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1.发明授权2,4-pyrimidinediamine compounds for treating or preventing autoimmune diseases 有权用于治疗或预防自身免疫疾病的2,4-嘧啶二胺化合物公开(公告)号：US08314093B2
公开(公告)日：2012-11-20
申请号：US12642406
申请日：2009-12-18
IPC分类号： C07D498/04 , A61K31/538
CPC分类号： C07D417/12 , C07D401/12 , C07D403/12 , C07D413/12 , C07D413/14 , C07D498/04
摘要： The present invention provides 3-hydroxyphenyl-2,4-pyrimidinediamine compounds of formula I, as well as related compositions and methods for treating a variety of autoimmune diseases.
摘要翻译： 本发明提供式I的3-羟基苯基-2,4-嘧啶二胺化合物，以及用于治疗多种自身免疫疾病的相关组合物和方法。
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2.发明授权2,4-pyrimidinediamine compounds for treating or preventing autoimmune diseases 有权用于治疗或预防自身免疫疾病的2,4-嘧啶二胺化合物公开(公告)号：US07659280B2
公开(公告)日：2010-02-09
申请号：US11676096
申请日：2007-02-16
IPC分类号： C07D403/12 , C07D411/12 , C07D413/12 , C07D417/12 , A61K31/506 , A61K31/535 , A61K31/541 , A61P19/02
CPC分类号： C07D417/12 , C07D401/12 , C07D403/12 , C07D413/12 , C07D413/14 , C07D498/04
摘要： The present invention provides 3-hydroxyphenyl-2,4-pyrimidinediamine compounds of formula I, as well as related compositions and methods for treating a variety of autoimmune diseases.
摘要翻译： 本发明提供式I的3-羟基苯基-2,4-嘧啶二胺化合物，以及用于治疗多种自身免疫疾病的相关组合物和方法。
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3.发明申请2,4-PYRIMIDINEDIAMINE COMPOUNDS FOR TREATING OR PREVENTING AUTOIMMUNE DISEASES 有权用于治疗或预防自发性疾病的2,4-二吡啶二胺化合物公开(公告)号：US20100152172A1
公开(公告)日：2010-06-17
申请号：US12642406
申请日：2009-12-18
IPC分类号： A61K31/5415 , A61K31/538 , A61K31/506 , A61P29/00 , A61P37/00 , C12N5/00
CPC分类号： C07D417/12 , C07D401/12 , C07D403/12 , C07D413/12 , C07D413/14 , C07D498/04
摘要： The present invention provides 3-hydroxyphenyl-2,4-pyrimidinediamine compounds of formula I, as well as related compositions and methods for treating a variety of autoimmune diseases.
摘要翻译： 本发明提供式I的3-羟基苯基-2,4-嘧啶二胺化合物，以及用于治疗多种自身免疫疾病的相关组合物和方法。
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4.发明申请2,4-PYRIMIDINEDIAMINE COMPOUNDS FOR TREATING OR PREVENTING AUTOIMMUNE DISEASES 有权用于治疗或预防自发性疾病的2,4-二吡啶二胺化合物公开(公告)号：US20070197782A1
公开(公告)日：2007-08-23
申请号：US11676096
申请日：2007-02-16
IPC分类号： C07D417/02 , C07D413/02 , C07D403/02
CPC分类号： C07D417/12 , C07D401/12 , C07D403/12 , C07D413/12 , C07D413/14 , C07D498/04
摘要： The present invention provides 3-hydroxyphenyl-2,4-pyrimidinediamine compounds of formula I, as well as related compositions and methods for treating a variety of autoimmune diseases.
摘要翻译： 本发明提供式I的3-羟基苯基-2,4-嘧啶二胺化合物，以及用于治疗多种自身免疫疾病的相关组合物和方法。
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公开(公告)号：US20110027856A1
公开(公告)日：2011-02-03
申请号：US12902052
申请日：2010-10-11
申请人： Hui Li , Vanessa Taylor , Somasekhar Bhamidipati , John Ramphal , Kin Tso , Arvinder Sran , Holger Keim , Vadim Markovtsov , David Carroll , Sambaiah Thota , Ankush Argade , Jeffrey Wayne Clough , Rajinder Singh , Robin Cooper
发明人： Hui Li , Vanessa Taylor , Somasekhar Bhamidipati , John Ramphal , Kin Tso , Arvinder Sran , Holger Keim , Vadim Markovtsov , David Carroll , Sambaiah Thota , Ankush Argade , Jeffrey Wayne Clough , Rajinder Singh , Robin Cooper
IPC分类号： C12N9/99
CPC分类号： A61K31/506 , A61K31/5375 , A61K31/538 , A61K31/5383 , C07D239/48 , C07D239/49 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D491/04 , C07D498/04
摘要： The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.
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公开(公告)号：US07834024B2
公开(公告)日：2010-11-16
申请号：US12053438
申请日：2008-03-21
申请人： Hui Li , Vanessa Taylor , Somasekhar Bhamidipati , John Ramphal , Kin Tso , Avinder Sran , Holger Keim , Vadim Markovtsov , David Carroll , Sambaiah Thota , Ankush Argade , Jeffrey Wayne Clough , Rajinder Singh , Robin Cooper
发明人： Hui Li , Vanessa Taylor , Somasekhar Bhamidipati , John Ramphal , Kin Tso , Avinder Sran , Holger Keim , Vadim Markovtsov , David Carroll , Sambaiah Thota , Ankush Argade , Jeffrey Wayne Clough , Rajinder Singh , Robin Cooper
IPC分类号： A61K31/505
CPC分类号： A61K31/506 , A61K31/5375 , A61K31/538 , A61K31/5383 , C07D239/48 , C07D239/49 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D491/04 , C07D498/04
摘要： The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.
摘要翻译： 本发明包括具有式I的化合物和使用这些化合物的组合物和方法用于治疗JAK途径的调节或JAK激酶，特别是JAK3的抑制在治疗上有用的条件。
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公开(公告)号：US08188276B2
公开(公告)日：2012-05-29
申请号：US12363537
申请日：2009-01-30
申请人： Rajinder Singh , Ankush Argade , Donald G Payan , Susan Molineaux , Sasha J Holland , Jeffrey Wayne Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li , Alexander B Rossi
发明人： Rajinder Singh , Ankush Argade , Donald G Payan , Susan Molineaux , Sasha J Holland , Jeffrey Wayne Clough , Holger Keim , Somasekhar Bhamidipati , Catherine Sylvain , Hui Li , Alexander B Rossi
IPC分类号： C07D239/02 , A61K31/505
CPC分类号： A61K31/505 , A61K31/506 , A61K31/519 , A61K31/5377 , A61K31/538 , A61K31/5383 , A61K31/5395 , A61K31/551 , A61K45/06 , C07D239/48 , C07D265/36 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D407/14 , C07D409/12 , C07D409/14 , C07D413/10 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D495/04 , C07D498/04 , C07D498/14 , C07F5/027
摘要： The present invention provides 2,4-pyrimidinediamine compounds that inhibit the IgE and/or IgG receptor signaling cascades that lead to the release of chemical mediators, intermediates and methods of synthesizing the compounds and methods of using the compounds in a variety of contexts, including in the treatment and prevention of diseases characterized by, caused by or associated with the release of chemical mediators via degranulation and other processes effected by activation of the IgE and/or IgG receptor signaling cascades.
摘要翻译： 本发明提供了抑制导致释放化学介质，中间体和合成化合物的方法的IgE和/或IgG受体信号级联的2,4-嘧啶二胺化合物和在多种情况下使用化合物的方法，包括 在治疗和预防以IgE和/或IgG受体信号传导级联的活化作用通过脱颗粒和其它方法释放化学介质引起或与之相关的疾病。
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公开(公告)号：US07947698B2
公开(公告)日：2011-05-24
申请号：US12053382
申请日：2008-03-21
申请人： Andy Atuegbu , Vadim Markovtsov , Somasekhar Bhamidipati , Rajinder Singh , Vanessa Taylor , Sambaiah Thota , Jeffrey Wayne Clough , David Carroll , Hui Li , Robin Cooper
发明人： Andy Atuegbu , Vadim Markovtsov , Somasekhar Bhamidipati , Rajinder Singh , Vanessa Taylor , Sambaiah Thota , Jeffrey Wayne Clough , David Carroll , Hui Li , Robin Cooper
IPC分类号： C07D239/02 , A01N43/54
CPC分类号： C07D239/48
摘要： The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.
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公开(公告)号：US08299087B2
公开(公告)日：2012-10-30
申请号：US12902052
申请日：2010-10-11
申请人： Hui Li , Vanessa Taylor , Somasekhar Bhamidipati , John Ramphal , Kin Tso , Arvinder Sran , Holger Keim , Vadim Markovtsov , David Carroll , Sambaiah Thota , Ankush Argade , Jeffrey Wayne Clough , Rajinder Singh , Robin Cooper
发明人： Hui Li , Vanessa Taylor , Somasekhar Bhamidipati , John Ramphal , Kin Tso , Arvinder Sran , Holger Keim , Vadim Markovtsov , David Carroll , Sambaiah Thota , Ankush Argade , Jeffrey Wayne Clough , Rajinder Singh , Robin Cooper
IPC分类号： A61K31/505
CPC分类号： A61K31/506 , A61K31/5375 , A61K31/538 , A61K31/5383 , C07D239/48 , C07D239/49 , C07D401/12 , C07D401/14 , C07D403/12 , C07D403/14 , C07D405/12 , C07D405/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D491/04 , C07D498/04
摘要： The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.
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公开(公告)号：US20080279867A1
公开(公告)日：2008-11-13
申请号：US12053382
申请日：2008-03-21
申请人： Andy Atuegbu , Vadim Markovtsov , Somasekhar Bhamidipati , Rajinder Singh , Vanessa Taylor , Sambaiah Thota , Jeffrey Wayne Clough , David Carroll , Hui Li , Robin Cooper
发明人： Andy Atuegbu , Vadim Markovtsov , Somasekhar Bhamidipati , Rajinder Singh , Vanessa Taylor , Sambaiah Thota , Jeffrey Wayne Clough , David Carroll , Hui Li , Robin Cooper
IPC分类号： A61K39/395 , C07D413/12 , C12N9/99 , A61K31/538 , C07D239/48 , A61K31/505 , C12N5/06 , A61K31/506 , C07D403/12 , A61P37/00 , A61P37/06
CPC分类号： C07D239/48
摘要： The invention encompasses compounds having formula I and the compositions and methods using these compounds in the treatment of conditions in which modulation of the JAK pathway or inhibition of JAK kinases, particularly JAK3, are therapeutically useful.
摘要翻译： 本发明包括具有式I的化合物和使用这些化合物的组合物和方法用于治疗JAK途径的调节或JAK激酶，特别是JAK3的抑制在治疗上有用的条件。
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