公开(公告)号：US20240071741A1

公开(公告)日：2024-02-29

申请号：US17823618

申请日：2022-08-31

Applicant: Thermo Fisher Scientific (Bremen) GmbH ,  California Institute of Technology

Inventor： Alexander Makarov ,  Dmitry Grinfeld ,  Mikhail Skoblin ,  Michael Roukes ,  Warren Fon ,  Eric Wapelhorst

IPC: H01J49/42 ,  H01J49/00 ,  H01J49/40

CPC classification number: H01J49/425 ,  H01J49/0018 ,  H01J49/0036 ,  H01J49/406

Abstract: An electrostatic ion trap or an array of electrostatic ion traps are provided having a longitudinal length of no more than 10 mm and/or at least one electrode with a capacitance to ground of no more than 1 pF. First and second sets of planar electrodes may be distributed along the longitudinal axis, at least some of the which are configured to receive an electrostatic potential for confinement of ions received in the space between the first and second sets of planar electrodes. An array may comprise an inlet for receiving an ion beam, configured such that a portion of the ion beam can be trapped in each of the ion traps. Signals indicative of ion mass and charge data may be obtained from multiple electrostatic ion traps in the array. This mass and charge data may be combined for identification of components of a mixture of different analyte ions.

公开(公告)号：US20230420236A1

公开(公告)日：2023-12-28

申请号：US18209074

申请日：2023-06-13

Applicant: Purdue Research Foundation

Inventor： Robert Graham Cooks ,  Guangtao Li ,  Guangming Huang ,  Jason Duncan ,  Xin Li ,  Ewa Sokol ,  Xin Yan

IPC: H01J49/04 ,  H01J49/00 ,  G01N27/62 ,  H01J49/42

CPC classification number: H01J49/04 ,  H01J49/0445 ,  H01J49/0018 ,  H01J49/045 ,  G01N27/62 ,  H01J49/0031 ,  H01J49/4205 ,  Y10T436/24

Abstract: The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface.

公开(公告)号：US09916957B2

公开(公告)日：2018-03-13

申请号：US15334067

申请日：2016-10-25

Applicant: Honeywell International Inc.

Inventor： Daniel Youngner

IPC: B01D59/44 ,  H01J3/38 ,  H01J9/14 ,  B82Y10/00 ,  G21K1/00 ,  H01J49/00 ,  G06N99/00 ,  H01L29/94

CPC classification number: H01J3/38 ,  B82Y10/00 ,  G06N99/002 ,  G21K1/00 ,  H01J9/14 ,  H01J49/0018 ,  H01L29/945

Abstract: Apparatuses, systems, and methods for ion traps are described herein. One apparatus includes a number of microwave (MW) rails and a number of radio frequency (RF) rails formed with substantially parallel longitudinal axes and with substantially coplanar upper surfaces. The apparatus includes two sequences of direct current (DC) electrodes with each sequence formed to extend substantially parallel to the substantially parallel longitudinal axes of the MW rails and the RF rails. The apparatus further includes a number of through-silicon vias (TSVs) formed through a substrate of the ion trap and a trench capacitor formed in the substrate around at least one TSV.

公开(公告)号：US20170330739A1

公开(公告)日：2017-11-16

申请号：US15329153

申请日：2015-07-29

Applicant: Takashi HOSAKA

Inventor： Takashi HOSAKA

IPC: H01J49/06 ,  H01J49/20 ,  H01J49/22 ,  H01J49/42

CPC classification number: H01J49/06 ,  G01N27/62 ,  H01J49/0018 ,  H01J49/20 ,  H01J49/22 ,  H01J49/326 ,  H01J49/38 ,  H01J49/4205 ,  H01J49/4215 ,  H05H5/03 ,  H05H7/04 ,  H05H7/22 ,  H05H9/00 ,  H05H13/04

Abstract: A mass analyzer includes a main substrate, an upper substrate adhered to the main substrate, and a lower substrate. A mass analysis room (cavity) is formed in the main substrate and penetrates from an upper surface of the first main substrate to a lower surface of the first main substrate. A vertical direction (Z direction) to the main substrate by the upper substrate, both sides of the lower substrate, a travelling direction (X direction) of charged particles and a right angle to the Z direction by the main substrate, and both sides of a right-angled direction (Y to Z direction) and the X direction by a side surface of the main substrate are surrounded. A central hole is open in the side plate of the main substrate that the charged particles enter. The charged particles enter the mass analysis room through the central hole formed in the first main substrate.

公开(公告)号：US20170038350A1

公开(公告)日：2017-02-09

申请号：US15231302

申请日：2016-08-08

Applicant: Waters Technologies Corporation

Inventor： Bernard Bunner ,  Theodore A. Dourdeville

IPC: G01N30/72 ,  B23K20/02 ,  B23H9/12 ,  C23F1/14 ,  B23H9/14 ,  B23K26/382 ,  B23B35/00 ,  C23C16/44 ,  G01N30/60 ,  C23C26/00

CPC classification number: G01N30/7266 ,  B01L3/502707 ,  B01L3/502753 ,  B01L2200/0689 ,  B01L2300/0816 ,  B01L2300/0887 ,  B01L2400/0487 ,  B23B35/00 ,  B23H9/12 ,  B23H9/14 ,  B23K20/023 ,  B23K20/233 ,  B23K26/382 ,  B23K2101/18 ,  B23K2103/14 ,  C23C16/44 ,  C23C26/00 ,  C23F1/14 ,  G01N30/6095 ,  H01J49/0018 ,  H01J49/167

Abstract: A microfluidic device for separating a sample by chromatography includes diffusion bonded metallic sheets joined together to create a hermetically sealed interface between each adjacent metallic sheet without the introduction of a secondary material. Enclosed within the diffusion bonded sheets is a separation channel accessible by at least one of an inlet or an outlet. The separation channel is packed with micrometer-sized particles serving as a stationary phase in a chromatographic separation. Wetted surfaces of the separation channel include a coating of an organic material at least one monolayer thick.

Abstract translation: 用于通过色谱分离样品的微流体装置包括连接在一起的扩散接合的金属片，以在每个相邻的金属片之间形成气密密封的界面，而不引入次级材料。 封隔在扩散接合片内的是可由入口或出口中的至少一个接近的分离通道。 分离通道用色谱分离中用作固定相的微米级颗粒填充。 分离通道的接液表面包括至少一层单层厚的有机材料的涂层。

公开(公告)号：US09362099B2

公开(公告)日：2016-06-07

申请号：US14369121

申请日：2013-01-03

Applicant: Danielle Toutoungi ,  Matthew Hart ,  John Somerville ,  Jon Pearson ,  Max Allsworth ,  Richard Orrell ,  Antoni Negri ,  Jeremy Spinks ,  Martin Holden ,  Andrew H. Koehl ,  Alastair Taylor

Inventor： Danielle Toutoungi ,  Matthew Hart ,  John Somerville ,  Jon Pearson ,  Max Allsworth ,  Richard Orrell ,  Antoni Negri ,  Jeremy Spinks ,  Martin Holden ,  Andrew H. Koehl ,  Alastair Taylor

IPC: H01J49/00 ,  H01J49/06 ,  G01N27/62

CPC classification number: H01J49/061 ,  G01N27/624 ,  H01J49/0018 ,  H01J49/068 ,  Y10T29/49147 ,  Y10T29/49149

Abstract: Ion filter for FAIMS fabricated using the LIGA technique. The ion filter is manufactured using a metal layer to form the ion channels and an insulating support layer to hold the structure rigidly together after separation of the metal layer into two electrodes.

Abstract translation: 使用LIGA技术制造的FAIMS离子过滤器。 使用金属层制造离子过滤器以形成离子通道和绝缘支撑层，以将金属层分离成两个电极之后将结构刚性地保持在一起。

公开(公告)号：US20150228467A1

公开(公告)日：2015-08-13

申请号：US14428144

申请日：2013-09-19

Applicant: THERMO FISHER SCIENTIFIC (BREMEN) GMBH

Inventor： Dmitry Grinfeld ,  Jan-Peter Hauschild ,  Wilko Balschun ,  Eduard Denisov ,  Alexander Makarov

IPC: H01J49/06

CPC classification number: H01J49/063 ,  H01J49/0018 ,  H01J49/062 ,  H01J49/068 ,  H05K1/02

Abstract: An ion guide for mass spectrometry comprising an electrode arrangement of at least two electrodes, at least one of which is an RF electrode, arranged adjacent to each other but spaced apart on a planar surface of a dielectric material and arranged at a distance from an ion flow path, wherein a portion of the dielectric surface is exposed between an adjacent pair of the spaced apart electrodes and wherein at least one electrode of said adjacent pair of electrodes is arranged to overhang the exposed portion of surface between them such that there is no direct line of sight from the ion flow path to the exposed portion of dielectric surface. The device enables RF guiding of ions accompanied by much reduced charging-up of dielectric surfaces and reduced amount of collisions of neutral species with electrodes.

Abstract translation: 一种用于质谱的离子导向器，包括至少两个电极的电极装置，至少两个电极的至少一个是RF电极，彼此相邻布置，但间隔开在电介质材料的平坦表面上并且布置在与离子 流动路径，其中电介质表面的一部分暴露在相邻的一对间隔开的电极之间，并且其中所述相邻电极对中的至少一个电极布置成突出在它们之间的表面的暴露部分，使得不存在直接 从离子流路到电介质表面的暴露部分的视线。 该器件能够使RF引导离子，同时电介质表面的充电很少，并减少了中性物质与电极的碰撞量。

公开(公告)号：US20150204827A1

公开(公告)日：2015-07-23

申请号：US14419108

申请日：2013-08-05

Applicant: Commissariat a L'Energie Atomique et aux Energies Alternatives ,  Analytical Pixels Technology-Apix Technology

Inventor： Laurent Duraffourg ,  Philippe Andreucci ,  Charles-Marie Tassetti ,  Eric Colinet ,  Pierre Puget ,  Joshua Whiting ,  Peter Thomas Stevens ,  Mélanie Petitjean

IPC: G01N30/72 ,  H01J49/00 ,  H01J49/40

CPC classification number: G01N30/7206 ,  G01N2030/025 ,  H01J49/0018 ,  H01J49/405

Abstract: The invention relates to a gas analysis system comprising, from upstream to downstream: a module (SEP) for separating at least a portion of the species contained in the gas to be analysed, comprising at least one microcapillary column (GC) for gas phase chromatography, and a time-of-flight mass spectrometer (TOFMS) coupled to said separation module, said spectrometer comprising a ion source (MS1, MS2) adapted to ionise at least a portion of said species and to emit a ion beam, and a free-flight zone (MS4) for said ions, said mass spectrometer (TOFMS) being arranged in the volume of at least one substrate and comprising a micro-reflectron (R) arranged between the source (MS1, MS2) and the free-flight zone (MS4), a wall (R1) of said micro-reflectron comprising a layer made from a resistive material designed to be polarised between at least two regions so as to create a continuous electrostatic field gradient in said reflectron.

Abstract translation: 本发明涉及一种气体分析系统，包括从上游到下游：用于分离包含在待分析气体中的物质的至少一部分的模块（SEP），其包括用于气相色谱的至少一个微毛细管柱（GC） ，以及耦合到所述分离模块的飞行时间质谱仪（TOFMS），所述光谱仪包括适于离子化所述物质的至少一部分并且发射离子束的离子源（MS1，MS2） （MS4），所述质谱仪（TOFMS）布置在至少一个衬底的体积中，并且包括布置在源（MS1，MS2）和自由飞行区之间的微反射器（R） （MS4），所述微反射器的壁（R1）包括由电阻材料制成的层，其被设计为在至少两个区域之间极化，以便在所述反射器中产生连续的静电场梯度。

公开(公告)号：US08866080B2

公开(公告)日：2014-10-21

申请号：US12921508

申请日：2009-02-27

Applicant: Christopher A. Bower ,  Kristin Hedgepath Gilchrist ,  Brian R. Stoner ,  Dorota Temple

Inventor： Christopher A. Bower ,  Kristin Hedgepath Gilchrist ,  Brian R. Stoner ,  Dorota Temple

IPC: G01N23/00 ,  H01J37/244 ,  H01J49/02 ,  H01J49/00

CPC classification number: H01J49/025 ,  H01J37/244 ,  H01J49/0018 ,  H01J2237/24405 ,  Y10T29/49002

Abstract: A detector array and method for making the detector array. The array includes a substrate including a plurality of trenches formed therein, and includes a plurality of collectors electrically isolated from each other, formed on the walls of the trenches, and configured to collect charge particles incident on respective ones of the collectors and to output from said collectors signals indicative of charged particle collection. The array includes a plurality of readout circuits disposed on a side of the substrate opposite openings to the collectors. The readout circuits are configured to read charge collection signals from respective ones of the plurality of collectors.

Abstract translation: 用于制造检测器阵列的检测器阵列和方法。 该阵列包括一个衬底，该衬底包括形成在其中的多个沟槽，并且包括彼此电隔离的多个集电极，形成在沟槽的壁上，并且被配置成收集入射在相应集电极上的电荷粒子，并从 所述收集器信号指示带电粒子收集。 该阵列包括多个读出电路，该读出电路设置在基板的与集电体相对的开口的一侧。 读出电路被配置为从多个收集器中的相应的一个收集器读取电荷收集信号。

公开(公告)号：US20140264021A1

公开(公告)日：2014-09-18

申请号：US14218109

申请日：2014-03-18

Applicant: Smiths Detection Montreal Inc.

Inventor： Bohdan Atamanchuk ,  Volodimir Bondarenko ,  Vlad Sergeyev ,  Henryk Zaleski ,  Daniel Levin ,  Mark Piniarski ,  Igor Kubelik ,  Qunzhou Bian ,  Simon Feldberg ,  Douglas J. Green ,  Brian Boso ,  Atin J. Patel

IPC: H01J49/06 ,  H01J49/26 ,  G01N27/62

CPC classification number: G01N27/622 ,  H01C3/06 ,  H01J49/0018 ,  H01J49/06 ,  H01J49/062 ,  H05K1/118

Abstract: An ion detection assembly is described that includes a drift chamber, an inlet assembly, and a collector assembly. The drift chamber is formed of substantially non-conductive material and/or semi-conductive material. A patterned resistive trace is deposited on one or more of an interior surface or an exterior surface of the drift chamber. The patterned resistive trace is configured to connect to a source of electrical energy. The inlet assembly and the collector assembly are in fluid communication with the drift chamber. The inlet assembly includes an inlet for receiving a sample, a reaction region for ionizing the sample, and a gate for controlling entrance of the ionized sample to the drift chamber. The collector assembly includes a collector plate for collecting the ionized sample after the ionized sample passes through the drift chamber.

Abstract translation: 描述了一种离子检测组件，其包括漂移室，入口组件和收集器组件。 漂移室由基本上不导电的材料和/或半导体材料形成。 图案化的电阻迹线沉积在漂移室的内表面或外表面的一个或多个上。 图案化电阻迹线被配置为连接到电能源。 入口组件和收集器组件与漂移室流体连通。 入口组件包括用于接收样品的入口，用于电离样品的反应区域和用于控制离子化样品进入漂移室的门。 集电器组件包括用于在电离样品通过漂移室之后收集电离样品的集电板。