公开(公告)号：US20190008947A1

公开(公告)日：2019-01-10

申请号：US16136503

申请日：2018-09-20

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Sunny Himansu ,  Eric Yi-Chun Huang ,  Tal Zaks ,  Sayda Mahgoub Elbashir

IPC: A61K39/12 ,  A61K9/127 ,  A61K9/51 ,  A61K39/015 ,  A61K39/39 ,  A61K39/42 ,  A61K9/00 ,  A61K39/00

Abstract: The disclosure relates to tropical diseases such as viral mosquito borne illnesses and the treatment thereof. The invention includes ribonucleic acid vaccines and combination vaccines, as well as methods of using the vaccines and compositions comprising the vaccines for treating and preventing tropical disease.

公开(公告)号：US11235052B2

公开(公告)日：2022-02-01

申请号：US16853973

申请日：2020-04-21

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Sunny Himansu ,  Eric Yi-Chun Huang ,  Tal Zaks ,  Sayda Mahgoub Elbashir

IPC: A61K39/12 ,  A61K39/015 ,  A61P11/00 ,  A61K39/39 ,  A61K39/42 ,  A61K9/00 ,  A61K9/127 ,  A61K9/51 ,  A61K48/00 ,  A61K39/00

Abstract: The disclosure relates to tropical diseases such as viral mosquito borne illnesses and the treatment thereof. The invention includes ribonucleic acid vaccines and combination vaccines, as well as methods of using the vaccines and compositions comprising the vaccines for treating and preventing tropical disease.

公开(公告)号：US10702597B2

公开(公告)日：2020-07-07

申请号：US16009880

申请日：2018-06-15

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Eric Yi-Chun Huang ,  Kapil Bahl ,  Tal Zaks ,  Sunny Himansu ,  Sayda Mahgoub Elbashir

IPC: A61K39/12 ,  C07K14/005 ,  A61K9/14 ,  A61K9/00 ,  C07K16/28 ,  C07K16/10 ,  A61K47/10 ,  A61K47/18 ,  A61K47/22 ,  A61K47/28 ,  C12N7/00 ,  A61P31/12 ,  A61P31/14 ,  A61K9/51 ,  A61K39/00

Abstract: Aspects of the disclosure relate to nucleic acid vaccines. The vaccines include one or more RNA polynucleotides having an open reading frame encoding one or more Chikungunya antigen(s), one or more Zika virus antigens, and one or more Dengue antigens. Methods for preparing and using such vaccines are also described.

公开(公告)号：US10238731B2

公开(公告)日：2019-03-26

申请号：US15674591

申请日：2017-08-11

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Sunny Himansu ,  Eric Yi-Chun Huang ,  Tal Zaks ,  Sayda Mahgoub Elbashir

IPC: A61K39/12 ,  A61K48/00 ,  A61K39/39 ,  A61K39/42 ,  A61K9/00 ,  A61K9/127 ,  A61K9/51 ,  A61K39/015 ,  A61K39/00

Abstract: The disclosure relates to tropical diseases such as viral mosquito borne illnesses and the treatment thereof. The invention includes ribonucleic acid vaccines and combination vaccines, as well as methods of using the vaccines and compositions comprising the vaccines for treating and preventing tropical disease.

公开(公告)号：US20230346914A1

公开(公告)日：2023-11-02

申请号：US17797784

申请日：2021-02-06

Applicant: ModernaTX, Inc.

Inventor： Guillaume Stewart-Jones ,  Andrea Carfi ,  Sayda Mahgoub Elbashir ,  Mihir Metkar

IPC: A61K39/215 ,  A61K39/145 ,  A61K47/10 ,  A61P37/04

CPC classification number: A61K39/215 ,  A61K39/145 ,  A61K47/10 ,  A61P37/04 ,  A61K2039/53

Abstract: The disclosure relates to coronavirus ribonucleic acid (RNA) vaccines as well as methods of using the vaccines and compositions comprising the vaccines. The RNA vaccines encode domains and subunits of coronavirus.

公开(公告)号：US20230020362A1

公开(公告)日：2023-01-19

申请号：US17737532

申请日：2022-05-05

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Eric Yi-Chun Huang ,  Kapil Bahl ,  Tal Zaks ,  Sunny Himansu ,  Sayda Mahgoub Elbashir

IPC: A61K39/12 ,  A61K9/14 ,  A61K9/51 ,  A61K47/10 ,  A61K47/18 ,  A61K47/22 ,  A61K47/28 ,  A61K48/00 ,  A61P31/12 ,  A61P31/14 ,  C07K14/005 ,  C07K14/18 ,  C07K16/10 ,  C07K16/28 ,  C12N7/00 ,  A61K9/00

Abstract: Aspects of the disclosure relate to nucleic acid vaccines. The vaccines include one or more RNA polynucleotides having an open reading frame encoding one or more Chikungunya antigen(s), one or more Zika virus antigens, and one or more Dengue antigens. Methods for preparing and using such vaccines are also described.

公开(公告)号：US20180344839A1

公开(公告)日：2018-12-06

申请号：US16009880

申请日：2018-06-15

Applicant: ModernaTX, Inc.

Inventor： Giuseppe Ciaramella ,  Eric Yi-Chun Huang ,  Kapil Bahl ,  Tal Zaks ,  Sunny Himansu ,  Sayda Mahgoub Elbashir

IPC: A61K39/12 ,  A61P31/12

Abstract: Aspects of the disclosure relate to nucleic acid vaccines. The vaccines include one or more RNA polynucleotides having an open reading frame encoding one or more Chikungunya antigen(s), one or more Zika virus antigens, and one or more Dengue antigens. Methods for preparing and using such vaccines are also described.