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公开(公告)号:US20240167062A1
公开(公告)日:2024-05-23
申请号:US18281982
申请日:2022-03-16
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor: Iftach YACOBY , Itzhak GRINBERG , Oren BENZVI , Ehud GAZIT , Lihi ADLER-ABRAMOVICH
Abstract: Methods which utilize a self-assembled structure formed of a plurality of peptides being of from 2 to 6 amino acids in length, and comprising at least one aromatic amino acid residue, wherein the self-assembled structure is capable of interacting with oxygen, are provided herewith. The methods may be for controlling (e.g., reducing) a concentration of free oxygen in an environment, and/or for transporting oxygen from a first environment to a second environment. Further described herein is a self-assembled structure as described herein having oxygen interacted therewith. Further described herein is a composition comprising the self-assembled structure and substance which is oxygen-sensitive and/or participates in an oxygen-sensitive reaction incorporated in the self-assembled structure, systems comprising such a composition and methods employing the composition or system. Further described herein are articles-of-manufacturing comprising any of the self-assembled structures or compositions as described herein and an oxygen-sensitive substance and uses thereof.
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2.
公开(公告)号:US20180298062A1
公开(公告)日:2018-10-18
申请号:US15769082
申请日:2016-10-19
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor: Or BERGER , Lihi ADLER-ABRAMOVICH , Ehud GAZIT
Abstract: Ordered structures composed of a plurality of self-assembled peptide nucleic acid (PNA) monomers, and processes of generating same are provided. The plurality of PNA monomers includes modified PNA monomers which are N-protected PNA monomers and/or which feature at least one aromatic moiety attached to a backbone, a nucleobase and/or a nucleobase linkage unit of the PNA monomer. Tunable photonic crystals formed of the provided ordered structures, uses thereof and articles-of-manufacturing containing same are also provided.
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公开(公告)号:US20160326215A1
公开(公告)日:2016-11-10
申请号:US15150622
申请日:2016-05-10
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor: Pini MARCU , Lihi ADLER-ABRAMOVICH , Ehud GAZIT
CPC classification number: C07K5/06078 , B82Y5/00 , B82Y40/00 , C09D7/70
Abstract: Nanostructures made up from two or more types of short peptides (e.g., aromatic dipeptides), which differ from one another by the presence (or absence) of an end-capping moiety, are disclosed. The disclosed nanostructures exhibit a closed tubular structure, short average length and narrow length distribution. Also disclosed are processes of preparing the nanostructures, articles comprising the nanostructures, and use of the nanostructures in, for example, reinforcement of materials.
Abstract translation: 公开了由两个或多个类型的短肽(例如芳族二肽)组成的纳米结构,其通过封端部分的存在(或不存在)而彼此不同。 所公开的纳米结构显示封闭的管状结构,平均长度短和长度分布窄。 还公开了制备纳米结构,包含纳米结构的制品以及在例如增强材料中使用纳米结构的方法。
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公开(公告)号:US20240425710A1
公开(公告)日:2024-12-26
申请号:US18822661
申请日:2024-09-03
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor: Lihi ADLER-ABRAMOVICH , Francesca NETTI
IPC: C09D11/04 , A61L27/26 , A61L27/52 , B29C64/112 , B29K105/00 , B29L31/00 , B33Y10/00 , B33Y70/00 , B33Y80/00 , C08L89/06
Abstract: Bioink compositions comprising a plurality of aromatic peptides and a matrix-forming material, formulations and kits for preparing same, additive manufacturing (bioprinting) processes utilizing same and three-dimensional objects obtained thereby are provided.
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5.
公开(公告)号:US20210128414A1
公开(公告)日:2021-05-06
申请号:US17145465
申请日:2021-01-11
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor: Lihi ADLER-ABRAMOVICH , Lee SCHNAIDER , Shlomo MATALON , Tamar BROSH , Raphael PILO , Ehud GAZIT
Abstract: A composition containing a plurality of self-assembled nanostructures formed of a plurality of aromatic molecules which include an aromatic amino acid, and which exhibits an antibacterial activity is provided. The composition can be a dental composition which further comprises a dental formulation such as a curable dental formulation, for forming dental composite materials such as dental restorative composite materials. Processes of preparing the composition and uses thereof are also provided.
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公开(公告)号:US20160008291A1
公开(公告)日:2016-01-14
申请号:US14770096
申请日:2014-02-27
Applicant: RAMOT AT TEL-AVIV UNIVERSITY LTD.
Inventor: Rafael ISCHAKOV , Ludmila BUZHANSKY , Lihi ADLER-ABRAMOVICH , Ehud GAZIT
IPC: A61K9/51 , A61K31/513 , A61K49/00 , A61K31/704
CPC classification number: A61K9/5123 , A61K9/5192 , A61K31/513 , A61K31/704 , A61K38/05 , A61K38/06 , A61K38/07 , A61K38/08 , A61K38/12 , A61K49/0093 , B82Y5/00 , C07K5/06078
Abstract: Compositions comprising self-assembled hydrogel particles formed of short peptides which comprise one or more aromatic amino acid residue(s) in an inverted emulsion are disclosed. Such hydrogel particles which encapsulate an active agent and uses thereof in therapeutic and diagnostic applications are also disclosed.
Abstract translation: 公开了包含由倒置乳液中的一个或多个芳族氨基酸残基构成的由短肽形成的自组装水凝胶颗粒的组合物。 还公开了将治疗和诊断应用包封活性剂及其用途的这种水凝胶颗粒。
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7.
公开(公告)号:US20240293316A1
公开(公告)日:2024-09-05
申请号:US18415811
申请日:2024-01-18
Applicant: Ramot at Tel-Aviv University Ltd. , Northwestern University
Inventor: Nathan GIANNESCHI , Yifei LIANG , Claudia Battistella , Lihi ADLER-ABRAMOVICH , Eyal ROSEN , Carlos NEMCOVSKY , Nathan SCHIFFMANN , Michal HALPERIN-STERNFELD
CPC classification number: A61K9/1075 , A61K47/59
Abstract: Micellar particles formed of a plurality of block copolymers, compositions comprising same, copolymers used to form the particles, and polymeric aggregates formed therefrom are provided. The micellar particles are for use in the treatment of inflammation, including chronic inflammation. The block copolymers forming the particles include at least a first block and a second block. The first block has an anti-inflammatory agent covalently attached, directly or via a linking moiety or group, to at least a portion of its backbone units; and the second block has a hydrophilic moiety that comprises an amino acid sequence that is capable of interacting with an inflammatory biomarker covalently attached to at least a portion of its backbone units, and the particle features a core made of the first block and a hydrophilic shell made of the second block.
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8.
公开(公告)号:US20230225332A1
公开(公告)日:2023-07-20
申请号:US18002251
申请日:2021-06-16
Inventor: Lihi ADLER-ABRAMOVICH , Livnat AFRIAT-JURNOU
CPC classification number: A01N63/50 , C12N9/16 , C12Y301/01025 , C12Y301/08001 , C12N11/04 , A01N25/34 , A01P1/00
Abstract: A composition including nano- or microspheres, and/or tubular nanostructures, each made of a plurality of aromatic dipeptides including end-capping modified aromatic dipeptides, non-modified aromatic dipeptides, or a combination thereof; and encapsulating an esterase or a functional fragment thereof; as well as methods of use. The plurality of aromatic dipeptides may include the end-capping modified aromatic dipeptides only.
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公开(公告)号:US20240358889A1
公开(公告)日:2024-10-31
申请号:US18766738
申请日:2024-07-09
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor: Lihi ADLER-ABRAMOVICH , Michal HALPERIN-STERNFELD , Moran AVIV , Itzhak BINDERMAN
CPC classification number: A61L27/20 , A61L27/227 , A61L27/52 , A61L2430/02
Abstract: Methods and compositions employing hybrid hydrogels formed of high molecular weight hyaluronic acid and a plurality of self-assembled peptides in inducing bone regeneration are provided.
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公开(公告)号:US20210030918A1
公开(公告)日:2021-02-04
申请号:US16942837
申请日:2020-07-30
Applicant: Ramot at Tel-Aviv University Ltd.
Inventor: Lihi ADLER-ABRAMOVICH , Ehud GAZIT , Irena GRIGORIANTS , Lialy KHADEJA , Sharon GILEAD
Abstract: Provided herein are composite structures that include a core fiber and a plurality of peptide-based self-assembled nanostructures attached thereto, wherein the nanostructures may be loaded with a bioactive agent, such that the composite structures may act as slow-release drug-delivery medical device. Also provided is process for producing the composite structures, and uses thereof.
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