公开(公告)号：US10246433B2

公开(公告)日：2019-04-02

申请号：US15585880

申请日：2017-05-03

Applicant: Pfizer Inc.

Inventor： Martin Paul Edwards ,  Robert Arnold Kumpf ,  Pei-Pei Kung ,  Indrawan James McAlpine ,  Sacha Ninkovic ,  Eugene Yuanjin Rui ,  Scott Channing Sutton ,  John Howard Tatlock ,  Martin James Wythes ,  Luke Raymond Zehnder

IPC: C07D401/06 ,  C07D401/14 ,  C07D403/14 ,  C07D407/14 ,  C07D405/14 ,  C07D413/06 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04

Abstract: This invention relates to compounds of general formula (I) in which R1, R2, U, V, L, M, R5, m, X, Y and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.

公开(公告)号：US20190040047A1

公开(公告)日：2019-02-07

申请号：US16156304

申请日：2018-10-10

Applicant: Pfizer Inc.

Inventor： Michael Raymond Collins ,  Robert Steven Kania ,  Robert Arnold Kumpf ,  Pei-Pei Kung ,  Daniel Tyler Richter ,  Scott Channing Sutton ,  Martin James Wythes

IPC: C07D405/14 ,  C07B59/00 ,  C07D409/14 ,  C07D401/06 ,  C07D401/14 ,  C07D413/14

Abstract: This invention relates to compounds of general formula (I) in which R1, R2, R3, R4, L, X and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.

公开(公告)号：US20210230196A1

公开(公告)日：2021-07-29

申请号：US17190924

申请日：2021-03-03

Applicant: PFIZER INC.

Inventor： Martin James Wythes ,  Indrawan James McAlpine ,  Ryan Patman ,  Eugene Yuanjin Rui ,  Andrew Fensome ,  Andreas Maderna ,  Mehran Jalaie ,  Ketan S. Gajiwala

IPC: C07F9/6574 ,  A61K47/68 ,  A61P35/00 ,  C07H19/213

Abstract: Compounds of the general formula (I): or a pharmaceutically acceptable salt thereof, processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

公开(公告)号：US10538542B2

公开(公告)日：2020-01-21

申请号：US16297910

申请日：2019-03-11

Applicant: PFIZER INC.

Inventor： Martin James Wythes ,  Indrawan James McAlpine ,  Ryan Patman ,  Eugene Yuanjin Rui ,  Andrew Fensome ,  Andreas Maderna ,  Mehran Jalaie ,  Ketan S. Gajiwala

IPC: A61K31/7084 ,  C07H21/02 ,  C07H21/04 ,  C07F9/6574 ,  A61K47/68 ,  A61P35/00

Abstract: Compounds of the general formula (I): or a pharmaceutically acceptable salt thereof, processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

公开(公告)号：US20160376254A1

公开(公告)日：2016-12-29

申请号：US15262230

申请日：2016-09-12

Applicant: Pfizer Inc.

Inventor： Michael Raymond COLLINS ,  Robert Steven Kania ,  Robert Arnold Kumpf ,  Pei-Pei Kung ,  Daniel Tyler Richter ,  Scott Channing Sutton ,  Martin James Wythes

IPC: C07D401/06 ,  C07D409/14 ,  C07D413/14 ,  C07B59/00 ,  C07D405/14 ,  C07D401/14

CPC classification number: C07D405/14 ,  C07B59/002 ,  C07B2200/05 ,  C07D401/06 ,  C07D401/14 ,  C07D409/14 ,  C07D413/14

Abstract: This invention relates to compounds of general formula (I) in which R1, R2, R3, R4, L, X and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.

Abstract translation: 其中R 1，R 2，R 3，R 4，L，X和Z如本文所定义，及其药学上可接受的盐，包含这些化合物和盐的药物组合物，以及使用这些化合物，盐和组合物进行治疗的方法 的细胞生长异常，包括癌症。

公开(公告)号：US09481666B2

公开(公告)日：2016-11-01

申请号：US14740439

申请日：2015-06-16

Applicant: PFIZER INC.

Inventor： Robert Steven Kania ,  Robert Arnold Kumpf ,  Pei-Pei Kung ,  Scott Channing Sutton ,  Martin James Wythes

IPC: C07D401/06 ,  C07D401/14 ,  A61K31/44 ,  A61K31/47 ,  C07D405/14 ,  C07D413/14 ,  C07D409/14

CPC classification number: C07D405/14 ,  C07B59/002 ,  C07B2200/05 ,  C07D401/06 ,  C07D401/14 ,  C07D409/14 ,  C07D413/14

Abstract: This invention relates to compounds of general formula (I) in which R1, R2, R3, R4, L, X and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.

Abstract translation: 本发明涉及其中R1，R2，R3，R4，L，X和Z如本文所定义的通式（I）化合物及其药学上可接受的盐，涉及包含这些化合物和盐的药物组合物，以及方法 使用这些化合物，盐和组合物来治疗异常细胞生长，包括癌症。

公开(公告)号：US20160244475A1

公开(公告)日：2016-08-25

申请号：US15045679

申请日：2016-02-17

Applicant: Pfizer Inc.

Inventor： John Howard Tatlock ,  Indrawan James McAlpine ,  Michelle Bich Tran-Dube ,  Eugene Yuanjin Rui ,  Martin James Wythes ,  Robert Arnold Kumpf ,  Michele Ann McTigue

IPC: C07H19/16 ,  C07H19/23 ,  C07H19/14

CPC classification number: C07H19/14 ,  A61K31/7064 ,  C07H19/16 ,  C07H19/23 ,  C07H19/24

Abstract: Compounds of the general formula (I): processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

Abstract translation: 通式（I）的化合物：这些化合物的制备方法，含有这些化合物的组合物，以及这些化合物的用途。

公开(公告)号：US11964978B2

公开(公告)日：2024-04-23

申请号：US17693197

申请日：2022-03-11

Applicant: PFIZER INC.

Inventor： Ketan Satish Gajiwala ,  Chan Woo Huh ,  Mehran Jalaie ,  Ryan Lloyd Patman ,  Eugene Yuanjin Rui ,  Jianmin Sun ,  Martin James Wythes

IPC: C07D487/04 ,  A61K31/437 ,  A61K31/519 ,  A61P35/00 ,  C07D471/04

CPC classification number: C07D487/04 ,  C07D471/04

Abstract: Provided herein are compounds of the general formula (I):




and pharmaceutically acceptable salts thereof, processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

公开(公告)号：US10968242B2

公开(公告)日：2021-04-06

申请号：US16702738

申请日：2019-12-04

Applicant: PFIZER INC.

Inventor： Martin James Wythes ,  Indrawan James McAlpine ,  Ryan Patman ,  Eugene Yuanjin Rui ,  Andreas Maderna ,  Mehran Jalaie ,  Ketan S. Gajiwala

IPC: A61K31/7084 ,  A61K47/68 ,  A61P35/00 ,  C07H21/02 ,  C07H21/04 ,  C07F9/6574 ,  C07H19/213

Abstract: Compounds of the general formula (I): or a pharmaceutically acceptable salt thereof, processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

公开(公告)号：US10220037B2

公开(公告)日：2019-03-05

申请号：US15612030

申请日：2017-06-02

Applicant: Pfizer Inc.

Inventor： John Howard Tatlock ,  Indrawan James McAlpine ,  Michelle Bich Tran-Dube ,  Eugene Yuanjin Rui ,  Martin James Wythes ,  Robert Arnold Kumpf ,  Michele Ann McTigue ,  Ryan Patman

IPC: C07D487/04 ,  A61K31/519 ,  C07D519/00 ,  A61K31/137 ,  A61K31/53 ,  C07D237/22 ,  C07D251/16 ,  C07D471/06 ,  C07D239/42 ,  C07D239/84 ,  C07D251/18 ,  C07D491/048 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  A61K31/02 ,  C07C255/34

Abstract: Compounds of the general formula): processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.