公开(公告)号：US20240083991A1

公开(公告)日：2024-03-14

申请号：US18326335

申请日：2023-05-31

Applicant: Pfizer Inc. ,  The Brigham and Women's Hospital, Inc. ,  The General Hospital Corporation

Inventor： Paul B. Yu ,  James Reasoner Apgar ,  Susan Adam Benard ,  Stephen Peter Berasi ,  Christine Huard ,  Oleg Victorovich Kovalenko ,  Lidia Mosyak ,  Xianchun Tang ,  Kathleen Elisabeth Tumelty ,  Luca Troncone ,  Ying Zhong

IPC: C07K16/22 ,  A61P9/12

CPC classification number: C07K16/22 ,  A61P9/12 ,  A61K2039/505 ,  C07K2317/34 ,  C07K2317/76 ,  C07K2317/92

Abstract: Antibodies, and antigen-binding fragments thereof, that specifically bind to bone morphogenetic protein-9 (BMP9) are provided. Embodiments include uses, and associated methods of using the antibodies, and antigen-binding fragments thereof.

公开(公告)号：US11858986B2

公开(公告)日：2024-01-02

申请号：US17092998

申请日：2020-11-09

Applicant: PFIZER INC. ,  THE BRIGHAM AND WOMEN'S HOSPITAL, INC.

Inventor： Stefano V. Gulla ,  Christine Huard ,  Janet Elizabeth Buhlmann ,  Juan Carlos Almagro ,  Sreekumar R. Kodangattil ,  Steven A. Greenberg ,  Edward Roland Lavallie ,  Eric M. Bennett ,  Lidia Mosyak ,  James Perry Hall ,  Anthony John Coyle

IPC: C07K16/24 ,  A61K39/00

CPC classification number: C07K16/249 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/55 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

Abstract: The invention relates to antibodies, or antigen-binding fragments thereof, that specifically binds to interferon beta (IFNβ). Such antibodies, or antigen-binding fragments thereof, are are useful for various therapeutic or diagnostic purposes.

公开(公告)号：US20190263877A1

公开(公告)日：2019-08-29

申请号：US16286158

申请日：2019-02-26

Applicant: Pfizer Inc.

Inventor： Yik Andy Yeung ,  Reid Martin Renny Feldman ,  Ling Hon Matthew Chu ,  Javier Fernando Chaparro Riggers ,  Ivana Djuretic ,  Laura Lin ,  Lidia Mosyak

IPC: C07K14/54 ,  C07K14/55 ,  A61K35/17 ,  C07K19/00 ,  A61P35/00 ,  A61K38/17 ,  C07K16/32 ,  C07K16/28 ,  C12N15/62

Abstract: The present invention relates to human interleukin 15 (IL-15) variants that have therapeutic and diagnostic use, and methods for making thereof. The present invention also provides fusion proteins comprising a human IL-15 variant. Also provided are methods of stimulating or suppressing immune responses in a mammal, and methods of treating a disorder (e.g., cancer) using the IL-15 variants or the fusion protein of such IL-15 variants.

公开(公告)号：US20170313769A1

公开(公告)日：2017-11-02

申请号：US15581079

申请日：2017-04-28

Applicant: PFIZER INC. ,  THE BRIGHAM AND WOMEN?S HOSPITAL, INC.

Inventor： Stefano V. Gulla ,  Christine Huard ,  Janet Elizabeth Buhlmann ,  Juan Carlos Almagro ,  Sreekumar R. Kodangattil ,  Steven A. Greenberg ,  Edward Roland Lavallie ,  Eric M. Bennett ,  Lidia Mosyak ,  James Perry Hall ,  Anthony John Coyle

IPC: C07K16/24

Abstract: The invention relates to antibodies, or antigen-binding fragments thereof, that specifically binds to interferon beta (IFNβ). Such antibodies, or antigen-binding fragments thereof, are useful for various therapeutic or diagnostic purposes.