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33 条记录 (耗时 0.043 秒)

    SUBSTITUTED 2-AMINOBENZIMIDAZOLES ANALOGS AS ANTIBIOFILM AGENTS
    11.
    发明公开
    SUBSTITUTED 2-AMINOBENZIMIDAZOLES ANALOGS AS ANTIBIOFILM AGENTS 审中-公开

    公开(公告)号：US20240156788A1

    公开(公告)日：2024-05-16

    申请号：US18545458

    申请日：2023-12-19

    申请人： Ohio State Innovation Foundation ,  North Carolina State University

    发明人： John Gunn ,  Laura Kuo ,  Christian Melander ,  William M. Huggins

    IPC分类号： A61K31/4184

    CPC分类号： A61K31/4184

    摘要： In one aspect, the disclosure relates to compositions and methods for dispersing exiting Salmonella biofilms and inhibiting formation of Salmonella biofilms. In various aspects, the disclosed compositions can be used in methods of treating a persistent Salmonella infection, including an asymptomatic infection. Such infections can colonize a variety of tissues, including the gall-bladder. Also disclosed are methods of treating typhoid fever. Also disclosed are methods for mitigating or preventing secondary outbreaks of typhoid fever by treating asymptomatic subjects who had been symptomatic for typhoid fever at a previous time. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

    SUBSTITUTED 2-AMINOBENZIMIDAZOLES ANALOGS AS ANTIBIOFILM AGENTS
    12.
    发明申请
    SUBSTITUTED 2-AMINOBENZIMIDAZOLES ANALOGS AS ANTIBIOFILM AGENTS 有权

    公开(公告)号：US20230138583A1

    公开(公告)日：2023-05-04

    申请号：US17841938

    申请日：2022-06-16

    申请人： Ohio State Innovation Foundation ,  North Carolina State University

    发明人： John Gunn ,  Laura Kuo ,  Christian Melander ,  William M. Huggins

    IPC分类号： A61K31/4184

    摘要： In one aspect, the disclosure relates to compositions and methods for dispersing exiting Salmonella biofilms and inhibiting formation of Salmonella biofilms. In various aspects, the disclosed compositions can be used in methods of treating a persistent Salmonella infection, including an asymptomatic infection. Such infections can colonize a variety of tissues, including the gall-bladder. Also disclosed are methods of treating typhoid fever. Also disclosed are methods for mitigating or preventing secondary outbreaks of typhoid fever by treating asymptomatic subjects who had been symptomatic for typhoid fever at a previous time. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.

    Inhibition and dispersion of biofilms in plants with imidazole-triazole derivatives
    15.
    发明授权
    Inhibition and dispersion of biofilms in plants with imidazole-triazole derivatives 有权
    生物膜在咪唑三唑衍生物中的抑制和分散

    公开(公告)号：US09351491B2

    公开(公告)日：2016-05-31

    申请号：US13946523

    申请日：2013-07-19

    申请人： North Carolina State University

    发明人： Christian Melander ,  John Cavanagh ,  David F. Ritchie ,  Steven A. Rogers ,  Robert W. Huigens, III ,  Catherine S. Reed

    IPC分类号： A01N43/647 ,  A01N63/00 ,  A01N59/20 ,  A01N43/653 ,  C07D403/06

    CPC分类号： A01N43/647 ,  A01N43/653 ,  A01N59/20 ,  A01N63/00 ,  C07D403/06

    摘要： Disclosure is provided for methods of preventing, removing or inhibiting microbial biofilm formation or microbial infection in a plant or plant part thereof, including applying thereto a treatment effective amount of an active compound as described herein, or an agriculturally acceptable salt thereof. Methods of enhancing a microbicide (e.g., including a copper, antibiotic, bacteriophage, etc.) and/or plant defense activator are also provided, including applying an active compound as described herein. Compositions comprising an active compound as described herein in an agriculturally acceptable carrier are also provided, and in some embodiments the compositions further include a microbicide (e.g., including copper, antibiotic, bacteriophage, etc.) and/or plant defense activator.

    摘要翻译： 提供了用于预防，去除或抑制植物或植物部分中的微生物生物膜形成或微生物感染的方法的公开，包括向其施用有效量的本文所述的活性化合物或其农业上可接受的盐。 还提供了增强杀微生物剂（例如包括铜，抗生素，噬菌体等）和/或植物防御活化剂的方法，包括施用如本文所述的活性化合物。 还提供了包含本文所述在农业上可接受的载体中的活性化合物的组合物，并且在一些实施方案中，组合物还包括杀微生物剂（例如包括铜，抗生素，噬菌体等）和/或植物防御活化剂。

    Use of aryl carbamates in agriculture and other plant-related areas
    17.
    发明授权
    Use of aryl carbamates in agriculture and other plant-related areas 有权
    在农业和其他植物相关领域使用芳基氨基甲酸酯

    公开(公告)号：US09125408B2

    公开(公告)日：2015-09-08

    申请号：US13778425

    申请日：2013-02-27

    申请人： North Carolina State University

    发明人： Christian Melander ,  Steven A. Rogers

    IPC分类号： A01N45/02 ,  A01N47/12 ,  A01N47/16 ,  A01N47/18

    CPC分类号： A01N47/18 ,  A01N47/12 ,  A01N47/16 ,  A01N59/20 ,  A01N63/00 ,  C07C271/34 ,  C07C2601/14 ,  C07D209/14 ,  C07D213/40

    摘要： Disclosure is provided for methods of preventing, removing or inhibiting microbial biofilm formation or microbial infection in a plant or plant part thereof, including applying thereto a treatment effective amount of an aryl carbamate as described herein, or an agriculturally acceptable salt thereof. Methods of enhancing a microbicide (e.g., including a copper, antibiotic, bacteriophage, etc.) and/or plant defense activator are also provided, including applying an active compound as described herein. Compositions comprising an aryl carbamate compound as described herein in an agriculturally acceptable carrier are also provided, and in some embodiments the compositions further include a microbicide (e.g., including copper, antibiotic, bacteriophage, etc.) and/or a plant defense activator.

    摘要翻译： 提供了用于预防，去除或抑制植物或植物部分中的微生物生物膜形成或微生物感染的方法的公开，包括向其施用有效量的本文所述的氨基甲酸芳基酯或其农业上可接受的盐。 还提供了增强杀微生物剂（例如包括铜，抗生素，噬菌体等）和/或植物防御活化剂的方法，包括施用如本文所述的活性化合物。 还提供了包含在农业上可接受的载体中的如本文所述的芳基氨基甲酸酯化合物的组合物，并且在一些实施方案中，组合物还包括杀微生物剂（例如包括铜，抗生素，噬菌体等）和/或植物防御活化剂。