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公开(公告)号：US20160244475A1
公开(公告)日：2016-08-25
申请号：US15045679
申请日：2016-02-17
Applicant: Pfizer Inc.
Inventor： John Howard Tatlock , Indrawan James McAlpine , Michelle Bich Tran-Dube , Eugene Yuanjin Rui , Martin James Wythes , Robert Arnold Kumpf , Michele Ann McTigue
CPC classification number: C07H19/14 , A61K31/7064 , C07H19/16 , C07H19/23 , C07H19/24
Abstract: Compounds of the general formula (I): processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.
Abstract translation: 通式（I）的化合物：这些化合物的制备方法，含有这些化合物的组合物，以及这些化合物的用途。
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公开(公告)号：US10220037B2
公开(公告)日：2019-03-05
申请号：US15612030
申请日：2017-06-02
Applicant: Pfizer Inc.
Inventor： John Howard Tatlock , Indrawan James McAlpine , Michelle Bich Tran-Dube , Eugene Yuanjin Rui , Martin James Wythes , Robert Arnold Kumpf , Michele Ann McTigue , Ryan Patman
IPC: C07D487/04 , A61K31/519 , C07D519/00 , A61K31/137 , A61K31/53 , C07D237/22 , C07D251/16 , C07D471/06 , C07D239/42 , C07D239/84 , C07D251/18 , C07D491/048 , A61P35/00 , A61P35/02 , A61P35/04 , A61K31/02 , C07C255/34
Abstract: Compounds of the general formula): processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.
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公开(公告)号：US20170348313A1
公开(公告)日：2017-12-07
申请号：US15612030
申请日：2017-06-02
Applicant: Pfizer Inc.
Inventor： John Howard Tatlock , Indrawan James McAlpine , Michelle Bich Tran-Dube , Eugene Yuanjin Rui , Martin James Wythes , Robert Arnold Kumpf , Michele Ann McTigue , Ryan Patman
IPC: A61K31/519 , C07D471/06 , C07D251/16 , A61K31/137 , A61K31/53 , C07D519/00 , C07D237/22 , A61K31/02 , C07C255/34
CPC classification number: A61K31/519 , A61K31/02 , A61K31/137 , A61K31/53 , C07C255/34 , C07D237/22 , C07D239/42 , C07D239/84 , C07D251/16 , C07D251/18 , C07D471/06 , C07D487/04 , C07D491/048 , C07D519/00
Abstract: Compounds of the general formula): processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.
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公开(公告)号：US20150239842A1
公开(公告)日：2015-08-27
申请号：US14430799
申请日：2013-09-16
Applicant: PFIZER INC.
Inventor： Martin Paul Edwards , Robert Arnold Kumpf , Pei-Pei Kung , Indrawan James Mcalpine , Eugene Yuanjin Rui , Scott Channing Sutton , John Howard Tatlock , Martin James Wythes
IPC: C07D213/64 , C07D487/08 , C07D491/08 , C07D405/14 , C07D413/14 , C07D401/12 , C07D401/14
CPC classification number: C07D401/14 , C07D213/64 , C07D401/12 , C07D405/14 , C07D407/14 , C07D409/14 , C07D413/14 , C07D487/08 , C07D491/08
Abstract: This invention relates to compounds of general formula (I), in which R1, R2, R6, U, V, W, X, Y and Z are as defined herein, and the pharmaceutically acceptable salts thereof, pharmaceutical compositions containing such compounds and salts, and to methods of using such compounds, salts and compositions.
Abstract translation: 本发明涉及通式（I）的化合物，其中R1，R2，R6，U，V，W，X，Y和Z如本文所定义，及其药学上可接受的盐，含有这些化合物和盐的药物组合物 以及使用这些化合物，盐和组合物的方法。
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Patent Agency Ranking
公开(公告)号：US10246433B2
公开(公告)日：2019-04-02
申请号：US15585880
申请日：2017-05-03
Applicant: Pfizer Inc.
Inventor： Martin Paul Edwards , Robert Arnold Kumpf , Pei-Pei Kung , Indrawan James McAlpine , Sacha Ninkovic , Eugene Yuanjin Rui , Scott Channing Sutton , John Howard Tatlock , Martin James Wythes , Luke Raymond Zehnder
IPC: C07D401/06 , C07D401/14 , C07D403/14 , C07D407/14 , C07D405/14 , C07D413/06 , C07D413/14 , C07D471/04 , C07D487/04
Abstract: This invention relates to compounds of general formula (I) in which R1, R2, U, V, L, M, R5, m, X, Y and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.
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公开(公告)号：US10709709B2
公开(公告)日：2020-07-14
申请号：US16224016
申请日：2018-12-18
Applicant: Pfizer Inc.
Inventor： John Howard Tatlock , Indrawan James McAlpine , Michelle Bich Tran-Dube , Eugene Yuanjin Rui , Martin James Wythes , Robert Arnold Kumpf , Michele Ann McTigue , Ryan Patman
IPC: A61K31/519 , A61P35/02 , A61P35/04 , C07D239/42 , C07D239/84 , C07D251/18 , C07D487/04 , C07D491/048 , A61K31/137 , A61K31/53 , C07D237/22 , C07D251/16 , C07D471/06 , C07D519/00 , C07C255/34 , A61K31/02
Abstract: Compounds of the general formula): processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.
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公开(公告)号：US10428104B2
公开(公告)日：2019-10-01
申请号：US15045679
申请日：2016-02-17
Applicant: Pfizer Inc.
Inventor： John Howard Tatlock , Indrawan James McAlpine , Michelle Bich Tran-Dube , Eugene Yuanjin Rui , Martin James Wythes , Robert Arnold Kumpf , Michele Ann McTigue
IPC: C07H19/14 , C07H19/23 , A61K31/7064 , C07H19/24 , C07H19/16
Abstract: Compounds such as: processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds to treat neoplasms have been disclosed.
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公开(公告)号：US20190111060A1
公开(公告)日：2019-04-18
申请号：US16224016
申请日：2018-12-18
Applicant: Pfizer Inc.
Inventor： John Howard Tatlock , Indrawan James McAlpine , Michelle Bich Tran-Dube , Eugene Yuanjin Rui , Martin James Wythes , Robert Arnold Kumpf , Michele Ann McTigue , Ryan Patman
IPC: A61K31/519 , C07D491/048 , C07D487/04 , C07D251/18 , C07D239/84 , C07D239/42 , A61K31/137 , C07D471/06 , A61K31/53 , C07D519/00 , C07D237/22 , C07D251/16
Abstract: Compounds of the general formula): processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.
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公开(公告)号：US09040515B2
公开(公告)日：2015-05-26
申请号：US14132567
申请日：2013-12-18
Applicant: Pfizer Inc.
Inventor： Martin Paul Edwards , Robert Arnold Kumpf , Pei-Pei Kung , Indrawan James McAlpine , Sacha Ninkovic , Eugene Yuanjin Rui , Scott Channing Sutton , John Howard Tatlock , Martin James Wythes , Luke Raymond Zehnder
IPC: C07D401/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D407/14 , C07D413/06 , C07D413/14 , C07D471/04 , C07D487/04
CPC classification number: C07D401/06 , C07D401/14 , C07D403/14 , C07D405/14 , C07D407/14 , C07D413/06 , C07D413/14 , C07D471/04 , C07D487/04
Abstract: This invention relates to compounds of general formula (I) in which R1, R2, U, V, L, M, R5, m, X, Y and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.
Abstract translation: 本发明涉及通式（I）的化合物，其中R1，R2，U，V，L，M，R5，m，X，Y和Z如本文所定义，及其药学上可接受的盐， 这些化合物和盐，以及使用这些化合物，盐和组合物用于治疗异常细胞生长（包括癌症）的方法。
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