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154 条记录 (耗时 0.046 秒)

    Transcription repressor
    13.
    发明授权
    Transcription repressor 失效
    转录阻遏物

    公开(公告)号：US5874246A

    公开(公告)日：1999-02-23

    申请号：US861549

    申请日：1997-05-22

    申请人： Olga Bandman ,  Surya K. Goli ,  Hong Zhang

    发明人： Olga Bandman ,  Surya K. Goli ,  Hong Zhang

    IPC分类号： A61K48/00 ,  C07K14/47 ,  C12P21/00 ,  C07H21/04 ,  C12N5/10 ,  C12N15/12

    CPC分类号： C07K14/4703 ,  A61K48/00

    摘要： The present invention provides a human transcription repressor (TRAREP) and polynucleotides which identify and encode TRAREP. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. In addition, the invention provides methods for producing TRAREP and for treating or preventing disorders associated with expression of TRAREP.

    摘要翻译： 本发明提供了人类转录阻遏物（TRAREP）和鉴定和编码TRAREP的多核苷酸。 本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。 此外，本发明提供了用于产生TRAREP和用于治疗或预防与TRAREP表达相关的疾病的方法。

    Proline-rich acidic protein
    14.
    发明授权
    Proline-rich acidic protein 失效
    脯氨酸丰富的酸性蛋白

    公开(公告)号：US5856139A

    公开(公告)日：1999-01-05

    申请号：US815175

    申请日：1997-03-11

    申请人： Preeti Lal ,  Jennifer L. Hillman ,  Surya K. Goli

    发明人： Preeti Lal ,  Jennifer L. Hillman ,  Surya K. Goli

    IPC分类号： C07K14/47 ,  C12N15/12 ,  C12N15/00 ,  C07H21/04 ,  C12N1/20 ,  C12P21/02

    CPC分类号： C07K14/47

    摘要： The present invention provides a human proline-rich acidic protein (PRAP) and polynucleotides which identify and encode PRAP. In addition, the invention provides expression vectors and host cells, agonists, antibodies, or antagonists. This invention also provides methods for preventing or treating disorders associated with the expression of PRAP.

    摘要翻译： 本发明提供了富含脯氨酸的酸性蛋白（PRAP）和识别和编码PRAP的多核苷酸。 此外，本发明提供表达载体和宿主细胞，激动剂，抗体或拮抗剂。 本发明还提供了预防或治疗与PRAP表达相关的疾病的方法。

    Subunits of NADH dehydrogenase
    15.
    发明授权
    Subunits of NADH dehydrogenase 失效
    NADH脱氢酶亚基

    公开(公告)号：US06399345B2

    公开(公告)日：2002-06-04

    申请号：US09151412

    申请日：1998-09-10

    申请人： Olga Bandman ,  Surya K. Goli ,  Jennifer L. Hillman

    发明人： Olga Bandman ,  Surya K. Goli ,  Jennifer L. Hillman

    IPC分类号： C12N906

    CPC分类号： C12N9/0036 ,  A61K38/00

    摘要： The present invention provides four NADH dehydrogenase subunits (designated individually as NDS-1, NDS-2, NDS-3, and NDS-4 and collectively as NDS) and polynucleotides which identify and encode NDS. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NDS and a method for producing NDS. The invention also provides for use of NDS and agonists, antibodies, or antagonists specifically binding NDS, in the prevention and treatment of diseases associated with expression of NDS. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NDS for the treatment of diseases associated with the expression of NDS. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NDS.

    摘要翻译： 本发明提供四种NADH脱氢酶亚基（分别称为NDS-1，NDS-2，NDS-3和NDS-4，统称为NDS）和鉴定和编码NDS的多核苷酸。 本发明还提供了遗传工程改造的表达载体和包含编码NDS的核酸序列和产生NDS的方法的宿主细胞。 本发明还提供使用NDS和特异性结合NDS的激动剂，抗体或拮抗剂来预防和治疗与NDS表达相关的疾病。 另外，本发明提供反义分子用于编码NDS的多核苷酸用于治疗与NDS表达相关的疾病。 本发明还提供了利用多核苷酸或其片段或其补体以及特异性结合NDS的抗体的诊断测定法。

    Human apoptosis regulator
    16.
    发明授权
    Human apoptosis regulator 失效
    人类凋亡调节因子

    公开(公告)号：US06307021B1

    公开(公告)日：2001-10-23

    申请号：US09199892

    申请日：1998-11-24

    申请人： Olga Bandman ,  Surya K. Goli ,  Jennifer L. Hillman

    发明人： Olga Bandman ,  Surya K. Goli ,  Jennifer L. Hillman

    IPC分类号： C07K100

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： The present invention provides a human apoptosis regulator protein (APRG) and polynucleotides which identify and encode APRG. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding APRG and a method for producing APRG. The invention also provides for agonists, antibodies, or antagonists specifically binding APRG, and their use, in the prevention and treatment of diseases associated with expression of APRG. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding APRG for the treatment of diseases associated with the expression of APRG. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding APRG.

    摘要翻译： 本发明提供了鉴定和编码APRG的人细胞凋亡调节蛋白（APRG）和多核苷酸。 本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码APRG的核酸序列和生产APRG的方法。 本发明还提供了特异性结合APRG的激动剂，抗体或拮抗剂及其在预防和治疗与APRG表达相关的疾病中的用途。 此外，本发明提供了反义分子用于编码APRG的多核苷酸用于治疗与APRG表达相关的疾病的用途。 本发明还提供利用多核苷酸或其片段或其补体以及特异性结合APRG的抗体的诊断测定法。

    DNA encoding a cytokine
    18.
    发明授权
    DNA encoding a cytokine 失效
    编码细胞因子的DNA

    公开(公告)号：US06204021B1

    公开(公告)日：2001-03-20

    申请号：US08792013

    申请日：1997-01-31

    申请人： Olga Bandman ,  Phillip R. Hawkins ,  Lynn E. Murry ,  Surya K. Goli

    发明人： Olga Bandman ,  Phillip R. Hawkins ,  Lynn E. Murry ,  Surya K. Goli

    IPC分类号： C12N1500

    CPC分类号： C07K14/52

    摘要： The present invention provides novel human cytokines (designated individually as NHC-1 and NHC-2, and collectively as NHC) and polynucleotides which identify and encode NHC. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NHC and a method for producing NHC. The invention also provides for use of NHC and agonists, antibodies, or antagonists specifically binding NHC, in the prevention and treatment of diseases associated with expression of NHC. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NHC for the treatment of diseases associated with the expression of NHC. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NHC.

    摘要翻译： 本发明提供新型人细胞因子（单独命名为NHC-1和NHC-2，统称为NHC）和识别和编码NHC的多核苷酸。 本发明还提供了包含编码NHC的核酸序列和生产NHC的方法的遗传工程表达载体和宿主细胞。 本发明还提供使用NHC和特异性结合NHC的激动剂，抗体或拮抗剂来预防和治疗与NHC表达有关的疾病。 另外，本发明提供了将反义分子用于编码NHC的多核苷酸用于治疗与NHC表达有关的疾病的用途。 本发明还提供利用多核苷酸或其片段或其补体以及特异性结合NHC的抗体的诊断测定法。

    Polynucleotides encoding human mitochondrial chaperone proteins
    19.
    发明授权
    Polynucleotides encoding human mitochondrial chaperone proteins 失效
    编码人线粒体伴侣蛋白的多核苷酸

    公开(公告)号：US6010879A

    公开(公告)日：2000-01-04

    申请号：US971158

    申请日：1997-11-14

    申请人： Olga Bandman ,  Surya K. Goli

    发明人： Olga Bandman ,  Surya K. Goli

    IPC分类号： A61K38/00 ,  C07K14/47 ,  C12N5/02 ,  C12N15/12 ,  C12P21/06 ,  C07H17/00 ,  C07K14/00 ,  C12Q1/68

    CPC分类号： C07K14/47 ,  A61K38/00

    摘要： The present invention provides a human mitochondrial chaperone protein (Hmt-GrpE) and polynucleotides which identify and encode Hmt-GrpE. The invention also provides expression vectors and host cells and a method for producing Hmt-GrpE. The invention also provides for antibodies or antagonists specifically binding Hmt-GrpE, and their use in the prevention and treatment of cancer. The invention also provides diagnostic assays. The invention also provides for the use of Hmt-GrpE in identifying antifungal and antiprotozoal therapeutics.

    摘要翻译： 本发明提供一种人线粒体伴侣蛋白（Hmt-GrpE）和识别和编码Hmt-GrpE的多核苷酸。 本发明还提供表达载体和宿主细胞以及生产Hmt-GrpE的方法。 本发明还提供特异性结合Hmt-GrpE的抗体或拮抗剂及其在预防和治疗癌症中的用途。 本发明还提供诊断测定。 本发明还提供了使用Hmt-GrpE鉴定抗真菌和抗原虫治疗剂。

    Human phosphatase inhibitor protein
    20.
    发明授权
    Human phosphatase inhibitor protein 失效

    公开(公告)号：US5916749A

    公开(公告)日：1999-06-29

    申请号：US766738

    申请日：1996-12-13

    申请人： Olga Bandman ,  Surya K. Goli

    发明人： Olga Bandman ,  Surya K. Goli

    IPC分类号： C07K14/47 ,  C12N1/21 ,  C12N15/12 ,  C12N15/63

    CPC分类号： C07K14/4703

    摘要： The present invention provides a novel human phosphatase inhibitor protein (HPIP) and polynucleotides which identify and encode HPIP. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding HPIP and a method for producing HPIP. The invention also provides for agonists, antibodies, or antagonists specifically binding HPIP, and their use, in the prevention and treatment of diseases associated with expression of HPIP. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding HPIP for the treatment of diseases associated with the expression of HPIP. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding HPIP.