公开(公告)号：US07501457B2

公开(公告)日：2009-03-10

申请号：US11482164

申请日：2006-07-07

申请人： Jörg Angermann ,  Peter Burtscher ,  Urs Karl Fischer ,  Norbert Moszner ,  Volker M. Rheinberger

发明人： Jörg Angermann ,  Peter Burtscher ,  Urs Karl Fischer ,  Norbert Moszner ,  Volker M. Rheinberger

IPC分类号： A61K6/083 ,  C08F28/06

CPC分类号： A61K6/083 ,  A61K6/0017 ,  A61K6/0023 ,  C08L33/00

摘要： Dental materials and associated methods are described based on multicyclic allyl sulphides with general Formula (I): in which R1 is H or a C1-C10 alkyl radical; R2 is H or a C1-C10 alkyl radical; R3 is absent or is a C1-C20 alkylene radical which can be interrupted by O or S, a cycloaliphatic C4-C12 radical, a bicyclic C6-C12 radical, a C6-C14 arylene or C7-C20 alkylene arylene radical; R4 is an n-times substituted aliphatic C2 to C20 hydrocarbon radical which can be interrupted by O or S, a cycloaliphatic C4-C12 radical, an aromatic C6-C14 radical, an aliphatic-aromatic C7-C20 radical or a heterocyclic radical which can contain 4 to 20 carbon atoms and 1 to 6 heteroatoms which are selected from N, O, P and/or S atoms, or which is formed exclusively by these heteroatoms; R5 is absent or is a C1-C10 alkylene radical; X is absent or is O, S, —O—CO— or —O—CO—NH—; Y is absent or is O, S, —O—CO— or —O—CO—NH—; m is 0 or 1 and n is an integer from 3 to 6.

摘要翻译： 基于具有通式（I）的多环烯丙基硫化物描述牙科材料和相关方法：其中R1是H或C1-C10烷基; R2是H或C1-C10烷基; R3不存在或是可被O或S间隔的C 1 -C 20亚烷基，脂环族C 4 -C 12基，双环C 6 -C 12基，C 6 -C 14亚芳基或C 7 -C 20亚烷基亚芳基; R4是可被O或S间隔的n次取代的脂族C 2 -C 20烃基，脂环族C 4 -C 12基团，芳族C 6 -C 14基团，脂族 - 芳族C 7 -C 20基团或杂环基团，其可以 含有4至20个碳原子和1至6个选自N，O，P和/或S原子的杂原子，或仅由这些杂原子形成的杂原子; R5不存在或是C1-C10亚烷基; X不存在或为O，S，-O-CO-或-O-CO-NH-; Y不存在或为O，S，-O-CO-或-O-CO-NH-; m为0或1，n为3至6的整数。

公开(公告)号：US20070203256A1

公开(公告)日：2007-08-30

申请号：US11482164

申请日：2006-07-07

申请人： Jorg Angermann ,  Peter Burtscher ,  Urs Karl Fischer ,  Norbert Moszner ,  Volker M. Rheinberger

发明人： Jorg Angermann ,  Peter Burtscher ,  Urs Karl Fischer ,  Norbert Moszner ,  Volker M. Rheinberger

IPC分类号： A61K6/08

CPC分类号： A61K6/083 ,  A61K6/0017 ,  A61K6/0023 ,  C08L33/00

摘要： Dental materials and associated methods are described based on multicyclic allyl sulphides with general Formula (I): in which R1 is H or a C1-C10 alkyl radical; R2 is H or a C1-C10 alkyl radical; R3 is absent or is a C1-C20 alkylene radical which can be interrupted by O or S, a cycloaliphatic C4-C12 radical, a bicyclic C6-C12 radical, a C6-C14 arylene or C7-C20 alkylene arylene radical; R4 is an n-times substituted aliphatic C2 to C20 hydrocarbon radical which can be interrupted by O or S, a cycloaliphatic C4-C12 radical, an aromatic C6-C14 radical, an aliphatic-aromatic C7-C20 radical or a heterocyclic radical which can contain 4 to 20 carbon atoms and 1 to 6 heteroatoms which are selected from N, O, P and/or S atoms, or which is formed exclusively by these heteroatoms; R5 is absent or is a C1-C10 alkylene radical; X is absent or is O, S, —O—CO— or —O—CO—NH—; Y is absent or is O, S, —O—CO— or —O—CO—NH—; m is 0 or 1 and n is an integer from 3 to 6.

摘要翻译： 牙科材料和相关方法基于通式（I）的多环烯丙基硫化物来描述：其中R 1是H或C 1 -C 10烷基， 烷基; R 2是H或C 1 -C 10烷基; R 3不存在或是可以被O或S中断的C 1 -C 20亚烷基，脂环族C 1 -C 20烷基， 4个-C 12 - 基团，双环C 6 -C 12 - 基团，C 6 - -C 14亚芳基或C 7 -C 20亚烷基亚芳基; R 4是可以被O或S间隔的n 20取代的C 20烃基C 2〜C 20烃基， 芳族C 6 -C 14 - 基团，脂族 - 芳族C 1 -C 12烷基，芳基C 6 -C 14 - 或者可以含有4至20个碳原子和1至6个选自N，O，P和/或S原子的杂原子的杂环基团，或其中 完全由这些杂原子形成; R 5不存在或者是C 1 -C 10亚烷基; X不存在或为O，S，-O-CO-或-O-CO-NH-; Y不存在或为O，S，-O-CO-或-O-CO-NH-; m为0或1，n为3至6的整数。

公开(公告)号：US07659324B2

公开(公告)日：2010-02-09

申请号：US11016461

申请日：2004-12-17

申请人： Norbert Moszner ,  Urs Karl Fischer ,  Peter Burtscher ,  Jörg Angermann ,  Volker M. Rheinberger

发明人： Norbert Moszner ,  Urs Karl Fischer ,  Peter Burtscher ,  Jörg Angermann ,  Volker M. Rheinberger

IPC分类号： C08F2/50 ,  C08J3/28 ,  A61K6/00 ,  A61K6/08 ,  A61K6/083

CPC分类号： C08F222/1006 ,  A61K6/0017 ,  A61K6/0023 ,  A61K6/083 ,  C08F2/50 ,  C08F4/00 ,  C08F220/28 ,  C08F220/30 ,  C08F230/08 ,  Y10S522/904 ,  Y10S522/908 ,  C08L51/085 ,  C08L101/02

摘要： Dental materials which contain a radically polymerizable organic binder, at least one radical polymerization initiator and at least one radical polymerization accelerator, both the initiator and the accelerator each having at least one radically polymerizable group.

摘要翻译： 含有可自由基聚合的有机粘合剂，至少一种自由基聚合引发剂和至少一种自由基聚合促进剂的牙科材料，引发剂和促进剂各自具有至少一个可自由基聚合的基团。

公开(公告)号：US20070287792A1

公开(公告)日：2007-12-13

申请号：US11585280

申请日：2006-10-24

申请人： Norbert Moszner ,  Jorg Angermann ,  Frank Zeuner ,  Armin de Mejere ,  Urs Karl Fischer ,  Volker Rheinberger

发明人： Norbert Moszner ,  Jorg Angermann ,  Frank Zeuner ,  Armin de Mejere ,  Urs Karl Fischer ,  Volker Rheinberger

IPC分类号： C08L31/00

CPC分类号： A61K6/0023 ,  A61K6/0017 ,  A61K6/083 ,  C08L33/00

摘要： Dental material which contains at least one radically polymerizable monomer according to the general formula (I): in which PG is a cyclic, ring-opening polymerizable group; X1 is absent, O, S, is an ester, amide or urethane group; X2 is absent with, O, S, is an ester, amide or urethane group; Y is absent, O, S, is an ester, amide or urethane group; R is an organic radical with a valency of (n+m), with 1 to 35 carbon atoms and 0 to 8 heteroatoms, the H atoms of which can be wholly or partially substituted by F atoms; R1 is absent or is a C1-C16 alkylene radical which can be interrupted by O atoms; R2 is absent or is a C1-C16 alkylene radical which can be interrupted by O atoms; n is 1, 2, 3, 4, 5 or 6; m is 1, 2 or 3; HG is —P═O(OH)2; —P═O(OH)(OR14); —O—P═O(OH)2, —O—P═O(OH)(OR15) or —SO2OH, wherein R14 is a C1-C15 alkyl radical, phenyl or benzyl radical; and R15 is a C1-C15 alkyl radical, phenyl or benzyl radical.

摘要翻译： 含有至少一种根据通式（I）的可自由基聚合的单体的牙科材料：其中PG是环状可开环聚合基团; X 1不存在，O，S是酯，酰胺或氨基甲酸酯基; O，S不是酯，酰胺或氨基甲酸酯基; Y不存在，O，S是酯，酰胺或氨基甲酸酯基; R为化合价为（n + m），有1至35个碳原子和0至8个杂原子的有机基团，其H原子可以被F原子全部或部分取代; R 1不存在或可被O原子间断的C 1 -C 16亚烷基; R 2不存在或可被O原子间隔的C 1 -C 16亚烷基; n为1,2,3,4,5或6; m为1,2或3; HG是-P-O（OH）2; -P-O（OH）（OR 14）; -OPO（OH）2，-OPO（OH）（OR 15）或-SO 2 OH，其中R 14， CH 2是C 1 -C 15烷基，苯基或苄基; R 15是C 1 -C 15烷基，苯基或苄基。

公开(公告)号：US07585901B2

公开(公告)日：2009-09-08

申请号：US11752652

申请日：2007-05-23

申请人： Norbert Moszner ,  Armin de Meijere ,  Frank Zeuner ,  Urs Karl Fischer

发明人： Norbert Moszner ,  Armin de Meijere ,  Frank Zeuner ,  Urs Karl Fischer

IPC分类号： A61K6/083 ,  A61C5/00 ,  C08F232/08

CPC分类号： A61K6/0023 ,  A61K6/0017 ,  A61K6/083 ,  A61K6/09 ,  C07C69/608 ,  C07C69/675 ,  C07C69/716 ,  C07C271/28 ,  C07C2602/18 ,  C07D307/93 ,  C07D311/94 ,  C07D335/04 ,  C08L33/00 ,  C08L75/16

摘要： Bicyclic cyclopropane derivatives of the general Formula (I) in which n+m is 0 to 8; r is 1 to 4; R1 is absent or is a C1-C20 alkylene radical which can be interrupted by O or S, a cycloaliphatic C4-C12 radical, a bicyclic C4-C12 radical, a C6-C14 arylene or C7-C20 alkylenearylene radical; R2 is for r=1 a C1-C20 alkyl radical which can be interrupted by O or S, a cycloaliphatic C4-C12 radical, a bicyclic C4-C12 radical, a C6-C14 aryl or a C7-C20 alkylaryl radical; is for r>1 an r-times substituted aliphatic C1 to C20 radical which can be interrupted by O or S, a cycloaliphatic C4-C12 radical, an aromatic C6-C14 radical or aliphatic-aromatic C7-C20 radical; X is absent or is —CO—O—, —CO—NH— or —O—CO—NH—, and Y is CH2, O or S which is suitable in particular for the preparation of dental materials.

摘要翻译： 通式（I）的双环环丙​​烷衍生物，其中n + m为0至8; r为1〜4; R1不存在或是可被O或S间隔的C 1 -C 20亚烷基，脂环族C 4 -C 12基团，双环C 4 -C 12基团，C 6 -C 14亚芳基或C 7 -C 20亚烷基亚芳基基团; R2为r = 1，可被O或S间隔的C1-C20烷基，脂环族C 4 -C 12基，双环C 4 -C 12基，C 6 -C 14芳基或C 7 -C 20烷基芳基; 对于r> 1，可以被O或S间隔的r-次取代的脂族C1至C20基团，脂环族C 4 -C 12基团，芳族C 6 -C 14基团或脂族 - 芳族C 7 -C 20基团; X不存在或是-CO-O-，-CO-NH-或-O-CO-NH-，Y是CH2，O或S，其特别适用于制备牙科材料。

公开(公告)号：US06900251B2

公开(公告)日：2005-05-31

申请号：US10606142

申请日：2003-06-25

申请人： Norbert Moszner ,  Ulrich Salz ,  Frank Zeuner ,  Jörg Zimmermann ,  Volker Rheinberger ,  Jorg Angermann ,  Urs Karl Fischer

发明人： Norbert Moszner ,  Ulrich Salz ,  Frank Zeuner ,  Jörg Zimmermann ,  Volker Rheinberger ,  Jorg Angermann ,  Urs Karl Fischer

IPC分类号： A61C13/087 ,  A61K6/00 ,  A61K6/083 ,  C07F9/38 ,  C08F30/02 ,  C08F220/54 ,  C08F230/02 ,  C09J4/00 ,  C09J4/02 ,  C09J11/04 ,  C09J11/06 ,  A61K8/00 ,  C07F9/09 ,  C08F2/46

CPC分类号： A61K6/0023 ,  A61K6/083 ,  C07F9/3808 ,  C08F30/02 ,  C08L33/00 ,  C08L43/02 ,  C08L39/06

摘要： Acrylic ester phosphonic acids of general formula (I), stereoisomers thereof and mixtures of these, wherein n is 1 or 2, on the condition that for n=1 R1 has the meaning and for n=2 R1 has the meaning R2 is a C1 to C12 alkylene radical, C4-C8 cycloalkylene radical or C7 to C15 alkylene phenylene radical; R3 is hydrogen, a C1 to C5 alkyl radical or a C1 to C5 O-alkyl radical; and R4, R5, independently of each other, each stand for a C1 to C5 alkyl radical or a C1 to C5 O-alkyl radical.

摘要翻译： 在通式（I）的丙烯酸酯膦酸，其立体异构体和它们的混合物，其中n为1或2，条件是对于n = 1的R 1具有含义，n = 2 R 1具有R 2是C 1至C 12亚烷基的C 1至C 4亚烷基，C 4 C 1 -C 8亚环烷基或C 7至C 15亚烷基亚苯基; R 3是氢，C 1至C 5烷基或C 1至C 6烷基， 5 O - 烷基; 和R 4，R 5，R 5彼此独立地代表C 1至C 5烷基 自由基或C 1至C 5 - O-烷基。

公开(公告)号：US07365222B2

公开(公告)日：2008-04-29

申请号：US10658993

申请日：2003-09-10

申请人： Norbert Moszner ,  Armin de Meijere ,  Frank Zeuner ,  Urs Karl Fischer

发明人： Norbert Moszner ,  Armin de Meijere ,  Frank Zeuner ,  Urs Karl Fischer

IPC分类号： C07C69/74 ,  C07D265/00 ,  C07D311/02 ,  A01N37/00

CPC分类号： A61K6/0023 ,  A61K6/0017 ,  A61K6/083 ,  A61K6/09 ,  C07C69/608 ,  C07C69/675 ,  C07C69/716 ,  C07C271/28 ,  C07C2602/18 ,  C07D307/93 ,  C07D311/94 ,  C07D335/04 ,  C08L33/00 ,  C08L75/16

摘要： Bicyclic cyclopropane derivatives of the general Formula (I) in which n+m is 0 to 8; r is 1 to 4; R1 is absent or is a C1-C20 alkylene radical which can be interrupted by O or S, a cycloaliphatic C4-C12 radical, a bicyclic C4-C12 radical, a C6-C14 arylene or C7-C20 alkylenearylene radical; R2 is for r=1 a C1-C20 alkyl radical which can be interrupted by O or S, a cycloaliphatic C4-C12 radical, a bicyclic C4-C12 radical, a C6-C14 aryl or a C7-C20 alkylaryl radical; is for r>1 an r-times substituted aliphatic C1 to C20 radical which can be interrupted by O or S, a cycloaliphatic C4-C12 radical, an aromatic C6-C14 radical or aliphatic-aromatic C7-C20 radical; X is absent or is —CO—O—, —CO—NH— or —O—CO—NH—, and Y is CH2, O or S which is suitable in particular for the preparation of dental materials.

摘要翻译： 通式（I）的双环环丙​​烷衍生物，其中n + m为0至8; r为1〜4; R 1不存在或可以被O或S中断的C 1 -C 20亚烷基，脂环族C 1 -C 20烷基， 4个C 12-12基团，双环C 4 -C 12 - 基团，C 6 - -C 14亚芳基或C 7 -C 20亚烷基亚芳基; R 2是针对r = 1，可以被O或S中断的C 1 -C 20 - 烷基，脂环族C _{4个C 12 - 基团，双环C 4 -C 12 - 基团，C 6 -C 14芳基或C 7 -C 20烷基芳基; 是r> 1，可以被O或S中断的r-次取代的脂族C 1至C 20 - 基团，脂环族C 4 -C 12 -C 12的基团，芳族C 6 -C 14基团或脂族 - 芳族C 7 -C 20个基团; X不存在或是-CO-O-，-CO-NH-或-O-CO-NH-，Y是CH 2，O或S，其特别适用于制备 牙科材料。}

公开(公告)号：US06653375B2

公开(公告)日：2003-11-25

申请号：US09236787

申请日：1999-01-25

申请人： Norbert Moszner ,  Volker Rheinberger ,  Thomas Völkel ,  Urs Karl Fischer

发明人： Norbert Moszner ,  Volker Rheinberger ,  Thomas Völkel ,  Urs Karl Fischer

IPC分类号： A61K6083

CPC分类号： A61K6/0023 ,  A61K6/0017 ,  A61K6/09 ,  C07C271/20 ,  C08L75/16

摘要： The invention relates to urethane di(meth)acrylate derivatives of 1-3-bis(1-isocyanato-1-methylethyl)benzene according to Formula (I) in which R is hydrogen or a straight-chained C1-C8 alkyl radical; X and Y independently of each other stand for R1 being a substituted or unsubstituted C6- to C12-aryl or C7- to C16-alkyl aryl radical; R2 hydrogen, a C1- to C5-alkyl or a substituted or unsubstituted C6- to C12-aryl radical; R3 hydrogen or a methyl radical; R4 a C1- to C8-alkylene radical which can be broken by oxygen atoms, or a phenylene radical; R5 hydrogen or a methyl radical; R6 a substituted or unsubstituted C6- to C12-aryl or C7- to C16-alkyl aryl radical; Z being —CO— or a chemical bond and W standing for oxygen, sulphur or NR7, R7 being hydrogen or a straight-chained C1- to C6-alkyl radical. The substances are suitable in particular for the production of dental materials.

摘要翻译： 本发明涉及式（I）的1,3-双（1-异氰酸基-1-甲基乙基）苯的氨基甲酸酯二（甲基）丙烯酸酯衍生物，其中R为氢或直链C1-C8烷基; X和Y彼此独立地代表R 1是取代或未取代的C 6 -C 12 - 芳基或C 7 -C 16烷基芳基; R 2为氢，C 1至C 5 - 烷基或取代或未取代的C 6至C 12 - 芳基; R 3氢或甲基; R 4可以被氧原子断裂的C1-至C8-亚烷基或亚苯基; R 5氢或甲基; R 6取代或未取代的C 6 -C 12 - 芳基或C 7 -C 16烷基芳基; Z是-CO-或化学键，W代表氧，硫或NR 7，R 7是氢或直链C 1至C 6烷基。 这些物质特别适用于生产牙科材料。

公开(公告)号：US06353039B1

公开(公告)日：2002-03-05

申请号：US09209905

申请日：1998-12-11

申请人： Volker Rheinberger ,  Ulrich Salz ,  Wolfram Höland ,  André Rumphorst ,  Kurt Grabher ,  Urs Karl Fischer ,  Marcel Schweiger ,  Norbert Moszner

发明人： Volker Rheinberger ,  Ulrich Salz ,  Wolfram Höland ,  André Rumphorst ,  Kurt Grabher ,  Urs Karl Fischer ,  Marcel Schweiger ,  Norbert Moszner

IPC分类号： A61K6083

CPC分类号： A61K6/0276 ,  A61K6/083 ,  A61K6/09 ,  C08F2/44 ,  C08K3/40 ,  C08K9/08 ,  C08L33/00 ,  C08L75/16

摘要： A composite material is described which contains polymerizable monomers plus a special transparent glass having high release of calcium ions and fluorine ions and, because of this release property and in particular of its optical properties, can be used as a restoration material in dentistry.

摘要翻译： 描述了一种复合材料，其包含可聚合单体加上具有高释放的钙离子和氟离子的特殊透明玻璃，并且由于该释放性质，特别是其光学性质，可用作牙科中的修复材料。

公开(公告)号：US08921450B2

公开(公告)日：2014-12-30

申请号：US13175988

申请日：2011-07-05

申请人： Norbert Moszner ,  Jörg Angermann ,  Urs Karl Fischer ,  Volker Rheinberger

发明人： Norbert Moszner ,  Jörg Angermann ,  Urs Karl Fischer ,  Volker Rheinberger

IPC分类号： A61K6/08 ,  A61K6/083 ,  C07D339/00 ,  A61K6/00

CPC分类号： C07D339/00 ,  A61K6/0023 ,  A61K6/083 ,  C08L33/08 ,  C08L33/10 ,  C08L65/00

摘要： The invention relates to a radically polymerizable monomer of formula (I) wherein W1 and W2 in each case independently represent H or X—R—Y—PG, wherein at least one of W1 and W2 represents X—R—Y—PG, X in each case independently is missing or represents an ether, ester, amide, urethane or urea group, Y in each case independently is missing or represents an ether, ester, amide, urethane or urea group, R in each case independently is missing or represents a C1-C16 alkylene radical which can be interrupted by one or more O atoms, wherein R can be missing only if X and/or Y is simultaneously also missing, and PG in each case independently represents a cyclic, ring-opening polymerizable group, a, b, c and d independently of each other can take the values 3 to 10. The invention also relates to polymerizable compositions which comprise the monomers according to the invention, as well as their use as dental materials and for the preparation of dental materials, in particular composites, cements, adhesives or coatings.

摘要翻译： 本发明涉及式（I）的自由基聚合性单体，其中W1和W2各自独立地表示H或X-R-Y-PG，其中W1和W2中的至少一个表示X-R-Y-PG，X 在每种情况下都独立地缺失或表示醚，酯，酰胺，氨基甲酸酯或脲基，Y在每种情况下独立地缺失或表示醚，酯，酰胺，氨基甲酸酯或脲基，R各自独立地缺失或表示 可以被一个或多个O原子中断的C1-C16亚烷基，其中只有当X和/或Y同时缺失时，R只能缺失，并且每种情况下PG都独立地表示环状的开环聚合基团， a，b，c和d可以取值为3至10.本发明还涉及包含根据本发明的单体的可聚合组合物，以及它们作为牙科材料和用于制备牙科材料的用途 ，特别是composi 水泥，粘合剂或涂料。