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公开(公告)号：US06399345B2
公开(公告)日：2002-06-04
申请号：US09151412
申请日：1998-09-10
申请人： Olga Bandman , Surya K. Goli , Jennifer L. Hillman
发明人： Olga Bandman , Surya K. Goli , Jennifer L. Hillman
IPC分类号： C12N906
CPC分类号： C12N9/0036 , A61K38/00
摘要： The present invention provides four NADH dehydrogenase subunits (designated individually as NDS-1, NDS-2, NDS-3, and NDS-4 and collectively as NDS) and polynucleotides which identify and encode NDS. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NDS and a method for producing NDS. The invention also provides for use of NDS and agonists, antibodies, or antagonists specifically binding NDS, in the prevention and treatment of diseases associated with expression of NDS. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NDS for the treatment of diseases associated with the expression of NDS. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NDS.
摘要翻译： 本发明提供四种NADH脱氢酶亚基（分别称为NDS-1，NDS-2，NDS-3和NDS-4，统称为NDS）和鉴定和编码NDS的多核苷酸。 本发明还提供了遗传工程改造的表达载体和包含编码NDS的核酸序列和产生NDS的方法的宿主细胞。 本发明还提供使用NDS和特异性结合NDS的激动剂，抗体或拮抗剂来预防和治疗与NDS表达相关的疾病。 另外，本发明提供反义分子用于编码NDS的多核苷酸用于治疗与NDS表达相关的疾病。 本发明还提供了利用多核苷酸或其片段或其补体以及特异性结合NDS的抗体的诊断测定法。
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公开(公告)号：US06307021B1
公开(公告)日：2001-10-23
申请号：US09199892
申请日：1998-11-24
申请人： Olga Bandman , Surya K. Goli , Jennifer L. Hillman
发明人： Olga Bandman , Surya K. Goli , Jennifer L. Hillman
IPC分类号： C07K100
摘要： The present invention provides a human apoptosis regulator protein (APRG) and polynucleotides which identify and encode APRG. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding APRG and a method for producing APRG. The invention also provides for agonists, antibodies, or antagonists specifically binding APRG, and their use, in the prevention and treatment of diseases associated with expression of APRG. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding APRG for the treatment of diseases associated with the expression of APRG. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding APRG.
摘要翻译： 本发明提供了鉴定和编码APRG的人细胞凋亡调节蛋白（APRG）和多核苷酸。 本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码APRG的核酸序列和生产APRG的方法。 本发明还提供了特异性结合APRG的激动剂，抗体或拮抗剂及其在预防和治疗与APRG表达相关的疾病中的用途。 此外，本发明提供了反义分子用于编码APRG的多核苷酸用于治疗与APRG表达相关的疾病的用途。 本发明还提供利用多核苷酸或其片段或其补体以及特异性结合APRG的抗体的诊断测定法。
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公开(公告)号：US06303297B1
公开(公告)日：2001-10-16
申请号：US08969987
申请日：1997-11-13
申请人： Steve E. Lincoln , Tod M. Klingler , Janice Au-Young , Y. Tom Tang , Richard D. Goold , Ingrid E. Akerblom , Jeffrey J. Seilhamer , Phillip R. Hawkins , Lynn E. Murry , Angelo M. Delegeane , Wendy B. Levine , Jennifer L. Hillman , Surya K. Goli , Christina M. Altus , Olga Bandman , Samuel T. LaBrie , Purvi Shah
发明人： Steve E. Lincoln , Tod M. Klingler , Janice Au-Young , Y. Tom Tang , Richard D. Goold , Ingrid E. Akerblom , Jeffrey J. Seilhamer , Phillip R. Hawkins , Lynn E. Murry , Angelo M. Delegeane , Wendy B. Levine , Jennifer L. Hillman , Surya K. Goli , Christina M. Altus , Olga Bandman , Samuel T. LaBrie , Purvi Shah
IPC分类号： C12Q168
CPC分类号： C12N9/6445 , A61K38/00 , C07K14/47 , C07K14/4703 , C07K14/82 , C07K16/303 , C12Q1/68 , C12Q1/6809 , G01N33/574 , G06F19/18 , G06F19/22 , G06F19/28
摘要： The present invention is a computerized storage and retrieval system for genetic information and related annotated information. The data of the system is stored in a relational database which interfaces with public databases to allow analysis both within the database of the invention and between information within that database and external public databases. The sequence data is edited before entry into the system, and is stored in a curated, functional clustering organization. The information associated with the data is stored in an expression database that is linked to the storage of the sequence data.
摘要翻译： 本发明是用于遗传信息和相关注释信息的计算机化存储和检索系统。 系统的数据存储在与公共数据库接口的关系数据库中，以便在本发明的数据库内以及该数据库内的信息和外部公共数据库之间进行分析。 序列数据在进入系统之前进行编辑，并存储在策略化的功能集群组织中。 与数据相关联的信息存储在链接到序列数据的存储的表达式数据库中。
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4.发明授权
公开(公告)号：US5858708A
公开(公告)日：1999-01-12
申请号：US700607
申请日：1996-08-12
IPC分类号： G01N33/53 , A61K38/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P25/28 , A61P35/00 , C07K14/47 , C07K16/18 , C07K16/28 , C12N1/21 , C12N15/09 , C12N15/12 , C12P21/08 , C12N15/85
CPC分类号： C07K16/18 , C07K14/47 , A61K38/00 , C07K2319/00
摘要： The present invention provides polynucleotides which identify and encode two novel human NSP-like proteins (NSPLP). The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NSPLP. The invention also provides for the use of substantially purified NSPLP, antagonists, and in pharmaceutical compositions for the treatment of diseases associated with the expression of NSPLP. Additionally, the invention provides for the use of antisense molecules to NSPLP in pharmaceutical compositions for treatment of diseases associated with the expression of NSPLP. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of polynucleotides encoding NSPLP or anti-NSPLP antibodies which specifically bind to NSPLP.
摘要翻译： 本发明提供鉴定和编码两种新型人NSP样蛋白（NSPLP）的多核苷酸。 本发明提供了包含编码NSPLP的核酸序列的基因工程表达载体和宿主细胞。 本发明还提供使用基本纯化的NSPLP，拮抗剂和药物组合物来治疗与NSPLP表达相关的疾病。 此外，本发明提供了用于治疗与NSPLP表达相关的疾病的药物组合物中NSPLP的反义分子的用途。 本发明还描述了使用包含多核苷酸，其片段或其互补体的诊断组合物的诊断测定法，其与编码特异性结合NSPLP的NSPLP或抗NSPLP抗体的多核苷酸的基因组序列或转录物杂交。
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公开(公告)号：US5847093A
公开(公告)日：1998-12-08
申请号：US773910
申请日：1996-12-27
申请人： Olga Bandman , Surya K. Goli , Jennifer L. Hillman
发明人： Olga Bandman , Surya K. Goli , Jennifer L. Hillman
IPC分类号： C12N15/09 , A61K38/00 , A61K45/00 , A61P7/06 , A61P9/06 , A61P19/10 , A61P21/04 , A61P25/00 , A61P25/16 , A61P25/28 , A61P43/00 , C07K14/47 , C07K16/18 , C12N15/12 , C12P21/02 , C12Q1/68 , C07H21/02 , C07H21/04
摘要： The present invention provides a human apoptosis regulator protein (APRG) and polynucleotides which identify and encode APRG. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding APRG and a method for producing APRG. The invention also provides for agonists, antibodies, or antagonists specifically binding APRG, and their use, in the prevention and treatment of diseases associated with expression of APRG. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding APRG for the treatment of diseases associated with the expression of APRG. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding APRG.
摘要翻译： 本发明提供了鉴定和编码APRG的人细胞凋亡调节蛋白（APRG）和多核苷酸。 本发明还提供了遗传工程改造的表达载体和宿主细胞，其包含编码APRG的核酸序列和生产APRG的方法。 本发明还提供了特异性结合APRG的激动剂，抗体或拮抗剂及其在预防和治疗与APRG表达相关的疾病中的用途。 此外，本发明提供了反义分子用于编码APRG的多核苷酸用于治疗与APRG表达相关的疾病的用途。 本发明还提供利用多核苷酸或其片段或其补体以及特异性结合APRG的抗体的诊断测定法。
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公开(公告)号：US5814451A
公开(公告)日：1998-09-29
申请号：US785065
申请日：1997-01-17
申请人： Olga Bandman , Surya K. Goli , Jennifer L. Hillman
发明人： Olga Bandman , Surya K. Goli , Jennifer L. Hillman
CPC分类号： C12N9/0036 , A61K38/00
摘要： The present invention provides four NADH dehydrogenase subunits (designated individually as NDS-1, NDS-2, NDS-3, and NDS-4 and collectively as NDS) and polynucleotides which identify and encode NDS. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding NDS and a method for producing NDS. The invention also provides for use of NDS and agonists, antibodies, or antagonists specifically binding NDS, in the prevention and treatment of diseases associated with expression of NDS. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding NDS for the treatment of diseases associated with the expression of NDS. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding NDS.
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公开(公告)号：US6020474A
公开(公告)日：2000-02-01
申请号：US783974
申请日：1997-01-15
申请人： Olga Bandman , Jennifer L. Hillman , Surya K. Goli
发明人： Olga Bandman , Jennifer L. Hillman , Surya K. Goli
摘要： The present invention provides two ATP synthase subunits (designated individually as Asy-1 and Asy-2, and collectively as Asy) and polynucleotides which identify and encode Asy. The invention also provides genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding Asy and a method for producing Asy. The invention also provides for use of Asy and agonists, antibodies, or antagonists specifically binding Asy, in the prevention and treatment of diseases associated with expression of Asy. Additionally, the invention provides for the use of antisense molecules to polynucleotides encoding Asy for the treatment of diseases associated with the expression of Asy. The invention also provides diagnostic assays which utilize the polynucleotide, or fragments or the complement thereof, and antibodies specifically binding Asy.
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公开(公告)号：US5885803A
公开(公告)日：1999-03-23
申请号：US878989
申请日：1997-06-19
申请人： Olga Bandman , Jennifer L. Hillman , Neil C. Corley , Karl J. Guegler , Preeti Lal , Surya K. Goli , Purvi Shah
发明人： Olga Bandman , Jennifer L. Hillman , Neil C. Corley , Karl J. Guegler , Preeti Lal , Surya K. Goli , Purvi Shah
CPC分类号： C12N9/1205 , A61K38/00
摘要： The invention provides human disease associated protein kinases and polynucleotides (collectively designated DAPK) which identify and encode them. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. The invention further provides methods for diagnosing and treating disorders associated with expression of human disease associated protein kinases.
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公开(公告)号：US5854022A
公开(公告)日：1998-12-29
申请号：US855140
申请日：1997-05-13
IPC分类号： C12N15/09 , A61K38/00 , A61K39/395 , A61K45/00 , A61P35/00 , A61P43/00 , C07K14/47 , C07K14/705 , C07K16/18 , C12N1/15 , C12N1/19 , C12N1/21 , C12N5/10 , C12N15/12 , C12P21/02 , C12Q1/02 , C12Q1/68 , C07H21/04
CPC分类号： C07K14/70596 , A61K38/00
摘要： The present invention provides a human transmembrane protein (ONMO) and polynucleotides which identify and encode ONMO. The invention also provides expression vectors, host cells, agonists, antibodies and antagonists. In addition, the invention provides methods for producing ONMO and for treating or preventing disorders associated with expression of ONMO.
摘要翻译： 本发明提供了人跨膜蛋白（ONMO）和识别和编码ONMO的多核苷酸。 本发明还提供表达载体，宿主细胞，激动剂，抗体和拮抗剂。 此外，本发明提供了用于生产ONMO和用于治疗或预防与ONMO表达相关的病症的方法。
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公开(公告)号：US5843715A
公开(公告)日：1998-12-01
申请号：US701935
申请日：1996-08-23
CPC分类号： C12N9/6421 , C12Y304/25001 , A61K38/00
摘要： The present invention provides polynucleotides which identify and encode novel human proteasome subunit proteins. The invention provides for genetically engineered expression vectors and host cells comprising the nucleic acid sequences encoding PSUB. The invention also provides for the use of substantially purified PSUB, antagonists, and in pharmaceutical compositions for the treatment of diseases associated with the expression of PSUB. Additionally, the invention provides for the use of antisense molecules to PSUB in pharmaceutical compositions for treatment of diseases associated with the expression of PSUB. The invention also describes diagnostic assays which utilize diagnostic compositions comprising the polynucleotide, fragments or the complement thereof, which hybridize with the genomic sequence or the transcript of polynucleotides encoding PSUB or anti-PSUB antibodies which specifically bind to PSUB.
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