07D233/68 , C07D249/08 , C07D403/12 , C07D417/12
摘要： The present invention relates to heterocyclic compounds, characterized in that they have the general formula I ##STR1## Wherein Ar, n and Z.sub.1 -Z.sub.6 are defined in the specification, are disclosed to have pharmaceutical activity on the central nervous system.
摘要翻译： 本发明涉及杂环化合物，其特征在于它们具有通式I（*化学结构*）（I）其中在说明书中定义Ar，n和Z1-Z6在中枢神经中具有药物活性 系统。
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公开(公告)号：US08217041B2
公开(公告)日：2012-07-10
申请号：US12093100
申请日：2006-11-07
申请人： Maria de las Ermitas Alcalde-Pais , Jordi Frigola-Constansa , Joerg Holenz , Ramon Merce-Vidal , Maria de les Neus Mesquida-Estevez , Sara Lopez-Perez
发明人： Maria de las Ermitas Alcalde-Pais , Jordi Frigola-Constansa , Joerg Holenz , Ramon Merce-Vidal , Maria de les Neus Mesquida-Estevez , Sara Lopez-Perez
IPC分类号： A61K31/50 , A61K31/435 , C07D221/18 , C09B5/00
CPC分类号： C07C311/21 , C07C205/45 , C07C205/56 , C07C211/30 , C07C225/22 , C07C233/11 , C07C309/86 , C07C311/37 , C07C311/44 , C07C311/46 , C07C2602/08 , C07D285/01 , C07D285/14 , C07D295/073 , C07D295/135 , C07D295/182 , C07D295/185 , C07D333/62 , C07D513/04
摘要： The present invention makes reference to new indene derivatives with general formula (I), as well as to their preparation procedures, their application as medicament and the pharmaceutical compositions containing them. The new compounds of formula (I) show affinity for 5-HT6 receptors and are, therefore, effective for treating diseases mediated by these receptors.
摘要翻译： 本发明涉及具有通式（I）的新的茚衍生物及其制备方法，它们作为药物的应用和含有它们的药物组合物。 式（I）的新化合物显示出对5-HT 6受体的亲和力，因此对于治疗由这些受体介导的疾病是有效的。
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9.发明申请Substituted indanyl sulfonamide compounds, their preparation and use as medicaments 失效取代的茚满基磺酰胺化合物，其制备和用作药物公开(公告)号：US20080027073A1
公开(公告)日：2008-01-31
申请号：US11506352
申请日：2006-08-18
申请人： Maria De Las Ermitas Alcalde-Pais , Maria De Les Neus Mesquida-Estevez , Sara Lopez-Perez , Jordi Frigola-Constansa , Joerg Holenz , Ramon Merce-Vidal
发明人： Maria De Las Ermitas Alcalde-Pais , Maria De Les Neus Mesquida-Estevez , Sara Lopez-Perez , Jordi Frigola-Constansa , Joerg Holenz , Ramon Merce-Vidal
IPC分类号： A61K31/496 , A61K31/43 , C07D498/02
CPC分类号： C07D295/135 , C07D333/62 , C07D513/04
摘要： The present invention refers to new indanyl sulphonamide compounds with general formula (I), as well as to their preparation procedure, their application as medicine and the pharmaceuticals composition which they are made up of. The new compounds of formula I show affinity for 5-HT6 receptors and are, therefore, effective for treating diseases mediated by these receptors.
摘要翻译： 本发明涉及具有通式（I）的新的茚满基磺酰胺化合物及其制备方法，它们作为药物及其组成的药物组合物的应用。 新的式I化合物显示出对5-HT 6受体的亲和力，因此对于治疗由这些受体介导的疾病是有效的。
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公开(公告)号：US20070021485A1
公开(公告)日：2007-01-25
申请号：US11187697
申请日：2005-07-22
IPC分类号： A61K31/415 , C07D231/02
CPC分类号： C07D231/12 , A61K31/415
摘要： The present application provides a method of treating a subject suffering from a form of urinary incontinence which comprises administering to the subject an amount of a compound having the structure: effective to treat the subject, wherein the compound is administered in a suitable form.
摘要翻译： 本申请提供了治疗患有尿失禁形式的受试者的方法，其包括向受试者施用一定量的具有以下有效结构的化合物：有效治疗受试者，其中所述化合物以适当形式给药。
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