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公开(公告)号：US20120122820A1
公开(公告)日：2012-05-17
申请号：US12671681
申请日：2008-07-23
申请人： Nicole Diedrichs , Thomas Krahn , Ursula Krenz , Jörg Keldenich , Hanna Tinel , Claudia Hirth-Dietrich , Hans-Georg Lerchen
发明人： Nicole Diedrichs , Thomas Krahn , Ursula Krenz , Jörg Keldenich , Hanna Tinel , Claudia Hirth-Dietrich , Hans-Georg Lerchen
IPC分类号： A61K31/675 , A61P9/00 , C07D417/14 , A61K31/4439 , C07F9/6539 , C07D417/12
CPC分类号： C07D417/12 , C07D417/14 , C07F9/65583
摘要： The present application relates to prodrug derivatives of 2-amino-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}thio)-4-[4-(2-hydroxyethoxy)phenyl]pyridine-3,5-dicarbonitrile, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of cardiovascular disorders.
摘要翻译： 本申请涉及2-氨基-6 - （{[2-（4-氯苯基）-1,3-噻唑-4-基]甲基}硫基）-4- [4-（2-羟基乙氧基） 苯基]吡啶-3,5-二腈，其制备方法，它们用于治疗和/或预防疾病的用途，及其用于制备用于治疗和/或预防疾病，特别是心血管疾病的药物的用途。
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公开(公告)号：US08703696B2
公开(公告)日：2014-04-22
申请号：US12671694
申请日：2008-07-23
申请人： Hans-Georg Lerchen , Ursula Krenz , Joerg Keldenich , Nicole Diedrichs , Thomas Krahn , Claudia Hirth-Dietrich , Barbara Albrecht-Küpper
发明人： Hans-Georg Lerchen , Ursula Krenz , Joerg Keldenich , Nicole Diedrichs , Thomas Krahn , Claudia Hirth-Dietrich , Barbara Albrecht-Küpper
IPC分类号： A61K38/00 , A61K31/44 , C07D417/00
CPC分类号： A61K47/48246 , A61K31/4439 , A61K47/542 , A61K47/64 , C07D417/12 , C07K5/06086
摘要： The present application relates to prodrug derivatives of 2-amino-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}thio)-4-[4-(2-hydroxyethoxy)phenyl]pyridine-3,5-dicarbonitrile, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of cardiovascular disorders.
摘要翻译： 本申请涉及2-氨基-6 - （{[2-（4-氯苯基）-1,3-噻唑-4-基]甲基}硫代）-4- [4-（2-羟基乙氧基） 苯基]吡啶-3,5-二腈，其制备方法，它们用于治疗和/或预防疾病的用途，及其用于制备用于治疗和/或预防疾病，特别是心血管疾病的药物的用途。
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公开(公告)号：US20110294718A1
公开(公告)日：2011-12-01
申请号：US12671694
申请日：2008-07-23
申请人： Hans-Georg Lerchen , Ursula Krenz , Joerg Keldenich , Nicole Diedrichs , Thomas Krahn , Claudia Hirth-Dietrich , Barbara Albrecht-Küpper
发明人： Hans-Georg Lerchen , Ursula Krenz , Joerg Keldenich , Nicole Diedrichs , Thomas Krahn , Claudia Hirth-Dietrich , Barbara Albrecht-Küpper
IPC分类号： A61K38/05 , A61P9/00 , C07D417/14 , C07D417/12 , A61K31/4439
CPC分类号： A61K47/48246 , A61K31/4439 , A61K47/542 , A61K47/64 , C07D417/12 , C07K5/06086
摘要： The present application relates to prodrug derivatives of 2-amino-6-({[2-(4-chlorophenyl)-1,3-thiazol-4-yl]methyl}thio)-4-[4-(2-hydroxyethoxy)phenyl]pyridine-3,5-dicarbonitrile, processes for their preparation, their use for the treatment and/or prophylaxis of diseases, and their use for the manufacture of medicaments for the treatment and/or prophylaxis of diseases, especially of cardiovascular disorders.
摘要翻译： 本申请涉及2-氨基-6 - （{[2-（4-氯苯基）-1,3-噻唑-4-基]甲基}硫基）-4- [4-（2-羟基乙氧基） 苯基]吡啶-3,5-二腈，其制备方法，它们用于治疗和/或预防疾病的用途，及其用于制备用于治疗和/或预防疾病，特别是心血管疾病的药物的用途。
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4.发明申请Substituted 2, 6-diamino-3, 5-dicyano-4-arylpyridines and their use as adenosine-receptor-selective ligands 失效取代的2,6-二氨基-3,5-二氰基-4-芳基吡啶及其作为腺苷受体选择配体的用途公开(公告)号：US20070213372A1
公开(公告)日：2007-09-13
申请号：US11607262
申请日：2006-12-01
申请人： Ulrich Rosentreter , Thomas Kramer , Andrea Vaupel , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch
发明人： Ulrich Rosentreter , Thomas Kramer , Andrea Vaupel , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch
IPC分类号： A61K31/44 , C07D213/02
CPC分类号： C07D401/12 , C07D213/85 , C07D405/12 , C07D405/14 , C07D409/12 , C07D417/14
摘要： The present invention relates to substituted 2,6-diamino-3,5-dicyano-4-arylpyridines of the formula (I) wherein the definitions of substituent groups R1-R7 are as provided in the specification and claims, to a pharmaceutical composition containing such a compound, to a process for preparation of such materials, and to their use as medicaments for the treatment of cardiovascular disorders and diabetes.
摘要翻译： 本发明涉及式（I）的取代的2,6-二氨基-3,5-二氰基-4-芳基吡啶，其中取代基R 1〜R 7的定义< SUP>如说明书和权利要求书中所述，涉及含有这种化合物的药物组合物，其制备方法和用作治疗心血管疾病和糖尿病的药物。
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5.发明授权Use of Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines in the treatment of nausea and vomiting 失效取代的2-硫代-3,5-二氰基-4-苯基-6-氨基吡啶在治疗恶心和呕吐中的用途公开(公告)号：US07709504B2
公开(公告)日：2010-05-04
申请号：US11631755
申请日：2005-06-23
IPC分类号： A61K31/4418 , A61K31/4436 , A61K31/444
CPC分类号： A61K31/4427
摘要： The present invention relates to the use of substituted 2-thio-3,5-dicyano-4-phenyl-6-amino-pyridines of the formula (I) wherein the terms A and R2 are herein defined, for treatment of nausea and vomiting.
摘要翻译： 本发明涉及式（I）的取代的2-硫代-3,5-二氰基-4-苯基-6-氨基 - 吡啶的用途，其中术语A和R2在本文中定义，用于治疗恶心和呕吐 。
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6.发明申请Substituted 2-thio-3,5-dicyano-4-phenyl-6-aminopyridines and the use of the same 审中-公开取代的2-硫代-3,5-二氰基-4-苯基-6-氨基吡啶并使用它们公开(公告)号：US20060217373A1
公开(公告)日：2006-09-28
申请号：US11443693
申请日：2006-05-30
申请人： Ulrich Rosentreter , Thomas Kramer , Mitsuyuki Shimada , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Kerstin Henninger , Johannes-Peter Stasch , Ralf Wischnat
发明人： Ulrich Rosentreter , Thomas Kramer , Mitsuyuki Shimada , Walter Hubsch , Nicole Diedrichs , Thomas Krahn , Kerstin Henninger , Johannes-Peter Stasch , Ralf Wischnat
IPC分类号： A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/497 , A61K31/4439 , A61K31/44
CPC分类号： C07D417/12 , C07D213/85 , C07D417/14
摘要： Compounds of the formula (I) a process for their preparation and their use as medicaments are described.
摘要翻译： 描述了式（I）化合物的制备方法及其作为药物的用途。
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公开(公告)号：US07825255B2
公开(公告)日：2010-11-02
申请号：US10471079
申请日：2002-02-28
申请人： Ulrich Rosentreter , Thomas Krämer , Andrea Vaupel , Walter Hübsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stásch
发明人： Ulrich Rosentreter , Thomas Krämer , Andrea Vaupel , Walter Hübsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stásch
IPC分类号： C07D401/00 , C07D409/00 , C07D405/00 , C07D213/84 , C07D213/72
CPC分类号： C07D401/12 , C07D213/85 , C07D401/14 , C07D405/04 , C07D405/12 , C07D405/14
摘要： The invention relates to the compounds of formula (I), to a method for producing the same and to the use thereof as medicaments.
摘要翻译： 本发明涉及式（I）的化合物，其制备方法及其作为药物的用途。
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8.发明授权Substituted 2-oxy-3,5-dicyano-4aryl-6-aminopyridines and use thereof 失效取代的2-氧基-3,5-二氰基-4-芳基-6-氨基吡啶及其用途公开(公告)号：US07855219B2
公开(公告)日：2010-12-21
申请号：US10469556
申请日：2002-02-20
申请人： Ulrich Rosentreter , Thomas Krämer , Andrea Vaupel , Walter Hübsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch
发明人： Ulrich Rosentreter , Thomas Krämer , Andrea Vaupel , Walter Hübsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch
IPC分类号： A61K31/44 , C07D405/00 , C07D401/00 , C07D417/00 , C07D409/00
CPC分类号： C07D405/04 , C07D213/85 , C07D409/14 , C07D417/14
摘要： This invention relates to compounds of formula (I) in which the variable groups are as defined in the text and claims. A pharmaceutical composition and methods of using these materials in treatment of various conditions are also disclosed and claimed.
摘要翻译： 本发明涉及式（I）化合物，其中可变基团如本文和权利要求中所定义。 还公开并要求保护的药物组合物和使用这些材料处理各种条件的方法。
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9.发明申请Use of Adenosine A1 and/or Dual A1/2ab Agonists for Production of Medicaments for Treating Diseases 审中-公开使用腺苷A1和/或双重A1 / 2ab激动剂生产用于治疗疾病的药物公开(公告)号：US20100048641A1
公开(公告)日：2010-02-25
申请号：US12224417
申请日：2007-02-16
申请人： Peter Nell , Barbara Albrecht-Küpper , Walter Hübsch , Martina Wuttke , Thomas Krahn , Nicole Diedrichs , Hilmar Bischoff
发明人： Peter Nell , Barbara Albrecht-Küpper , Walter Hübsch , Martina Wuttke , Thomas Krahn , Nicole Diedrichs , Hilmar Bischoff
IPC分类号： A61K31/4439 , C07D417/12 , A61P3/00 , A61P3/10
CPC分类号： C07D417/12
摘要： The present invention relates to the use of A1 and/or dual A1/A2b agonists of the formulae (IA) and (IB) for preparing a medicament for treating dyslipidemia, metabolic syndrome and diabetes and dyslipidemia, metabolic syndrome and diabetes in association with hypertension and cardiovascular disorders.
摘要翻译： 本发明涉及式（IA）和（IB）的A1和/或双重A1 / A2b激动剂在制备用于治疗血脂异常，代谢综合征和糖尿病和血脂异常，代谢综合征和与高血压相关的糖尿病的药物中的用途 和心血管疾病。
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10.发明授权Substituted 2-carba-3,5-dicyano-4-aryl-6-aminopyridines and the use of the same as selective ligands of the adenosine receptor 失效取代的2-咔唑-3,5-二氰基-4-芳基-6-氨基吡啶并使用其作为腺苷受体的选择性配体公开(公告)号：US07129255B2
公开(公告)日：2006-10-31
申请号：US10473371
申请日：2002-03-25
申请人： Ulrich Rosentreter , Thomas Krämer , Andrea Vaupel , Walter Hübsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch , Mitsuyuki Shimada
发明人： Ulrich Rosentreter , Thomas Krämer , Andrea Vaupel , Walter Hübsch , Nicole Diedrichs , Thomas Krahn , Klaus Dembowsky , Johannes-Peter Stasch , Mitsuyuki Shimada
IPC分类号： A61K31/44 , C07D213/85
CPC分类号： C07D405/04 , C07D213/85
摘要： This application relates to compounds of the formula wherein the groups R1–R6 are as defined in the specification and claims, and to a pharmaceutical composition containing the same, and to a method of using the same in treatment of cardiovascular disorders.
摘要翻译： 本申请涉及下式的化合物，其中基团R 1〜6 6如说明书和权利要求中所定义，并且含有该化合物的药物组合物，以及 使用该方法治疗心血管疾病的方法。
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