-
公开(公告)号：US08410093B2
公开(公告)日：2013-04-02
申请号：US12951949
申请日：2010-11-22
申请人： Hui Li , Ankush Argade , Rajinder Singh , Sambaiah Thota , David Carroll , Kin Tso , Vanessa Taylor , John McLaughlin , Vadim Markovtsov
发明人： Hui Li , Ankush Argade , Rajinder Singh , Sambaiah Thota , David Carroll , Kin Tso , Vanessa Taylor , John McLaughlin , Vadim Markovtsov
IPC分类号： C07D239/48 , A61K31/506
CPC分类号： C07D239/48 , A61K31/505 , A61K31/506 , C07D205/12 , C07D239/42 , C07D295/155 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D471/08 , C07D487/08
摘要： The present disclosure provides 2,4-pyrimidinediamine compounds having antiproliferative activity, compositions comprising the compounds and methods of using the compounds to inhibit cellular proliferation and to treat proliferate diseases such as tumorigenic cancers.
摘要翻译： 本公开提供具有抗增殖活性的2,4-嘧啶二胺化合物，包含该化合物的组合物和使用该化合物抑制细胞增殖并治疗增殖性疾病如致瘤性癌症的方法。
-
12.发明申请公开(公告)号：US20180072756A1
公开(公告)日：2018-03-15
申请号：US15468467
申请日：2017-03-24
申请人： Rajinder Singh , Ankush Argade , Hui Li , Somasekhar Bhamidipati , David Carroll , Catherine Sylvain , Jeffrey Clough , Holger Keim
发明人： Rajinder Singh , Ankush Argade , Hui Li , Somasekhar Bhamidipati , David Carroll , Catherine Sylvain , Jeffrey Clough , Holger Keim
IPC分类号： C07D498/04 , C07D498/06 , C07D417/14 , C07D417/12 , C07D413/14 , A61K31/506 , C07D405/14 , C07D405/12 , C07D403/12 , A61K31/541 , C07D413/12
CPC分类号： C07D498/04 , A61K31/506 , A61K31/538 , A61K31/541 , A61P19/02 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D498/02 , C07D498/06
摘要： The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms associated with such diseases. Specific examples of autoimmune diseases that can be treated or prevented with the compounds include rheumatoid arthritis and/or its associated symptoms, systemic lupus erythematosis and/or its associated symptoms and multiple sclerosis and/or its associated symptoms.
-
公开(公告)号：US20150133404A1
公开(公告)日：2015-05-14
申请号：US14534784
申请日：2014-11-06
IPC分类号： A61K31/675
CPC分类号： A61K31/675 , A61K9/0053 , C07D498/04 , C07F9/6561
摘要： The present disclosure provides prodrugs of biologically active 2,4-pyrimidinediamine compounds, salts and hydrates of the prodrugs, compositions comprising the prodrugs, intermediates and methods for synthesizing the prodrugs and methods of using the prodrugs in a variety of applications.
摘要翻译： 本公开提供了前体药物的生物活性2,4-嘧啶二胺化合物，盐和水合物的前药，包含前体药物的组合物，用于合成前药的中间体和方法以及在各种应用中使用前药的方法。
-
公开(公告)号：US08476263B2
公开(公告)日：2013-07-02
申请号：US13475037
申请日：2012-05-18
IPC分类号： A61K31/5383
CPC分类号： C07D498/04 , A61K31/5383 , A61K31/675 , C07F9/65583 , C07F9/6561 , C07F9/65742
摘要： The present disclosure provides prodrugs of biologically active 2,4-pyrimidinediamine compounds, compositions comprising the prodrugs, intermediates and methods for synthesizing the prodrugs and methods of using the prodrugs in a variety of applications.
摘要翻译： 本公开提供了生物活性2,4-嘧啶二胺化合物的前药，包含前体药物的组合物，用于合成前药的中间体和方法以及在各种应用中使用前药的方法。
-
公开(公告)号：US08415365B2
公开(公告)日：2013-04-09
申请号：US12030031
申请日：2008-02-12
申请人： Hui Li , Sambaiah Thota , David Carroll , Ankush Argade , Kin Tso , Arvinder Sran , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Vanessa Taylor , Robin Cooper , Rajinder Singh , Brian Wong
发明人： Hui Li , Sambaiah Thota , David Carroll , Ankush Argade , Kin Tso , Arvinder Sran , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Vanessa Taylor , Robin Cooper , Rajinder Singh , Brian Wong
IPC分类号： C07D239/48 , A61K31/505
CPC分类号： C07D413/12 , A61K31/343 , A61K31/436 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/541 , A61K31/695 , A61K38/13 , A61K39/3955 , A61K45/06 , C07D239/42 , C07D239/48 , C07D285/22 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D413/14 , C07D417/12 , C07D498/04 , C07F7/0812 , C07F7/10
摘要： The invention encompasses compounds having formula I-V and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, may be therapeutically useful.
-
公开(公告)号：US08399472B2
公开(公告)日：2013-03-19
申请号：US12193627
申请日：2008-08-18
申请人： Hui Li , Sambaiah Thota , David Carroll , Ankush Argade , Kin Tso , Arvinder Sran , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Vanessa Taylor , Robin Cooper , Rajinder Singh , Brian Wong
发明人： Hui Li , Sambaiah Thota , David Carroll , Ankush Argade , Kin Tso , Arvinder Sran , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Vanessa Taylor , Robin Cooper , Rajinder Singh , Brian Wong
IPC分类号： C07D239/48 , A61K31/506
CPC分类号： C07D413/12 , A61K31/343 , A61K31/436 , A61K31/505 , A61K31/506 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/541 , A61K31/695 , A61K38/13 , A61K39/3955 , A61K45/06 , C07D239/42 , C07D239/48 , C07D285/22 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D413/14 , C07D417/12 , C07D498/04 , C07F7/0812 , C07F7/10
摘要： The invention encompasses compounds having formula I-V and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, may be therapeutically useful.
-
17.发明申请PYRIMIDINE-2-AMINE COMPOUNDS AND THEIR USE AS INHIBITORS OF JAK KINASES 有权吡嗪-2-胺化合物及其作为JAK KINASES的抑制剂的用途公开(公告)号：US20130018041A1
公开(公告)日：2013-01-17
申请号：US13619843
申请日：2012-09-14
申请人： Somasekhar Bhamidipati , Jeffrey Clough , Ankush Argade , Rajinder Singh , Vadim Markovtosov , Pingyu Ding , Jiaxin Yu , Andy Atuegbu , Hui Hong , Ihab Darwish , Sambaiah Thota
发明人： Somasekhar Bhamidipati , Jeffrey Clough , Ankush Argade , Rajinder Singh , Vadim Markovtosov , Pingyu Ding , Jiaxin Yu , Andy Atuegbu , Hui Hong , Ihab Darwish , Sambaiah Thota
IPC分类号： A61K31/506 , A61K31/5377 , A61K31/5386 , A61K31/538 , A61K31/551 , A61K31/553 , A61K31/541 , A61K31/5415 , A61K31/55 , A61P35/02 , A61P35/00 , A61P37/06 , A61P29/00 , A61P7/00 , A61K31/5383
CPC分类号： C07D487/08 , C07D451/00 , C07D451/04 , C07D491/08 , C07D519/00
摘要： This invention is directed to compounds of formula (I): where n, m, Y, R1, R2, R3, R4 and R5 are disclosed herein, as isolated stereoisomers or mixtures thereof, or pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising the compounds of formula (I); and methods of using the compounds and the pharmaceutical compositions in treating diseases or conditions associated with JAK2 activity.
摘要翻译： 本发明涉及式（I）的化合物：其中n，m，Y，R 1，R 2，R 3，R 4和R 5在本文中公开，作为其分离的立体异构体或其混合物或其药学上可接受的盐; 包含式（I）化合物的药物组合物; 以及使用化合物和药物组合物治疗与JAK2活性相关的疾病或病症的方法。
-
18.发明授权2,4-pyrimidinediamine compounds for treating or preventing autoimmune diseases 有权用于治疗或预防自身免疫疾病的2,4-嘧啶二胺化合物公开(公告)号：US08314093B2
公开(公告)日：2012-11-20
申请号：US12642406
申请日：2009-12-18
IPC分类号： C07D498/04 , A61K31/538
CPC分类号： C07D417/12 , C07D401/12 , C07D403/12 , C07D413/12 , C07D413/14 , C07D498/04
摘要： The present invention provides 3-hydroxyphenyl-2,4-pyrimidinediamine compounds of formula I, as well as related compositions and methods for treating a variety of autoimmune diseases.
摘要翻译： 本发明提供式I的3-羟基苯基-2,4-嘧啶二胺化合物，以及用于治疗多种自身免疫疾病的相关组合物和方法。
-
19.发明申请Methods of Treating or Preventing Autoimmune Diseases With 2,4-Pyrimidinediamine Compounds 有权用2,4-嘧啶二胺化合物治疗或预防自身免疫性疾病的方法公开(公告)号：US20120230984A1
公开(公告)日：2012-09-13
申请号：US13418696
申请日：2012-03-13
申请人： Rajinder Singh , Ankush Argade , Donald G. Payan , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li
发明人： Rajinder Singh , Ankush Argade , Donald G. Payan , Jeffrey Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li
IPC分类号： A61K31/506 , A61K31/5383 , A61K31/56 , A61K31/616 , A61K31/519 , A61P37/06 , A61P37/08 , A61K39/395 , A61P7/06 , A61P25/00 , A61P7/00 , A61P27/02 , A61P21/04 , A61P1/16 , A61P13/12 , A61P29/00 , A61P19/02 , A61P19/04 , A61K31/538
CPC分类号： A61K31/506 , A61K31/519 , C07D401/12 , C07D403/12 , C07D405/12 , C07D407/12 , C07D413/12 , C07D413/14 , C07D471/04 , C07D498/04 , Y10S514/825 , Y10S514/903
摘要： The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms associated with such diseases. Specific examples of autoimmune diseases that can be treated or prevented with the compounds include rheumatoid arthritis and/or its associated symptoms, systemic lups erythematosis and/or its associated symptoms and multiple sclerosis and/or its associated symptoms.
摘要翻译： 本发明提供了用2,4-嘧啶二胺化合物治疗或预防自身免疫疾病的方法，以及治疗，预防或改善与这些疾病相关的症状的方法。 可以用化合物治疗或预防的自身免疫性疾病的具体实例包括类风湿性关节炎和/或其相关症状，系统性红斑狼疮病和/或其相关症状和多发性硬化症和/或其相关症状。
-
20.发明授权Methods of treating or preventing autoimmune diseases with 2, 4-pyrimidinediamine compounds 有权用2,4-嘧啶二胺化合物治疗或预防自身免疫性疾病的方法公开(公告)号：US08178671B2
公开(公告)日：2012-05-15
申请号：US10903263
申请日：2004-07-30
申请人： Rajinder Singh , Ankush Argade , Hui Li , Somasekhar Bhamidipati , David Carroll , Catherine Sylvain , Jeffrey Clough , Holger Keim
发明人： Rajinder Singh , Ankush Argade , Hui Li , Somasekhar Bhamidipati , David Carroll , Catherine Sylvain , Jeffrey Clough , Holger Keim
IPC分类号： C07D239/48 , C07D403/12 , C07D403/14 , C07D413/12 , C07D417/12 , A61K31/506 , A61K31/498 , A61K31/5375 , A61K31/5383 , A61K31/5415 , A61P19/02
CPC分类号： C07D498/04 , A61K31/506 , A61K31/541 , C07D403/12 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D498/06
摘要： The present invention provides methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds, as well as methods of treating, preventing or ameliorating symptoms associated with such diseases. Specific examples of autoimmune diseases that can be treated or prevented with the compounds include rheumatoid arthritis and/or its associated symptoms, systemic lups erythematosis and/or its associated symptoms and multiple sclerosis and/or its associated symptoms.
摘要翻译： 本发明提供了用2,4-嘧啶二胺化合物治疗或预防自身免疫疾病的方法，以及治疗，预防或改善与这些疾病相关的症状的方法。 可以用化合物治疗或预防的自身免疫性疾病的具体实例包括类风湿性关节炎和/或其相关症状，系统性红斑狼疮和/或其相关症状和多发性硬化症和/或其相关症状。
-
-
-
-
-
-
-
-
-
搜索结果
365 条记录 (耗时 0.102 秒)
