公开(公告)号：US10087211B2

公开(公告)日：2018-10-02

申请号：US15341573

申请日：2016-11-02

Applicant: RESEARCH TRIANGLE INSTITUTE ,  The United States of America, as represented by the Secretary, Department of Health and Human Services

Inventor： Scott P. Runyon ,  Michael Rogawski ,  Edgar Cook ,  John Kepler ,  Hernan Navarro ,  Rafal Kaminski ,  Matthew Orr

IPC: C07J7/00 ,  C07J41/00 ,  C07J31/00

Abstract: This invention describes compounds of Structures 1, 2, and 3 and their use as allosteric modulators of the GABA receptor chloride ionophore complex to alleviate stress, anxiety, mood disorders, seizures, depression, treatment of drug and alcohol abuse, memory, premenstrual disorders, and neural system damage.

公开(公告)号：US20150005315A1

公开(公告)日：2015-01-01

申请号：US14364003

申请日：2012-12-10

Applicant: RESEARCH TRIANGLE INSTITUTE

Inventor： Frank I. Carroll ,  James B. Thomas ,  Hernan A. Navarro ,  S. Wayne Mascarella ,  Scott P. Runyon ,  Chunyang Jin ,  Chad M. Kormos

IPC: C07D401/12 ,  C07D241/04

CPC classification number: C07D401/12 ,  C07D241/04 ,  C07D295/13

Abstract: Provided are compounds represented by the formula: where R, Y3, R1, R2, R3, R4, R6, G, R7, E1, E2, A, B, W, X, Y and Z are as defined herein.

Abstract translation: 提供了由下式表示的化合物：其中R，Y3，R1，R2，R3，R4，R6，G，R7，E1，E2，A，B，W，X，Y和Z如本文所定义。

公开(公告)号：US11292783B2

公开(公告)日：2022-04-05

申请号：US16333849

申请日：2017-09-15

Applicant: Research Triangle Institute

Inventor： Frank Ivy Carroll ,  Chad M. Kormos ,  Pauline W. Ondachi ,  Scott P. Runyon ,  Hernan A. Navarro ,  James B. Thomas ,  S. Wayne Mascarella

IPC: A61K31/472 ,  C07D217/26 ,  C07D401/12 ,  A61P25/34 ,  A61P25/36 ,  A61P25/32 ,  A61P25/18 ,  A61P25/24 ,  C07D211/18 ,  C07D413/12 ,  C07D487/08 ,  A61P25/00

Abstract: Potent opioid receptor antagonists of formula (I) and their use as pharmacotherapies for treating depression, anxiety, schizophrenia, eating disorders, and addiction to cocaine, methamphetamine, nicotine, alcohol, and opiates are disclosed. More specifically, the disclosure provides potent and selective kappa opioid receptor antagonist compounds, pharmaceutical compositions of those compounds and uses of those compounds to ameliorate or treat addictions, eating disorders, etc.

公开(公告)号：US10377718B2

公开(公告)日：2019-08-13

申请号：US15023510

申请日：2015-06-05

Applicant: Research Triangle Institute ,  Scott P. Runyon ,  Rangan Maitra ,  Sanju Narayanan ,  James Barnwell Thomas

Inventor： Scott P. Runyon ,  Rangan Maitra ,  Sanju Narayanan ,  James Barnwell Thomas

IPC: C07D231/14 ,  A61K45/06 ,  A61K31/415 ,  C07D405/12 ,  A61K31/422 ,  A61K31/454 ,  A61K31/4155 ,  A61K31/496 ,  C07D413/12 ,  C07D403/12 ,  C07D403/06 ,  C07D407/12

Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.

公开(公告)号：US20170166577A1

公开(公告)日：2017-06-15

申请号：US15374386

申请日：2016-12-09

Applicant: Research Triangle Institute

Inventor： Scott P. Runyon ,  Rangan Maitra ,  Sanju Narayanan ,  James Barnwell Thomas ,  Kenneth S. Rehder ,  Srinivas Olepu

IPC: C07D491/107 ,  A61K31/454 ,  C07D231/14 ,  A61K31/415 ,  A61K31/5377 ,  A61K31/497 ,  A61K31/4439 ,  C07D401/12 ,  C07D401/14 ,  A61K31/55 ,  C07D487/08 ,  C07D405/12 ,  A61K31/427 ,  C07D417/12 ,  A61K31/422 ,  C07D413/12 ,  C07D409/04 ,  C07D403/04 ,  C07D413/04 ,  C07D417/04 ,  C07D417/14 ,  A61K31/4196 ,  A61K31/4245 ,  C07D403/14 ,  C07D403/12 ,  A61K31/439 ,  C07D471/08 ,  A61K45/06

CPC classification number: C07D491/107 ,  A61K31/415 ,  A61K31/4196 ,  A61K31/422 ,  A61K31/4245 ,  A61K31/427 ,  A61K31/439 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/497 ,  A61K31/5377 ,  A61K31/55 ,  A61K45/06 ,  C07D231/14 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/06 ,  C07D403/12 ,  C07D403/14 ,  C07D405/12 ,  C07D407/12 ,  C07D409/04 ,  C07D413/04 ,  C07D413/12 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D471/08 ,  C07D487/08

Abstract: This disclosure is directed to agonists of the apelin receptor (APJ) and uses of such agonists.