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公开(公告)号：US2747334A
公开(公告)日：1956-05-29
申请号：US28895452
申请日：1952-05-20
Applicant: PFIZER & CO C
Inventor： ROUTIEN JOHN B , NICKELL LOUIS G
IPC: A01H4/00
CPC classification number: A01H4/00
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公开(公告)号：US3884763A
公开(公告)日：1975-05-20
申请号：US45007174
申请日：1974-03-11
Applicant: PFIZER
Inventor： CELMER WALTER D , CULLEN WALTER P , ROUTIEN JOHN B
IPC: C07D498/08 , C12D9/14
CPC classification number: C07D498/08 , Y10S435/803 , Y10S435/864 , Y10S435/872 , Y10S435/886
Abstract: A process for producing rifamycin S and rifamycin SV by aerobically fermenting an aqueous nutrient medium with a strain of Micromonospora chalcea. The rifamycins are separated and recovered by reducing all the activity to rifamycin SV by treatment with ascorbic acid at the clarified fermentation broth stage or at one of the solvent stages of extraction and concentration. Rifamycin SV may be converted to rifamycin S by oxidation with activated manganese dioxide.
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公开(公告)号：US2875134A
公开(公告)日：1959-02-24
申请号：US63560157
申请日：1957-01-23
Applicant: PFIZER & CO C
Inventor： ROUTIEN JOHN B , SHULL GILBERT M
IPC: C12P33/00
CPC classification number: C12P33/00 , Y10S435/911
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公开(公告)号：US2866737A
公开(公告)日：1958-12-30
申请号：US63559957
申请日：1957-01-23
Applicant: PFIZER & CO C
Inventor： SHULL GILBERT M , ROUTIEN JOHN B
IPC: C12P33/00
CPC classification number: C12P33/00 , Y10S435/911
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公开(公告)号：US2787580A
公开(公告)日：1957-04-02
申请号：US39176653
申请日：1953-11-12
Applicant: PFIZER & CO C
Inventor： SOBIN BEN A , ENGLISH ARTHUR R , LEES THOMAS M , ROUTIEN JOHN B
CPC classification number: C12P13/00 , Y10S435/902
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Patent Agency Ranking
公开(公告)号：US3914218A
公开(公告)日：1975-10-21
申请号：US43184574
申请日：1974-01-09
Applicant: PFIZER
Inventor： CELMER WALTER D , SCIAVOLINO FRANK C , CULLEN WALTER P , ROUTIEN JOHN B
IPC: C12P17/18 , A61K31/34 , A61K31/395 , A61K36/06 , A61P31/04 , C07D498/08 , C07G11/00 , C12P1/06 , C12R1/29 , C07D201/02
CPC classification number: A61K36/06 , C07D498/08 , C07G11/00 , Y10S435/863
Abstract: A new species of Micromonospora, designated Micromonospora lacustris sp. nov. Routien, when subjected to submerged aerobic fermentation under controlled conditions, produces a mixture of at least 13 antibiotics. Two of these antibiotics are rifamycin S and rifamycin SV. Two other members of the antibiotic mixture are the 3-thiomethyl derivatives of rifamycin S and rifamycin SV.
Abstract translation: 一种新的小单孢菌属，命名为小单孢菌属（Micromonospora lacustris sp。）。 nov。 Routien在受控条件下进行浸没需氧发酵时，产生至少13种抗生素的混合物。 其中两种抗生素为利福霉素S和利福霉素SV。 抗生素混合物的另外两个成员是利福霉素S和利福霉素SV的3-硫代甲基衍生物。
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公开(公告)号：US3655876A
公开(公告)日：1972-04-11
申请号：US3655876D
申请日：1970-08-07
Applicant: PFIZER
Inventor： SCIAVOLINO FRANK C , ROUTIEN JOHN B , TYNAN EDWARD J , CELMER WALTER D
CPC classification number: C12P1/06 , Y10S435/902
Abstract: A NEW CRYSTALLINE ANTIBIOTIC, IS PRODUCTION BY FERMENTATION, METHODS FOR ITS RECOVERY AND CONCENTRATION AND ITS PURIFICATION ARE DESCRIBED.
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8.发明授权
公开(公告)号：US2872380A
公开(公告)日：1959-02-03
申请号：US64031857
申请日：1957-02-15
Applicant: PFIZER & CO C
Inventor： SHULL GILBERT M , ROUTIEN JOHN B
IPC: C12P33/00
CPC classification number: C12P33/00 , Y10S435/911
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公开(公告)号：US2796379A
公开(公告)日：1957-06-18
申请号：US27029852
申请日：1952-02-07
Applicant: PFIZER & CO C
Inventor： TANNER JR FRED W , LEES THOMAS M , ROUTIEN JOHN B
IPC: C07H17/08
CPC classification number: C07H17/08 , Y10S435/886
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公开(公告)号：US3646194A
公开(公告)日：1972-02-29
申请号：US3646194D
申请日：1968-08-19
Applicant: PFIZER
Inventor： SOBIN BEN A , ROUTIEN JOHN B , RAO KOPPAKA V , MARSH WILLIAM S , GARRETSON ALINE L
IPC: A61K21/00
CPC classification number: A61K31/70
Abstract: THE MITHRAMYCIN A IS USEFUL IN INHIBITING THE GROWTH OF TESTICULAR TUMORS IN MAN. THE MITHRAMYCIN A, B AND C ARE USEFUL IN INHIBITING THE GROWTH OF TRANSPLANTED TUMORS IN LOWER ANIMALS.
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