公开(公告)号：US3579545A

公开(公告)日：1971-05-18

申请号：US3579545D

申请日：1969-08-25

Applicant: ROUSSEL UCLAF

Inventor： BERTIN DANIEL ,  PIERDET ANDRE

IPC: A61K31/565 ,  A61K31/566 ,  A61K31/567 ,  B42F15/04 ,  C07J1/00 ,  C07J75/00 ,  C07C169/08

CPC classification number: C07J1/00 ,  A61K31/565 ,  A61K31/566 ,  A61K31/567 ,  C07J75/00 ,  Y10S514/874

Abstract: NOVEL 11B-LOWER ALKOXY-$1,3,5(10)-GONATRIENES SUBSTITUTED IN THE 3-POSITION BY A MEMBER SELECTED FROM THE GROUP CONSISTING OF HYDROXY, ALKOXY OF 1 TO 4 CARBON ATOMS, CYCLOALKOXY OF 5 TO 6 CARBON ATOMS, AND ACYLOXY, WHEREIN THE ACYL IS DERIVED FROM AN ORGANIC CARBOXYLIC ACID HAVING 1 TO 18 CARBON ATOMS, IN THE 13-POSITION BY A LOWER ALKYL RADICAL, AND IN THE 17-POSITION BY THE GROUPING.

(X-O-),(--Y)

WHEREIN X IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND ALKYL OF 1 TO 4 CARBON ATOMS, AND Y IS SELECTED FROM THE GROUP CONSISTING OF A HYDROCARBON RADICAL AND A SUBSTITUTED HYDROCARBON RADICAL. THESE COMPOUNDS POSSESS ESTROGENIC ACTIVITY.

公开(公告)号：US3526648A

公开(公告)日：1970-09-01

申请号：US3526648D

申请日：1967-06-02

Applicant: ROUSSEL UCLAF

Inventor： BERTIN DANIEL ,  PIERDET ANDRE

IPC: A61K31/565 ,  A61K31/566 ,  A61K31/567 ,  B42F15/04 ,  C07J1/00 ,  C07J75/00 ,  C07C169/08 ,  C07C169/10

CPC classification number: C07J1/00 ,  A61K31/565 ,  A61K31/566 ,  A61K31/567 ,  C07J75/00 ,  Y10S514/874

公开(公告)号：US3697510A

公开(公告)日：1972-10-10

申请号：US3697510D

申请日：1970-10-20

Applicant: ROUSSEL UCLAF

Inventor： BUCOURT ROBERT ,  NEDELEC LUCIEN ,  GASC JEAN-CLAUDE ,  PIERDET ANDRE

IPC: A61K31/57 ,  C07J5/00 ,  C07J7/00 ,  C07J21/00 ,  C07J41/00 ,  C07J51/00 ,  C07J71/00 ,  C07J75/00 ,  C07C173/00

CPC classification number: C07J5/00 ,  C07J7/0045 ,  C07J21/006 ,  C07J41/0094 ,  C07J51/00 ,  C07J71/001 ,  C07J75/00

Abstract: Novel process for the preparation of steroids of the pregnane series from certain estrane derivatives which pregnanes are intermediates for cortisone derivatives.

Abstract translation: 用于从某些雌激素衍生物制备孕烷系列类固醇的新方法，其中孕烷是可的松衍生物的中间体。

公开(公告)号：US3519654A

公开(公告)日：1970-07-07

申请号：US3519654D

申请日：1969-05-13

Applicant: ROUSSEL UCLAF

Inventor： BERTIN DANIEL ,  PIERDET ANDRE ,  NEDELEC LUCIEN ,  GASC JEAN-CLAUDE

IPC: C07J41/00 ,  C07C173/00

CPC classification number: C07J41/0027

公开(公告)号：US3494917A

公开(公告)日：1970-02-10

申请号：US3494917D

申请日：1968-03-26

Applicant: ROUSSEL UCLAF

Inventor： BERTIN DANIEL ,  PIERDET ANDRE

IPC: C07D217/26 ,  C07D499/00 ,  C07D499/76 ,  C07D99/16 ,  A61K21/00

CPC classification number: C07D499/00 ,  C07D217/26

公开(公告)号：US3922292A

公开(公告)日：1975-11-25

申请号：US47988974

申请日：1974-06-17

Applicant: ROUSSEL UCLAF

Inventor： TORELLI VESPERTO ,  PIERDET ANDRE

IPC: G01N33/53 ,  A61K31/565 ,  A61P37/04 ,  C07J1/00 ,  C07J41/00 ,  C07J71/00 ,  C07J75/00 ,  G01N33/74

CPC classification number: G01N33/743 ,  C07J1/0059 ,  C07J1/007 ,  C07J41/0005 ,  C07J71/001 ,  Y10S436/823

Abstract: Novel steroids of the formula

WHEREIN X is selected from the group consisting of O and,

Y is selected from the group consisting of hydrogen and -OH and when R1 is -(CH2)a-COOH in which a is equal to 2n + 3 and n is 0, 1 or 2, R2 is

and when R1 is hydrogen, R2 is selected from the group consisting of AND N-Z-(CH2)c-COOH, b is a number from 3 to 18, c is a number from 1 to 8 and Z is selected from the group consisting of -Oand -NHCONH- which are haptenes or compounds capable of producing antibodies in vitro but are derived of antigenic properties and their preparation.

Abstract translation: 式WHEREIN X的新型类固醇选自= O，OH ANGLE，HY选自氢和-OH，当R1是 - （CH2）a-COOH时，其中a等于 2n + 3，n为0,1或2，R2为H ANGLE H，当R1为氢时，R2选自AND = NZ-（CH2）c-COOH，b为3至18的数 ，c为1至8的数，Z选自-O-和-NHCONH-，其为半抗原或能在体外产生抗体但衍生自抗原性质及其制备的化合物。

公开(公告)号：US3518296A

公开(公告)日：1970-06-30

申请号：US3518296D

申请日：1964-04-22

Applicant: ROUSSEL UCLAF

Inventor： BUCOURT ROBERT ,  PIERDET ANDRE ,  COSTEROUSSE GERMAIN ,  HAINAUT DANIEL ,  JOLY ROBERT ,  WARNANT JULIEN ,  GOFFINET BERNARD

IPC: C07C45/67 ,  C07C69/74

CPC classification number: C07C45/676

公开(公告)号：US3472884A

公开(公告)日：1969-10-14

申请号：US3472884D

申请日：1966-10-17

Applicant: ROUSSEL UCLAF

Inventor： BERTIN DANIEL ,  PIERDET ANDRE ,  NEDELEC LUCIEN ,  GASC JEAN-CLAUDE

IPC: C07J41/00 ,  C07C167/34 ,  C07C167/30 ,  C07C169/10

CPC classification number: C07J41/0027

公开(公告)号：US3873702A

公开(公告)日：1975-03-25

申请号：US42366373

申请日：1973-12-11

Applicant: ROUSSEL UCLAF

Inventor： PIERDET ANDRE

IPC: C07J71/00 ,  A61K17/00

CPC classification number: C07J71/0047

Abstract: 21-M-SULFOBENZOATES OF 6,16 Alpha -DIMETHYL-2''-PHENYL- Delta 2,4,6-PREGNATRIENEOLO (3,2-C)-PYRAZOL-11 Beta , 17, 21-TRIOL-20ONE OF THE FORMULA

WHEREIN R is selected from the group consisting of hydrogen and alkali metal useful as anti-inflammatory agents having prolonged activity and their preparation.

Abstract translation: 6,16α-二甲基-2'-苯基 - 二乙酰基-2,4,6-三羟基苯并[3,2-C] - 吡唑-11β，17,21-三氟乙烯-20-酮的21-M-磺基甲酸酯 制剂R选自氢和碱金属，其可用作具有延长活性的抗炎剂及其制备。

公开(公告)号：US3574690A

公开(公告)日：1971-04-13

申请号：US3574690D

申请日：1968-11-13

Applicant: ROUSSEL UCLAF

Inventor： PIERDET ANDRE ,  MULLER GEORGES

IPC: A47G21/06 ,  A61K31/565 ,  A61K31/567 ,  C07J1/00 ,  C07C169/22

CPC classification number: A61K31/567 ,  A47G21/06 ,  A61K31/565 ,  C07J1/00

Abstract: $4,9,11-GONATRIENE-3-ONES OF THE FORMULA

13-R,17-(R''-O-),17-(CH3-C*C-CH2-)GONANE-4,9,11-TRIEN-

3-ONE

WHEREIN R IS ALKYL OF 1 TO 3 CARBON ATOMS AND R'' IS SELECTED FROM THE GROUP CONSISTING OF HYDROGEN AND AN ACYL RADICAL OF 1 TO 18 CARBON ATOMS AND NOVEL PROCESS AND INTERMEDIATES THEREFOR, THE SAID PRODUCTS HAVING PROGESTOMIMETIC AND HYPOPHYSIAL INHIBITING ACTIVITY.