公开(公告)号：US10261066B2

公开(公告)日：2019-04-16

申请号：US15098147

申请日：2016-04-13

Applicant: Quantum Biosystems Inc.

Inventor： Shuji Ikeda ,  Mark Oldham ,  Eric S. Nordman

IPC: G01N27/447 ,  G01N33/487 ,  C23C16/455 ,  G01N27/327

Abstract: A system for detecting a biomolecule comprises a nano-gap electrode device including a first electrode and a second electrode adjacent to the first electrode. The first electrode can be separated from the second electrode by a nano-gap that is dimensioned to permit the biomolecule to flow through the nano-gap. The nano-gap can have at least a first gap region and a second gap region. The second gap region can be oriented at an angle that is greater than zero degrees with respect to a plane having the first gap region. The system can further include an electrical circuit coupled to the nano-gap electrode device. The electrical circuit can receive electrical signals from the first electrode and the second electrode upon the flow of the biomolecule through the nano-gap.

公开(公告)号：US20170146510A1

公开(公告)日：2017-05-25

申请号：US15344184

申请日：2016-11-04

Applicant: Quantum Biosystems Inc. ,  Osaka University

Inventor： Shuji Ikeda ,  Masateru Taniguchi

IPC: G01N33/487 ,  G01N27/447 ,  C12Q1/68

CPC classification number: G01N33/48721 ,  C12Q1/6869 ,  G01N27/44791

Abstract: The present disclosure provides methods and structures for effectuating nanoelectrodes with an adjustable nanogap. Devices with integrated actuators (e.g., piezoelectric devices) and/or materials with different coefficients of expansion are described. Also described are methods for calibrations nanoelectrode pairs.

公开(公告)号：US10466228B2

公开(公告)日：2019-11-05

申请号：US16178924

申请日：2018-11-02

Applicant: Quantum Biosystems Inc.

Inventor： Shuji Ikeda ,  Mark Oldham ,  Eric S. Nordman

IPC: G01N27/447 ,  G01N33/487 ,  C23C16/455 ,  G01N27/327

Abstract: A system for detecting a biomolecule comprises a nano-gap electrode device including a first electrode and a second electrode adjacent to the first electrode. The first electrode can be separated from the second electrode by a nano-gap that is dimensioned to permit the biomolecule to flow through the nano-gap. The nano-gap can have at least a first gap region and a second gap region. The second gap region can be oriented at an angle that is greater than zero degrees with respect to a plane having the first gap region. The system can further include an electrical circuit coupled to the nano-gap electrode device. The electrical circuit can receive electrical signals from the first electrode and the second electrode upon the flow of the biomolecule through the nano-gap.

公开(公告)号：US20170131237A1

公开(公告)日：2017-05-11

申请号：US15336515

申请日：2016-10-27

Applicant: Quantum Biosystems Inc.

Inventor： Shuji Ikeda

IPC: G01N27/447 ,  G01N33/487

CPC classification number: G01N27/44791 ,  G01N33/48721

Abstract: The present disclosure provides biopolymer detection devices and systems, and methods for forming such devices and systems. A device for detecting a biopolymer comprises a channel that is configured to direct the biopolymer and a pair of electrodes in a portion of the channel. The pair of electrodes has surfaces that are substantially coplanar with adjacent surfaces of the channel. Surfaces of the pair of electrodes are exposed during use of the device to enable detection the biopolymer or a portion thereof with the aid of the pair of electrodes.

公开(公告)号：US20160320364A1

公开(公告)日：2016-11-03

申请号：US15098147

申请日：2016-04-13

Applicant: Quantum Biosystems Inc.

Inventor： Shuji Ikeda ,  Mark Oldham ,  Eric S. Nordman

IPC: G01N33/487 ,  C23C16/455 ,  G01N27/447

CPC classification number: G01N33/48721 ,  C23C16/45525 ,  G01N27/44791

Abstract: A system for detecting a biomolecule comprises a nano-gap electrode device including a first electrode and a second electrode adjacent to the first electrode. The first electrode can be separated from the second electrode by a nano-gap that is dimensioned to permit the biomolecule to flow through the nano-gap. The nano-gap can have at least a first gap region and a second gap region. The second gap region can be oriented at an angle that is greater than zero degrees with respect to a plane having the first gap region. The system can further include an electrical circuit coupled to the nano-gap electrode device. The electrical circuit can receive electrical signals from the first electrode and the second electrode upon the flow of the biomolecule through the nano-gap.

Abstract translation: 用于检测生物分子的系统包括纳米间隙电极装置，其包括与第一电极相邻的第一电极和第二电极。 第一电极可以通过纳米间隙与第二电极分离，其尺寸被设计成允许生物分子流过纳米间隙。 纳米间隙可以具有至少第一间隙区域和第二间隙区域。 第二间隙区域可相对于具有第一间隙区域的平面以大于零度的角度定向。 该系统还可以包括耦合到纳米间隙电极器件的电路。 当生物分子流过纳米间隙时，电路可以接收来自第一电极和第二电极的电信号。

公开(公告)号：US20190310240A1

公开(公告)日：2019-10-10

申请号：US16178924

申请日：2018-11-02

Applicant: Quantum Biosystems Inc.

Inventor： Shuji Ikeda ,  Mark Oldham ,  Eric S. Nordman

IPC: G01N33/487 ,  G01N27/327 ,  C23C16/455 ,  G01N27/447

Abstract: A system for detecting a biomolecule comprises a nano-gap electrode device including a first electrode and a second electrode adjacent to the first electrode. The first electrode can be separated from the second electrode by a nano-gap that is dimensioned to permit the biomolecule to flow through the nano-gap. The nano-gap can have at least a first gap region and a second gap region. The second gap region can be oriented at an angle that is greater than zero degrees with respect to a plane having the first gap region. The system can further include an electrical circuit coupled to the nano-gap electrode device. The electrical circuit can receive electrical signals from the first electrode and the second electrode upon the flow of the biomolecule through the nano-gap.

公开(公告)号：US10438811B1

公开(公告)日：2019-10-08

申请号：US14687856

申请日：2015-04-15

Applicant: Quantum Biosystems Inc.

Inventor： Shuji Ikeda

IPC: H01L21/311 ,  H01L21/285 ,  C12Q1/6869

Abstract: Methods for forming electrodes for use in nano-gap electrodes are provided. Such methods can be used to form electrodes for use in devices that can be used to sense or detect biomolecules, such as in biomolecule sequence applications.

公开(公告)号：US20160245789A1

公开(公告)日：2016-08-25

申请号：US15048810

申请日：2016-02-19

Applicant: Quantum Biosystems Inc.

Inventor： Shuji Ikeda ,  Mark Oldham ,  Eric Nordman

IPC: G01N33/487 ,  C23C16/34 ,  C12Q1/68 ,  C23C16/56 ,  C23C14/06 ,  C23C14/58 ,  G01N27/447 ,  C23C16/06

CPC classification number: G01N33/48721 ,  B82Y40/00 ,  C12Q1/6869 ,  C23C14/0641 ,  C23C14/5886 ,  C23C16/06 ,  C23C16/345 ,  C23C16/56 ,  G01N27/3278 ,  G01N27/44704 ,  G01N27/44791

Abstract: The present disclosure provides methods for forming a nano-gap electrode. In some cases, a nano-gap having a width adjusted by a film thickness of a sidewall may be formed between a first electrode-forming part and a second electrode-forming part using sidewall which has contact with first electrode-forming part as a mask. Surfaces of the first electrode-forming part, the sidewall and the second electrode-forming part may then be exposed. The sidewall may then be removed to form a nano-gap between the first electrode-forming part and the second electrode-forming part.

Abstract translation: 本公开提供了形成纳米间隙电极的方法。 在一些情况下，可以使用与第一电极形成部分接触的侧壁作为掩模，在第一电极形成部分和第二电极形成部分之间形成具有由侧壁的膜厚度调节的宽度的纳米间隙 。 然后可以露出第一电极形成部分，侧壁和第二电极形成部分的表面。 然后可以去除侧壁以在第一电极形成部分和第二电极形成部分之间形成纳米间隙。