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    PROCESSING REAGENT AND USE THEREOF IN ASSAYS FOR DETECTION OF ANALYTES ASSOCIATED WITH A BINDING PROTEIN
    11.
    发明申请
    PROCESSING REAGENT AND USE THEREOF IN ASSAYS FOR DETECTION OF ANALYTES ASSOCIATED WITH A BINDING PROTEIN 审中-公开

    公开(公告)号：US20190271711A1

    公开(公告)日：2019-09-05

    申请号：US16412218

    申请日：2019-05-14

    申请人： Quidel Corporation

    发明人： Richard L. Egan ,  Judson McFarland ,  Mark Renshaw

    IPC分类号： G01N33/82

    摘要： Methods for preparing a sample for detection of an analyte of interest that is bound in vivo to a protein are provided. The method comprises providing a processing reagent comprising metaperiodate and contacting a sample suspected of comprising an analyte of interest associated with a protein with the processing reagent to form a mixture. The analyte of interest, if present in the sample (or mixture), is separated from its associated protein for detection of the analyte of interest. In one embodiment, the method is applied to samples for the detection of levels of vitamin D circulating in the blood. Samples are processed using the reagent disclosed herein to separate the analyte of interest, vitamin D or a metabolite thereof, from the vitamin D binding protein and/or albumin, for detection of the analyte separated from its binding protein(s).

    INTERACTIVE TEST DEVICE AND APPARATUS WITH TIMING MECHANISM
    12.
    发明申请
    INTERACTIVE TEST DEVICE AND APPARATUS WITH TIMING MECHANISM 审中-公开
    交互式测试设备和具有时序机制的设备

    公开(公告)号：US20130230845A1

    公开(公告)日：2013-09-05

    申请号：US13783065

    申请日：2013-03-01

    申请人： QUIDEL CORPORATION

    发明人： Richard L. Egan ,  Michael Jon Hale

    IPC分类号： G01N33/53

    CPC分类号： G01N33/5302 ,  G01N33/558 ,  G01N33/585

    摘要： A system comprised of an apparatus and a test device is described. The test device and the apparatus are designed to interact to determine the presence or absence of an analyte of interest in a sample placed on the test device. The test device and apparatus interact to provide a timer feature for determining a test device specific adjustable cut-off value that is used to ascertain whether signal from a test line in the device corresponds to a positive or negative results, irrespective of the time elapsed since placement of sample on the test device. The adjustable cut-off value renders the system relatively insensitive to incubation time of the test device, where if the incubation time is shorter or longer than needed for accuracy of a test result, the analyzer will report an invalid result, thus preventing the reporting of an incorrect (false negative or false positive) result.

    摘要翻译： 描述了由装置和测试装置组成的系统。 设计测试装置和设备以相互作用以确定放置在测试装置上的样品中是否存在感兴趣的分析物。 测试装置和装置相互作用以提供用于确定测试装置特定的可调节截止值的定时器特征，其用于确定来自装置中的测试线的信号是否对应于正或负结果，而与经过的时间无关，因为 样品放置在测试设备上。 可调节的截止值使得系统对测试装置的孵育时间相对不敏感，如果孵化时间比测试结果精度要短的或更长，则分析仪将报告无效结果，从而防止报告 错误（假阴性或假阳性）结果。

    PROCESSING REAGENT AND USE THEREOF IN ASSAYS FOR DETECTION OF ANALYTES ASSOCIATED WITH A BINDING PROTEIN
    16.
    发明申请
    PROCESSING REAGENT AND USE THEREOF IN ASSAYS FOR DETECTION OF ANALYTES ASSOCIATED WITH A BINDING PROTEIN 审中-公开

    公开(公告)号：US20170292964A1

    公开(公告)日：2017-10-12

    申请号：US15482332

    申请日：2017-04-07

    申请人： Quidel Corporation

    发明人： Richard L. Egan ,  Judson McFarland ,  Mark Renshaw

    IPC分类号： G01N33/82

    CPC分类号： G01N33/82

    摘要： Methods for preparing a sample for detection of an analyte of interest that is bound in vivo to a protein are provided. The method comprises providing a processing reagent comprising metaperiodate and contacting a sample suspected of comprising an analyte of interest associated with a protein with the processing reagent to form a mixture. The analyte of interest, if present in the sample (or mixture), is separated from its associated protein for detection of the analyte of interest. In one embodiment, the method is applied to samples for the detection of levels of vitamin D circulating in the blood. Samples are processed using the reagent disclosed herein to separate the analyte of interest, vitamin D or a metabolite thereof, from the vitamin D binding protein and/or albumin, for detection of the analyte separated from its binding protein(s).