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公开(公告)号:US20220199383A1
公开(公告)日:2022-06-23
申请号:US17691294
申请日:2022-03-10
Applicant: Purdue Research Foundation
Inventor: Robert Graham Cooks , Xin Yan , Christopher Pulliam , Ryan M. Bain , Tawnya Flick
Abstract: The invention generally relates to systems and methods for on-line reaction monitoring. In certain embodiments, the invention provides systems that include a reaction vessel having an outlet, a quantitation unit coupled to the outlet and configured to introduce internal standard and solvent into reaction solution flowed from the reaction vessel, one or more ion generating devices that receive flow from the quantitation unit, and a mass spectrometer. In certain embodiments, the invention provides systems for multiple reaction monitoring that include a plurality of reaction vessels, a plurality of ion generating devices, a plurality of channels, each channel coupling a reaction vessel to an ion generating device, an actuator coupled to the plurality of ion generating devices to thereby allow movement of the plurality of ion generating devices, and a mass spectrometer
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公开(公告)号:US09761426B2
公开(公告)日:2017-09-12
申请号:US14936197
申请日:2015-11-09
Applicant: Purdue Research Foundation
Inventor: Robert Graham Cooks , Jason Duncan , Guangming Huang , Guangtao Li , Xin Yan , Ewa Sokol , Xin Li
CPC classification number: H01J49/04 , G01N27/62 , H01J49/0031 , H01J49/0445 , H01J49/4205 , Y10T436/24
Abstract: The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface.
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公开(公告)号:US11309172B2
公开(公告)日:2022-04-19
申请号:US15672862
申请日:2017-08-09
Applicant: Purdue Research Foundation
Inventor: Robert Graham Cooks , Xin Yan , Christopher Pulliam , Ryan M. Bain , Tawnya Flick
Abstract: The invention generally relates to systems and methods for on-line reaction monitoring. In certain embodiments, the invention provides systems that include a reaction vessel having an outlet, a quantitation unit coupled to the outlet and configured to introduce internal standard and solvent into reaction solution flowed from the reaction vessel, one or more ion generating devices that receive flow from the quantitation unit, and a mass spectrometer. In certain embodiments, the invention provides systems for multiple reaction monitoring that include a plurality of reaction vessels, a plurality of ion generating devices, a plurality of channels, each channel coupling a reaction vessel to an ion generating device, an actuator coupled to the plurality of ion generating devices to thereby allow movement of the plurality of ion generating devices, and a mass spectrometer.
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公开(公告)号:US10755910B2
公开(公告)日:2020-08-25
申请号:US16260924
申请日:2019-01-29
Applicant: Purdue Research Foundation
Inventor: Robert Graham Cooks , Guangtao Li , Guangming Huang , Jason Duncan , Xin Li , Ewa Sokol , Xin Yan
Abstract: The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface.
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15.
公开(公告)号:US20190189415A1
公开(公告)日:2019-06-20
申请号:US16260924
申请日:2019-01-29
Applicant: Purdue Research Foundation
Inventor: Robert Graham Cooks , Guangtao Li , Guangming Huang , Jason Duncan , Xin Li , Ewa Sokol , Xin Yan
CPC classification number: H01J49/045 , G01N27/62 , H01J49/0018 , H01J49/0445 , Y10T436/24
Abstract: The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface.
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