公开(公告)号：US20230263883A1

公开(公告)日：2023-08-24

申请号：US18014947

申请日：2021-07-08

申请人： The Brigham and Women`s Hospital, Inc.

发明人： Stephen J. Elledge ,  Ellen Shrock ,  Eric Fujimura

IPC分类号： A61K39/215 ,  C07K16/10 ,  A61K49/00 ,  G01N33/569

CPC分类号： A61K39/215 ,  C07K16/10 ,  A61K49/0004 ,  G01N33/56983 ,  G01N2333/165 ,  G01N2469/20

摘要： Peptide epitopes identified in subjects infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and methods of use thereof for diagnosing, determining prognosis, and treating Coronavirus Disease 2019 (COVID-19), and developing prophylactic or therapeutic vaccines against SARS-CoV-2.

公开(公告)号：US20220362285A1

公开(公告)日：2022-11-17

申请号：US17875831

申请日：2022-07-28

申请人： The Brigham and Women`s Hospital, Inc.

发明人： Jeffrey M. Karp ,  Yuhan Lee ,  Ali Tavakkoli ,  Tarawatie E. Deelman

IPC分类号： A61K31/737 ,  A61P3/10 ,  A61K47/38

摘要： This disclosure relates to compositions including formulated sucralfate or other aluminum-crosslinked sulfated agents for delivery of agents to biological surfaces and/or the modulation of nutrient absorption through the intestinal lining as well as methods for the manufacture of and the use of these compositions for treating disorders including diabetes type II and clinical obesity that require a modulation of certain nutrients to the body.

公开(公告)号：US20220290104A1

公开(公告)日：2022-09-15

申请号：US17828393

申请日：2022-05-31

申请人： The Brigham and Women`s Hospital, Inc.

发明人： Dhvanit I. Shah

IPC分类号： C12N5/0789 ,  A61K35/28

摘要： In some aspects and embodiments, the invention provides methods for making hematopoietic stem cells, including for HSCT. The method comprises providing a cell population comprising hemogenic endothelial (HE) or endothelial cells, and increasing activity or expression of DNA (cytosine-5-)-methyltransferase 3 beta (Dnmt3b) and/or GTPase IMAP Family Member 6 (Gimap6) in the HE and/or endothelial cells under conditions sufficient for stimulating formation of HSCs.

公开(公告)号：US20210324058A1

公开(公告)日：2021-10-21

申请号：US17290960

申请日：2019-11-05

申请人： The Brigham and Women`s Hospital, Inc.

发明人： George A. Alba ,  Joseph Loscalzo ,  Bradley A. Maron

IPC分类号： C07K16/18

摘要： Anti-NEDD9 antibodies and methods of making and using said antibodies.

公开(公告)号：US20200061162A1

公开(公告)日：2020-02-27

申请号：US16348383

申请日：2017-11-09

申请人： The Brigham and Women`s Hospital, Inc. ,  Children`s Medical Center Corporation

发明人： Jinjun Shi ,  Mohammad Ariful Islam ,  Yingjie Xu ,  Omid C. Farokhzad ,  Bruce Zetter

IPC分类号： A61K38/46 ,  A61K9/51 ,  A61K47/59 ,  A61P35/00

摘要： Compositions and methods for treating cancer that include administering a therapeutically effective amount of a tumor suppressor mRNA complexed with a delivery vehicle as described herein, e.g., a nanoparticle.

公开(公告)号：US20200054583A1

公开(公告)日：2020-02-20

申请号：US16609048

申请日：2018-04-26

申请人： The Brigham and Women`s Hospital, Inc.

发明人： D. Andrew Wellman ,  Luigi Taranto-Montemurro

IPC分类号： A61K31/137 ,  A61K31/216 ,  A61P1/00 ,  A61K9/00

摘要： Methods and compositions for the treatment of conditions associated with pharyngeal airway muscle collapse while the subject is in a non-fully conscious state, e.g., sleep apnea and snoring, comprising administration of a norepinephrine reuptake inhibitor (NRI) and a muscarinic receptor antagonist.

公开(公告)号：US20190314399A1

公开(公告)日：2019-10-17

申请号：US16349715

申请日：2017-11-14

申请人： The Brigham and Women`s Hospital, Inc.

发明人： Wolfram Goessling ,  Saireudee Chaturantabut

IPC分类号： A61K31/7105 ,  A61P35/00 ,  A61K31/713 ,  C12Q1/6886 ,  A61K38/17

摘要： Provided herein are methods for the prevention and treatment of an abnormal tissue condition in the liver (e.g., liver cancer) of a subject, based on the administration of an inhibitor of a G protein-coupled estrogen receptor 1 (GPER1).

公开(公告)号：US20190203256A1

公开(公告)日：2019-07-04

申请号：US16298521

申请日：2019-03-11

申请人： The Brigham and Women`s Hospital, Inc.

发明人： Sophia Koo ,  Horatio R. Thomas ,  Lindsey R. Baden ,  Francisco M. Marty

IPC分类号： C12Q1/04 ,  A61B5/08 ,  G01N33/497 ,  A61B5/00

CPC分类号： C12Q1/04 ,  A61B5/08 ,  A61B5/082 ,  A61B5/14546 ,  A61B5/4836 ,  G01N33/497 ,  G01N2033/4975 ,  G01N2333/38 ,  G01N2800/18 ,  G01N2800/26 ,  G01N2800/52

摘要： Methods for diagnosing, treating, and monitoring the treatment of invasive aspergillosis (IA) are described. The methods can include detecting the presence of one or more volatile organic compounds (VOCs) in the breath of subjects suspected of having IA.

公开(公告)号：US09884129B2

公开(公告)日：2018-02-06

申请号：US14589037

申请日：2015-01-05

申请人： The Brigham and Women s Hospital, Inc.

发明人： Jeffrey M. Karp ,  Debanjan Sarkar ,  Praveen Kumar Vemula

IPC分类号： A01N63/00 ,  A61K47/48 ,  A61K38/18 ,  A61K31/573 ,  A61K31/704 ,  A61K35/28 ,  C12N5/0775 ,  A61K47/69

CPC分类号： A61K47/6937 ,  A61K31/573 ,  A61K31/704 ,  A61K35/28 ,  A61K38/1816 ,  A61K47/6921 ,  A61K47/6935 ,  C12N5/0662

摘要： A composition includes an isolated cell; at least one particle within said cell; and at least one active agent associated with the particle, wherein the active agent is capable of being released from the cell. A method includes administration of such a cell to a subject.

公开(公告)号：US20180023142A1

公开(公告)日：2018-01-25

申请号：US15699546

申请日：2017-09-08

申请人： The Brigham and Women`s Hospital, Inc. ,  The General Hospital Corporation

发明人： Howard Weiner ,  Oleg Butovsky ,  Merit Cudkowicz ,  James Berry

IPC分类号： C12Q1/68 ,  C12N15/113

CPC分类号： C12Q1/6883 ,  C12N15/113 ,  C12N2310/113 ,  C12N2310/3231 ,  C12Q2600/158 ,  C12Q2600/178

摘要： Provided herein are methods of treating a neurodegenerative disorder such as Amyotrophic Lateral Sclerosis (ALS) or Multiple Sclerosis (MS) that include administering to a subject at least one inhibitory nucleic acid that decreases the level or activity of microRNA has-miR-155.