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公开(公告)号：US20230174522A1
公开(公告)日：2023-06-08
申请号：US17946101
申请日：2022-09-16
Applicant: Pfizer Inc. , CTXT PTY LTD
Inventor： Ylva Elisabet Bergman Bozikis , Oleg Brodsky , Michelle Ang Camerino , Samantha Elizabeth Greasley , Robert Louis Hoffman , Robert Arnold Kumpf , Pei-Pei Kung , Paul Francis Richardson , Paul Anthony Stupple , Scott Channing Sutton
IPC: C07D413/06 , A61P35/04
CPC classification number: C07D413/06 , A61P35/04 , A61K45/06
Abstract: The present invention relates to compounds of formula (I)
or pharmaceutically acceptable salts thereof, wherein Ring A, R1-R8, and n are defined herein. The novel benzisoxazole sulfonamide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in patients. Additional embodiments relate to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth in patients.-
公开(公告)号：US10220037B2
公开(公告)日：2019-03-05
申请号：US15612030
申请日：2017-06-02
Applicant: Pfizer Inc.
Inventor： John Howard Tatlock , Indrawan James McAlpine , Michelle Bich Tran-Dube , Eugene Yuanjin Rui , Martin James Wythes , Robert Arnold Kumpf , Michele Ann McTigue , Ryan Patman
IPC: C07D487/04 , A61K31/519 , C07D519/00 , A61K31/137 , A61K31/53 , C07D237/22 , C07D251/16 , C07D471/06 , C07D239/42 , C07D239/84 , C07D251/18 , C07D491/048 , A61P35/00 , A61P35/02 , A61P35/04 , A61K31/02 , C07C255/34
Abstract: Compounds of the general formula): processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.
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公开(公告)号：US10246433B2
公开(公告)日：2019-04-02
申请号：US15585880
申请日：2017-05-03
Applicant: Pfizer Inc.
Inventor： Martin Paul Edwards , Robert Arnold Kumpf , Pei-Pei Kung , Indrawan James McAlpine , Sacha Ninkovic , Eugene Yuanjin Rui , Scott Channing Sutton , John Howard Tatlock , Martin James Wythes , Luke Raymond Zehnder
IPC: C07D401/06 , C07D401/14 , C07D403/14 , C07D407/14 , C07D405/14 , C07D413/06 , C07D413/14 , C07D471/04 , C07D487/04
Abstract: This invention relates to compounds of general formula (I) in which R1, R2, U, V, L, M, R5, m, X, Y and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.
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公开(公告)号：US20190040047A1
公开(公告)日：2019-02-07
申请号：US16156304
申请日：2018-10-10
Applicant: Pfizer Inc.
Inventor： Michael Raymond Collins , Robert Steven Kania , Robert Arnold Kumpf , Pei-Pei Kung , Daniel Tyler Richter , Scott Channing Sutton , Martin James Wythes
IPC: C07D405/14 , C07B59/00 , C07D409/14 , C07D401/06 , C07D401/14 , C07D413/14
Abstract: This invention relates to compounds of general formula (I) in which R1, R2, R3, R4, L, X and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.
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公开(公告)号：US20160376254A1
公开(公告)日：2016-12-29
申请号：US15262230
申请日：2016-09-12
Applicant: Pfizer Inc.
Inventor： Michael Raymond COLLINS , Robert Steven Kania , Robert Arnold Kumpf , Pei-Pei Kung , Daniel Tyler Richter , Scott Channing Sutton , Martin James Wythes
IPC: C07D401/06 , C07D409/14 , C07D413/14 , C07B59/00 , C07D405/14 , C07D401/14
CPC classification number: C07D405/14 , C07B59/002 , C07B2200/05 , C07D401/06 , C07D401/14 , C07D409/14 , C07D413/14
Abstract: This invention relates to compounds of general formula (I) in which R1, R2, R3, R4, L, X and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.
Abstract translation: 其中R 1，R 2，R 3，R 4，L，X和Z如本文所定义，及其药学上可接受的盐，包含这些化合物和盐的药物组合物，以及使用这些化合物，盐和组合物进行治疗的方法 的细胞生长异常，包括癌症。
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Patent Agency Ranking
公开(公告)号：US09481666B2
公开(公告)日：2016-11-01
申请号：US14740439
申请日：2015-06-16
Applicant: PFIZER INC.
Inventor： Robert Steven Kania , Robert Arnold Kumpf , Pei-Pei Kung , Scott Channing Sutton , Martin James Wythes
IPC: C07D401/06 , C07D401/14 , A61K31/44 , A61K31/47 , C07D405/14 , C07D413/14 , C07D409/14
CPC classification number: C07D405/14 , C07B59/002 , C07B2200/05 , C07D401/06 , C07D401/14 , C07D409/14 , C07D413/14
Abstract: This invention relates to compounds of general formula (I) in which R1, R2, R3, R4, L, X and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.
Abstract translation: 本发明涉及其中R1，R2，R3，R4，L，X和Z如本文所定义的通式（I）化合物及其药学上可接受的盐，涉及包含这些化合物和盐的药物组合物，以及方法 使用这些化合物，盐和组合物来治疗异常细胞生长，包括癌症。
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公开(公告)号：US20160244475A1
公开(公告)日：2016-08-25
申请号：US15045679
申请日：2016-02-17
Applicant: Pfizer Inc.
Inventor： John Howard Tatlock , Indrawan James McAlpine , Michelle Bich Tran-Dube , Eugene Yuanjin Rui , Martin James Wythes , Robert Arnold Kumpf , Michele Ann McTigue
CPC classification number: C07H19/14 , A61K31/7064 , C07H19/16 , C07H19/23 , C07H19/24
Abstract: Compounds of the general formula (I): processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.
Abstract translation: 通式（I）的化合物：这些化合物的制备方法，含有这些化合物的组合物，以及这些化合物的用途。
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公开(公告)号：US10570121B2
公开(公告)日：2020-02-25
申请号：US16156304
申请日：2018-10-10
Applicant: Pfizer Inc.
Inventor： Michael Raymond Collins , Robert Steven Kania , Robert Arnold Kumpf , Pei-Pei Kung , Daniel Tyler Richter , Scott Channing Sutton , Martin James Wythes
IPC: C07D401/06 , C07B59/00 , A61K31/4725 , C07D405/14 , C07D401/14 , C07D413/14 , C07D409/14
Abstract: This invention relates to compounds of general formula (I) in which R1, R2, R3, R4, L, X and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.
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公开(公告)号：US20170348313A1
公开(公告)日：2017-12-07
申请号：US15612030
申请日：2017-06-02
Applicant: Pfizer Inc.
Inventor： John Howard Tatlock , Indrawan James McAlpine , Michelle Bich Tran-Dube , Eugene Yuanjin Rui , Martin James Wythes , Robert Arnold Kumpf , Michele Ann McTigue , Ryan Patman
IPC: A61K31/519 , C07D471/06 , C07D251/16 , A61K31/137 , A61K31/53 , C07D519/00 , C07D237/22 , A61K31/02 , C07C255/34
CPC classification number: A61K31/519 , A61K31/02 , A61K31/137 , A61K31/53 , C07C255/34 , C07D237/22 , C07D239/42 , C07D239/84 , C07D251/16 , C07D251/18 , C07D471/06 , C07D487/04 , C07D491/048 , C07D519/00
Abstract: Compounds of the general formula): processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.
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公开(公告)号：US20150361067A1
公开(公告)日：2015-12-17
申请号：US14740439
申请日：2015-06-16
Applicant: PFIZER INC.
Inventor： Michael Raymond Collins , Robert Steven Kania , Robert Arnold Kumpf , Pei-Pei Kung , Daniel Tyler Richter , Scott Channing Sutton , Martin James Wythes
IPC: C07D401/06 , C07D409/14 , C07D413/14 , C07D405/14 , C07D401/14
CPC classification number: C07D405/14 , C07B59/002 , C07B2200/05 , C07D401/06 , C07D401/14 , C07D409/14 , C07D413/14
Abstract: This invention relates to compounds of general formula (I) in which R1, R2, R3, R4, L, X and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.
Abstract translation: 本发明涉及其中R1，R2，R3，R4，L，X和Z如本文所定义的通式（I）化合物及其药学上可接受的盐，涉及包含这些化合物和盐的药物组合物，以及方法 使用这些化合物，盐和组合物来治疗异常细胞生长，包括癌症。
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