公开(公告)号：US20190310240A1

公开(公告)日：2019-10-10

申请号：US16178924

申请日：2018-11-02

Applicant: Quantum Biosystems Inc.

Inventor： Shuji Ikeda ,  Mark Oldham ,  Eric S. Nordman

IPC: G01N33/487 ,  G01N27/327 ,  C23C16/455 ,  G01N27/447

Abstract: A system for detecting a biomolecule comprises a nano-gap electrode device including a first electrode and a second electrode adjacent to the first electrode. The first electrode can be separated from the second electrode by a nano-gap that is dimensioned to permit the biomolecule to flow through the nano-gap. The nano-gap can have at least a first gap region and a second gap region. The second gap region can be oriented at an angle that is greater than zero degrees with respect to a plane having the first gap region. The system can further include an electrical circuit coupled to the nano-gap electrode device. The electrical circuit can receive electrical signals from the first electrode and the second electrode upon the flow of the biomolecule through the nano-gap.

公开(公告)号：US10261066B2

公开(公告)日：2019-04-16

申请号：US15098147

申请日：2016-04-13

Applicant: Quantum Biosystems Inc.

Inventor： Shuji Ikeda ,  Mark Oldham ,  Eric S. Nordman

IPC: G01N27/447 ,  G01N33/487 ,  C23C16/455 ,  G01N27/327

Abstract: A system for detecting a biomolecule comprises a nano-gap electrode device including a first electrode and a second electrode adjacent to the first electrode. The first electrode can be separated from the second electrode by a nano-gap that is dimensioned to permit the biomolecule to flow through the nano-gap. The nano-gap can have at least a first gap region and a second gap region. The second gap region can be oriented at an angle that is greater than zero degrees with respect to a plane having the first gap region. The system can further include an electrical circuit coupled to the nano-gap electrode device. The electrical circuit can receive electrical signals from the first electrode and the second electrode upon the flow of the biomolecule through the nano-gap.

公开(公告)号：US20190071720A1

公开(公告)日：2019-03-07

申请号：US15937327

申请日：2018-03-27

Applicant: Quantum Biosystems Inc.

Inventor： Eric S. Nordman ,  Mark Oldham ,  Takeshi Akatsu

IPC: C12Q1/6869

Abstract: The present disclosure provides devices, systems and methods for sequencing nucleic acid molecules. A sequence of a nucleic acid molecule may be identified at high accuracy using a chip comprising an array of sensors, wherein each individual sensor comprises at least one nano-gap electrode pair configured to generate electrical signals upon flow of the nucleic acid molecule through or in proximity to at least one nano-gap of the nano-gap electrode pair.

公开(公告)号：US10466228B2

公开(公告)日：2019-11-05

申请号：US16178924

申请日：2018-11-02

Applicant: Quantum Biosystems Inc.

Inventor： Shuji Ikeda ,  Mark Oldham ,  Eric S. Nordman

IPC: G01N27/447 ,  G01N33/487 ,  C23C16/455 ,  G01N27/327

Abstract: A system for detecting a biomolecule comprises a nano-gap electrode device including a first electrode and a second electrode adjacent to the first electrode. The first electrode can be separated from the second electrode by a nano-gap that is dimensioned to permit the biomolecule to flow through the nano-gap. The nano-gap can have at least a first gap region and a second gap region. The second gap region can be oriented at an angle that is greater than zero degrees with respect to a plane having the first gap region. The system can further include an electrical circuit coupled to the nano-gap electrode device. The electrical circuit can receive electrical signals from the first electrode and the second electrode upon the flow of the biomolecule through the nano-gap.

公开(公告)号：US20160320364A1

公开(公告)日：2016-11-03

申请号：US15098147

申请日：2016-04-13

Applicant: Quantum Biosystems Inc.

Inventor： Shuji Ikeda ,  Mark Oldham ,  Eric S. Nordman

IPC: G01N33/487 ,  C23C16/455 ,  G01N27/447

CPC classification number: G01N33/48721 ,  C23C16/45525 ,  G01N27/44791

Abstract: A system for detecting a biomolecule comprises a nano-gap electrode device including a first electrode and a second electrode adjacent to the first electrode. The first electrode can be separated from the second electrode by a nano-gap that is dimensioned to permit the biomolecule to flow through the nano-gap. The nano-gap can have at least a first gap region and a second gap region. The second gap region can be oriented at an angle that is greater than zero degrees with respect to a plane having the first gap region. The system can further include an electrical circuit coupled to the nano-gap electrode device. The electrical circuit can receive electrical signals from the first electrode and the second electrode upon the flow of the biomolecule through the nano-gap.

Abstract translation: 用于检测生物分子的系统包括纳米间隙电极装置，其包括与第一电极相邻的第一电极和第二电极。 第一电极可以通过纳米间隙与第二电极分离，其尺寸被设计成允许生物分子流过纳米间隙。 纳米间隙可以具有至少第一间隙区域和第二间隙区域。 第二间隙区域可相对于具有第一间隙区域的平面以大于零度的角度定向。 该系统还可以包括耦合到纳米间隙电极器件的电路。 当生物分子流过纳米间隙时，电路可以接收来自第一电极和第二电极的电信号。