公开(公告)号：US20140135339A1

公开(公告)日：2014-05-15

申请号：US14156144

申请日：2014-01-15

Applicant: PFIZER INC.

Inventor： Simon Bailey ,  Benjamin Joseph Burke ,  Michael Raymond Collins ,  Jingrong Jean Cui ,  Judith Gail Deal ,  Robert Louis Hoffman ,  Qinhua Huang ,  Ted William Johnson ,  Robert Steven Kania ,  John Charles Kath ,  Phuong Thi Quy Le ,  Michele Ann McTigue ,  Cynthia Louise Palmer ,  Paul Francis Richardson ,  Neal William Sach

IPC: C07D498/18 ,  C07D498/22

CPC classification number: C07D498/08 ,  C07D273/02 ,  C07D413/04 ,  C07D413/14 ,  C07D491/08 ,  C07D491/18 ,  C07D498/18 ,  C07D498/22 ,  C07D513/18

Abstract: The invention relates to compounds of formula (Φ) as further defined herein and to the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to the uses thereof. The compounds and salts of the present invention inhibit anaplastic lymphoma kinase (ALK) and/or EML4-ALK and are useful for treating or ameliorating abnormal cell proliferative disorders, such as cancer.

Abstract translation: 本发明涉及本文进一步定义的式（Φ）化合物及其药学上可接受的盐，涉及包含这些化合物和盐的药物组合物及其用途。 本发明的化合物和盐抑制间变性淋巴瘤激酶（ALK）和/或EML4-ALK，并且可用于治疗或改善异常细胞增殖性疾病如癌症。

公开(公告)号：US20220401424A1

公开(公告)日：2022-12-22

申请号：US17246551

申请日：2021-04-30

Applicant: PFIZER INC.

Inventor： Joyann Barber ,  Sujin Cho-Schultz ,  Matthew L. Del Bel ,  Rebecca Anne Gallego ,  Mingying He ,  Mehran Jalaie ,  Robert Steven Kania ,  Michele Ann McTigue ,  Sajiv Krishnan Nair ,  Anne-Marie Dechert Schmitt ,  Jamison Bryce Tuttle ,  Dahui Zhou ,  Ru Zhou

IPC: A61K31/444 ,  A61K45/06 ,  C07D519/00 ,  C07D471/04

Abstract: This invention relates to compounds of general Formula I and pharmaceutically acceptable salts thereof, in which R1, R2, R3a, R3b, and R4 are as defined herein, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.

公开(公告)号：US10709709B2

公开(公告)日：2020-07-14

申请号：US16224016

申请日：2018-12-18

Applicant: Pfizer Inc.

Inventor： John Howard Tatlock ,  Indrawan James McAlpine ,  Michelle Bich Tran-Dube ,  Eugene Yuanjin Rui ,  Martin James Wythes ,  Robert Arnold Kumpf ,  Michele Ann McTigue ,  Ryan Patman

IPC: A61K31/519 ,  A61P35/02 ,  A61P35/04 ,  C07D239/42 ,  C07D239/84 ,  C07D251/18 ,  C07D487/04 ,  C07D491/048 ,  A61K31/137 ,  A61K31/53 ,  C07D237/22 ,  C07D251/16 ,  C07D471/06 ,  C07D519/00 ,  C07C255/34 ,  A61K31/02

Abstract: Compounds of the general formula): processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

公开(公告)号：US10428104B2

公开(公告)日：2019-10-01

申请号：US15045679

申请日：2016-02-17

Applicant: Pfizer Inc.

Inventor： John Howard Tatlock ,  Indrawan James McAlpine ,  Michelle Bich Tran-Dube ,  Eugene Yuanjin Rui ,  Martin James Wythes ,  Robert Arnold Kumpf ,  Michele Ann McTigue

IPC: C07H19/14 ,  C07H19/23 ,  A61K31/7064 ,  C07H19/24 ,  C07H19/16

Abstract: Compounds such as: processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds to treat neoplasms have been disclosed.

公开(公告)号：US20190111060A1

公开(公告)日：2019-04-18

申请号：US16224016

申请日：2018-12-18

Applicant: Pfizer Inc.

Inventor： John Howard Tatlock ,  Indrawan James McAlpine ,  Michelle Bich Tran-Dube ,  Eugene Yuanjin Rui ,  Martin James Wythes ,  Robert Arnold Kumpf ,  Michele Ann McTigue ,  Ryan Patman

IPC: A61K31/519 ,  C07D491/048 ,  C07D487/04 ,  C07D251/18 ,  C07D239/84 ,  C07D239/42 ,  A61K31/137 ,  C07D471/06 ,  A61K31/53 ,  C07D519/00 ,  C07D237/22 ,  C07D251/16

Abstract: Compounds of the general formula): processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.