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公开(公告)号：US12111378B2
公开(公告)日：2024-10-08
申请号：US18217976
申请日：2023-07-03
发明人： Joseph V. Rispoli , Xin Li
IPC分类号： G01R33/565 , A61B5/055 , G01R33/28 , G01R33/3415 , G01R33/54
CPC分类号： G01R33/5659 , A61B5/055 , G01R33/288 , G01R33/3415 , G01R33/543
摘要： A method of operating a multi-coil magnetic resonance imaging system is disclosed which includes a controller performing a simulation using a predefined tissue model, determining output values of a variable of interest (VOI) associated with operation of two or more coils of an MRI system based on the simulation, comparing the simulated output values of the VOI to an a priori target values of the VOI, if the simulated output values of the VOI are outside of a predetermined envelope about the a priori target values of the VOI, then performing an optimization, wherein the optimization includes iteratively adjusting the circuit values until the simulated output values of the VOI are within the predetermined envelope about the a priori target values of the VOI thereby establishing VOI optimized values, and loading the established VOI optimized values and operating the magnetic resonance imaging system on the tissue to be imaged.
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公开(公告)号：US11699580B2
公开(公告)日：2023-07-11
申请号：US16930388
申请日：2020-07-16
发明人： Robert Graham Cooks , Guangtao Li , Guangming Huang , Jason Duncan , Xin Li , Ewa Sokol , Xin Yan
CPC分类号： H01J49/04 , G01N27/62 , H01J49/0018 , H01J49/0031 , H01J49/045 , H01J49/0445 , H01J49/4205 , Y10T436/24
摘要： The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface.
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公开(公告)号：US20220199384A9
公开(公告)日：2022-06-23
申请号：US16930388
申请日：2020-07-16
发明人： Robert Graham Cooks , Guangtao Li , Guangming Huang , Jason Duncan , Xin Li , Ewa Sokol , Xin Yan
摘要： The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface.
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公开(公告)号：US09500623B2
公开(公告)日：2016-11-22
申请号：US14052815
申请日：2013-10-14
发明人： Robert Graham Cooks , Jason Duncan , Guangming Huang , Guangtao Li , Xin Yan , Ewa Sokol , Xin Li
CPC分类号： H01J49/045 , G01N27/62 , H01J49/0018 , H01J49/0445 , Y10T436/24
摘要： The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface.
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5.发明申请公开(公告)号：US20160118236A1
公开(公告)日：2016-04-28
申请号：US14936197
申请日：2015-11-09
发明人： Robert Graham Cooks , Jason Duncan , Guangming Huang , Guangtao Li , Xin Yan , Ewa Sokol , Xin Li
CPC分类号： H01J49/04 , G01N27/62 , H01J49/0031 , H01J49/0445 , H01J49/4205 , Y10T436/24
摘要： The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface.
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6.发明授权公开(公告)号：US09184036B2
公开(公告)日：2015-11-10
申请号：US13887911
申请日：2013-05-06
发明人： Robert Graham Cooks , Jason Duncan , Guangming Huang , Guangtao Li , Xin Yan , Ewa Sokol , Xin Li
CPC分类号： H01J49/04 , G01N27/62 , H01J49/0031 , H01J49/0445 , H01J49/4205 , Y10T436/24
摘要： The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface.
摘要翻译： 本发明一般涉及用于使离子产生与不连续大气界面的循环同步的方法和装置。 在某些实施方案中，本发明提供了一种用于分析样品的系统，该样品包括产生样品离子的质谱探针，不连续大气界面和质量分析仪，其中该系统配置成使得离子形成与 不连续大气界面。
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7.发明公开公开(公告)号：US20230420236A1
公开(公告)日：2023-12-28
申请号：US18209074
申请日：2023-06-13
发明人： Robert Graham Cooks , Guangtao Li , Guangming Huang , Jason Duncan , Xin Li , Ewa Sokol , Xin Yan
CPC分类号： H01J49/04 , H01J49/0445 , H01J49/0018 , H01J49/045 , G01N27/62 , H01J49/0031 , H01J49/4205 , Y10T436/24
摘要： The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface.
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公开(公告)号：US09761426B2
公开(公告)日：2017-09-12
申请号：US14936197
申请日：2015-11-09
发明人： Robert Graham Cooks , Jason Duncan , Guangming Huang , Guangtao Li , Xin Yan , Ewa Sokol , Xin Li
CPC分类号： H01J49/04 , G01N27/62 , H01J49/0031 , H01J49/0445 , H01J49/4205 , Y10T436/24
摘要： The invention generally relates to methods and devices for synchronization of ion generation with cycling of a discontinuous atmospheric interface. In certain embodiments, the invention provides a system for analyzing a sample that includes a mass spectrometry probe that generates sample ions, a discontinuous atmospheric interface, and a mass analyzer, in which the system is configured such that ion formation is synchronized with cycling of the discontinuous atmospheric interface.
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公开(公告)号：US11693078B2
公开(公告)日：2023-07-04
申请号：US17667480
申请日：2022-02-08
发明人： Joseph V. Rispoli , Xin Li
IPC分类号： G01R33/565 , G01R33/28 , A61B5/055 , G01R33/3415 , G01R33/54
CPC分类号： G01R33/5659 , A61B5/055 , G01R33/288 , G01R33/3415 , G01R33/543
摘要： A method of operating a multi-coil magnetic resonance imaging system, is disclosed which includes establishing initial circuit values of a drive circuit, loading a tissue model associated with a tissue to be imaged, loading target values for a variable of interest (VOI) associated with operation of two or more coils of a magnetic resonance imaging system, performing a simulation based on the established circuit values and the loaded tissue model, determining output values of the VOI based on the simulation, comparing the simulated output values of the VOI to the loaded target values of the VOI, if the simulated output values are outside of a predetermined envelope about the loaded target values of the VOI, then performing a first optimization until the simulated output values are within the predetermined envelope.
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公开(公告)号：US20220260661A1
公开(公告)日：2022-08-18
申请号：US17667480
申请日：2022-02-08
发明人： Joseph V. Rispoli , Xin Li
IPC分类号： G01R33/565 , G01R33/28 , G01R33/54 , G01R33/3415 , A61B5/055
摘要： A method of operating a multi-coil magnetic resonance imaging system, is disclosed which includes establishing initial circuit values of a drive circuit, loading a tissue model associated with a tissue to be imaged, loading target values for a variable of interest (VOI) associated with operation of two or more coils of a magnetic resonance imaging system, performing a simulation based on the established circuit values and the loaded tissue model, determining output values of the VOI based on the simulation, comparing the simulated output values of the VOI to the loaded target values of the VOI, if the simulated output values are outside of a predetermined envelope about the loaded target values of the VOI, then performing a first optimization until the simulated output values are within the predetermined envelope.
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