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11.发明授权Use of Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines in the treatment of nausea and vomiting 失效取代的2-硫代-3,5-二氰基-4-苯基-6-氨基吡啶在治疗恶心和呕吐中的用途公开(公告)号：US07709504B2
公开(公告)日：2010-05-04
申请号：US11631755
申请日：2005-06-23
IPC分类号： A61K31/4418 , A61K31/4436 , A61K31/444
CPC分类号： A61K31/4427
摘要： The present invention relates to the use of substituted 2-thio-3,5-dicyano-4-phenyl-6-amino-pyridines of the formula (I) wherein the terms A and R2 are herein defined, for treatment of nausea and vomiting.
摘要翻译： 本发明涉及式（I）的取代的2-硫代-3,5-二氰基-4-苯基-6-氨基 - 吡啶的用途，其中术语A和R2在本文中定义，用于治疗恶心和呕吐 。
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12.发明申请Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines and the use of the same 审中-公开取代的2-硫代-3,5-二氰基-4-苯基-6-氨基吡啶并使用它们公开(公告)号：US20060217373A1
公开(公告)日：2006-09-28
申请号：US11443693
申请日：2006-05-30
申请人： Ulrich Rosentreter , Thomas Kramer , Mitsuyuki Shimada , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Kerstin Henninger , Johannes-Peter Stasch , Ralf Wischnat
发明人： Ulrich Rosentreter , Thomas Kramer , Mitsuyuki Shimada , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Kerstin Henninger , Johannes-Peter Stasch , Ralf Wischnat
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/497 , A61K31/4439 , A61K31/44
CPC分类号： C07D417/12 , C07D213/85 , C07D417/14
摘要： Compounds of the formula (I) a process for their preparation and their use as medicaments are described.
摘要翻译： 描述了式（I）化合物的制备方法及其作为药物的用途。
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公开(公告)号：US20060154969A1
公开(公告)日：2006-07-13
申请号：US10471079
申请日：2002-02-28
申请人： Ulrich Rosentreter , Thomas Kramer , Andrea Vaupel , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch
发明人： Ulrich Rosentreter , Thomas Kramer , Andrea Vaupel , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch
IPC分类号： A61K31/44 , C07D213/84
CPC分类号： C07D401/12 , C07D213/85 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14
摘要： The invention relates to the compounds of formula (I), to a method for producing the same and to the use thereof as medicaments.
摘要翻译： 本发明涉及式（I）化合物，其制备方法及其作为药物的用途。
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14.发明申请Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines and the use of the same 有权取代的2-硫代-3,5-二氰基-4-苯基-6-氨基吡啶并使用它们公开(公告)号：US20050227972A1
公开(公告)日：2005-10-13
申请号：US10497120
申请日：2002-11-28
申请人： Ulrich Rosentreter , Thomas Kramer , Mitsuyuki Shimada , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Kerstin Henninger , Johannes-Peter Stasch , Ralf Wischnat
发明人： Ulrich Rosentreter , Thomas Kramer , Mitsuyuki Shimada , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Kerstin Henninger , Johannes-Peter Stasch , Ralf Wischnat
IPC分类号： A61K31/454 , A61K31/4545 , A61K31/5377 , A61K45/00 , A61P3/10 , A61P9/00 , A61P9/06 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P13/00 , A61P13/10 , A61P15/00 , A61P15/10 , A61P17/00 , A61P25/00 , A61P25/04 , A61P25/28 , A61P29/00 , A61P29/02 , A61P35/00 , A61P43/00 , C07D213/85 , C07D417/12 , C07D417/14 , A61K31/541 , A61K31/444 , A61K31/496 , C07D413/14
CPC分类号： C07D417/12 , C07D213/85 , C07D417/14
摘要： Compounds of the formula (I) a process for their preparation and their use as medicaments are described.
摘要翻译： 描述了式（I）化合物的制备方法及其作为药物的用途。
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15.发明授权Substituted 2, 6-diamino-3, 5-dicyano-4-arylpyridines and their use as adenosine-receptor-selective ligands 失效取代的2,6-二氨基-3,5-二氰基-4-芳基吡啶及其作为腺苷受体选择配体的用途公开(公告)号：US08242281B2
公开(公告)日：2012-08-14
申请号：US11607262
申请日：2006-12-01
申请人： Ulrich Rosentreter , Thomas Kramer , Andrea Vaupel , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch
发明人： Ulrich Rosentreter , Thomas Kramer , Andrea Vaupel , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch
IPC分类号： C07D213/72 , C07D213/00 , A01N43/40
CPC分类号： C07D401/12 , C07D213/85 , C07D405/12 , C07D405/14 , C07D409/12 , C07D417/14
摘要： The present invention relates to substituted 2,6-diamino-3,5-dicyano-4-arylpyridines of the formula (I) wherein the definitions of substituent groups R1-R7 are as provided in the specification and claims, to a pharmaceutical composition containing such a compound, to a process for preparation of such materials, and to their use as medicaments for the treatment of cardiovascular disorders and diabetes.
摘要翻译： 本发明涉及式（I）的取代的2,6-二氨基-3,5-二氰基-4-芳基吡啶，其中取代基R1-R7的定义如说明书和权利要求中所述，含有 这样的化合物，制备这种材料的方法，以及它们作为用于治疗心血管疾病和糖尿病的药物的用途。
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公开(公告)号：US20120122820A1
公开(公告)日：2012-05-17
申请号：US12671681
申请日：2008-07-23
申请人： Nicole Diedrichs , Thomas Krahn , Ursula Krenz , Jörg Keldenich , Hanna Tinel , Claudia Hirth-Dietrich , Hans-Georg Lerchen
发明人： Nicole Diedrichs , Thomas Krahn , Ursula Krenz , Jörg Keldenich , Hanna Tinel , Claudia Hirth-Dietrich , Hans-Georg Lerchen
IPC分类号： A61K31/675 , A61P9/00 , C07D417/14 , A61K31/4439 , C07F9/6539 , C07D417/12
CPC分类号： C07D417/12 , C07D417/14 , C07F9/65583
摘要： The present application relates to prodrug derivatives of 2-amino-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}thio)-4-[4-(2-hydroxyethoxy)phenyl]pyridine-3,5-dicarbonitrile, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of cardiovascular disorders.
摘要翻译： 本申请涉及2-氨基-6 - （{[2-（4-氯苯基）-1,3-噻唑-4-基]甲基}硫基）-4- [4-（2-羟基乙氧基） 苯基]吡啶-3,5-二腈，其制备方法，它们用于治疗和/或预防疾病的用途，及其用于制备用于治疗和/或预防疾病，特别是心血管疾病的药物的用途。
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17.发明申请Use of Substituted 2-Thio-3,5-Dicyano-4-Phenyl-6-Aminopyridines In the Treatment of Nausea and Vomiting 失效取代的2-硫代-3,5-二氰基-4-苯基-6-氨基吡啶在恶心和呕吐的治疗中的应用公开(公告)号：US20080249133A1
公开(公告)日：2008-10-09
申请号：US11631755
申请日：2005-06-23
IPC分类号： A61K31/444 , A61K31/44 , A61K31/4436 , A61P1/08
CPC分类号： A61K31/4427
摘要： The present invention relates to the use of substituted 2-thio-3,5-dicyano-4-phenyl-6-amino-pyridines of the formula (I) for production of a medicament for the prophylaxis and/or treatment of nausea and vomiting.
摘要翻译： 本发明涉及式（I）的取代的2-硫代-3,5-二氰基-4-苯基-6-氨基 - 吡啶在制备用于预防和/或治疗恶心和呕吐的药物中的用途 。
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18.发明授权Substituted 2-thio-3, 5-dicyano-4-phenyl-6-aminopyridines and their use as adenosine receptor-selective ligands 失效取代的2-硫代-3,5-二氰基-4-苯基-6-氨基吡啶并将其用作腺苷受体选择配体公开(公告)号：US07045631B2
公开(公告)日：2006-05-16
申请号：US10484133
申请日：2002-07-03
申请人： Ulrich Rosentreter , Thomas Kramer , Mitsuyuki Shimada , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Kerstin Henninger , Johannes-Peter Stasch
发明人： Ulrich Rosentreter , Thomas Kramer , Mitsuyuki Shimada , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Kerstin Henninger , Johannes-Peter Stasch
IPC分类号： C07D213/62 , C07D417/12
CPC分类号： C07D417/12 , C07D213/85
摘要： Compounds of the formula (I) a process for preparing them, and their use as medicaments are described.
摘要翻译： 描述了式（I）化合物的制备方法及其作为药物的用途。
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19.发明申请Substituted 2-oxy-3,5-dicyano-4-aryl-6-aminopyridines and use thereof 失效取代的2-氧基-3,5-二氰基-4-芳基-6-氨基吡啶及其用途公开(公告)号：US20050261502A1
公开(公告)日：2005-11-24
申请号：US10469556
申请日：2002-02-20
申请人： Ulrich Rosentreter , Thomas Kramer , Andrea Vaupel , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch
发明人： Ulrich Rosentreter , Thomas Kramer , Andrea Vaupel , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch
IPC分类号： A61K31/44 , A61K31/443 , A61K31/4436 , A61K31/4439 , A61K31/444 , A61P1/16 , A61P3/10 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P13/00 , A61P13/10 , A61P15/10 , A61P17/00 , A61P25/00 , A61P25/04 , A61P25/16 , A61P25/28 , A61P29/00 , A61P35/00 , C07D213/85 , C07D405/04 , C07D409/14 , C07D417/14 , C07D213/84
CPC分类号： C07D405/04 , C07D213/85 , C07D409/14 , C07D417/14
摘要： The use of compounds of formula (I) as medicaments, novel compounds of formula (I) and a method for production thereof are disclosed. Compounds of formula (I) are effective as adenosine receptor ligands.
摘要翻译： 公开了使用式（I）化合物作为药物，新的式（I）化合物及其制备方法。 式（I）化合物作为腺苷受体配体是有效的。
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20.发明授权Substituted 2-thio-3,5-dicyano-4-aryl-6-aminopyridines and their use 失效取代的2-硫代-3,5-二氰基-4-芳基-6-氨基吡啶及其用途公开(公告)号：US07504421B2
公开(公告)日：2009-03-17
申请号：US11359927
申请日：2006-02-21
申请人： Ulrich Rosentreter , Rolf Henning , Marcus Bauser , Thomas Krämer , Andrea Vaupel , Walter Hübsch , Klaus Dembowsky , Olga Salcher-Schraufstatter , Johannes-Peter Stasch , Thomas Krahn , Elisabeth Perzborn
发明人： Ulrich Rosentreter , Rolf Henning , Marcus Bauser , Thomas Krämer , Andrea Vaupel , Walter Hübsch , Klaus Dembowsky , Olga Salcher-Schraufstatter , Johannes-Peter Stasch , Thomas Krahn , Elisabeth Perzborn
IPC分类号： C07D213/85 , A61K31/44
CPC分类号： C07D401/12 , C07D213/85 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： The invention relates to compounds of general formula (I), a method for the production thereof and the use thereof as pharmacologically effective substances for a broad medical indication spectrum. Furthermore, selective adenosine receptor ligands, preferably selective adenosine A1-, adenosine A2a- and/or adenosine A2b-receptor ligands are provided for the prophylaxis and/or the treatment of diseases, especially cardiovascular diseases, diseases of the urogenital region, diseases of the respiratory tract, inflammatory and neuroinflammatory diseases, diabetes, especially pancreatic diabetes, neurodegenerative diseases, pain states, cancer as well as liver fibrosis and liver cirrhosis.
摘要翻译： 本发明涉及通式（I）的化合物，其制备方法及其作为广泛医学指征谱的药理学有效物质的用途。 此外，提供选择性腺苷受体配体，优选选择性腺苷A1-，腺苷A2a-和/或腺苷A2b-受体配体用于预防和/或治疗泌尿生殖区疾病，特别是心血管疾病，泌尿生殖系疾病 呼吸道，炎性和神经炎症性疾病，糖尿病，特别是胰腺糖尿病，神经变性疾病，疼痛状态，癌症以及肝纤维化和肝硬化。
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