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11.发明授权Pseudooligosaccharides with an .alpha.-glucosidase-inhibiting action, their use and pharmaceutical products 失效具有α-葡糖苷酶抑制作用的伪低聚糖，其用途和药物产品
公开(公告)号：US4632917A
公开(公告)日：1986-12-30
申请号：US771610
申请日：1985-09-03
IPC分类号： G01N33/66 , A61K8/00 , A61K8/73 , A61K31/70 , A61K31/7028 , A61K31/715 , A61P1/02 , A61P3/00 , A61P3/06 , A61P43/00 , A61Q11/00 , C07H3/06 , C07H15/00 , C07H15/22 , C08B37/00 , C12P19/04 , C12P19/12 , C12P19/44 , C12R1/465 , A61K31/73
CPC分类号： C12R1/465 , C07H15/22 , C07H3/06 , C12P19/12 , C12P19/44 , Y10S514/835 , Y10S514/866
摘要： Pseudooligosaccharides of the formula I ##STR1## in which l, m and n have the meanings given, physiologically acceptable salts thereof with acids, a process for their preparation, pharmaceutical products and their use are described. The compounds have an .alpha.-glucosidase-inhibiting action.
摘要翻译： 其中l，m和n具有给定的含义，式Ⅰ的假寡糖，其酸的生理上可接受的盐，其制备方法，药物产品及其用途。 该化合物具有α-葡糖苷酶抑制作用。
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公开(公告)号：US4379785A
公开(公告)日：1983-04-12
申请号：US217524
申请日：1980-12-17
申请人： Rudi Weyer , Volker Hitzel , Karl Geisen , Gunter Regitz
发明人： Rudi Weyer , Volker Hitzel , Karl Geisen , Gunter Regitz
IPC分类号： C07D207/27 , A61K31/40 , A61K31/4015 , A61K31/403 , A61K31/4035 , A61K31/445 , A61K31/47 , A61K31/472 , A61K31/64 , A61P3/08 , A61P3/10 , C07D207/26 , C07D207/263 , C07D207/38 , C07D209/46 , C07D211/76 , C07D217/24 , C07D223/10 , A61K31/44
CPC分类号： C07D207/27 , C07D207/38 , C07D209/46 , C07D211/76 , C07D217/24 , C07D223/10 , Y10S514/884
摘要： What are disclosed are sulfonyl ureas of the formula ##STR1## in which R.sup.1, X and Y are as defined in the specification, and their physiologically acceptable salts, pharmaceutical formulations on the basis of these compounds, and their use in the treatment of diabetes.
摘要翻译： 所公开的是式“IMAGE”的磺酰脲，其中R1，X和Y如说明书中所定义，以及它们的生理上可接受的盐，基于这些化合物的药物制剂及其在治疗糖尿病中的用途。
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13.发明授权公开(公告)号：US06476059B1
公开(公告)日：2002-11-05
申请号：US09501209
申请日：2000-02-10
申请人： Gerhard Jähne , Karl Geisen , Hans-Jochen Lang , Martin Bickel
发明人： Gerhard Jähne , Karl Geisen , Hans-Jochen Lang , Martin Bickel
IPC分类号： A61P304
CPC分类号： C07D277/60 , C07D277/82 , C07D513/04 , Y10S514/909
摘要： The invention relates to the use of polycyclic 2-aminothiazole systems and their physiologically tolerated salts and physiologically functional derivatives for the treatment of obesity. The treatment involves administration of a compound of formula I, in which the radicals have the stated meanings, and of their physiologically tolerated salts and physiologically functional derivatives.
摘要翻译： 本发明涉及多环2-氨基噻唑体系及其生理上耐受的盐和生理功能衍生物用于治疗肥胖症的用途。治疗涉及给予式I化合物，其中基团具有所述含义，以及它们 生理上耐受的盐和生理功能衍生物。
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14.发明授权公开(公告)号：US06291486B1
公开(公告)日：2001-09-18
申请号：US09604666
申请日：2000-06-27
申请人： Gerhard Jaehne , Heiner Glombik , Karl Geisen , Martin Bickel
发明人： Gerhard Jaehne , Heiner Glombik , Karl Geisen , Martin Bickel
IPC分类号： A61K314439
CPC分类号： C07D277/60 , C07D409/04
摘要： Polycyclic dihydrothiazoles, processes for their preparation, and their pharmaceutical uses are provided. Preferred compounds are represented by the formula I wherein the radicals may have various meanings. The compounds are particularly useful as anorectics.
摘要翻译： 提供多环二氢噻唑，其制备方法及其药物用途。 优选的化合物由式I表示，其中基团可以具有各种含义。 这些化合物特别适用于止痛药。
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15.发明授权公开(公告)号：US06288094B1
公开(公告)日：2001-09-11
申请号：US09774053
申请日：2001-01-31
申请人： Gerhard Jähne , Karl Geisen , Hans-Jochen Lang , Martin Bickel
发明人： Gerhard Jähne , Karl Geisen , Hans-Jochen Lang , Martin Bickel
IPC分类号： A61K31429
摘要： The invention relates to polycyclic thiazolidin-2-ylidene amines and their physiologically tolerated salts and physiologically functional derivatives. Polycyclic thiazolidin-2-ylidene amines of the formula I, in which the radicals have the stated meanings, and their physiologically tolerated salts and processes for their preparation are described. The compounds are suitable, for example as anorectics and in the treatment or prophylaxis of type II diabetes.
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16.发明授权
公开(公告)号：US6090833A
公开(公告)日：2000-07-18
申请号：US406855
申请日：1999-09-29
申请人： Gerhard Jaehne , Heiner Glombik , Karl Geisen , Martin Bickel
发明人： Gerhard Jaehne , Heiner Glombik , Karl Geisen , Martin Bickel
IPC分类号： A61K31/428 , A61K31/44 , A61K31/4439 , A61K45/00 , A61P3/04 , A61P3/10 , C07D277/60 , C07D409/04 , C07D417/04 , C07D417/06 , C07D417/10 , C07D417/12 , C07D417/14
CPC分类号： C07D277/60 , C07D409/04
摘要： Polycyclic dihydrothiazoles, processes for their preparation, and their pharmaceutical uses are provided. Preferred compounds are represented by the formula I ##STR1## wherein the radicals may have various meanings. The compounds are particularly useful as anorectics.
摘要翻译： 提供多环二氢噻唑，其制备方法及其药物用途。 优选的化合物由式I表示，其中基团可以具有各种含义。 这些化合物特别适用于止痛药。
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公开(公告)号：US4315940A
公开(公告)日：1982-02-16
申请号：US211331
申请日：1980-11-26
申请人： Volker Hitzel , Rudi Weyer , Karl Geisen , Gunter Regitz
发明人： Volker Hitzel , Rudi Weyer , Karl Geisen , Gunter Regitz
IPC分类号： C07D401/12 , A61K31/4427 , A61K31/4465 , A61K31/45 , A61P3/08 , C07D211/96 , A61K31/445
CPC分类号： C07D211/96 , Y10S514/866
摘要： Sulfonylureas of the formula ##STR1## wherein n, R, R.sup.1 and X have the indicated meanings, as well as their physiologically acceptable salts, pharmaceutical preparations on the basis of these compounds and their use for treating diabetes.
摘要翻译： 其中n，R，R 1和X具有指定含义的磺酰脲，以及它们的生理上可接受的盐，这些化合物的药物制剂及其用于治疗糖尿病的用途。
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公开(公告)号：US4157395A
公开(公告)日：1979-06-05
申请号：US903548
申请日：1978-05-08
申请人： Volker Hitzel , Rudi Weyer , Werner Pfaff , Karl Geisen
发明人： Volker Hitzel , Rudi Weyer , Werner Pfaff , Karl Geisen
IPC分类号： C07D213/81 , A61K31/63 , A61P3/08 , A61P3/10 , C07D213/82 , C07D213/56 , A61K31/44
CPC分类号： C07D213/82 , Y10S514/866
摘要： Benzenesulfonyl ureas of the formula ##STR1## in which R, R.sup.1, X, X.sup.1 and Y have the defined meanings, and the salts thereof, process for preparing these compounds, pharmaceutical preparations containing them and their use for lowering the blood sugar level.
摘要翻译： 其中R，R1，X，X1和Y具有定义的式“IMAGE”的苯磺酰脲及其盐，制备这些化合物的方法，含有它们的药物制剂及其降低血糖水平的用途。
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公开(公告)号：US06329407B1
公开(公告)日：2001-12-11
申请号：US09500463
申请日：2000-02-09
申请人： Gerhard Jähne , Karl Geisen , Hans-Jochen Lang , Martin Bickel
发明人： Gerhard Jähne , Karl Geisen , Hans-Jochen Lang , Martin Bickel
IPC分类号： A61K31425
CPC分类号： A61K31/428 , A61K31/425 , A61K2300/00
摘要： The invention relates to the use of polycyclic thiazole systems and their physiologically tolerated salts and physiologically functional derivatives for the treatment of obesity. The treatment involves administration of a compound of formula I, in which the radicals have the stated meanings, and of their physiologically tolerated salts and physiologically functional derivatives.
摘要翻译： 本发明涉及多环噻唑体系及其生理学耐受盐和生理功能衍生物用于治疗肥胖症的用途。治疗涉及给予式Ⅰ化合物，其中自由基具有所述含义及其生理耐受性 盐和生理功能衍生物。
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20.发明授权Polycyclic 2- aminothiazole systems, processes for their preparation and pharmaceuticals comprising these compounds 有权多环2-氨基噻唑体系，其制备方法和包含这些化合物的药物公开(公告)号：US06251922B1
公开(公告)日：2001-06-26
申请号：US09501208
申请日：2000-02-10
申请人： Gerhard Jähne , Karl Geisen , Hans-Jochen Lang , Martin Bickel
发明人： Gerhard Jähne , Karl Geisen , Hans-Jochen Lang , Martin Bickel
IPC分类号： A61K314439
CPC分类号： C07D277/60
摘要： The invention relates to polycyclic 2-aminothiazole systems and their physiologically tolerated salts and physiologically functional derivatives. The polycyclic 2-aminothiazole systems are according to formula I, in which the radicals have the stated meanings, and their physiologically tolerated salts and processes for their preparation are described. The compounds are suitable, for example, as anorectics.
摘要翻译： 本发明涉及多环2-氨基噻唑体系及其生理上耐受的盐和生理功能衍生物。 多环2-氨基噻唑系统是根据式I，其中基团具有所述含义，并且描述了它们的生理学耐受盐及其制备方法。 所述化合物例如适合作为抗精神病药。
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