公开(公告)号：US20250042982A1

公开(公告)日：2025-02-06

申请号：US18717136

申请日：2022-12-06

Applicant: OSAKA UNIVERSITY ,  PERIOTHERAPIA CO., LTD.

Inventor： Yoshiaki TANIYAMA ,  Fumihiro SANADA ,  Ryuichi MORISHITA

IPC: C07K16/18 ,  A61K39/00 ,  A61P35/00

Abstract: An object is to provide a novel antibody or antigen-binding fragment thereof against exon 21 of human periostin. The object is achieved by an antibody or antigen-binding fragment thereof bindable to a conformational epitope on human periostin, wherein the epitope contains the amino acid sequence A represented by SEQ ID NO: 61 and the amino acid sequence B represented by any one of SEQ ID NOs: 62 to 64.

公开(公告)号：US20230374103A1

公开(公告)日：2023-11-23

申请号：US18027695

申请日：2021-09-27

Applicant: OSAKA UNIVERSITY

Inventor： Munehisa SHIMAMURA ,  Hironori NAKAGAMI ,  Ryuichi MORISHITA

IPC: C07K14/705 ,  A61P11/00 ,  A61P35/00

CPC classification number: C07K14/70575 ,  A61P11/00 ,  A61P35/00 ,  A61K38/00

Abstract: Provided are preventive or therapeutic agents for fibrotic diseases and cancer. A Wnt signaling pathway inhibitor or a preventive and therapeutic agent for fibrotic diseases or cancer, both comprising an oligopeptide consisting of an amino acid sequence containing a DE loop sequence of RANKL protein and a β-strand sequence of RANKL protein placed adjacent to the N-terminal side of the DE loop sequence.

公开(公告)号：US20230310561A1

公开(公告)日：2023-10-05

申请号：US18023573

申请日：2021-09-07

Applicant: OSAKA UNIVERSITY

Inventor： Hironori NAKAGAMI ,  Ryuichi MORISHITA ,  Shuko TAKEDA ,  Hiroki HAYASHI

IPC: A61K39/00 ,  A61P25/28

CPC classification number: A61K39/0005 ,  A61P25/28 ,  A61K2039/6031 ,  A61K2039/575

Abstract: The present invention provides an immunogenic composition comprising an antigenic peptide and a carrier protein, wherein the antigenic peptide is capable of eliciting production of an antibody against a phosphorylated tau protein and is a human tau protein fragment containing (1) YSpSPGpSPG (SEQ ID NO: 2), (2) AKpSpTPpTAE (SEQ ID NO: 5), (3) AKpSpTPTAE (SEQ ID NO: 31), (4) AKpSTPpTAE (SEQ ID NO: 32), (5) AKSpTPpTAE (SEQ ID NO: 33), or (6) IVpYKpSPV (SEQ ID NO: 24).

公开(公告)号：US20230141614A1

公开(公告)日：2023-05-11

申请号：US17913066

申请日：2021-02-12

Applicant: OSAKA UNIVERSITY

Inventor： Shuko TAKEDA ,  Ryuichi MORISHITA

IPC: A61B5/00 ,  A61B3/113

CPC classification number: A61B5/4088 ,  A61B3/113 ,  A61B5/7445

Abstract: A cognitive impairment diagnostic device includes: an obtainer that obtains a distribution map representing a distribution of gaze points of a subject on a movie for cognitive assessment; and a diagnoser. The movie for cognitive assessment includes, in time order: a first movie including a first region including an image for encoding displayed in a visually enhanced manner, and a plurality of second regions including normal images displayed without being enhanced; and an assessment movie including a third region including an assessment image similar to the image for encoding and displayed at a same position as the image for encoding without being visually enhanced, and the second regions. The diagnoser calculates, in a distribution map on the assessment movie, a percentage of fixation duration for which the third region is focused on, and makes diagnosis of suspected memory impairment when the percentage of fixation duration is lower than a threshold.

公开(公告)号：US20160193308A1

公开(公告)日：2016-07-07

申请号：US14916448

申请日：2014-08-27

Applicant: OSAKA UNIVERSITY

Inventor： Hironori NAKAGAMI ,  Ryuichi MORISHITA ,  Hiroshi KORIYAMA

IPC: A61K39/00

CPC classification number: A61K39/0005 ,  A61K2039/55594 ,  A61K2039/58 ,  C07K16/2896 ,  C07K16/40 ,  C07K2317/76 ,  C07K2317/94 ,  C12N9/6421

Abstract: The present invention provides a vaccine for the prophylaxis or treatment of diabetes using a polypeptide containing the amino acid sequence shown by SEQ ID NO: 2 or an amino acid sequence of a non-human mammal, which corresponds to SEQ ID NO: 2, and the like as an immunogen, which induces a neutralizing antibody to DPP-4, and a prophylactic or therapeutic agent for diabetes, which contains a DDP-4 neutralizing antibody that recognizes a partial amino acid sequence of the aforementioned DDP-4.

Abstract translation: 本发明提供了使用含有SEQ ID NO：2所示的氨基酸序列的多肽或非人哺乳动物的氨基酸序列（其对应于SEQ ID NO：2）预防或治疗糖尿病的疫苗，以及 作为免疫原的类似物，其诱导DPP-4的中和抗体，以及含有识别上述DDP-4的部分氨基酸序列的DDP-4中和抗体的糖尿病预防或治疗剂。