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公开(公告)号：US20050192853A1
公开(公告)日：2005-09-01
申请号：US10880512
申请日：2004-07-01
申请人： Peter Ebert , Michael Heinrich , Ian Kimbell , Janaki Kumar , Steven Mann , Frederic Samson , Bernhard Schweizer , Zia Yusuf
发明人： Peter Ebert , Michael Heinrich , Ian Kimbell , Janaki Kumar , Steven Mann , Frederic Samson , Bernhard Schweizer , Zia Yusuf
CPC分类号： G06Q30/02
摘要： A feedback system for visual content is described that allows individual users to obtain feedback regarding selected visual content. A user of the system uploads any desired visual content, and associates the content with a feedback campaign having user-defined characteristics. The user also may associate feedback elements with the visual content, such as comments regarding the visual content or the type of feedback that is desired. The feedback system provides the visual content and feedback elements to selected other users, perhaps by sending a link to the other users via email. In this way, the receiving users may provide feedback regarding the visual content. In particular, the receiving users may generate a virtual note to be placed on a selected portion of the visual content, so as to provide comment specific to the selected portion. As a result, individual users are enabled to create and manage multiple feedback campaigns.
摘要翻译： 描述了用于视觉内容的反馈系统，其允许个别用户获得关于所选视觉内容的反馈。 系统的用户上传任何所需的视觉内容，并且将内容与具有用户定义特征的反馈活动相关联。 用户还可以将反馈元素与视觉内容相关联，例如关于视觉内容的意见或期望的反馈的类型。 反馈系统向选定的其他用户提供可视内容和反馈元素，可能通过电子邮件发送链接给其他用户。 以这种方式，接收用户可以提供关于视觉内容的反馈。 特别地，接收用户可以生成要放置在可视内容的所选部分上的虚拟音符，以便提供特定于所选部分的注释。 因此，个人用户可以创建和管理多个反馈广告系列。
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公开(公告)号：US20200147466A1
公开(公告)日：2020-05-14
申请号：US16191246
申请日：2018-11-14
申请人： Michael Heinrich
发明人： Michael Heinrich
摘要： People love fun fast paced family friendly party games having elements of skill and luck allowing everyone to get in on the fun. Fast paced game play can be a more hygienic alternative to beer pong with the receptacle target being portable, lightweight, durable, compactly storable, placeable for instance onto a table or a truck tailgate. Embodiments can be used as amusement games with players stacking game pieces on or tossing game pieces towards a receptacle target. Innovative elegant designs brings out the natural beauty of wood or other stylistic materials in a fun functional manner.
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公开(公告)号：US06990923B2
公开(公告)日：2006-01-31
申请号：US10929889
申请日：2004-08-30
申请人： Patrick M. Hein , Jeffrey S. Hanson , Michael Heinrich , Frank Hoelscher , Larry G. Larson , Peter Kaever , Karsten Schonrock
发明人： Patrick M. Hein , Jeffrey S. Hanson , Michael Heinrich , Frank Hoelscher , Larry G. Larson , Peter Kaever , Karsten Schonrock
IPC分类号： A01J5/00
摘要： A rotary milking parlor milker detacher having a pivoting support arm and retracting chain arrangement that is synchronized with a rotating platform position to move the detacher between a storage position, a presentation position, and a milking position to protect the detacher from damage and provide a superior ergonomic design that reduces operator fatigue and turnover.
摘要翻译： 一种具有枢转支撑臂和回缩链条装置的旋转挤奶室挤奶器分离器，其与旋转平台位置同步，以在存储位置，呈现位置和挤奶位置之间移动分离器，以保护分离器免受损坏并提供优越性 符合人体工学的设计，减少操作员的疲劳和更换。
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14.发明申请公开(公告)号：US20050100891A1
公开(公告)日：2005-05-12
申请号：US11019987
申请日：2004-12-23
申请人： Mattias Luukkonen , Ashlee Moses , Klaus Frueh , Jay Nelson , Yolanda Bell , Michael Heinrich , Kenneth Simmen
发明人： Mattias Luukkonen , Ashlee Moses , Klaus Frueh , Jay Nelson , Yolanda Bell , Michael Heinrich , Kenneth Simmen
IPC分类号： G01N33/53 , A61K31/00 , A61K31/07 , A61K31/337 , A61K31/704 , A61K38/21 , A61K45/00 , A61K45/06 , A61P31/22 , C12M1/00 , C12N15/09 , C12Q1/02 , C12Q1/68 , C12Q1/6837 , C12Q1/6883 , G01N21/77 , G01N21/78 , G01N33/58 , G01N37/00 , G06Q50/22 , C12Q1/70 , C12M1/34 , A61K38/16
CPC分类号： C12Q1/6883 , A61K31/00 , A61K31/337 , A61K31/704 , A61K38/212 , A61K45/06 , C12Q1/6837 , C12Q2600/158 , G06Q50/22 , Y02A90/22 , A61K2300/00
摘要： The present invention utilizes nucleic acid microarray technology to identify changes in the host endothelial cell transcription pattern that occurs during the latent and lytic phase of the KSHV life cycle. The production or activity of some genes up regulated during the lytic cycle were subsequently inhibited, and two such targets were shown to have a role in expression of late viral genes. Using this combined approach we have identified cellular pathways previously unknown to be important for KSHV infection, and present evidence for the efficiency of the novel antiviral approaches thus discovered. In addition, the present invention identifies a wide variety of endothelial cells genes and pathways that are involved in a variety of endothelial cell-mediated activity, including angiogenesis and transformation.
摘要翻译： 本发明利用核酸微阵列技术鉴定在KSHV生命周期的潜伏期和裂解期期间发生的宿主内皮细胞转录模式的变化。 随后抑制溶解循环中上调的一些基因的产生或活性，并且显示出两个这样的靶点在晚期病毒基因的表达中起作用。 使用这种组合方法，我们已经确定以前未知对KSHV感染重要的细胞途径，并提供了因此发现的新型抗病毒方法的效率的证据。 此外，本发明鉴定参与多种内皮细胞介导的活性的多种内皮细胞基因和途径，包括血管生成和转化。
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公开(公告)号：US20050051105A1
公开(公告)日：2005-03-10
申请号：US10929889
申请日：2004-08-30
申请人： Patrick Hein , Jeffrey Hanson , Michael Heinrich , Frank Hoelscher , Larry Larson , Peter Kaever , Karsten Schonrock
发明人： Patrick Hein , Jeffrey Hanson , Michael Heinrich , Frank Hoelscher , Larry Larson , Peter Kaever , Karsten Schonrock
摘要： A rotary milking parlor milker detacher having a pivoting support arm and retracting chain arrangement that is synchronized with a rotating platform position to move the detacher between a storage position, a presentation position, and a milking position to protect the detacher from damage and provide a superior ergonomic design that reduces operator fatigue and turnover.
摘要翻译： 一种具有枢转支撑臂和回缩链条装置的旋转挤奶室挤奶器分离器，其与旋转平台位置同步，以在存储位置，呈现位置和挤奶位置之间移动分离器，以保护分离器免受损坏并提供优越性 符合人体工学的设计，减少操作员的疲劳和更换。
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公开(公告)号：US06814027B2
公开(公告)日：2004-11-09
申请号：US10242271
申请日：2002-09-12
申请人： Patrick M. Hein , Jeffrey S. Hanson , Michael Heinrich , Frank Hoelscher , Larry G. Larson , Peter Kaever , Karsten Schonrock
发明人： Patrick M. Hein , Jeffrey S. Hanson , Michael Heinrich , Frank Hoelscher , Larry G. Larson , Peter Kaever , Karsten Schonrock
IPC分类号： A01J300
摘要： A rotary milking parlor milker detacher having a pivoting support arm and retracting chain arrangement that is synchronized with a rotating platform position to move the detacher between a storage position, a presentation position, and a milking position to protect the detacher from damage and provide a superior ergonomic design that reduces operator fatigue and turnover.
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17.发明申请Use of N-Phenyl-2-pyrimidineamine Derivatives Against Mast Cell-based Diseases Like Allergic Disorders 审中-公开使用N-苯基-2-嘧啶胺衍生物对抗基于细胞的疾病如过敏性疾病公开(公告)号：US20120277246A1
公开(公告)日：2012-11-01
申请号：US13523198
申请日：2012-06-14
IPC分类号： A61K31/506 , A61P35/00
CPC分类号： A61K31/506
摘要： Use of the N-phenyl-2-pyrimidine-amine derivatives of formula I, in which the symbols and substituents have the meaning as given herein in free form or in pharmaceutically acceptable salt form in the manufacture of a pharmaceutical composition for the treatment of allergic rhinitis, allergic dermatitis, drug allergy or food allergy, angioedema, urticaria, sudden infant death syndrome, bronchopulmonary aspergillosis, multiple sclerosis or mastocytosis;
摘要翻译： 使用式I的N-苯基-2-嘧啶 - 胺衍生物，其中符号和取代基具有本文给出的含义，以游离形式或药学上可接受的盐形式用于制备用于治疗过敏性的药物组合物 鼻炎，过敏性皮炎，药物过敏或食物过敏，血管性水肿，荨麻疹，婴儿猝死综合征，支气管肺曲霉病，多发性硬化或肥大细胞增多症;
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18.发明申请Use of N-Phenyl-2-pyrimidineamine Derivatives Against Mast Cell-based Diseases Like Allergic Disorders 审中-公开使用N-苯基-2-嘧啶胺衍生物对抗基于细胞的疾病如过敏性疾病公开(公告)号：US20110201619A1
公开(公告)日：2011-08-18
申请号：US13090752
申请日：2011-04-20
IPC分类号： A61K31/506 , C07D401/14 , A61P17/00 , A61P35/00 , A61P37/08
CPC分类号： A61K31/506
摘要： Use of the N-phenyl-2-pyrimidine-amine derivatives of formula I, in which the symbols and substituents have the meaning as given herein in free form or in pharmaceutically acceptable salt form in the manufacture of a pharmaceutical composition for the treatment of allergic rhinitis, allergic dermatitis, drug allergy or food allergy, angioedema, urticaria, sudden infant death syndrome, bronchopulmonary aspergillosis, multiple sclerosis or mastocytosis;
摘要翻译： 使用式I的N-苯基-2-嘧啶 - 胺衍生物，其中符号和取代基具有本文给出的含义，以游离形式或药学上可接受的盐形式用于制备用于治疗过敏性的药物组合物 鼻炎，过敏性皮炎，药物过敏或食物过敏，血管性水肿，荨麻疹，婴儿猝死综合征，支气管肺曲霉病，多发性硬化或肥大细胞增多症;
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19.发明申请Use of N-Phenyl-2-Pyrimidineamine Derivatives Against Mast Cell-Based Diseases Like Allergic Disorders 审中-公开使用N-苯基-2-嘧啶胺衍生物对抗肥大细胞性疾病如过敏性疾病公开(公告)号：US20100144750A1
公开(公告)日：2010-06-10
申请号：US12687544
申请日：2010-01-14
CPC分类号： A61K31/506
摘要： Use of the N-phenyl-2-pyrimidine-amine derivatives of formula I, in which the symbols and substituents have the meaning as given herein in free form or in pharmaceutically acceptable salt form in the manufacture of a pharmaceutical composition for the treatment of allergic rhinitis, allergic dermatitis, drug allergy or food allergy, angioedema, urticaria, sudden infant death syndrome, bronchopulmonary aspergillosis, multiple sclerosis or mastocytosis;
摘要翻译： 使用式I的N-苯基-2-嘧啶 - 胺衍生物，其中符号和取代基具有本文给出的含义，以游离形式或药学上可接受的盐形式用于制备用于治疗过敏性的药物组合物 鼻炎，过敏性皮炎，药物过敏或食物过敏，血管性水肿，荨麻疹，婴儿猝死综合征，支气管肺曲霉病，多发性硬化或肥大细胞增多症;
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20.发明申请Activating mutations of platelet derived growth factor receptor alpha (pdgfra) as diagnostic markers and therapeutics targets 失效激活血小板衍生生长因子受体α（pdgfra）的突变作为诊断标志物和治疗靶标公开(公告)号：US20060084142A1
公开(公告)日：2006-04-20
申请号：US10517905
申请日：2003-06-13
CPC分类号： C07K14/71 , A61K38/00 , G01N33/57484 , G01N2333/49 , G01N2500/04
摘要： This disclosure provides tyrosine kinase protein and nucleic acid variants, particularly PDGFRA variants, which are activating forms of these molecules and are linked to neoplasms and/or the development or progression of cancer. The disclosure further provides methods of diagnosis and prognosis, and development of new therapeutic agents using these molecules and fragments thereof, and kits for employing these methods and compositions.
摘要翻译： 本公开提供酪氨酸激酶蛋白和核酸变体，特别是PDGFRA变体，其是这些分子的活化形式并与肿瘤和/或癌症的发展或进展相关联。 本公开进一步提供诊断和预后的方法，以及使用这些分子及其片段开发新的治疗剂，以及使用这些方法和组合物的试剂盒。
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