公开(公告)号：US3271439A

公开(公告)日：1966-09-06

申请号：US26282963

申请日：1963-03-05

Applicant: PFIZER & CO C

Inventor： CELMER WALTER D

IPC: C07D499/00

CPC classification number: C07D499/00 ,  Y10S435/888

公开(公告)号：US3154564A

公开(公告)日：1964-10-27

申请号：US22917662

申请日：1962-10-08

Applicant: PFIZER & CO C

Inventor： CELMER WALTER D

IPC: C07H17/08

CPC classification number: C07H17/08

公开(公告)号：US3144466A

公开(公告)日：1964-08-11

申请号：US26374363

申请日：1963-03-08

Applicant: PFIZER & CO C

Inventor： CELMER WALTER D

IPC: C07H17/08

CPC classification number: C07H17/08

公开(公告)号：US3040033A

公开(公告)日：1962-06-19

申请号：US84393259

申请日：1959-10-02

Applicant: PFIZER & CO C

Inventor： CELMER WALTER D

IPC: C07D499/00 ,  C07D499/62

CPC classification number: C07D499/00

公开(公告)号：US3884763A

公开(公告)日：1975-05-20

申请号：US45007174

申请日：1974-03-11

Applicant: PFIZER

Inventor： CELMER WALTER D ,  CULLEN WALTER P ,  ROUTIEN JOHN B

IPC: C07D498/08 ,  C12D9/14

CPC classification number: C07D498/08 ,  Y10S435/803 ,  Y10S435/864 ,  Y10S435/872 ,  Y10S435/886

Abstract: A process for producing rifamycin S and rifamycin SV by aerobically fermenting an aqueous nutrient medium with a strain of Micromonospora chalcea. The rifamycins are separated and recovered by reducing all the activity to rifamycin SV by treatment with ascorbic acid at the clarified fermentation broth stage or at one of the solvent stages of extraction and concentration. Rifamycin SV may be converted to rifamycin S by oxidation with activated manganese dioxide.

公开(公告)号：US3584012A

公开(公告)日：1971-06-08

申请号：US3584012D

申请日：1968-09-20

Applicant: PFIZER & CO C

Inventor： CELMER WALTER D ,  WADLOW JAMES W JR

IPC: C07H17/08 ,  C07D9/00

CPC classification number: A61K36/06 ,  C07H17/08 ,  Y10S435/888

Abstract: YIELDS OF OLEANDOMYCIN FROM FERMENTATION BROTHS ARE GREATLY IMPROVED BY ADJUSTING THE FERMENTATION BROTH TO A PH OF FROM ABOUT 5 TO ABOUT 6 WITH MINERAL ACID DURING THE POST-FERMENTATION PERIOD AND MAINTAINING SAID PH FOR AT LEAST TWO HOURS.

公开(公告)号：US3303210A

公开(公告)日：1967-02-07

申请号：US29284863

申请日：1963-07-05

Applicant: PFIZER & CO C

Inventor： CELMER WALTER D

IPC: C07D499/00

CPC classification number: C07D499/00 ,  Y10S435/888

公开(公告)号：US3268418A

公开(公告)日：1966-08-23

申请号：US16567362

申请日：1962-01-11

Applicant: PFIZER & CO C

Inventor： CELMER WALTER D ,  NICKELL LOUIS G

CPC classification number: C12P1/06 ,  Y10S435/896

公开(公告)号：US3116285A

公开(公告)日：1963-12-31

申请号：US3156360

申请日：1960-05-25

Applicant: PFIZER & CO C

Inventor： CELMER WALTER D ,  HOBBS DONALD C

IPC: C07D499/00 ,  C07D499/58

CPC classification number: C07D499/00

公开(公告)号：US3113074A

公开(公告)日：1963-12-03

申请号：US55832956

申请日：1956-01-10

Applicant: PFIZER & CO C

Inventor： SOBIN BEN A ,  CELMER WALTER D ,  KOE BILLIE K

CPC classification number: C12P1/06 ,  Y10S435/886