公开(公告)号：US11293914B2

公开(公告)日：2022-04-05

申请号：US16393177

申请日：2019-04-24

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA ,  Boston Scientific Scimed, Inc.

Inventor： Xue Zhen ,  Philippe Pierre Joseph Buhlmann ,  Steven J. Koester ,  Justin Theodore Nelson

IPC: G01N33/497 ,  G01N27/22 ,  G01N27/12

Abstract: Embodiments include chemical sensors, devices and systems including the same, and related methods. In an embodiment, a medical device is provided. The medical device can include a graphene varactor, including a graphene layer and a self-assembled monolayer disposed on an outer surface of the graphene layer through electrostatic interactions between a partial positive charge on hydrogen atoms of one or more hydrocarbons of the self-assembled monolayer and a it-electron system of graphene. The self-assembled monolayer can include one or more substituted porphyrins or substituted metalloporphyrins, or derivatives thereof. Other embodiments are also included herein.

公开(公告)号：US20210356457A1

公开(公告)日：2021-11-18

申请号：US17387503

申请日：2021-07-28

Applicant: Boston Scientific Scimed, Inc. ,  REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Xue Zhen ,  Philippe Pierre Joseph Buhlmann ,  Steven Koester ,  Yao Zhang ,  Justin Theodore Nelson

IPC: G01N33/53 ,  G01N27/12 ,  G01N27/22

Abstract: Embodiments herein relate to chemical sensors, devices and systems including the same, and related methods. In an embodiment, a medical device is included. The medical device can include a graphene varactor. The graphene varactor can include a graphene layer and a self-assembled monolayer disposed on an outer surface of the graphene layer through π-π stacking interactions. The self-assembled monolayer can provide a Langmuir theta value of at least 0.9. The self-assembled monolayer can include polycyclic aromatic hydrocarbons, tetraphenylporphyrins or derivatives thereof, metallotetraphenylporphyrins, or aromatic cyclodextrins. Other embodiments are also included herein.

公开(公告)号：US11079371B2

公开(公告)日：2021-08-03

申请号：US16280635

申请日：2019-02-20

Applicant: REGENTS OF THE UNIVERSITY OF MINNESOTA ,  Boston Scientific Scimed, Inc.

Inventor： Xue Zhen ,  Philippe Pierre Joseph Buhlmann ,  Steven J. Koester ,  Yao Zhang ,  Justin Theodore Nelson

IPC: G01N33/53 ,  G01N27/12 ,  G01N27/22 ,  A61B5/08 ,  G01N27/414

Abstract: Embodiments herein relate to chemical sensors, devices and systems including the same, and related methods. In an embodiment, a medical device is included. The medical device can include a graphene varactor. The graphene varactor can include a graphene layer and a self-assembled monolayer disposed on an outer surface of the graphene layer through π-π stacking interactions. The self-assembled monolayer can provide a Langmuir theta value of at least 0.9. The self-assembled monolayer can include polycyclic aromatic hydrocarbons, tetraphenylporphyrins or derivatives thereof, metallotetraphenylporphyrins, or aromatic cyclodextrins. Other embodiments are also included herein.

公开(公告)号：US20210057526A1

公开(公告)日：2021-02-25

申请号：US16996537

申请日：2020-08-18

Applicant: Boston Scientific Scimed, Inc. ,  REGENTS OF THE UNIVERSITY OF MINNESOTA

Inventor： Xue Zhen ,  Philippe Pierre Joseph Buhlmann ,  Steven J. Koester

IPC: H01L29/16 ,  H01L29/93 ,  A61B5/08 ,  C01B32/194 ,  G01N27/22 ,  G01N27/04

Abstract: Embodiments herein relate to chemical sensors, devices and systems including the same, and related methods. In an embodiment, a medical device is included having a graphene varactor including a graphene layer and a self-assembled monolayer disposed on an outer surface of the graphene layer through non-covalent interactions between the self-assembled monolayer and a π-electron system of graphene. The self-assembled monolayer includes one or more pillarenes, substituted pillarenes, calixarenes, substituted calixarenes, peralkylated cyclodextrins, substituted peralkylated cyclodextrins, pyrenes, or substituted pyrenes, or derivatives thereof. Other embodiments are also included herein.

公开(公告)号：US20180024087A1

公开(公告)日：2018-01-25

申请号：US15655457

申请日：2017-07-20

Applicant: Regents of the University of Minnesota

Inventor： Jinbo Hu ,  Philippe Buhlmann ,  Andreas Stein ,  Xue Zhen

IPC: G01N27/333

CPC classification number: G01N27/333

Abstract: Solid-contact electrodes include a molecular redox buffer that is covalently attached to one of the components of the electrodes. These electrodes can be incorporated into electrochemical sensor systems. The electrode components are an electron conductor, a membrane and optionally, an interlayer. The electrode includes covalent attachment of the molecular redox buffer to the interlayer, to the electron conductor or the membrane. The interlayer includes nanoporous carbon such as CIM-carbon. The molecular redox buffer includes a well-defined redox pair, e.g., a complex of Co(II)/Co(III). The electrodes are ion-selective electrodes (ISEs) or reference electrodes. Methods include constructing solid contact electrodes and using the electrodes in electrochemical sensor systems to determine the quantity of an analyte in a sample. The electrochemical sensor systems include disposable paper-based devices and/or wearable devices for measuring analytes in a sample.