公开(公告)号：US20150239842A1

公开(公告)日：2015-08-27

申请号：US14430799

申请日：2013-09-16

Applicant: PFIZER INC.

Inventor： Martin Paul Edwards ,  Robert Arnold Kumpf ,  Pei-Pei Kung ,  Indrawan James Mcalpine ,  Eugene Yuanjin Rui ,  Scott Channing Sutton ,  John Howard Tatlock ,  Martin James Wythes

IPC: C07D213/64 ,  C07D487/08 ,  C07D491/08 ,  C07D405/14 ,  C07D413/14 ,  C07D401/12 ,  C07D401/14

CPC classification number: C07D401/14 ,  C07D213/64 ,  C07D401/12 ,  C07D405/14 ,  C07D407/14 ,  C07D409/14 ,  C07D413/14 ,  C07D487/08 ,  C07D491/08

Abstract: This invention relates to compounds of general formula (I), in which R1, R2, R6, U, V, W, X, Y and Z are as defined herein, and the pharmaceutically acceptable salts thereof, pharmaceutical compositions containing such compounds and salts, and to methods of using such compounds, salts and compositions.

Abstract translation: 本发明涉及通式（I）的化合物，其中R1，R2，R6，U，V，W，X，Y和Z如本文所定义，及其药学上可接受的盐，含有这些化合物和盐的药物组合物 以及使用这些化合物，盐和组合物的方法。

公开(公告)号：US20250122183A1

公开(公告)日：2025-04-17

申请号：US18903849

申请日：2024-10-01

Applicant: Pfizer Inc. ,  CTXT PTY LTD

Inventor： Alexander Burtea ,  Michael Raymond Collins ,  Matthew L. Del Bel ,  Samantha Elizabeth Greasley ,  Eric Johnson ,  Ted William Johnson ,  Robert Arnold Kumpf ,  Pei-Pei Kung ,  Timothy Patrick Montgomery ,  Sacha Ninkovic ,  Gwenaella Christine Rescourio ,  Paul Francis Richardson ,  Stephanie Anne Scales ,  Scott Channing Sutton

IPC: C07D413/14 ,  A61K31/423 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/501 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5377 ,  C07D413/12 ,  C07D471/04

Abstract: The present invention relates to compounds of Formula (I): or pharmaceutically acceptable salts thereof, wherein Ring A, Ring B, R1—R16, n and p are defined herein. The novel nitrogen-linked benzisoxazole sulfonamide derivatives are useful in the treatment of abnormal cell growth, such as cancer, in patients. Additional embodiments relate to pharmaceutical compositions containing the compounds and to methods of using the compounds and compositions in the treatment of abnormal cell growth, such as cancer, in patients.

公开(公告)号：US10709709B2

公开(公告)日：2020-07-14

申请号：US16224016

申请日：2018-12-18

Applicant: Pfizer Inc.

Inventor： John Howard Tatlock ,  Indrawan James McAlpine ,  Michelle Bich Tran-Dube ,  Eugene Yuanjin Rui ,  Martin James Wythes ,  Robert Arnold Kumpf ,  Michele Ann McTigue ,  Ryan Patman

IPC: A61K31/519 ,  A61P35/02 ,  A61P35/04 ,  C07D239/42 ,  C07D239/84 ,  C07D251/18 ,  C07D487/04 ,  C07D491/048 ,  A61K31/137 ,  A61K31/53 ,  C07D237/22 ,  C07D251/16 ,  C07D471/06 ,  C07D519/00 ,  C07C255/34 ,  A61K31/02

Abstract: Compounds of the general formula): processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

公开(公告)号：US10428104B2

公开(公告)日：2019-10-01

申请号：US15045679

申请日：2016-02-17

Applicant: Pfizer Inc.

Inventor： John Howard Tatlock ,  Indrawan James McAlpine ,  Michelle Bich Tran-Dube ,  Eugene Yuanjin Rui ,  Martin James Wythes ,  Robert Arnold Kumpf ,  Michele Ann McTigue

IPC: C07H19/14 ,  C07H19/23 ,  A61K31/7064 ,  C07H19/24 ,  C07H19/16

Abstract: Compounds such as: processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds to treat neoplasms have been disclosed.

公开(公告)号：US20190111060A1

公开(公告)日：2019-04-18

申请号：US16224016

申请日：2018-12-18

Applicant: Pfizer Inc.

Inventor： John Howard Tatlock ,  Indrawan James McAlpine ,  Michelle Bich Tran-Dube ,  Eugene Yuanjin Rui ,  Martin James Wythes ,  Robert Arnold Kumpf ,  Michele Ann McTigue ,  Ryan Patman

IPC: A61K31/519 ,  C07D491/048 ,  C07D487/04 ,  C07D251/18 ,  C07D239/84 ,  C07D239/42 ,  A61K31/137 ,  C07D471/06 ,  A61K31/53 ,  C07D519/00 ,  C07D237/22 ,  C07D251/16

Abstract: Compounds of the general formula): processes for the preparation of these compounds, compositions containing these compounds, and the uses of these compounds.

公开(公告)号：US20170298048A1

公开(公告)日：2017-10-19

申请号：US15635648

申请日：2017-06-28

Applicant: Pfizer Inc.

Inventor： Michael Raymond Collins ,  Robert Steven Kania ,  Robert Arnold Kumpf ,  Pei-Pei Kung ,  Daniel Tyler Richter ,  Scott Channing Sutton ,  Martin James Wythes

IPC: C07D405/14 ,  C07D401/06 ,  C07D401/14 ,  C07D409/14

CPC classification number: C07D405/14 ,  C07B59/002 ,  C07B2200/05 ,  C07D401/06 ,  C07D401/14 ,  C07D409/14 ,  C07D413/14

Abstract: This invention relates to compounds of general formula (I) in which R1, R2, R3, R4, L, X and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.

公开(公告)号：US09040515B2

公开(公告)日：2015-05-26

申请号：US14132567

申请日：2013-12-18

Applicant: Pfizer Inc.

Inventor： Martin Paul Edwards ,  Robert Arnold Kumpf ,  Pei-Pei Kung ,  Indrawan James McAlpine ,  Sacha Ninkovic ,  Eugene Yuanjin Rui ,  Scott Channing Sutton ,  John Howard Tatlock ,  Martin James Wythes ,  Luke Raymond Zehnder

IPC: C07D401/06 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D407/14 ,  C07D413/06 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04

CPC classification number: C07D401/06 ,  C07D401/14 ,  C07D403/14 ,  C07D405/14 ,  C07D407/14 ,  C07D413/06 ,  C07D413/14 ,  C07D471/04 ,  C07D487/04

Abstract: This invention relates to compounds of general formula (I) in which R1, R2, U, V, L, M, R5, m, X, Y and Z are as defined herein, and the pharmaceutically acceptable salts thereof, to pharmaceutical compositions comprising such compounds and salts, and to methods of using such compounds, salts and compositions for the treatment of abnormal cell growth, including cancer.

Abstract translation: 本发明涉及通式（I）的化合物，其中R1，R2，U，V，L，M，R5，m，X，Y和Z如本文所定义，及其药学上可接受的盐， 这些化合物和盐，以及使用这些化合物，盐和组合物用于治疗异常细胞生长（包括癌症）的方法。