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11.
公开(公告)号:US20210128414A1
公开(公告)日:2021-05-06
申请号:US17145465
申请日:2021-01-11
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor: Lihi ADLER-ABRAMOVICH , Lee SCHNAIDER , Shlomo MATALON , Tamar BROSH , Raphael PILO , Ehud GAZIT
Abstract: A composition containing a plurality of self-assembled nanostructures formed of a plurality of aromatic molecules which include an aromatic amino acid, and which exhibits an antibacterial activity is provided. The composition can be a dental composition which further comprises a dental formulation such as a curable dental formulation, for forming dental composite materials such as dental restorative composite materials. Processes of preparing the composition and uses thereof are also provided.
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公开(公告)号:US20190276513A1
公开(公告)日:2019-09-12
申请号:US16357340
申请日:2019-03-19
Applicant: TEL HASHOMER MEDICAL RESEARCH INFRASTRUCTURE AND SERVICES LTD. , RAMOT AT TEL AVIV UNIVERSITY LTD.
Inventor: Genady KOSTENICH , Mor ORON-HERMAN , Arie ORENSTEIN , Talia SHEKHTER ZAHAVI , Ehud GAZIT , Yoseph SALITRA , Ludmila BUZHANSKY
IPC: C07K14/655 , A61K47/69 , A61K38/08 , A61K47/62 , A61K38/12
Abstract: Disclosed are Somatostatin receptor ligands comprising a peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and an active agent moiety covalently bonded to the cyclic peptide moiety through a nitrogen atom of a side chain functional group of an internal residue of the cyclic peptide moiety, pharmaceutical compositions and uses thereof. Disclosed are also synthetic Somatostatin receptor ligands comprising a cyclic peptide moiety and a nanoparticle active agent moiety covalently bonded to the cyclic peptide moiety, pharmaceutical compositions and uses thereof.
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公开(公告)号:US20170198021A1
公开(公告)日:2017-07-13
申请号:US15460372
申请日:2017-03-16
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor: Yaron BRAM , Ehud GAZIT
IPC: C07K14/575 , C07K16/26 , A61K39/00 , C07C305/06
CPC classification number: C07K14/575 , A61K38/17 , A61K39/0005 , C07C305/06 , C07K16/26 , G01N33/6893 , G01N2333/4709 , G01N2500/10
Abstract: A composition of matter is disclosed which comprises isolated oligomers of human islet amyloid polypeptide (IAPP). Antibodies recognizing same are also disclosed. Use of the composition of matter and the antibodies are also disclosed.
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公开(公告)号:US20160008291A1
公开(公告)日:2016-01-14
申请号:US14770096
申请日:2014-02-27
Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventor: Rafael ISCHAKOV , Ludmila BUZHANSKY , Lihi ADLER-ABRAMOVICH , Ehud GAZIT
IPC: A61K9/51 , A61K31/513 , A61K49/00 , A61K31/704
CPC classification number: A61K9/5123 , A61K9/5192 , A61K31/513 , A61K31/704 , A61K38/05 , A61K38/06 , A61K38/07 , A61K38/08 , A61K38/12 , A61K49/0093 , B82Y5/00 , C07K5/06078
Abstract: Compositions comprising self-assembled hydrogel particles formed of short peptides which comprise one or more aromatic amino acid residue(s) in an inverted emulsion are disclosed. Such hydrogel particles which encapsulate an active agent and uses thereof in therapeutic and diagnostic applications are also disclosed.
Abstract translation: 公开了包含由倒置乳液中的一个或多个芳族氨基酸残基构成的由短肽形成的自组装水凝胶颗粒的组合物。 还公开了将治疗和诊断应用包封活性剂及其用途的这种水凝胶颗粒。
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公开(公告)号:US20240167062A1
公开(公告)日:2024-05-23
申请号:US18281982
申请日:2022-03-16
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor: Iftach YACOBY , Itzhak GRINBERG , Oren BENZVI , Ehud GAZIT , Lihi ADLER-ABRAMOVICH
Abstract: Methods which utilize a self-assembled structure formed of a plurality of peptides being of from 2 to 6 amino acids in length, and comprising at least one aromatic amino acid residue, wherein the self-assembled structure is capable of interacting with oxygen, are provided herewith. The methods may be for controlling (e.g., reducing) a concentration of free oxygen in an environment, and/or for transporting oxygen from a first environment to a second environment. Further described herein is a self-assembled structure as described herein having oxygen interacted therewith. Further described herein is a composition comprising the self-assembled structure and substance which is oxygen-sensitive and/or participates in an oxygen-sensitive reaction incorporated in the self-assembled structure, systems comprising such a composition and methods employing the composition or system. Further described herein are articles-of-manufacturing comprising any of the self-assembled structures or compositions as described herein and an oxygen-sensitive substance and uses thereof.
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公开(公告)号:US20230301200A1
公开(公告)日:2023-09-21
申请号:US17909774
申请日:2021-03-08
Applicant: Ramot at Tel-Aviv University Ltd. , Yeda Research and Development Co. Ltd. , Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.
Inventor: Ehud GAZIT , Ron NAAMAN , Yossi PALTIEL , Shira YOCHELIS , Sharon GILEAD , Pandeeswar MAKAM , Amit Kumar MONDAL , Noam BROWN , Naama GOREN
Abstract: A spin-selective conduction structure comprises a crystal having a monolayer of metal atoms between two layers of chiral organic molecules. Each metal atom is coupled to two chiral organic molecules, one at each layer, wherein a chirality of organic molecules in one of the two layers is the same as a chirality of organic molecules in another one of the two layers.
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17.
公开(公告)号:US20180298062A1
公开(公告)日:2018-10-18
申请号:US15769082
申请日:2016-10-19
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor: Or BERGER , Lihi ADLER-ABRAMOVICH , Ehud GAZIT
Abstract: Ordered structures composed of a plurality of self-assembled peptide nucleic acid (PNA) monomers, and processes of generating same are provided. The plurality of PNA monomers includes modified PNA monomers which are N-protected PNA monomers and/or which feature at least one aromatic moiety attached to a backbone, a nucleobase and/or a nucleobase linkage unit of the PNA monomer. Tunable photonic crystals formed of the provided ordered structures, uses thereof and articles-of-manufacturing containing same are also provided.
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公开(公告)号:US20170209845A1
公开(公告)日:2017-07-27
申请号:US15482867
申请日:2017-04-10
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor: Ehud GAZIT , Meital RECHES
IPC: B01J19/00
CPC classification number: B01J19/0046 , B01J2219/00596 , B01J2219/00709 , B01J2219/00725 , B81B2203/0361 , B81C1/00031 , B81C2201/0149 , B82Y5/00 , B82Y15/00 , B82Y25/00 , B82Y30/00 , B82Y40/00 , C07K5/06078 , C07K17/14 , Y10S977/793 , Y10S977/896
Abstract: A nanostructure array is disclosed. The nanostructure array comprises a plurality of elongated organic nanostructures arranged generally perpendicularly to a plane.
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公开(公告)号:US20160326215A1
公开(公告)日:2016-11-10
申请号:US15150622
申请日:2016-05-10
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor: Pini MARCU , Lihi ADLER-ABRAMOVICH , Ehud GAZIT
CPC classification number: C07K5/06078 , B82Y5/00 , B82Y40/00 , C09D7/70
Abstract: Nanostructures made up from two or more types of short peptides (e.g., aromatic dipeptides), which differ from one another by the presence (or absence) of an end-capping moiety, are disclosed. The disclosed nanostructures exhibit a closed tubular structure, short average length and narrow length distribution. Also disclosed are processes of preparing the nanostructures, articles comprising the nanostructures, and use of the nanostructures in, for example, reinforcement of materials.
Abstract translation: 公开了由两个或多个类型的短肽(例如芳族二肽)组成的纳米结构,其通过封端部分的存在(或不存在)而彼此不同。 所公开的纳米结构显示封闭的管状结构,平均长度短和长度分布窄。 还公开了制备纳米结构,包含纳米结构的制品以及在例如增强材料中使用纳米结构的方法。
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公开(公告)号:US20240376480A1
公开(公告)日:2024-11-14
申请号:US18692766
申请日:2022-09-29
Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventor: Shai ZILBERZWIGE-TAL , Danielle GAZIT , Ehud GAZIT
Abstract: A novel nano-carrier system and method include a virus-like particle, and a functional RNA encapsulated inside the virus-like particle. The virus-like particle protects the functional RNA from nuclease degradation in vivo, and the functional RNA maintains its functionality while being encapsulated inside the virus-like particle. The system and method may be used to modify, reduce, or treat a disease in a subject.
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