公开(公告)号：US20220411361A1

公开(公告)日：2022-12-29

申请号：US17761984

申请日：2020-09-18

Applicant: ModernaTX, Inc.

Inventor： Kerry E. BENENATO ,  Souvik BISWAS ,  Mark CORNEBISE ,  Edward HENNESSY ,  Ellalahewage S. KUMARASINGHE

IPC: C07C217/08 ,  A61K9/127

Abstract: The disclosure features novel lipids and compositions involving the same. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

公开(公告)号：US20220409536A1

公开(公告)日：2022-12-29

申请号：US17278040

申请日：2019-09-19

Applicant: ModernaTX, Inc.

Inventor： Kerry E. BENENATO ,  Mark CORNEBISE ,  Edward HENNESSY

IPC: A61K9/127 ,  A61K47/10 ,  A61K47/28 ,  A61K47/24 ,  A61K31/7105 ,  A61K31/573 ,  A61K31/519 ,  A61K31/167 ,  A61K45/06 ,  C07C229/12 ,  C07C229/16 ,  C07D239/54 ,  C07D239/47 ,  C07D473/34 ,  C07C233/47 ,  C07C275/14 ,  C07C335/08 ,  C07D233/61 ,  C07C311/05 ,  C07D473/18 ,  C07C229/14 ,  C07C311/64 ,  C07D249/04 ,  C07D209/48 ,  C07D295/13 ,  C07C279/36 ,  C07C279/28 ,  C07C215/08 ,  C07C235/10 ,  C07F9/09 ,  C07C311/14

Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

公开(公告)号：US20220106259A1

公开(公告)日：2022-04-07

申请号：US17324426

申请日：2021-05-19

Applicant: ModernaTX, Inc.

Inventor： Kerry E. BENENATO ,  Mark CORNEBISE ,  Edward HENNESSY ,  Ellalahewage S. KUMARASINGHE

IPC: C07C229/24 ,  A61K47/54 ,  A61K9/127 ,  A61K31/713 ,  A61K48/00

Abstract: The disclosure features novel lipids and compositions involving the same. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Lipid nanoparticles (e.g., empty LNPs or loaded LNPs) further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

公开(公告)号：US20210154148A1

公开(公告)日：2021-05-27

申请号：US17029436

申请日：2020-09-23

Applicant: ModernaTX, Inc.

Inventor： Kerry E. BENENATO ,  Ellalahewage Sathyajith KUMARASINGHE ,  Mark CORNEBISE

IPC: A61K9/51 ,  A61K38/18 ,  A61K48/00 ,  C07C229/24

Abstract: The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.