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    Method for Producing Radioactively Labeled Polypeptide
    11.
    发明申请
    Method for Producing Radioactively Labeled Polypeptide 审中-公开
    生产放射性标记多肽的方法

    公开(公告)号：US20130052132A1

    公开(公告)日：2013-02-28

    申请号：US13369903

    申请日：2012-02-09

    申请人： Hideo Saji ,  Nobuya Inagaki ,  Hiroyuki Kimura ,  Kentaro Toyoda ,  Konomu Hirao ,  Hirokazu Matsuda

    发明人： Hideo Saji ,  Nobuya Inagaki ,  Hiroyuki Kimura ,  Kentaro Toyoda ,  Konomu Hirao ,  Hirokazu Matsuda

    IPC分类号： C07K14/00 ,  A61K51/08

    CPC分类号： C07K14/57563 ,  A61K51/088 ,  C07K1/13

    摘要： The present invention relates to a method for producing a polypeptide. The method includes labeling a molecular probe precursor represented by an amino acid sequence of the formula (1) using a labeling compound capable of labeling a lysine or lysine derivative: (1) Y1-Leu-Ser-Xaa12-Gln-Met-Glu-Glu-Glu-Ala-Val-Arg- Leu-Phe-Ile-Glu-Trp-Leu-Xaa27-Asn-Gly-Y2 where Y1 represents an amino acid sequence represented by the formula (2) or the amino acid sequence represented by the formula (2) with 1 to 8 amino acids from the N-terminus being deleted, Xaa12 represents a lysine or lysine derivative, Xaa27 represents a basic amino acid having no functional group at its side chain that reacts with the labeling compound or represents methyl lysine or acetylated lysine, and Y2 represents an amino acid sequence represented by the formula (3) or the amino acid sequence represented by the formula (3) with 1 to 9 amino acids from the C-terminus being deleted: (2) His-Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp (3) Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro-Ser

    摘要翻译： 本发明涉及一种生产多肽的方法。 该方法包括使用能够标记赖氨酸或赖氨酸衍生物的标记化合物来标记由式（1）的氨基酸序列表示的分子探针前体：（1）Y1-Leu-Ser-Xaa12-Gln-Met-Glu- Glu-Glu-Ala-Val-Arg-Leu-Phe-Ile-Glu-Trp-Leu-Xaa27-Asn-Gly-Y2，其中Y1表示由式（2）表示的氨基酸序列或由 缺失N末端1〜8个氨基酸的式（2），Xaa12表示赖氨酸或赖氨酸衍生物，Xaa27表示其侧链上没有与标记化合物反应的官能团的碱性氨基酸， 赖氨酸或乙酰化赖氨酸，Y2表示由式（3）表示的氨基酸序列或由式（3）表示的氨基酸序列，其中C末端具有1至9个氨基酸缺失：（2）His- Gly-Glu-Gly-Thr-Phe-Thr-Ser-Asp（3）Gly-Pro-Ser-Ser-Gly-Ala-Pro-Pro-Pro

    METHOD FOR SYNTHESIZING [18F]SFB USING MICROSYNTHESIS TECHNIQUE
    14.
    发明申请
    METHOD FOR SYNTHESIZING [18F]SFB USING MICROSYNTHESIS TECHNIQUE 审中-公开
    使用微结构技术合成[18 F] SFB的方法

    公开(公告)号：US20120029209A1

    公开(公告)日：2012-02-02

    申请号：US13254152

    申请日：2010-03-01

    申请人： Hiroaki Nakanishi ,  Hidekazu Saiki ,  Hideo Saji ,  Hiroyuki Kimura ,  Hidekazu Kawashima ,  Kenji Tomatsu ,  Yuji Kuge

    发明人： Hiroaki Nakanishi ,  Hidekazu Saiki ,  Hideo Saji ,  Hiroyuki Kimura ,  Hidekazu Kawashima ,  Kenji Tomatsu ,  Yuji Kuge

    IPC分类号： C07D207/46

    CPC分类号： C07D207/404 ,  A61K51/00 ,  C07B59/001 ,  C07B59/002

    摘要： A method for synthesizing [18F]SFB is disclosed, which comprises using a microreactor including a substrate having one channel formed therein so as to have a cross-sectional width of 1 mm or less and a cross-sectional depth of 1 mm or less, the channel being connected to a raw material injection port and a first reagent injection port at one end thereof, and connected to a second reagent injection port at a position far from the one end thereof, and connected to a third reagent injection port at a position far from the second reagent injection port in a direction toward another end thereof, and connected to a liquid discharge port at the other end thereof; and continuously performing a three-step reaction by allowing a reaction solution to flow through the channel serving as a reaction channel from the one end to the other end thereof without taking out the reaction solution from anywhere between the one end and the other end of the channel.

    摘要翻译： 公开了一种合成[18F] SFB的方法，其包括使用包括其中形成有一个通道的基板的微反应器，以使其横截面宽度为1mm以下，横截面深度为1mm以下， 所述通道在其一端连接到原料注入口和第一试剂注入口，并且在远离其一端的位置处连接到第二试剂注入口，并且连接到位于其的一端的第三试剂注入口 远离第二试剂注入口朝向其另一端的方向，并且在另一端连接到液体排出口; 并且通过使反应溶液从一端到另一端流过作为反应通道的通道而不从其一端到另一端的任何位置取出反应溶液，从而连续进行三步反应 渠道。

    Compound accumulating in inflammatory site, diagnostic agent containing the compound in labeled state and its precursor compound for labeling
    15.
    发明授权
    Compound accumulating in inflammatory site, diagnostic agent containing the compound in labeled state and its precursor compound for labeling 有权
    化合物累积在炎症部位，含有标记状态的化合物的诊断剂及其前体化合物进行标记

    公开(公告)号：US09044520B2

    公开(公告)日：2015-06-02

    申请号：US13434722

    申请日：2012-03-29

    申请人： Hideo Saji ,  Hiroyuki Kimura ,  Masahiro Ono ,  Ikuya Seki

    发明人： Hideo Saji ,  Hiroyuki Kimura ,  Masahiro Ono ,  Ikuya Seki

    IPC分类号： A61K51/00 ,  A61M36/14 ,  A61K51/08

    CPC分类号： A61K51/088 ,  G01N2800/042

    摘要： Embodiments of the invention provide a compound accumulating in an inflammatory site, a diagnostic agent containing the compound in labeled state and its precursor compound for labeling. Such a compound accumulating in inflammatory site may be represented by the following formula (1): Z—Y-Leu-Phe-(X)n-DLys(-(DLys)m-HalB)-(DLys)k-NH2  (1) wherein in the formula (1), Z represents a protective group for an amino group; Y represents Met or Nle; X represents a spacer consisting of one or more of amino acid and/or synthetic organic compounds; n represents 1 or 0; m represents 1 or 0; k represents 1 or 0; and HalB represents a substituted benzoic acid having a radioactive halogen in an aromatic ring.

    摘要翻译： 本发明的实施方案提供了一种在炎症部位中积聚的化合物，含有标记状态的化合物的诊断剂及其用于标记的前体化合物。 Z-Y-Leu-Phe-（X）n-DLys（ - （DLys）m-HalB） - （DLys）k-NH 2（1）的化合物可以由下述式（1）表示： ）其中在式（1）中，Z表示氨基的保护基; Y表示Met或Nle; X表示由一种或多种氨基酸和/或合成有机化合物组成的间隔物; n表示1或0; m表示1或0; k表示1或0; HalB表示在芳香环中具有放射性卤素的取代苯甲酸。

    COMPOUND ACCUMULATING IN INFLAMMATORY SITE, DIAGNOSTIC AGENT CONTAINING THE COMPOUND IN LABELED STATE AND ITS PRECURSOR COMPOUND FOR LABELING
    16.
    发明申请
    COMPOUND ACCUMULATING IN INFLAMMATORY SITE, DIAGNOSTIC AGENT CONTAINING THE COMPOUND IN LABELED STATE AND ITS PRECURSOR COMPOUND FOR LABELING 有权
    包含化合物在标签状态的诊断试剂盒及其前体化合物标签中的化合物累积

    公开(公告)号：US20120253010A1

    公开(公告)日：2012-10-04

    申请号：US13434722

    申请日：2012-03-29

    申请人： Hideo Saji ,  Hiroyuki Kimura ,  Masahiro Ono ,  Ikuya Seki

    发明人： Hideo Saji ,  Hiroyuki Kimura ,  Masahiro Ono ,  Ikuya Seki

    IPC分类号： C07K7/06

    CPC分类号： A61K51/088 ,  G01N2800/042

    摘要： Embodiments of the invention provide a compound accumulating in an inflammatory site, a diagnostic agent containing the compound in labeled state and its precursor compound for labeling. Such a compound accumulating in inflammatory site may be represented by the following formula (1): Z—Y-Leu-Phe-(X)n-DLys(-(DLys)m-HalB)-(DLys)k-NH2  (1) wherein in the formula (1), Z represents a protective group for an amino group; Y represents Met or Nle; X represents a spacer consisting of one or more of amino acid and/or synthetic organic compounds; n represents 1 or 0; m represents 1 or 0; k represents 1 or 0; and HalB represents a substituted benzoic acid having a radioactive halogen in an aromatic ring.

    摘要翻译： 本发明的实施方案提供了一种在炎症部位中积聚的化合物，含有标记状态的化合物的诊断剂及其用于标记的前体化合物。 Z-Y-Leu-Phe-（X）n-DLys（ - （DLys）m-HalB） - （DLys）k-NH 2（1）的化合物可以由下述式（1）表示： ）其中在式（1）中，Z表示氨基的保护基; Y表示Met或Nle; X表示由一种或多种氨基酸和/或合成有机化合物组成的间隔物; n表示1或0; m表示1或0; k表示1或0; HalB表示在芳香环中具有放射性卤素的取代苯甲酸。

    Display apparatus and method of driving the same
    18.
    发明授权
    Display apparatus and method of driving the same 有权
    显示装置及其驱动方法

    公开(公告)号：US09104257B2

    公开(公告)日：2015-08-11

    申请号：US13425648

    申请日：2012-03-21

    申请人： Satoshi Maruyama ,  Takanori Tsunashima ,  Hiroyuki Kimura ,  Kenji Harada ,  Hirotaka Hayashi

    发明人： Satoshi Maruyama ,  Takanori Tsunashima ,  Hiroyuki Kimura ,  Kenji Harada ,  Hirotaka Hayashi

    IPC分类号： G06F3/041 ,  G09G3/36

    CPC分类号： G06F3/0412 ,  G09G3/3648 ,  G09G2356/00

    摘要： According to one embodiment, a display apparatus includes signal lines, and pixels. Each of the pixels includes a pixel electrode and a pixel control switch, and being classified into any of pixel groups. Each of the pixel groups includes a memory, and a sensor circuit which is configured to provide data for a detection signal to the memory when detecting the input information. The pixel control switch is configured to switch the voltage level of the pixel electrode in accordance with data for the display signal input via the signal line and the data for the detection signal input from the memory.

    摘要翻译： 根据一个实施例，显示装置包括信号线和像素。 每个像素包括像素电极和像素控制开关，并且被分类为任何像素组。 每个像素组包括存储器和传感器电路，其被配置为当检测到输入信息时向存储器提供用于检测信号的数据。 像素控制开关被配置为根据用于经由信号线输入的显示信号的数据和用于从存储器输入的检测信号的数据来切换像素电极的电压电平。

    Method of switching from immersion objective lens to dry objective lens
    19.
    发明授权
    Method of switching from immersion objective lens to dry objective lens 有权
    从浸没式物镜切换到干式物镜的方法

    公开(公告)号：US08456770B2

    公开(公告)日：2013-06-04

    申请号：US12603652

    申请日：2009-10-22

    申请人： Hiroyuki Kimura

    发明人： Hiroyuki Kimura

    IPC分类号： G02B7/14

    CPC分类号： G02B21/248 ,  G02B21/33 ,  G02B27/0006

    摘要： A microscope apparatus capable of removing liquid from an observation field of view of a dry objective lens, when an immersion objective lens is switched to the dry objective lens, is provided. The microscope apparatus includes a specimen XY stage on which a specimen is placed, a dry objective lens and an immersion objective lens that collect light from the specimen, a movable revolver that selectively disposes one of these objective lenses at a position facing the specimen, and a control unit that controls the specimen XY stage and movable revolver such that the relative positions in the XY direction are changed until the immersion objective lens is disposed at a non-observation region of the dry objective lens, prior to switching of these objective lenses.

    摘要翻译： 提供了一种显示装置，当将浸没物镜切换到干物镜时，能够从干物镜的观察视场中去除液体。 显微镜装置包括：放置试样的试样XY台，干物镜和收集来自试样的光的浸没物镜;选择性地将这些物镜中的一个物镜放置在与试样相对的位置的可动轮，以及 控制单元，其在切换这些物镜之前控制样本XY平台和可移动旋转臂，使得XY方向上的相对位置改变，直到浸没物镜设置在干燥物镜的非观察区域。