公开(公告)号：US3484462A

公开(公告)日：1969-12-16

申请号：US3484462D

申请日：1967-02-10

Applicant: ROUSSEL UCLAF

Inventor： BERTIN DANIEL ,  PIERDET ANDRE

IPC: C07J1/00 ,  C07J75/00 ,  C07C169/34

CPC classification number: C07J1/00 ,  C07J75/00

公开(公告)号：US3906096A

公开(公告)日：1975-09-16

申请号：US44756174

申请日：1974-03-04

Applicant: ROUSSEL UCLAF

Inventor： BUCOURT ROBERT ,  PIERDET ANDRE ,  SALMON JEAN

IPC: C07J1/00 ,  A61K31/56

CPC classification number: C07J1/0088

Abstract: 11 Beta -ALKOXY- Delta 4-GONENES OF THE FORMULA
WHEREIN R and X are alkyl of 1 to 4 carbon atoms, R1 is a saturated or unsaturated hydrocarbon of 1 to 6 carbon atoms, R2 is selected from the group consisting of hydrogen and acyl of an organic carboxylic acid of 1 to 18 carbon atoms and Y and Y'' are selected from the group consisting of hydrogen and methyl and the enolic esters thereof with an organic carboxylic acid of 1 to 18 carbon atoms which possess anti-androgenic and anti-estrogenic activity, their preparation and novel intermediates.

Abstract translation: 其中R和X为1-4个碳原子的烷基，R1为1至6个碳原子的饱和或不饱和烃基，R2选自氢和酰基 的1至18个碳原子的有机羧酸，Y和Y'选自氢和甲基及其烯醇与具有1至18个碳原子的有机羧酸，其具有抗雄激素和抗 - 雌激素活性，其制备和新型中间体。

公开(公告)号：US3579504A

公开(公告)日：1971-05-18

申请号：US3579504D

申请日：1965-04-26

Applicant: ROUSSEL UCLAF

Inventor： NOMINE GERARD ,  BUCOURT ROBERT ,  PIERDET ANDRE

IPC: C07J21/00 ,  C07J75/00 ,  C07C173/00

CPC classification number: C07J21/00 ,  C07J75/00

Abstract: THE PRESENT INVENTION RELATES TO A NEW DERIVATIVE OF $4,9-GONADIENE OF FORMULA I;

3-(O=),13-(CH3-CH2-CH2-),17-(HO-),17-(CL-C*C-)-

GONA-4,9-DIENE

AS WELL AS A PROCESS OF PREPARATION OF THE SAID COMPOUND. THE INVENTION ALSO RELATES TO INTERMEDIATES USEFUL IN THE PRODUCTION OF THE COMPOUND OF FORMULA I.

公开(公告)号：US3573284A

公开(公告)日：1971-03-30

申请号：US3573284D

申请日：1968-09-04

Applicant: ROUSSEL UCLAF

Inventor： MULLER GEORGES ,  PIERDET ANDRE

IPC: C07J1/00 ,  C07C173/00

CPC classification number: C07J1/00

Abstract: $4,9,11-GONTRIENE-3-ONES OF THE FORMULA

13-R,17-(HO-),17-(CH2=C(-R'')-CH2-)GONANE-4,9,11-TRIEN-

3-ONE

WHEREIN R IS ALKYL OF 1 TO 4 CARBON ATOMS AND R'' IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND METHYL WITH THE PROVISO THAT R IS OTHER THAN METHYL WHEN R'' IS HYDROGEN WHICH HAVE A STRONG PROGESTOMIMETIC ACTIVITY AND PROCESS FOR THEIR PREPARATION AND INTERMEDIATES FORMED THEREIN.

公开(公告)号：US3478067A

公开(公告)日：1969-11-11

申请号：US3478067D

申请日：1967-03-10

Applicant: ROUSSEL UCLAF

Inventor： BERTIN DANIEL ,  PIERDET ANDRE

IPC: C07J1/00 ,  C07J75/00 ,  C07C167/14 ,  C07C169/10

CPC classification number: C07J1/00 ,  C07J75/00

公开(公告)号：US3444297A

公开(公告)日：1969-05-13

申请号：US3444297D

申请日：1962-06-21

Applicant: ROUSSEL UCLAF

Inventor： NOMINE GERARD ,  BUCOURT ROBERT ,  PIERDET ANDRE ,  SNOZZI CANDIDO

IPC: A61K31/567 ,  C07J1/00 ,  C07J21/00 ,  C07J71/00 ,  C07J75/00 ,  A61K17/08 ,  C07C169/22

CPC classification number: A61K31/567 ,  C07J1/00 ,  C07J21/00 ,  C07J71/00 ,  C07J75/00