公开(公告)号：US20160319342A1

公开(公告)日：2016-11-03

申请号：US15061871

申请日：2016-03-04

Applicant: Osaka University ,  Quantum Biosystems Inc.

Inventor： Tomoji Kawai ,  Masateru Taniguchi ,  Takahito Ohshiro ,  Mark Oldham ,  Eric Nordman

IPC: C12Q1/68 ,  G01N27/04 ,  G06F19/22

CPC classification number: C12Q1/6869 ,  G01N27/04 ,  G01N33/48721 ,  G06F19/22 ,  C12Q2563/116 ,  C12Q2565/631

Abstract: Devices, systems and methods for sequencing protein samples are provided. In some examples, currents generated when a monomer passes through between electrodes of a nanogap electrode pair are measured for each of several different distances, so that monomers are identified when compared to a reference physical quantity of a known monomer, which may be obtained from a current measured with a similar inter-electrode distance(s) at which each of plural kinds of monomers are identifiable and ordered with predetermined accuracy and based on a detected physical quantity obtained from a tunneling current, which may be further normalized by the use of one or more reference substances.

Abstract translation: 提供了用于测序蛋白质样品的设备，系统和方法。 在一些实例中，当在几个不同距离中的每一个测量单体通过纳米缝电极对的电极之间产生的电流，使得当与已知单体的参考物理量相比时，识别单体，其可以从 以类似的电极间距测量的电流，其中可以以预定精度识别和排序多种单体中的每一种，并且基于从隧道电流获得的检测到的物理量，其可以通过使用一个 或更多的参考物质。

公开(公告)号：US10261066B2

公开(公告)日：2019-04-16

申请号：US15098147

申请日：2016-04-13

Applicant: Quantum Biosystems Inc.

Inventor： Shuji Ikeda ,  Mark Oldham ,  Eric S. Nordman

IPC: G01N27/447 ,  G01N33/487 ,  C23C16/455 ,  G01N27/327

Abstract: A system for detecting a biomolecule comprises a nano-gap electrode device including a first electrode and a second electrode adjacent to the first electrode. The first electrode can be separated from the second electrode by a nano-gap that is dimensioned to permit the biomolecule to flow through the nano-gap. The nano-gap can have at least a first gap region and a second gap region. The second gap region can be oriented at an angle that is greater than zero degrees with respect to a plane having the first gap region. The system can further include an electrical circuit coupled to the nano-gap electrode device. The electrical circuit can receive electrical signals from the first electrode and the second electrode upon the flow of the biomolecule through the nano-gap.

公开(公告)号：US20190071720A1

公开(公告)日：2019-03-07

申请号：US15937327

申请日：2018-03-27

Applicant: Quantum Biosystems Inc.

Inventor： Eric S. Nordman ,  Mark Oldham ,  Takeshi Akatsu

IPC: C12Q1/6869

Abstract: The present disclosure provides devices, systems and methods for sequencing nucleic acid molecules. A sequence of a nucleic acid molecule may be identified at high accuracy using a chip comprising an array of sensors, wherein each individual sensor comprises at least one nano-gap electrode pair configured to generate electrical signals upon flow of the nucleic acid molecule through or in proximity to at least one nano-gap of the nano-gap electrode pair.